Opportunity Information: Apply for PAR 13 109
Apply for PAR 13 109
- The National Institutes of Health in the food and nutrition health income security and social services sector is offering a public funding opportunity titled "Mechanistic Insights from Birth Cohorts (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113 Environmental Health 93.399 Cancer Control 93.838 Lung Diseases Research 93.839 Blood Diseases and Resources Research 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Jul 11, 2013 and posted on Feb 6, 2013.
- Applicants must submit their applications by May 7, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- Eligible applicants include: County governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses City or township governments Public housing authorities/Indian housing authorities For profit organizations other than small businesses Special district governments State governments Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal governments (Federally recognized) Independent school districts Private institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
Mechanistic Insights from Birth Cohorts (R01) (Funding Opportunity Number PAR-13-109) was a National Institutes of Health (NIH) discretionary grant opportunity designed to fund R01 research projects that use existing birth cohort studies to answer focused, mechanistic questions about how prenatal exposures shape health and disease across the lifespan. The central theme is the developmental origins of health and disease: the idea that exposures during pregnancy can influence how organs and biological systems develop, potentially increasing or decreasing risk for chronic diseases and other long-term health conditions later in childhood, adolescence, or adulthood. Rather than supporting the creation of brand-new cohorts, the FOA emphasized leveraging established, well-characterized birth cohorts that already have participants, samples, exposure information, and follow-up data, so investigators can move quickly into hypothesis-driven analyses that reveal biological pathways.
The research scope covered both normal and abnormal development of organ systems, with a clear emphasis on mechanistic insight. Projects were expected to go beyond simply showing that an exposure is associated with an outcome; the intent was to clarify how and why those relationships happen. In practical terms, this could include examining biological mediators and pathways such as endocrine signaling, immune programming, epigenetic regulation, oxidative stress, metabolism, placental function, or early-life changes in lung, cardiovascular, kidney, neurodevelopmental, or hematologic systems. The participating NIH Institutes and Centers signaled broad interests spanning environmental health, cancer control, lung diseases, blood diseases and resources, diabetes/digestive/kidney diseases, and child health and human development, as reflected in the CFDA listings (93.113, 93.399, 93.838, 93.839, 93.847, 93.865). The overall aim was to use cohort resources to pinpoint actionable mechanisms that connect prenatal environments to later chronic disease risk, potentially informing prevention strategies and early interventions.
From an administrative perspective, this was an R01 grant mechanism with an award ceiling listed at $500,000. Cost sharing or matching was not required. The opportunity was posted February 6, 2013, with the funding announcement created July 11, 2013. The original and final closing date was May 7, 2016, and it was archived June 7, 2016. NIH was the sponsoring agency, and applicants were directed to the full FOA text at the NIH grants guide page (http://grants.nih.gov/grants/guide/pa-files/PAR-13-109.html). For technical issues accessing the announcement, the NIH Office of Extramural Research (OER) webmaster contact was provided.
Eligibility was intentionally broad to encourage participation from many sectors with access to cohort data or the capacity to collaborate with cohort-holding institutions. Eligible applicants included public and private institutions of higher education, nonprofits (including those with and without 501(c)(3) status), small businesses and other for-profit organizations (other than small businesses), and a wide range of government entities (state, county, city/township, special district governments, independent school districts, and public housing authorities/Indian housing authorities). Tribal entities were eligible, including federally recognized tribal governments and other tribal organizations, as were tribally controlled colleges and universities. The FOA also allowed applications from foreign organizations and foreign institutions, as well as non-U.S. components of U.S. organizations, and permitted foreign components as defined by the NIH Grants Policy Statement. It explicitly included institutions and organizations serving specific populations, such as HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian serving institutions, and Asian American Native American Pacific Islander-serving institutions, along with faith-based or community-based organizations and regional organizations.
In short, PAR-13-109 sought to accelerate rigorous, mechanism-focused science on prenatal exposures and later-life chronic disease by capitalizing on the depth and longitudinal power of existing birth cohorts. The emphasis was on targeted hypotheses and biological explanation, not just correlation, aligning developmental biology, epidemiology, and disease-focused research priorities across multiple NIH components.
Frequently Asked Questions (FAQs): Mechanistic Insights from Birth Cohorts (R01) - PAR-13-109
1. What is the PAR-13-109 funding opportunity?
PAR-13-109, titled "Mechanistic Insights from Birth Cohorts (R01)," was a National Institutes of Health (NIH) discretionary grant opportunity that funded R01 research projects using existing birth cohort studies to answer focused, mechanistic questions about how prenatal exposures influence health and disease across the lifespan.
2. What was the main scientific theme of this opportunity?
The central theme was the developmental origins of health and disease, meaning exposures during pregnancy can affect how organs and biological systems develop and may change risk for chronic diseases and other long-term health conditions later in life (childhood, adolescence, or adulthood).
3. What type of grant mechanism did this opportunity use?
This opportunity used the NIH R01 research project grant mechanism.
4. What kind of studies were applicants expected to use?
Applicants were expected to leverage established, well-characterized birth cohorts that already had participants, biological samples, exposure information, and follow-up data. The opportunity emphasized using existing cohorts rather than creating new ones.
5. Did the FOA support creating a brand-new birth cohort?
No. The FOA emphasized leveraging existing birth cohort studies instead of supporting the creation of brand-new cohorts.
6. What did NIH mean by "mechanistic" questions in this program?
Projects were expected to go beyond demonstrating that a prenatal exposure is associated with a later outcome. The intent was to clarify how and why those relationships occur by identifying biological mediators, pathways, or processes connecting exposures to later health outcomes.
7. What kinds of biological pathways or mediators were relevant to this FOA?
Examples mentioned included endocrine signaling, immune programming, epigenetic regulation, oxidative stress, metabolism, placental function, and early-life changes in organ systems.
8. Which organ systems and development areas were included in the research scope?
The scope covered both normal and abnormal development of organ systems, including early-life changes in lung, cardiovascular, kidney, neurodevelopmental, and hematologic systems.
9. What was the overall purpose or end goal of the funded research?
The overall aim was to use birth cohort resources to pinpoint actionable mechanisms linking prenatal environments to later chronic disease risk, potentially informing prevention strategies and early interventions.
10. Which NIH agency sponsored the opportunity?
The sponsoring agency was the National Institutes of Health (NIH).
11. Which NIH mission areas were reflected in the participating interests?
The participating NIH Institutes and Centers signaled broad interests spanning environmental health, cancer control, lung diseases, blood diseases and resources, diabetes/digestive/kidney diseases, and child health and human development.
12. Which CFDA program listings were associated with this opportunity?
The CFDA listings provided were 93.113, 93.399, 93.838, 93.839, 93.847, and 93.865.
13. What was the award ceiling listed for this opportunity?
The award ceiling was listed at $500,000.
14. Was cost sharing or matching required?
No. Cost sharing or matching was not required.
15. When was the opportunity posted?
The opportunity was posted on February 6, 2013.
16. When was the funding announcement created?
The funding announcement was created on July 11, 2013.
17. What was the closing date for applications?
The original and final closing date was May 7, 2016.
18. Is this funding opportunity still open?
No. The opportunity was archived on June 7, 2016.
19. Where could applicants find the full FOA text?
Applicants were directed to the NIH Grants Guide page for the full FOA text at: http://grants.nih.gov/grants/guide/pa-files/PAR-13-109.html
20. Who was listed as a contact for technical issues accessing the announcement?
For technical issues accessing the announcement, the NIH Office of Extramural Research (OER) webmaster contact was provided.
21. Who was eligible to apply?
Eligibility was broad and included public and private institutions of higher education; nonprofits (with and without 501(c)(3) status); small businesses; other for-profit organizations (other than small businesses); and many types of government entities.
22. What types of government entities were eligible?
Eligible government entities included state, county, city/township, special district governments, independent school districts, and public housing authorities/Indian housing authorities.
23. Were tribal entities eligible to apply?
Yes. Federally recognized tribal governments and other tribal organizations were eligible, as were tribally controlled colleges and universities.
24. Were foreign organizations or institutions allowed to apply?
Yes. The FOA allowed applications from foreign organizations and foreign institutions, as well as non-U.S. components of U.S. organizations, and permitted foreign components as defined by the NIH Grants Policy Statement.
25. Did the FOA encourage participation from organizations serving specific populations?
Yes. It explicitly included institutions and organizations serving specific populations, including HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian serving institutions, and Asian American Native American Pacific Islander-serving institutions.
26. Were faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations were included among eligible applicants.
27. What was the practical advantage of using existing cohorts under this FOA?
By relying on cohorts with existing participants, samples, exposure data, and follow-up information, investigators could move more quickly into hypothesis-driven analyses aimed at identifying biological pathways.
28. What kinds of prenatal factors were the focus of these studies?
The FOA focused on prenatal exposures during pregnancy and how those exposures shape development and later health and disease risk across the lifespan.
29. What made a project a good fit, based on the FOA description?
A good fit was a targeted, hypothesis-driven R01 project that used an existing birth cohort to investigate mechanisms explaining how prenatal exposures affect later outcomes, rather than stopping at exposure-outcome correlations.
30. What is the short summary of what PAR-13-109 tried to accomplish?
PAR-13-109 sought to accelerate rigorous, mechanism-focused research on how prenatal exposures influence later-life chronic disease risk by capitalizing on the depth and longitudinal power of established birth cohorts.
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