Opportunity Information: Apply for PA 08 030
Apply for PA 08 030
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Exfoliated Cells, Bioactive Food Components, and Cancer (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393 Cancer Cause and Prevention Research 93.399 Cancer Control.
- This funding opportunity was created on Dec 5, 2008 and posted on Nov 26, 2007.
- Applicants must submit their applications by Jan 7, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Small businesses County governments Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Independent school districts Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments Special district governments City or township governments Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments).
- Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith based or community based organizations can apply.
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Opportunity Summary:
The Exfoliated Cells, Bioactive Food Components, and Cancer (R01) opportunity (Funding Opportunity Number PA 08 030) is a National Institutes of Health (NIH), National Cancer Institute (NCI) funding announcement that supports research aimed at improving how scientists study diet-related cancer prevention in people. The central idea is to use exfoliated cells, meaning cells that naturally shed from body surfaces such as the gastrointestinal tract or other epithelial tissues, as a practical and minimally invasive way to track what happens in the body after someone consumes dietary bioactive food components. These bioactive components can include naturally occurring compounds in foods that may influence cancer risk, and the program is focused on determining whether exfoliated cells can reliably reflect key biological effects linked to cancer prevention.
A major scientific goal of the announcement is to push the field beyond simply measuring dietary intake or blood markers and instead evaluate exfoliated cells as a model system for monitoring both exposure and biological response. Specifically, NCI is looking for projects that can assess whether exfoliated cells can be used to measure absorption and retention of these food-derived bioactive compounds and, at the same time, detect meaningful downstream cellular changes. The FOA highlights genomic and epigenetic events as especially important outcomes, signaling an interest in studies that examine how diet-related compounds may affect gene expression, DNA damage response, DNA methylation, chromatin structure, or other molecular features that could plausibly relate to cancer initiation or prevention. The emphasis is on a critical evaluation of utility, meaning applicants should be prepared to validate, compare, and rigorously test whether exfoliated cells provide accurate and interpretable information about intact tissue biology.
The announcement also has a strong collaboration and cross-disciplinary theme. NCI explicitly wants to encourage interdisciplinary teams that bring together investigators experienced in exfoliated cell collection, handling, and analysis with investigators who specialize in nutrition science and diet-related cancer prevention. In practice, this could include collaborations among molecular biologists, nutrition researchers, cancer prevention scientists, epidemiologists, bioinformaticians, and clinicians, particularly where combining expertise strengthens study design, biomarker measurement, and interpretation of mechanistic endpoints.
Funding is provided through the NIH Research Project Grant (R01) mechanism, which is intended for more mature, hypothesis-driven projects with a solid rationale, preliminary data when appropriate, and a clear plan for rigorous experimentation and analysis. The FOA notes that it runs in parallel with a separate but scientifically identical announcement using the R21 exploratory/developmental mechanism (PA 08 031), which is typically better suited for earlier-stage, higher-risk proof-of-concept work. For this specific R01 FOA, the number of awards is not fixed; funding decisions depend on available funds and the number of applications that score well in peer review.
Eligibility is broad and includes a wide range of domestic and non-domestic organizations. Eligible applicants include public and private institutions of higher education, nonprofits (with or without 501(c)(3) status), small businesses and other for-profit organizations, state and local governments, U.S. territories, tribal governments and tribally designated organizations, and a variety of designated institution types such as Hispanic Serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), and Alaska Native and Native Hawaiian Serving Institutions and regional organizations. The FOA also allows foreign organizations to apply and states that eligible federal agencies, as well as faith-based and community-based organizations, may submit applications. There is no cost sharing or matching requirement listed for this opportunity.
On the investigator side, the FOA is open to any qualified Project Director/Principal Investigator (PD/PI) with the expertise, resources, and institutional support needed to carry out the research. It explicitly encourages applications from individuals from underrepresented racial and ethnic groups and individuals with disabilities, consistent with NIH-wide inclusion goals. The announcement also permits multi-PI applications, allowing teams to formally designate more than one PD/PI when the project leadership is genuinely shared across disciplines.
From an application management standpoint, applicants may submit more than one application as long as each proposal is scientifically distinct. Resubmissions are allowed, but they must include an introduction that addresses the prior peer review critique, and renewals are possible through the usual competitive process for additional project periods. Key administrative dates in the source information indicate the FOA was posted November 26, 2007, with a closing date of January 7, 2011, and an archive date of February 7, 2011, meaning it is a historical opportunity rather than an active open call today.
In short, this FOA is designed to strengthen cancer prevention research by supporting R01 projects that test whether exfoliated cells can serve as a credible, noninvasive window into how bioactive food components are taken up and how they influence molecular pathways relevant to cancer, with a clear preference for well-integrated collaborations between exfoliated-cell method experts and nutrition/cancer prevention researchers.
FAQs: Exfoliated Cells, Bioactive Food Components, and Cancer (R01) - PA 08 030
What is this funding opportunity?
This is a National Institutes of Health (NIH), National Cancer Institute (NCI) funding announcement titled "Exfoliated Cells, Bioactive Food Components, and Cancer (R01)." The Funding Opportunity Number is PA 08 030, and it supports research intended to improve how scientists study diet-related cancer prevention in people.
What is the main scientific idea behind this FOA?
The core idea is to use exfoliated cells (cells that naturally shed from body surfaces such as the gastrointestinal tract or other epithelial tissues) as a practical, minimally invasive way to track what happens in the body after consumption of dietary bioactive food components. The FOA focuses on whether exfoliated cells can reliably reflect biological effects relevant to cancer prevention.
What are "exfoliated cells" in the context of this announcement?
Exfoliated cells are cells that naturally shed from body surfaces, including the gastrointestinal tract and other epithelial tissues. In this FOA, they are proposed as a model system for monitoring both exposure to dietary bioactive components and downstream biological responses.
What kinds of dietary factors are being studied?
The program centers on dietary bioactive food components, meaning naturally occurring compounds in foods that may influence cancer risk and cancer prevention biology.
What problem is NCI trying to solve with this research?
A major goal is to move beyond approaches that only measure dietary intake or blood markers. NCI is looking for studies that evaluate exfoliated cells as a potentially better way to assess both (1) exposure to food-derived bioactive compounds and (2) meaningful biological responses that could relate to cancer prevention.
What outcomes or endpoints does the FOA emphasize?
The FOA highlights genomic and epigenetic events as especially important outcomes. This includes interest in studying how diet-related compounds may influence gene expression, DNA damage response, DNA methylation, chromatin structure, or other molecular features plausibly connected to cancer initiation or prevention.
Does the FOA require validation of exfoliated cells as a model system?
Yes. A key theme is critical evaluation of utility. Applicants should be prepared to validate, compare, and rigorously test whether exfoliated cells provide accurate and interpretable information about intact tissue biology.
What does the FOA mean by assessing both "exposure" and "response"?
It means projects should evaluate whether exfoliated cells can be used to measure absorption and retention of food-derived bioactive compounds (exposure) while also detecting downstream cellular changes (response), particularly molecular changes relevant to cancer prevention.
Is this opportunity focused on human studies?
The announcement emphasizes improving how scientists study diet-related cancer prevention in people and describes exfoliated cells as a practical, minimally invasive way to monitor what happens after a person consumes dietary bioactive components.
What funding mechanism does this FOA use?
Funding is provided through the NIH Research Project Grant (R01) mechanism, which is generally intended for mature, hypothesis-driven projects with a strong rationale and a clear plan for rigorous experimentation and analysis. Preliminary data are referenced as appropriate for this type of work.
Is there a related opportunity for earlier-stage or exploratory projects?
Yes. The FOA notes it runs in parallel with a separate, scientifically identical announcement using the R21 exploratory/developmental mechanism (PA 08 031), which is typically more suitable for earlier-stage, higher-risk proof-of-concept work.
How many awards will be made?
The number of awards is not fixed. Funding decisions depend on the availability of funds and the number of applications that score well in peer review.
Who is eligible to apply (organizational eligibility)?
Eligibility is broad and includes domestic and non-domestic organizations. Eligible applicants include public and private institutions of higher education, nonprofits (with or without 501(c)(3) status), small businesses and other for-profit organizations, state and local governments, U.S. territories, tribal governments and tribally designated organizations, and various designated institution types such as Hispanic Serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), and Alaska Native and Native Hawaiian Serving Institutions and regional organizations.
Are foreign (non-U.S.) organizations allowed to apply?
Yes. The FOA allows foreign organizations to apply.
Can federal agencies apply?
Yes. The FOA states that eligible federal agencies may submit applications.
Are faith-based and community-based organizations eligible?
Yes. The FOA indicates that faith-based and community-based organizations may submit applications.
Is cost sharing or matching required?
No. The information provided indicates there is no cost sharing or matching requirement listed for this opportunity.
Who is eligible to serve as PD/PI?
Any qualified Project Director/Principal Investigator (PD/PI) may apply, as long as they have the expertise, resources, and institutional support needed to carry out the research.
Does the FOA encourage applications from underrepresented groups?
Yes. It explicitly encourages applications from individuals from underrepresented racial and ethnic groups and individuals with disabilities, consistent with NIH-wide inclusion goals.
Are multi-PI applications allowed?
Yes. The announcement permits multi-PI applications, allowing teams to designate more than one PD/PI when project leadership is genuinely shared across disciplines.
Does NCI encourage interdisciplinary collaboration?
Yes. The FOA has a strong cross-disciplinary theme and encourages teams that combine expertise in exfoliated cell collection/handling/analysis with expertise in nutrition science and diet-related cancer prevention.
What types of collaborators or disciplines are mentioned as relevant?
The FOA references potential collaborations among molecular biologists, nutrition researchers, cancer prevention scientists, epidemiologists, bioinformaticians, and clinicians, especially where combining expertise strengthens study design, biomarker measurement, and interpretation of mechanistic endpoints.
Can an applicant submit more than one application?
Yes. Applicants may submit more than one application as long as each proposal is scientifically distinct.
Are resubmissions allowed?
Yes. Resubmissions are allowed, but they must include an introduction that addresses the prior peer review critique.
Are renewals allowed?
Yes. Renewals are possible through the usual competitive process for additional project periods.
What were the key dates for this FOA?
The FOA was posted on November 26, 2007. The closing date was January 7, 2011, and the archive date was February 7, 2011.
Is this an active funding opportunity today?
Based on the dates provided (closing date January 7, 2011; archive date February 7, 2011), this appears to be a historical opportunity rather than an active open call.
What is the overall purpose of the FOA in plain terms?
In practical terms, the FOA aims to strengthen cancer prevention research by supporting R01 projects that test whether exfoliated cells can serve as a credible, minimally invasive window into how bioactive food components are taken up and how they influence molecular pathways relevant to cancer prevention, with a preference for well-integrated collaborations across relevant disciplines.
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Applicants also applied for:
Applicants who have applied for this opportunity (PA 08 030) also looked into and applied for these:
| Funding Opportunity |
|---|
| Exfoliated Cells, Bioactive Food Components, and Cancer (R21) Apply for PA 08 031 Funding Number: PA 08 031 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Molecular Approaches to Diet and Pancreatic Cancer Prevention (R01) Apply for PA 08 032 Funding Number: PA 08 032 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Thyroid in Aging (R01) Apply for PA 08 037 Funding Number: PA 08 037 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Thyroid in Aging (R21) Apply for PA 08 038 Funding Number: PA 08 038 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Thyroid in Aging (R03) Apply for PA 08 039 Funding Number: PA 08 039 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Outcomes, Cost Effectiveness and the Decision Making Process to Use Complementary and Alternative Medicine (R01) Apply for PAR 08 045 Funding Number: PAR 08 045 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Understanding and Preventing Brain Tumor Dispersal (R01) Apply for PAS 08 048 Funding Number: PAS 08 048 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Understanding and Preventing Brain Tumor Dispersal (R21) Apply for PAS 08 049 Funding Number: PAS 08 049 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Long Acting, Sustainable Therapies for Opiate Addiction (R01) Apply for PAS 08 061 Funding Number: PAS 08 061 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Alzheimer s Disease Pilot Clinical Trials (R01) Apply for PAR 08 062 Funding Number: PAR 08 062 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Decision Making in Cancer Single Event Decisions (R01) Apply for PA 08 063 Funding Number: PA 08 063 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Decision Making in Cancer Single Event Decisions (R21) Apply for PA 08 064 Funding Number: PA 08 064 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Research on the Economics of Diet, Activity and Energy Balance (R21) Apply for PA 08 077 Funding Number: PA 08 077 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| NLM Express Research Grants in Biomedical Informatics (R01) Apply for PAR 08 080 Funding Number: PAR 08 080 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| The Effect of Racial and Ethnic Discrimination/Bias on Health Care Delivery (R21) Apply for PA 08 084 Funding Number: PA 08 084 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| The Effect of Racial and Ethnic Discrimination/Bias on Health Care Delivery (R03) Apply for PA 08 085 Funding Number: PA 08 085 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Functional Links between the Immune System, Brain Function and Behavior (R01) Apply for PA 08 097 Funding Number: PA 08 097 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Functional Links between the Immune System, Brain Function and Behavior (R21) Apply for PA 08 098 Funding Number: PA 08 098 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Cancer Education Grants Program (R25) Apply for PAR 08 120 Funding Number: PAR 08 120 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Symptom Interactions in Cancer and Immune Disorders (R01) Apply for PA 08 121 Funding Number: PA 08 121 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
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