Opportunity Information: Apply for PA 08 029
Apply for PA 08 029
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Research on Co Morbid Mental and Other Physical Disorders (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants 93.361 Nursing Research.
- This funding opportunity was created on Nov 27, 2009 and posted on Nov 21, 2007.
- Applicants must submit their applications by Jan 7, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Independent school districts For profit organizations other than small businesses County governments Small businesses Private institutions of higher education City or township governments Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) State governments Public and State controlled institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Special district governments.
- Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith based or community based organizations can apply.
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Opportunity Summary:
The NIH funding opportunity titled "Research on Co-Morbid Mental and Other Physical Disorders (R01)" (Funding Opportunity Number PA-08-029) supports research focused on how mental disorders co-occur with physical health conditions, and what can be done to prevent, treat, or better manage these overlapping problems. Sponsored by the National Institute of Mental Health (NIMH) and the National Institute of Nursing Research (NINR), the central aim is to generate findings that are directly useful for improving health outcomes in people who experience both mental and physical disorders at the same time. A major through-line in the announcement is the idea that co-morbidity is not just a clinical complication, but a major public health issue that can drive worse functioning, higher mortality, more complicated care, and greater costs, especially when conditions interact across long stretches of a persons life.
A key priority of the announcement is identifying strong, modifiable risk factors and protective factors that contribute to the development and persistence of co-morbid mental and physical disorders. The FOA makes clear that these factors can come from multiple domains, including biological influences (for example, inflammation pathways, genetics, neuroendocrine functioning), psychosocial influences (such as stress exposure, trauma history, social support, socioeconomic strain), behavioral contributors (like smoking, diet, physical activity, medication adherence, sleep patterns), and environmental conditions (including neighborhood factors, access to care, and broader structural barriers). The expectation is not only to describe these contributors, but to focus on those that can realistically be changed and then used as levers for prevention or early intervention.
Another major emphasis is moving from observational or explanatory work into translation, meaning applicants are encouraged to take what is learned about risk and protection and use it to design and run initial tests of theory-driven prevention and early intervention strategies. This can include studies that evaluate the efficacy and effectiveness of interventions, assess long-term outcomes, and examine safety across the lifespan. The FOA explicitly welcomes clinical trials and intervention studies that target both functional outcomes (how people do in daily life, work, relationships, self-care) and symptomatic outcomes (severity of mental health symptoms, physical disease markers, relapse rates, and related endpoints). Interventions can be pharmacological, psychosocial, behavioral, or environmental, and the announcement encourages approaches that combine these methods when it makes scientific and clinical sense.
The opportunity also highlights practical real-world implementation problems that often block progress for people with multiple conditions. Specifically, it encourages research aimed at improving recruitment and retention of individuals who have co-morbid disorders, especially in real-world practice settings where complexity and barriers to participation are common. In addition, the FOA is interested in the effects of having separate organizational systems for mental health and physical health care, and how different financing mechanisms can shape access, continuity, and outcomes. In other words, applicants can address not only individual-level mechanisms and treatments, but also health-system and policy-level factors that influence whether integrated, effective care is actually delivered.
A distinctive focus in this announcement is behavior change: the FOA places major weight on identifying principles that motivate and sustain behavior changes that reduce the risk of co-occurring disorders. That includes understanding what helps people start and maintain changes that matter for both mental and physical health, such as adhering to complex treatment regimens, maintaining healthy activity, avoiding substance use, managing stress, and staying engaged in care over time. This emphasis signals that proposals should take behavior seriously as a central mechanism linking mental and physical illness and as a realistic target for intervention.
In terms of target conditions, the FOA particularly encourages studies where mental disorders co-occur with high-burden physical diseases that drive morbidity and mortality in the United States. Examples listed include heart disease, cancer, stroke, chronic obstructive pulmonary disease, and diabetes. At the same time, the announcement leaves the door open to any combination of mental and physical disorders across the lifespan, as long as the applicant clearly makes the public health case. Applicants are expected to demonstrate significance by describing the severity and/or prevalence of the conditions being studied and why their co-occurrence matters.
The primary mechanism of support is the NIH Research Project Grant (R01), which generally funds full-scale research projects of varying size and duration depending on scope. The announcement also points investigators to related mechanisms for similar scientific topics at different stages or scales, including the NIH Small Research Grant (R03) and the NIMH Clinical Exploratory/Developmental Research Grant (R34), referenced as PA-06-180 and PA-06-248. Funding levels and the number of awards are not fixed; they depend on the number, quality, duration, and cost of applications received, reflecting the broad range of projects that could fit under this topic area.
Eligibility is broad and includes many types of U.S.-based organizations such as higher education institutions (public and private), nonprofit organizations (including those with and without 501(c)(3) status), small businesses, for-profit organizations (other than small businesses are listed as eligible), state, county, and city governments, school districts, public housing authorities, tribal governments and tribal organizations, and special district governments. The FOA also notes that foreign institutions are eligible to apply, that eligible federal agencies may apply, and that faith-based and community-based organizations are eligible as well. There is no cost sharing or matching requirement.
Administratively, this is an NIH discretionary grant opportunity under CFDA numbers 93.242 (Mental Health Research Grants) and 93.361 (Nursing Research). The FOA was posted on November 21, 2007, and includes an archived timeline with a current closing date listed as January 7, 2010 (with an original closing date of January 7, 2011 and an archive date of February 7, 2010). The full announcement is linked through the NIH grants guide at http://grants.nih.gov/grants/guide/pa-files/PA-08-029.html, and NIH provides an Office of Extramural Research (OER) webmaster contact for technical access issues.
Frequently Asked Questions (FAQs): NIH PA-08-029 - Research on Co-Morbid Mental and Other Physical Disorders (R01)
What is the purpose of this NIH funding opportunity?
This opportunity supports research on how mental disorders co-occur with physical health conditions, and what can be done to prevent, treat, or better manage these overlapping problems. The stated aim is to generate findings that are directly useful for improving health outcomes for people experiencing both mental and physical disorders at the same time.
What is the funding opportunity number and title?
The funding opportunity is titled "Research on Co-Morbid Mental and Other Physical Disorders (R01)" and the Funding Opportunity Number is PA-08-029.
Which NIH Institutes sponsor this announcement?
The announcement is sponsored by the National Institute of Mental Health (NIMH) and the National Institute of Nursing Research (NINR).
What does the FOA mean by co-morbidity being a public health issue?
The FOA frames co-morbidity as more than a clinical complication. It describes co-occurring mental and physical disorders as a major public health problem that can contribute to worse functioning, higher mortality, more complicated care, and greater costs, particularly when conditions interact across long stretches of a person's life.
What kinds of research topics are encouraged?
Research is encouraged that examines why and how mental and physical disorders co-occur, identifies modifiable risk factors and protective factors, and uses what is learned to design and test prevention and early intervention strategies. The FOA also encourages work on real-world implementation barriers, including recruitment/retention challenges and the effects of separate mental and physical health care systems.
What are "modifiable risk factors" and "protective factors" in this FOA?
The FOA prioritizes identifying strong factors that contribute to the development and persistence of co-morbid disorders, with an emphasis on factors that can realistically be changed and used as leverage for prevention or early intervention.
What domains of risk and protection does the FOA mention?
The FOA notes that risk and protective factors can come from multiple domains, including:
- Biological influences (for example, inflammation pathways, genetics, neuroendocrine functioning)
- Psychosocial influences (such as stress exposure, trauma history, social support, socioeconomic strain)
- Behavioral contributors (like smoking, diet, physical activity, medication adherence, sleep patterns)
- Environmental conditions (including neighborhood factors, access to care, and broader structural barriers)
Does this FOA support intervention research or only observational studies?
It supports intervention research and explicitly encourages moving from observational or explanatory work into translation. Applicants are encouraged to use knowledge about risk and protective factors to design and run initial tests of theory-driven prevention and early intervention strategies.
Are clinical trials allowed under this FOA?
Yes. The FOA explicitly welcomes clinical trials and intervention studies.
What outcomes does the FOA want interventions to address?
The FOA encourages studies targeting both:
- Functional outcomes (how people do in daily life, work, relationships, self-care)
- Symptomatic outcomes (severity of mental health symptoms, physical disease markers, relapse rates, and related endpoints)
What types of interventions are considered responsive?
Interventions can be pharmacological, psychosocial, behavioral, or environmental. The FOA also encourages combined approaches when it makes scientific and clinical sense.
Is behavior change a major focus of this opportunity?
Yes. A distinctive emphasis is placed on identifying principles that motivate and sustain behavior changes that reduce the risk of co-occurring disorders. The FOA highlights behavior as a central mechanism linking mental and physical illness and as a realistic target for intervention.
What kinds of behavior change targets are mentioned?
Examples include adherence to complex treatment regimens, maintaining healthy activity, avoiding substance use, managing stress, and staying engaged in care over time.
Does the FOA encourage studies across the lifespan?
Yes. The FOA notes examining safety across the lifespan and discusses co-morbidity and its impacts across long stretches of a person's life.
Which co-morbid physical conditions are specifically encouraged?
The FOA particularly encourages studies where mental disorders co-occur with high-burden physical diseases associated with morbidity and mortality in the United States. Examples listed include heart disease, cancer, stroke, chronic obstructive pulmonary disease, and diabetes.
Are applicants limited to those specific physical diseases?
No. The FOA leaves the door open to any combination of mental and physical disorders across the lifespan, as long as the applicant clearly makes the public health case.
How should applicants justify the significance of the conditions being studied?
Applicants are expected to demonstrate significance by describing the severity and/or prevalence of the conditions being studied and why their co-occurrence matters.
Does this FOA include health-system or policy-related research topics?
Yes. It encourages research on real-world implementation problems and highlights interest in the effects of separate organizational systems for mental health and physical health care, as well as how different financing mechanisms can shape access, continuity, and outcomes.
Does the FOA address recruitment and retention challenges for co-morbid populations?
Yes. The FOA encourages research aimed at improving recruitment and retention of individuals who have co-morbid disorders, especially in real-world practice settings where complexity and barriers to participation are common.
What is the primary grant mechanism used for this opportunity?
The primary mechanism is the NIH Research Project Grant (R01), which generally supports full-scale research projects of varying size and duration depending on scope.
Are other NIH mechanisms mentioned for similar topics?
Yes. The FOA points to related mechanisms including the NIH Small Research Grant (R03) and the NIMH Clinical Exploratory/Developmental Research Grant (R34), referenced as PA-06-180 and PA-06-248.
Are the funding levels or number of awards fixed?
No. Funding levels and the number of awards are not fixed. They depend on the number, quality, duration, and cost of applications received.
Who is eligible to apply?
Eligibility is broad. The FOA lists many eligible organization types, including higher education institutions (public and private), nonprofit organizations (with or without 501(c)(3) status), small businesses, for-profit organizations (other than small businesses are listed as eligible), state/county/city governments, school districts, public housing authorities, tribal governments and tribal organizations, and special district governments. Faith-based and community-based organizations are also eligible.
Are foreign institutions eligible?
Yes. The FOA notes that foreign institutions are eligible to apply.
Can federal agencies apply?
Yes. The FOA notes that eligible federal agencies may apply.
Is cost sharing or matching required?
No. The FOA states that there is no cost sharing or matching requirement.
What CFDA numbers are associated with this opportunity?
The FOA is listed under CFDA 93.242 (Mental Health Research Grants) and 93.361 (Nursing Research).
When was this FOA posted and what dates are listed?
The FOA was posted on November 21, 2007. It includes an archived timeline with a current closing date listed as January 7, 2010. It also shows an original closing date of January 7, 2011 and an archive date of February 7, 2010.
Where can the full announcement be found?
The full announcement is available in the NIH Grants Guide at: http://grants.nih.gov/grants/guide/pa-files/PA-08-029.html.
Who should be contacted for technical access issues with the FOA webpage?
NIH provides an Office of Extramural Research (OER) webmaster contact for technical access issues.
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