Opportunity Information: Apply for PAS 10 215
Apply for PAS 10 215
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Expanding and Personalizing Treatment Options for Alcohol Use Disorders Including Pharmacogenomics (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs.
- This funding opportunity was created on Jun 16, 2010 and posted on Jun 16, 2010.
- Applicants must submit their applications by Sep 7, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,000,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 4 candidate(s).
- Eligible applicants include: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments For profit organizations other than small businesses Others (see text field entitled Additional Information on Eligibility for clarification) State governments Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Special district governments Independent school districts Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Small businesses Public housing authorities/Indian housing authorities Private institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The funding opportunity "Expanding and Personalizing Treatment Options for Alcohol Use Disorders Including Pharmacogenomics (R01)" (Funding Opportunity Number PAS-10-215) is a National Institutes of Health grant announcement issued through the National Institute on Alcohol Abuse and Alcoholism (NIAAA). Its central goal is to move alcohol use disorder (AUD) treatment toward a more personalized, genetics-informed approach by supporting studies that explain why people respond differently to AUD medications. The FOA focuses specifically on pharmacogenomics, meaning research that links genetic variation to differences in medication response, including both how well a drug works and how likely it is to cause adverse effects.
The scientific emphasis is on understanding how genetic differences influence both pharmacodynamic and pharmacokinetic factors. Pharmacodynamics refers to what the drug does to the body, such as how it affects receptors, signaling pathways, reward circuits, craving, withdrawal, stress responses, or other biological systems tied to alcohol use. Pharmacokinetics refers to what the body does to the drug, including absorption, distribution, metabolism, and elimination, which can change drug exposure levels and therefore effectiveness or toxicity. NIAAA is encouraging applicants to capture the "full range" of relevant genetic variability that could alter these parameters, which implies interest in a broad and rigorous look at genetic contributors rather than narrow candidate-only approaches.
The FOA explicitly welcomes a wide range of study types. Human studies are encouraged, which could include clinical pharmacogenomic studies, treatment response analyses, biomarker-driven stratification, or genotype-informed trials, as long as the work is aimed at clarifying how genetics shape medication outcomes in AUD. Animal studies are also encouraged, allowing researchers to examine genetic effects under controlled conditions, test causal mechanisms, and explore treatment response across genetically defined strains or engineered models. In addition, the announcement highlights mechanistic research, including work that uses animal models and/or in vitro or ex vivo systems. This could involve cellular models, brain slice preparations, organotypic cultures, or other laboratory approaches designed to pin down the biological pathways that connect genotype to drug response, efficacy, or adverse events.
In terms of funding structure, this opportunity uses the NIH R01 mechanism, meaning it supports discrete, investigator-initiated research projects with a defined scope and set of aims. The announcement reported that NIAAA planned to make approximately two to four awards, supported by an estimated total of about $2,000,000 in total costs for fiscal year 2011. The opportunity falls under the Health funding activity category and is associated with CFDA number 93.273 (Alcohol Research Programs). Cost sharing or matching is not required, which is typical for NIH research project grants.
Eligibility is broad and includes many types of domestic and non-domestic organizations. Eligible applicants include public and private institutions of higher education, nonprofit organizations (including both 501(c)(3) and non-501(c)(3) entities), for-profit organizations (other than small businesses), small businesses, and multiple levels of government (state, county, city/township, special district, and independent school districts), as well as public housing authorities/Indian housing authorities. The FOA also lists a range of additional eligible applicants, such as federally recognized and other tribal governments and organizations, Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and foreign organizations (non-U.S. entities). This eligibility scope signals NIAAA interest in attracting a diverse applicant pool and supporting research capacity across different institutional settings.
Administratively, the opportunity was posted and created on June 16, 2010, with a closing date of September 7, 2011, and an archive date of October 8, 2011. The full announcement was made available through the NIH Grants Guide (linked in the listing). For access or technical issues, the contact point provided is the NIH Office of Extramural Research (OER) webmaster email (FBOWebmaster@OD.NIH.GOV), which is intended to help applicants who have difficulty retrieving or linking to the electronic FOA.
Overall, PAS-10-215 is aimed at expanding AUD treatment options by generating actionable knowledge about genetic moderators of medication response. By supporting human, animal, and mechanistic laboratory studies that connect genotype to both drug action and drug handling, the FOA is designed to lay the groundwork for better targeted therapies, improved outcomes, and reduced adverse effects in the treatment of alcohol use disorders.
Frequently Asked Questions (FAQs)
What is the name of this funding opportunity?
The opportunity is titled "Expanding and Personalizing Treatment Options for Alcohol Use Disorders Including Pharmacogenomics (R01)."
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is PAS-10-215.
Which agency and NIH Institute are offering this grant?
This is a National Institutes of Health (NIH) grant announcement issued through the National Institute on Alcohol Abuse and Alcoholism (NIAAA).
What is the main goal of PAS-10-215?
The central goal is to move alcohol use disorder (AUD) treatment toward a more personalized, genetics-informed approach by supporting studies that explain why people respond differently to AUD medications.
What scientific area does the FOA focus on?
The FOA focuses specifically on pharmacogenomics, meaning research that links genetic variation to differences in medication response, including both how well a drug works and how likely it is to cause adverse effects.
What kinds of medication outcomes are of interest?
The FOA highlights outcomes related to medication efficacy (how well a drug works) and adverse effects (how likely it is to cause negative or harmful effects).
What does the FOA mean by pharmacodynamics in this context?
Pharmacodynamics refers to what the drug does to the body, such as effects on receptors, signaling pathways, reward circuits, craving, withdrawal, stress responses, or other biological systems tied to alcohol use.
What does the FOA mean by pharmacokinetics in this context?
Pharmacokinetics refers to what the body does to the drug, including absorption, distribution, metabolism, and elimination. These processes can change drug exposure levels and therefore influence effectiveness or toxicity.
Does NIAAA want studies that look at only a few genetic variants?
The FOA encourages applicants to capture the "full range" of relevant genetic variability that could alter pharmacodynamic and pharmacokinetic parameters, signaling interest in broad and rigorous coverage of genetic contributors rather than narrow approaches.
Are human studies allowed under this FOA?
Yes. Human studies are encouraged, including clinical pharmacogenomic studies, treatment response analyses, biomarker-driven stratification, or genotype-informed trials, as long as the work aims to clarify how genetics shape medication outcomes in AUD.
Are animal studies allowed under this FOA?
Yes. Animal studies are encouraged and can be used to examine genetic effects under controlled conditions, test causal mechanisms, and explore treatment response across genetically defined strains or engineered models.
Does the FOA support mechanistic or laboratory-based research?
Yes. The announcement highlights mechanistic research, including work using animal models and/or in vitro or ex vivo systems to identify biological pathways connecting genotype to drug response, efficacy, or adverse events.
What are examples of in vitro or ex vivo systems mentioned?
Examples described include cellular models, brain slice preparations, organotypic cultures, and other laboratory approaches designed to pin down pathways linking genotype to medication response or adverse effects.
What grant mechanism is used for this opportunity?
This opportunity uses the NIH R01 mechanism, which supports discrete, investigator-initiated research projects with a defined scope and set of aims.
How many awards did NIAAA plan to make?
The announcement reported that NIAAA planned to make approximately two to four awards.
What was the estimated total funding amount for the planned awards?
The FOA estimated a total of about $2,000,000 in total costs for fiscal year 2011 to support the planned awards.
What is the funding activity category?
The opportunity falls under the Health funding activity category.
What CFDA number is associated with this opportunity?
The opportunity is associated with CFDA number 93.273 (Alcohol Research Programs).
Is cost sharing or matching required?
No. Cost sharing or matching is not required.
What types of organizations are eligible to apply?
Eligibility is broad and includes public and private institutions of higher education; nonprofit organizations (501(c)(3) and non-501(c)(3)); for-profit organizations (other than small businesses); small businesses; and multiple levels of government (state, county, city/township, special district, and independent school districts), as well as public housing authorities/Indian housing authorities.
Are tribal governments and tribal organizations eligible?
Yes. The FOA lists federally recognized and other tribal governments and organizations as eligible applicants.
Are minority-serving institutions specifically included in eligibility?
Yes. The FOA includes Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs) among eligible applicants.
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are included in the eligibility list.
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are included in the eligibility list.
Are foreign (non-U.S.) organizations eligible to apply?
Yes. The FOA states that foreign organizations (non-U.S. entities) are eligible applicants.
When was the funding opportunity posted and created?
The opportunity was posted and created on June 16, 2010.
What was the closing date for applications?
The closing date listed for the opportunity was September 7, 2011.
When was the opportunity archived?
The archive date was October 8, 2011.
Where could applicants find the full announcement?
The full announcement was made available through the NIH Grants Guide (linked in the listing).
Who is the contact for access or technical issues retrieving the FOA?
For access or technical issues, the contact point provided is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
What is the broader intended impact of this FOA?
The FOA is aimed at expanding AUD treatment options by generating actionable knowledge about genetic moderators of medication response, helping lay the groundwork for better targeted therapies, improved outcomes, and reduced adverse effects in treating alcohol use disorders.
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