Expanding Efforts and Strategies to Prevent and Control TB including Multidrug Resistant TB, and TB in vulnerable populations | Apply Online

Opportunity Summary:

This CDC funding opportunity (RFA PS14-1412) offered FY 2014 support through a cooperative agreement to expand and strengthen global tuberculosis (TB) prevention and control, with specific emphasis on multidrug-resistant TB (MDR TB) and TB in vulnerable populations, including people living with HIV/AIDS. The core intent was to help countries and partners build stronger, more coordinated systems for TB detection, treatment, and program management, especially where TB and HIV epidemics overlap and where drug resistance creates additional barriers to cure. Because this was structured as a cooperative agreement, the award was designed for an active partnership model, meaning the recipient and CDC would work closely together on implementation, technical collaboration, and progress monitoring rather than operating as a hands-off grant.

The work described in the announcement focused on providing practical assistance to national governments, regional authorities, non-governmental organizations, public and private health care systems, donors, and other stakeholders to develop, establish, and coordinate procedures that make TB programs function better at scale. A central strategy was to formalize and strengthen collaborations with Ministries of Health and other aligned national programs (for example TB, HIV/AIDS, and related health initiatives). The opportunity emphasized reducing TB burden in both adults and children, while also prioritizing populations at elevated risk, including people living with HIV/AIDS and other vulnerable groups. A recurring theme was that TB control depends not just on clinical services, but also on the underlying systems that ensure patients are found, started on the right regimen, supported to stay on treatment, and tracked through completion, including referral pathways and coordination across TB and HIV services.

Another major component was addressing obstacles that routinely prevent TB programs from reaching control targets, particularly drug-resistant TB and TB/HIV co-infection. The announcement framed this as a need to implement treatment and control activities that directly confront operational barriers, such as gaps in coordination between TB and HIV programs, weaknesses in treatment follow-up, and challenges that arise when MDR TB requires more complicated regimens and longer durations of care. In practical terms, the program aimed to strengthen the end-to-end “system and procedures” side of TB control: planning and coordination mechanisms, standardized approaches that can be adopted across partners, and structures that help countries organize effective national responses rather than fragmented projects.

Performance measurement was tied to a clear treatment-outcome goal aligned with the National Center for HIV, Viral Hepatitis, STD, and TB Prevention (NCHHSTP): increasing the percentage of TB patients, including MDR TB patients, who complete curative TB treatment within 12 months of starting therapy (with the recognition that some patients require longer than 12 months). This outcome focus underscores that the funding was not only about expanding activities, but also about improving the real-world results of TB care, especially treatment completion, which is critical to curing individuals, reducing transmission, and limiting the emergence or spread of drug resistance. The announcement also noted alignment with the Healthy People 2020 TB reduction focus area, while clarifying that Healthy People 2020 requirements do not apply to foreign entities.

In terms of basic award mechanics, this was a discretionary funding opportunity in the health category, administered by the Centers for Disease Control and Prevention. The expected number of awards was one, suggesting a single primary implementer or coordinating entity. The estimated total funding amount was $2,500,000, and both the award ceiling and floor were listed as $500,000, indicating that individual budget periods or annual funding levels were set at that amount within the broader total. There was no cost sharing or matching requirement. The CFDA number listed was 93.099, and the opportunity also referenced collaboration with the World Health Organization and its regional offices in the context of global health security, reflecting the international scope and the importance of working through established global TB coordination channels.

Eligibility was limited and specifically identified the World Health Organization (WHO) as the eligible applicant, which signals that the CDC intended this cooperative agreement to be carried out through WHO’s convening role, technical expertise, and regional infrastructure. Operationally, that fits the announcement’s emphasis on assisting national governments and coordinating with ministries and partners across multiple countries and regions. The application timeline shows the funding notice was posted May 16, 2014, with an original Grants.gov deadline of June 16, 2014 (11:59 pm Eastern), later extended to July 7, 2014 (11:59 pm Eastern), and an archive date of July 16, 2014. For access issues related to the full announcement, the notice directed applicants to CDC’s Procurement and Grants Office Technical Information Management Section (TIMS) via the provided phone number.

Overall, the opportunity centered on scaling up coordinated, partner-driven TB and TB/HIV control efforts worldwide by strengthening the systems that make diagnosis, treatment, and completion reliable, with particular attention to MDR TB and populations facing higher risk and higher barriers to care. The success of the program, as described, would be reflected in measurable improvements in treatment completion and in better-functioning national and regional TB control structures capable of sustaining progress against both standard TB and drug-resistant TB in settings heavily affected by HIV.

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