Opportunity Information: Apply for PAS 10 148
Apply for PAS 10 148
- The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "Exploratory/Developmental Investigations on Primary Immunodeficiency Diseases (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.855 Allergy, Immunology and Transplantation Research 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Feb 21, 2013 and posted on Mar 22, 2010.
- Applicants must submit their applications by Sep 7, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $650,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Public and State controlled institutions of higher education Independent school districts Others (see text field entitled Additional Information on Eligibility for clarification) Private institutions of higher education Native American tribal governments (Federally recognized) For profit organizations other than small businesses City or township governments Native American tribal organizations (other than Federally recognized tribal governments) Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments Small businesses Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Opportunity Summary:
This NIH grant opportunity, Funding Opportunity Number PAS-10-148, supports early-stage, high-impact research on primary immunodeficiency diseases (PIDs) using the R21 exploratory/developmental grant mechanism. The program is designed for projects that are innovative and potentially transformative, especially those that may be too preliminary for a larger, more conventional research grant. The scientific focus is on studies that use human specimens in ex vivo settings and on studies that leverage existing or newly developed animal models. In practical terms, the announcement is looking for creative approaches that can improve how PIDs are detected, clarify their molecular and genetic causes, or lay the groundwork for new and better therapies.
A key theme is innovation in both tools and strategy. Applicants are encouraged to propose novel clinical approaches for recognizing and diagnosing PIDs, methods to pinpoint the underlying molecular basis of disease, and exploratory therapeutic concepts that could eventually translate into patient care. Because PIDs are often genetically driven and clinically diverse, the FOA is broad enough to accommodate a range of experimental directions, as long as the work clearly advances understanding or intervention in primary immunodeficiency. The emphasis on ex vivo human studies signals interest in work that directly interrogates patient-derived cells or tissues, while the emphasis on animal models highlights the importance of testing mechanisms and interventions in systems that can model immune function and disease progression.
This FOA is also explicitly welcoming to investigators who are new to NIH independent funding or who have not previously held independent NIH support in this particular field. That encouragement is meant to broaden the pool of applicants and bring in new ideas and new research teams. The announcement runs in parallel with another NIH opportunity of the same scientific scope (PA-10-147) that uses the R03 small grant mechanism, giving investigators an option depending on project scope and stage of development, with PAS-10-148 specifically tied to the R21 mechanism.
On funding, NIH anticipated roughly $650,000 total being available under this FOA, with an expectation of about two new awards each fiscal year, assuming funds are available and enough strong applications are received. The listed award ceiling is $200,000. No cost sharing or matching is required, which reduces barriers for many applicants and institutions.
Eligibility is broad and includes many organization types: public and private institutions of higher education, nonprofit organizations (including 501(c)(3) and non-501(c)(3) entities), for-profit organizations other than small businesses, small businesses, and a wide range of government entities (state, county, city/township, special district), as well as public housing authorities/Indian housing authorities. The FOA also identifies additional eligible applicants such as federally recognized and other tribal governments and organizations, Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based and community-based organizations, regional organizations, eligible federal agencies, and U.S. territories or possessions. This wide eligibility aligns with NIH’s interest in supporting a diverse research ecosystem and enabling participation across many institutional settings.
Administratively, the opportunity is categorized as a discretionary grant in the health area, tied to CFDA numbers 93.855 (Allergy, Immunology and Transplantation Research) and 93.865 (Child Health and Human Development Extramural Research). The agency is the National Institutes of Health. Key dates included a posted date of March 22, 2010, and the submission window reflected in the listing shows an original closing date of May 7, 2013, a later current closing date of September 7, 2013, and an archive date of October 7, 2013, indicating the announcement as provided is from an older cycle and was later archived. For applicants needing the full text or having access issues, the listing provides NIH Office of Extramural Research (OER) webmaster contacts and a link to the full announcement on the NIH grants site.
FAQs: NIH PAS-10-148 (R21) Primary Immunodeficiency Diseases (PIDs)
What is Funding Opportunity Number PAS-10-148?
PAS-10-148 is a National Institutes of Health (NIH) funding opportunity that supports early-stage, high-impact research focused on primary immunodeficiency diseases (PIDs) using the R21 exploratory/developmental grant mechanism.
What type of grant mechanism does this opportunity use?
This opportunity uses the NIH R21 exploratory/developmental mechanism, which is intended for innovative projects that may be too early or too preliminary for larger, more conventional research grants.
What is the overall goal of this FOA?
The FOA aims to encourage creative, potentially transformative research that can improve how PIDs are detected, clarify their molecular and genetic causes, or lay the groundwork for new and better therapies.
What research areas or scientific topics are emphasized?
The FOA emphasizes research on primary immunodeficiency diseases, particularly studies that (1) use human specimens in ex vivo settings and (2) leverage existing or newly developed animal models to study disease mechanisms and potential interventions.
Does this FOA focus on human studies, animal studies, or both?
Both. The announcement highlights interest in ex vivo studies using human specimens (such as patient-derived cells or tissues studied outside the body) and in studies using animal models, including models that are newly developed for PID research.
What does "ex vivo" mean in the context of this FOA?
In this FOA, ex vivo refers to work that directly interrogates human specimens outside the body, such as experiments performed on patient-derived cells or tissues to understand immune function, disease mechanisms, or responses to exploratory therapeutic concepts.
What kinds of projects are considered a good fit for PAS-10-148?
Projects are a strong fit if they are innovative and exploratory and aim to advance PID research by improving recognition and diagnosis, identifying the molecular basis of disease, and/or testing early therapeutic concepts that could later translate toward patient care.
Is innovation a key requirement for this program?
Yes. A central theme is innovation in both tools and strategy, with encouragement for novel clinical approaches to recognizing and diagnosing PIDs, methods to pinpoint underlying molecular causes, and exploratory therapeutic approaches.
Is this opportunity limited to a specific type of primary immunodeficiency disease?
The FOA is described as broad in scope within primary immunodeficiency, reflecting the genetic drivers and clinical diversity of PIDs. Projects may pursue a range of experimental directions as long as they clearly advance understanding or intervention in primary immunodeficiency.
Who is the sponsoring agency for this grant opportunity?
The sponsoring agency is the National Institutes of Health (NIH).
What CFDA numbers are associated with this opportunity?
This opportunity is associated with CFDA 93.855 (Allergy, Immunology and Transplantation Research) and 93.865 (Child Health and Human Development Extramural Research).
Is this a discretionary grant?
Yes. The opportunity is categorized as a discretionary grant in the health area.
How much funding was NIH anticipating for this FOA?
NIH anticipated approximately $650,000 total being available under this FOA, with an expectation of about two new awards each fiscal year, assuming funds are available and enough meritorious applications are received.
What is the listed award ceiling?
The listed award ceiling is $200,000.
Is cost sharing or matching required?
No. The FOA states that no cost sharing or matching is required.
Who is eligible to apply?
Eligibility is broad and includes: public and private institutions of higher education; nonprofit organizations (501(c)(3) and non-501(c)(3)); for-profit organizations (other than small businesses); small businesses; and many government entities (state, county, city/township, special district), including public housing authorities/Indian housing authorities.
Are tribal governments and tribal organizations eligible?
Yes. The FOA identifies federally recognized tribal governments and other tribal governments and organizations as eligible applicants.
Are minority-serving institutions eligible to apply?
Yes. The FOA lists Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs) as eligible applicants.
Can faith-based or community-based organizations apply?
Yes. Faith-based and community-based organizations are specifically included among the eligible applicant types.
Are U.S. territories or possessions eligible?
Yes. The FOA includes U.S. territories or possessions among the eligible applicants.
Are federal agencies eligible to apply?
Yes. The FOA lists eligible federal agencies among the applicant types.
Does the FOA encourage applications from new investigators?
Yes. The announcement explicitly welcomes investigators who are new to NIH independent funding or who have not previously held independent NIH support in this particular field, to broaden participation and bring in new research teams and ideas.
Is there a related NIH opportunity using a different mechanism?
Yes. The FOA runs in parallel with another NIH opportunity of the same scientific scope (PA-10-147) that uses the R03 small grant mechanism. PAS-10-148 is specifically tied to the R21 mechanism.
What are the key dates listed for this FOA?
The listing includes a posted date of March 22, 2010. It also shows an original closing date of May 7, 2013, a later current closing date of September 7, 2013, and an archive date of October 7, 2013.
Is this opportunity still open?
Based on the dates provided, the announcement reflects an older cycle and was later archived (archive date: October 7, 2013).
Where can applicants find the full announcement text or get help if they have access issues?
The listing points applicants to the full announcement on the NIH grants site and provides NIH Office of Extramural Research (OER) webmaster contacts for help accessing the full text.
Browse more opportunities from the same category: Health Income Security and Social Services
Next opportunity: Office of Innovation and Improvement (OII) Ready to Learn Television Program CFDA 84.295A
Previous opportunity: Small Grants on Primary Immunodeficiency Diseases (R03)
USGrants.org Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for PAS 10 148
[Watch] how do funding administrators access proposals?
Applicants also applied for:
Applicants who have applied for this opportunity (PAS 10 148) also looked into and applied for these:
| Funding Opportunity |
|---|
| Pelvic Floor Disorders Network Data Coordinating Center (U01) Apply for RFA HD 10 024 Funding Number: RFA HD 10 024 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Pelvic Floor Disorders Network Clinical Sites (U10) Apply for RFA HD 10 002 Funding Number: RFA HD 10 002 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Child Health Research Career Development Award (CHRCDA) Program K12 Apply for RFA HD 10 007 Funding Number: RFA HD 10 007 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $400,000 |
| International Extramural Associates Research Development Awards (IEARDA) G11 Apply for PAR 10 172 Funding Number: PAR 10 172 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Advanced Tools and Technologies for Deep Brain Stimulation (STTR R41/R42) Apply for PA 10 175 Funding Number: PA 10 175 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Advanced Tools and Technologies for Deep Brain Stimulation (SBIR R43/R44) Apply for PA 10 176 Funding Number: PA 10 176 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Awards (NRSA) for Individual Predoctoral Fellows in PharmD/PhD Programs (F31) Apply for PA 10 178 Funding Number: PA 10 178 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Postdoctoral Research Training in Pediatric Clinical and Developmental Pharmacology (T32) Apply for RFA HD 10 005 Funding Number: RFA HD 10 005 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Vulvodynia Systematic Epidemiologic, Etiologic or Therapeutic Studies (R01) Apply for PAR 10 190 Funding Number: PAR 10 190 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Vulvodynia Systematic Epidemiologic, Etiologic or Therapeutic Studies (R21) Apply for PAR 10 192 Funding Number: PAR 10 192 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Vulvodynia Systematic Epidemiologic, Etiologic or Therapeutic Studies (R03) Apply for PAR 10 191 Funding Number: PAR 10 191 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Natural History of Disorders Identifiable by Newborn Screening (R01) Apply for RFA HD 10 019 Funding Number: RFA HD 10 019 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $1,000,000 |
| Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Predoctoral Training Program in Systems Biology of Developmental Biology and Birth Defects(T32) Apply for PAR 10 193 Funding Number: PAR 10 193 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Predoctoral and Postdoctoral Training Program in Reproductive, Obstetric, Perinatal and Pediatric Epidemiology and Pharmacoepidemiology (T32) Apply for PAR 10 194 Funding Number: PAR 10 194 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Postdoctoral Research Training for Obstetricians and Gynecologists (T32) Apply for PAR 10 203 Funding Number: PAR 10 203 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Biophysical and Biomechanical Aspects of Embryonic Development (R21) Apply for PAR 10 222 Funding Number: PAR 10 222 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $200,000 |
| Biophysical and Biomechanical Aspects of Embryonic Development (R01) Apply for PAR 10 221 Funding Number: PAR 10 221 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Safe and Effective Instruments and Devices for Use in the Neonatal Intensive Care Units (SBIR R43) Apply for RFA HD 10 012 Funding Number: RFA HD 10 012 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $225,000 |
| Safe and Effective Instruments and Devices for Use in the Neonatal Intensive Care Units (STTR R41) Apply for RFA HD 10 013 Funding Number: RFA HD 10 013 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $225,000 |
| Innovative Therapies and Tools for Screenable Disorders in Newborns (R03) Apply for PAR 10 231 Funding Number: PAR 10 231 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Subscribe to Leads
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "PAS 10 148", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.