Opportunity Information: Apply for PA 10 147
Apply for PA 10 147
- The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "Small Grants on Primary Immunodeficiency Diseases (R03)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.855 Allergy, Immunology and Transplantation Research 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Feb 21, 2013 and posted on Mar 22, 2010.
- Applicants must submit their applications by Sep 7, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Native American tribal governments (Federally recognized) State governments Special district governments Others (see text field entitled Additional Information on Eligibility for clarification) For profit organizations other than small businesses Small businesses Public housing authorities/Indian housing authorities County governments Public and State controlled institutions of higher education Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Small Grants on Primary Immunodeficiency Diseases (R03) opportunity (Funding Opportunity Number PA 10 147) is a National Institutes of Health (NIH) discretionary grant program designed to fund small, focused research projects in the area of primary immunodeficiency diseases. The core aim is to move the field forward through tightly scoped studies that use ex vivo approaches with human specimens and/or experiments using existing or newly developed animal models. Within that scientific focus, the program is especially interested in work that advances clinically relevant strategies, such as better ways to detect or diagnose primary immunodeficiencies, efforts to identify their molecular or genetic causes, and early-stage development of innovative therapies.
A key feature of this announcement is that it uses the NIH R03 mechanism, which is meant for projects that are modest in size and can be completed relatively quickly with limited resources. The FOA explicitly highlights several project types that fit the R03 format: pilot and feasibility studies that generate preliminary data, secondary analyses of existing datasets, small self-contained research projects with narrow and achievable aims, and the development of research methods or new research technologies that could enable bigger studies later. In practical terms, this mechanism is well suited for proof-of-concept work, testing a novel assay or workflow, validating a model system, or exploring a targeted hypothesis without the scale expected of larger NIH awards.
The announcement also makes a point of encouraging applications from investigators who are earlier in their independent funding trajectory, including researchers with no prior history of receiving independent NIH funding, or those who have not previously held independent NIH funding specifically in primary immunodeficiency diseases research. This emphasis signals that NIH is using the R03 pathway not only to advance specific scientific questions, but also to help bring additional investigators into the primary immunodeficiency research space by supporting accessible, entry-level projects that can later grow into larger programs of research.
In terms of how the program is structured, PA 10 147 runs in parallel with another NIH funding opportunity of identical scientific scope, PAS 10 148, which supports the same general research area but through the R21 mechanism. That parallel structure effectively gives applicants two potential entry points depending on the nature of their proposed work and the size/risk profile of the project, while keeping the scientific goals aligned across both announcements.
Funding expectations in the announcement indicate that NIH anticipated approximately $150,000 being available under this FOA and projected making about two new awards per fiscal year. As with many federal opportunities, the FOA notes that awards depend on the availability of appropriated funds and on receiving a sufficient number of meritorious applications, meaning funding is competitive and not guaranteed simply because an application is submitted.
Eligibility is broad and includes a wide range of public and private entities. Eligible applicants include federal, state, county, city/township, and special district governments; public and state-controlled institutions of higher education as well as private institutions of higher education; nonprofit organizations (including 501(c)(3) and non-501(c)(3) entities, with distinctions noted in the FOA); for-profit organizations other than small businesses; and small businesses. The eligibility list also explicitly includes tribal governments and tribal organizations in multiple categories, along with public housing authorities/Indian housing authorities and independent school districts. The FOA further clarifies additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based and community-based organizations, regional organizations, and U.S. territories or possessions. The opportunity does not require cost sharing or matching.
Administratively, the FOA was posted on March 22, 2010, with an original closing date of May 7, 2013, a later listed closing date of September 7, 2013, and an archive date of October 7, 2013. The CFDA numbers associated with the program include 93.855 (Allergy, Immunology and Transplantation Research) and 93.865 (Child Health and Human Development Extramural Research), which reflects the immunology and child health relevance of many primary immunodeficiency conditions. For full details, NIH provided an official announcement link (http://grants.nih.gov/grants/guide/pa-files/PA-10-147.html) and contact information through the NIH Office of Extramural Research (OER) webmaster for access or technical issues.
Frequently Asked Questions (FAQs): Small Grants on Primary Immunodeficiency Diseases (R03) - PA-10-147
What is the Small Grants on Primary Immunodeficiency Diseases (R03) opportunity (PA-10-147)?
PA-10-147 is a National Institutes of Health (NIH) discretionary grant opportunity that uses the R03 mechanism to support small, focused research projects in primary immunodeficiency diseases. The intent is to move the field forward through tightly scoped studies that can be completed relatively quickly with limited resources.
What is the main scientific focus of PA-10-147?
The opportunity focuses on primary immunodeficiency diseases research using ex vivo approaches with human specimens and/or experiments using existing or newly developed animal models. Within that scope, NIH is especially interested in projects that advance clinically relevant strategies.
What kinds of clinically relevant strategies are emphasized?
The announcement highlights interest in work that improves detection or diagnosis of primary immunodeficiencies, identifies molecular or genetic causes, and supports early-stage development of innovative therapies.
What does the NIH R03 mechanism mean in practical terms for project size and scope?
The R03 mechanism is designed for modest-sized projects with narrow, achievable aims that can be completed relatively quickly. It is well suited for proof-of-concept studies and other tightly scoped efforts that do not require the scale of larger NIH awards.
What types of projects are specifically described as a good fit for this R03 FOA?
PA-10-147 explicitly notes several project types that align with R03 expectations: pilot and feasibility studies that generate preliminary data, secondary analyses of existing datasets, small self-contained research projects with narrow and achievable aims, and development of research methods or new research technologies that could enable larger studies later.
Does this opportunity support proof-of-concept or early validation work?
Yes. The R03 format described in the announcement is positioned as a good fit for proof-of-concept work, testing a novel assay or workflow, validating a model system, or exploring a targeted hypothesis without the scale expected of larger awards.
Are ex vivo studies with human specimens allowed or encouraged?
Yes. The FOA specifically mentions ex vivo approaches with human specimens as part of the core scientific approaches of interest.
Are animal model studies allowed or encouraged?
Yes. The FOA includes experiments using existing or newly developed animal models as a key approach for projects under this opportunity.
Is NIH encouraging applications from early-career or new-to-NIH investigators?
Yes. The FOA encourages applications from investigators who are earlier in their independent funding trajectory, including researchers with no prior history of receiving independent NIH funding, or those who have not previously held independent NIH funding specifically in primary immunodeficiency diseases research.
How does PA-10-147 relate to PAS-10-148?
PA-10-147 runs in parallel with PAS-10-148, which supports the same general research area and scientific scope but uses the R21 mechanism. This provides two potential entry points depending on project nature and the size/risk profile, while keeping scientific goals aligned across both announcements.
How much funding was NIH expecting to be available for PA-10-147?
The FOA indicates NIH anticipated approximately $150,000 being available under this opportunity and projected making about two new awards per fiscal year, subject to appropriations and application quality.
How many awards did NIH project making per fiscal year?
The FOA projected about two new awards per fiscal year, depending on availability of appropriated funds and the number of meritorious applications received.
Is funding guaranteed if an application is submitted?
No. The FOA notes that awards depend on the availability of appropriated funds and on receiving a sufficient number of meritorious applications, meaning the program is competitive and funding is not guaranteed.
Who is eligible to apply for PA-10-147?
Eligibility is broad and includes many public and private entities. The FOA lists eligible applicants including federal, state, county, city/township, and special district governments; public and state-controlled institutions of higher education and private institutions of higher education; nonprofit organizations (including 501(c)(3) and non-501(c)(3) entities, with distinctions noted in the FOA); for-profit organizations other than small businesses; and small businesses.
Are tribal governments and tribal organizations eligible?
Yes. The eligibility list explicitly includes tribal governments and tribal organizations in multiple categories.
Are public housing authorities or Indian housing authorities eligible applicants?
Yes. The FOA explicitly includes public housing authorities/Indian housing authorities among eligible applicants.
Are independent school districts eligible?
Yes. Independent school districts are explicitly included in the eligibility list.
Are minority-serving institutions and similar organizations included in the eligible applicant types?
Yes. The FOA further clarifies additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs).
Are faith-based, community-based, regional organizations, and U.S. territories eligible?
Yes. The FOA indicates eligibility includes faith-based and community-based organizations, regional organizations, and U.S. territories or possessions.
Is cost sharing or matching required under this opportunity?
No. The opportunity does not require cost sharing or matching.
When was PA-10-147 posted, and what were the listed closing and archive dates?
The FOA was posted on March 22, 2010. It lists an original closing date of May 7, 2013, a later listed closing date of September 7, 2013, and an archive date of October 7, 2013.
What CFDA numbers are associated with PA-10-147?
The CFDA numbers associated with this opportunity include 93.855 (Allergy, Immunology and Transplantation Research) and 93.865 (Child Health and Human Development Extramural Research).
Why are two CFDA numbers listed for this opportunity?
The FOA indicates CFDA 93.855 and 93.865, reflecting the immunology and child health relevance of many primary immunodeficiency conditions.
Where can applicants find the official NIH announcement page for PA-10-147?
NIH provided an official announcement link at http://grants.nih.gov/grants/guide/pa-files/PA-10-147.html.
Who should be contacted for access or technical issues related to the announcement?
The FOA states that contact information for access or technical issues is available through the NIH Office of Extramural Research (OER) webmaster.
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Applicants also applied for:
Applicants who have applied for this opportunity (PA 10 147) also looked into and applied for these:
| Funding Opportunity |
|---|
| Exploratory/Developmental Investigations on Primary Immunodeficiency Diseases (R21) Apply for PAS 10 148 Funding Number: PAS 10 148 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $200,000 |
| Pelvic Floor Disorders Network Data Coordinating Center (U01) Apply for RFA HD 10 024 Funding Number: RFA HD 10 024 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Pelvic Floor Disorders Network Clinical Sites (U10) Apply for RFA HD 10 002 Funding Number: RFA HD 10 002 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Child Health Research Career Development Award (CHRCDA) Program K12 Apply for RFA HD 10 007 Funding Number: RFA HD 10 007 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $400,000 |
| International Extramural Associates Research Development Awards (IEARDA) G11 Apply for PAR 10 172 Funding Number: PAR 10 172 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Advanced Tools and Technologies for Deep Brain Stimulation (STTR R41/R42) Apply for PA 10 175 Funding Number: PA 10 175 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Advanced Tools and Technologies for Deep Brain Stimulation (SBIR R43/R44) Apply for PA 10 176 Funding Number: PA 10 176 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Ruth L. Kirschstein National Research Service Awards (NRSA) for Individual Predoctoral Fellows in PharmD/PhD Programs (F31) Apply for PA 10 178 Funding Number: PA 10 178 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Postdoctoral Research Training in Pediatric Clinical and Developmental Pharmacology (T32) Apply for RFA HD 10 005 Funding Number: RFA HD 10 005 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Vulvodynia Systematic Epidemiologic, Etiologic or Therapeutic Studies (R01) Apply for PAR 10 190 Funding Number: PAR 10 190 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Vulvodynia Systematic Epidemiologic, Etiologic or Therapeutic Studies (R21) Apply for PAR 10 192 Funding Number: PAR 10 192 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Vulvodynia Systematic Epidemiologic, Etiologic or Therapeutic Studies (R03) Apply for PAR 10 191 Funding Number: PAR 10 191 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Natural History of Disorders Identifiable by Newborn Screening (R01) Apply for RFA HD 10 019 Funding Number: RFA HD 10 019 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $1,000,000 |
| Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Predoctoral Training Program in Systems Biology of Developmental Biology and Birth Defects(T32) Apply for PAR 10 193 Funding Number: PAR 10 193 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Predoctoral and Postdoctoral Training Program in Reproductive, Obstetric, Perinatal and Pediatric Epidemiology and Pharmacoepidemiology (T32) Apply for PAR 10 194 Funding Number: PAR 10 194 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Postdoctoral Research Training for Obstetricians and Gynecologists (T32) Apply for PAR 10 203 Funding Number: PAR 10 203 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Biophysical and Biomechanical Aspects of Embryonic Development (R21) Apply for PAR 10 222 Funding Number: PAR 10 222 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $200,000 |
| Biophysical and Biomechanical Aspects of Embryonic Development (R01) Apply for PAR 10 221 Funding Number: PAR 10 221 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Safe and Effective Instruments and Devices for Use in the Neonatal Intensive Care Units (SBIR R43) Apply for RFA HD 10 012 Funding Number: RFA HD 10 012 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $225,000 |
| Safe and Effective Instruments and Devices for Use in the Neonatal Intensive Care Units (STTR R41) Apply for RFA HD 10 013 Funding Number: RFA HD 10 013 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $225,000 |
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