Opportunity Information: Apply for RFA DE 14 005
Apply for RFA DE 14 005
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "FaceBase 2 Craniofacial Development and Dysmorphology Data Management and Integration Hub (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121 Oral Diseases and Disorders Research.
- This funding opportunity was created on Apr 5, 2013 and posted on Apr 5, 2013.
- Applicants must submit their applications by Aug 22, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,000,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Small businesses Public housing authorities/Indian housing authorities Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Special district governments State governments Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses City or township governments Independent school districts.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
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Opportunity Summary:
The FaceBase 2 Craniofacial Development and Dysmorphology Data Management and Integration Hub (U01) opportunity (RFA-DE-14-005) was a National Institutes of Health (NIH), National Institute of Dental and Craniofacial Research (NIDCR) funding announcement aimed at supporting the central coordinating and public-facing infrastructure for the FaceBase Consortium. FaceBase, originally launched in 2009, was created to accelerate craniofacial research by generating, organizing, and broadly sharing high-value datasets on craniofacial development and craniofacial dysmorphologies. The Consortium operates as a spoke-and-hub model: multiple independently funded "spoke" projects produce datasets, analytic tools, and related resources, and the hub serves as the central point that receives those outputs, standardizes and integrates them, and then distributes them to the broader scientific community through the FaceBase website (www.facebase.org). In practical terms, this FOA was not primarily about funding new wet-lab discovery projects; it was about funding the informatics, governance, and dissemination engine that makes the entire consortium usable and valuable to researchers outside the individual spoke teams.
The core purpose of the award was to establish or maintain a robust data management and integration hub that can reliably collect consortium-generated datasets and tools, curate them to consistent quality and metadata standards, integrate them so they can be queried together, and disseminate them publicly. Because the hub is described as the Consortium's "public face," the expectation was that the funded group would run the FaceBase platform in a way that is accessible and useful to the wider craniofacial research community, not just to participating consortium members. That implies responsibilities like maintaining a stable web presence, ensuring datasets are findable and reusable, and providing user-oriented interfaces for browsing, searching, and downloading resources. A major emphasis of the description is on integration and usability: the hub was expected to lead development of more sophisticated methods for searching across integrated FaceBase data and for visualizing those data in ways that help researchers interpret and reuse them. This generally points to building modern data discovery tools, cross-dataset query functionality, and visualization approaches appropriate for complex biological and craniofacial research data types.
Another central expectation was close, ongoing collaboration with the spoke projects. The hub was expected to work directly with data generators to create efficient, consistent processes for data deposition, organization, and annotation. In a consortium setting, this typically means the hub defines submission guidelines, data dictionaries and metadata requirements, quality control checks, and timelines, then helps spoke projects package their data in compliant formats so the resulting resources can be integrated rather than sitting in isolated silos. The hub role also extended beyond informatics into consortium operations and coordination. The FOA explicitly lists coordinating consortium-wide activities such as working group meetings, Steering Committee meetings, and the annual all-hands consortium meeting. So the funded organization would be responsible not only for technology and data workflows, but also for the administrative and collaborative backbone that keeps a multi-site consortium aligned on standards, schedules, and shared goals.
Administratively, this funding opportunity used the U01 mechanism, which is a cooperative agreement. That matters because it signals substantial NIH involvement in the project: unlike a standard research project grant, a cooperative agreement typically involves more active partnership with NIH program staff in areas such as milestone setting, coordination expectations, data-sharing practices, and consortium governance. The opportunity fell under the health funding activity category, with CFDA number 93.121 (Oral Diseases and Disorders Research). The FOA anticipated making one award, with an estimated total funding level of about $2,000,000 (as listed in the source details), indicating a single hub site was intended to serve the consortium as the centralized platform rather than having multiple competing hubs.
Eligibility was broad across U.S.-based organizations, spanning public and private institutions of higher education, nonprofits (including those with and without 501(c)(3) status), state, county, city, township and special district governments, independent school districts, tribal governments and tribal organizations, public housing authorities/Indian housing authorities, small businesses, and other for-profit organizations (excluding small businesses only where specified otherwise). The FOA also clarifies that certain institution types are included under "other eligible applicants," such as HBCUs, Hispanic-serving institutions, AANAPISI institutions, tribal colleges and universities, and Alaska Native/Native Hawaiian-serving institutions, as well as faith-based or community-based organizations and eligible federal agencies. At the same time, it clearly excludes foreign institutions and other non-U.S. entities: non-domestic (non-U.S.) entities were not eligible to apply, non-domestic components of U.S. organizations were not eligible, and foreign components (as NIH defines them) were not allowed. There was no cost sharing or matching requirement.
Key dates in the archived announcement show it was posted on April 5, 2013, with an original and current closing date of August 22, 2013, and an archive date of September 22, 2013. In other words, this was a time-limited solicitation for a specific consortium role, designed to select a single team to run and evolve the FaceBase data management and integration hub for the FaceBase 2 phase. For further details, the announcement pointed applicants to the full FOA text hosted on the NIH Grants Guide website (link provided in the source information) and provided NIH Office of Extramural Research (OER) webmaster contacts for access or technical linking issues.
FaceBase 2 Data Management and Integration Hub (U01) - FAQs
What is the FaceBase 2 Craniofacial Development and Dysmorphology Data Management and Integration Hub (U01) opportunity?
It was an NIH funding opportunity announcement (FOA) from the National Institute of Dental and Craniofacial Research (NIDCR) to support the central coordinating, data management, integration, and public-facing infrastructure for the FaceBase Consortium. The FOA identifier was RFA-DE-14-005, using the U01 cooperative agreement mechanism.
Which NIH institute sponsored this FOA?
The FOA was sponsored by NIH's National Institute of Dental and Craniofacial Research (NIDCR).
What is FaceBase, and why does it exist?
FaceBase is a consortium-based effort (originally launched in 2009) created to accelerate craniofacial research by generating, organizing, and broadly sharing high-value datasets on craniofacial development and craniofacial dysmorphologies.
What does the "spoke-and-hub" model mean in this program?
In the FaceBase Consortium, multiple independently funded "spoke" projects produce datasets, analytic tools, and related resources. The "hub" serves as the central point that receives those outputs, standardizes and integrates them, and distributes them to the broader scientific community through the FaceBase website (www.facebase.org).
What was the main purpose of funding under this FOA?
The purpose was to establish or maintain a robust data management and integration hub that can reliably collect consortium-generated datasets and tools, curate them to consistent quality and metadata standards, integrate them so they can be queried together, and disseminate them publicly.
Was this FOA intended to fund new wet-lab discovery research projects?
No. The description emphasizes that the FOA was not primarily about funding new wet-lab discovery projects. It focused on funding the informatics, governance, coordination, and dissemination engine that makes the consortium's outputs usable and valuable to the broader research community.
What kinds of deliverables were expected from the funded hub?
Expected deliverables included a stable and usable FaceBase platform; processes for receiving and managing datasets and tools from spoke projects; standardized curation, metadata, and quality control; integrated data that can be queried across datasets; and public dissemination via the FaceBase website.
Why is the hub described as the consortium's "public face"?
Because the hub is responsible for running the FaceBase platform in a way that is accessible and useful to the wider craniofacial research community, not only to consortium members. This includes public dissemination, user-oriented interfaces, and making datasets findable and reusable.
What was the emphasis on integration and usability?
The FOA emphasized improving how users can search across integrated FaceBase data and visualize those data to support interpretation and reuse. This points to building stronger data discovery, cross-dataset query functionality, and visualization approaches for complex craniofacial and biological data types.
What was the hub expected to do with respect to data standards and metadata?
The hub was expected to curate consortium datasets and tools to consistent quality and metadata standards, helping ensure outputs can be integrated rather than remaining isolated in separate silos.
How was the hub expected to work with spoke projects?
The hub was expected to collaborate closely and continuously with data-generating spoke projects to create efficient and consistent processes for data deposition, organization, and annotation.
What operational or administrative coordination responsibilities were included?
Beyond informatics, the FOA explicitly included coordinating consortium-wide activities such as working group meetings, Steering Committee meetings, and the annual all-hands consortium meeting.
What is the U01 mechanism, and why does it matter here?
U01 is a cooperative agreement mechanism, which indicates substantial NIH involvement compared to a standard research project grant. This typically implies more active NIH partnership in areas such as milestone setting, coordination expectations, data-sharing practices, and consortium governance.
How many awards were anticipated under this FOA?
The FOA anticipated making one award, reflecting an intent to support a single centralized hub site rather than multiple competing hubs.
What was the estimated total funding level for the award?
The source details listed an estimated total funding level of about $2,000,000.
What is the CFDA number and program area associated with this opportunity?
The opportunity fell under the health funding activity category with CFDA number 93.121, titled Oral Diseases and Disorders Research.
Who was eligible to apply?
Eligibility was broad across U.S.-based organizations, including public and private institutions of higher education; nonprofits (with and without 501(c)(3) status); state, county, city, township and special district governments; independent school districts; tribal governments and tribal organizations; public housing authorities/Indian housing authorities; small businesses; other for-profit organizations; and other eligible applicants identified in the FOA.
Which types of institutions were explicitly included under "other eligible applicants"?
The FOA noted inclusion of institution types such as HBCUs, Hispanic-serving institutions, AANAPISI institutions, tribal colleges and universities, and Alaska Native/Native Hawaiian-serving institutions, as well as faith-based or community-based organizations and eligible federal agencies.
Were foreign institutions or non-U.S. entities allowed to apply?
No. The FOA excluded foreign institutions and other non-U.S. entities. Non-domestic (non-U.S.) entities were not eligible to apply, non-domestic components of U.S. organizations were not eligible, and foreign components (as NIH defines them) were not allowed.
Was cost sharing or matching required?
No. The FOA stated there was no cost sharing or matching requirement.
What were the key dates for this funding opportunity?
The FOA was posted on April 5, 2013. The original closing date and the current closing date were August 22, 2013. The archive date was September 22, 2013.
Is this FOA still open?
No. Based on the provided dates and the archive status, it was a time-limited solicitation that closed on August 22, 2013 and was archived on September 22, 2013.
Where were applicants directed to find the full FOA text?
Applicants were directed to the full FOA text hosted on the NIH Grants Guide website (via the link provided in the source information).
Who was listed for technical or linking support related to the announcement?
The announcement referenced NIH Office of Extramural Research (OER) webmaster contacts for access or technical linking issues.
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