Opportunity Information: Apply for RFA DE 14 004
Apply for RFA DE 14 004
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "FaceBase 2 Craniofacial Development and Dysmorphology Dataset, Tool, and Resource Development (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121 Oral Diseases and Disorders Research.
- This funding opportunity was created on Apr 5, 2013 and posted on Apr 5, 2013.
- Applicants must submit their applications by Aug 22, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $4,500,000.00 to eligible and selected applicants.
- Eligible applicants include: Special district governments County governments Public housing authorities/Indian housing authorities For profit organizations other than small businesses Independent school districts State governments Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses City or township governments Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Others (see text field entitled Additional Information on Eligibility for clarification).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The FaceBase 2 Craniofacial Development and Dysmorphology Dataset, Tool, and Resource Development (U01) opportunity (RFA-DE-14-004) is a National Institute of Dental and Craniofacial Research (NIDCR), NIH-funded cooperative agreement aimed at expanding the FaceBase Consortium into its second phase. FaceBase, originally launched in 2009, is built around a straightforward mission: accelerate craniofacial research by generating high-quality, well-annotated datasets on normal craniofacial development and craniofacial dysmorphologies, and then making those data broadly usable by the research community through public dissemination at www.facebase.org. The consortium structure is intentionally networked, with multiple investigator-led "spoke" projects producing data, analytical tools, and other resources, all feeding into a central data management and integration hub that standardizes, integrates, and distributes these outputs so they can be searched, accessed, and reused by others.
This FOA specifically solicits applications for a new round of spoke projects that will make up FaceBase's second iteration. Proposed projects are expected to align with FaceBase's core goals of experimental data collection and careful annotation, plus strong attention to data coordination and integration so that what is produced can be meaningfully combined with other consortium outputs. A major emphasis is that new submissions should be complementary to what FaceBase already offers rather than duplicating existing datasets, tools, or resources. In practice, this means applicants should demonstrate awareness of what is currently available on FaceBase and clearly justify how their proposed resource fills a gap, adds a new dimension, improves interoperability, or enables analyses that are not currently feasible with existing FaceBase content.
Scientifically, the program remains centered on both normal craniofacial development and dysmorphology, but it is not limited to the midface and palate. The FOA explicitly allows applications that investigate other parts of the skull beyond those regions. Even with that openness, NIDCR signals clear programmatic priorities: high priority is given to studies addressing facial development, palatal development, and cranial vault development, as well as dysmorphologies affecting these structures. In other words, while broader skull research is welcome, the strongest alignment is with projects that deepen understanding of how the face, palate, and cranial vault form, vary, and become altered in developmental disorders, and that generate reusable resources that other researchers can immediately build on.
From an administrative standpoint, the funding mechanism is a U01 cooperative agreement, which typically indicates substantial NIH scientific or programmatic involvement compared with a standard research project grant. The opportunity falls under the Health activity category and is associated with CFDA 93.121 (Oral Diseases and Disorders Research). The estimated total funding amount listed for the FOA is $4,500,000, and there is no cost sharing or matching requirement. The FOA was posted April 5, 2013, with an original and current closing date of August 22, 2013, and an archive date of September 22, 2013.
Eligibility is broad and spans many organization types, including federal, state, local, and tribal government entities; public and private institutions of higher education; nonprofit organizations (including both 501(c)(3) and other nonprofit types); for-profit organizations (other than small businesses) as well as small businesses; independent school districts; special district governments; and public housing authorities/Indian housing authorities. The FOA also clarifies inclusion of a wide range of institution categories and community-based entities, such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, AANAPISI institutions, faith-based or community-based organizations, and eligible federal agencies. Importantly, non-U.S. entities are eligible: foreign organizations and foreign institutions may apply, non-U.S. components of U.S. organizations are eligible, and foreign components (as defined by NIH policy) are allowed, signaling an intent to capture globally relevant expertise and datasets as long as they fit the consortium's sharing and integration goals.
Operationally, the main deliverable expectation is not just a conventional research outcome but a well-constructed, community-facing resource: comprehensive datasets paired with sufficient metadata, annotation, and potentially analytic tools that can be integrated into the FaceBase hub and redistributed publicly. The consortium model implies that applicants should be prepared to collaborate, follow common standards where applicable, and design their outputs for interoperability and reuse. The full announcement is linked through NIH at http://grants.nih.gov/grants/guide/rfa-files/RFA-DE-14-004.html, and technical access issues are directed to the NIH Office of Extramural Research webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs)
What is the FaceBase 2 Craniofacial Development and Dysmorphology Dataset, Tool, and Resource Development (U01) funding opportunity?
This opportunity (RFA-DE-14-004) is an NIH/NIDCR-funded cooperative agreement (U01) that supports new investigator-led projects ("spokes") for the second phase of the FaceBase Consortium. The focus is on generating high-quality, well-annotated craniofacial datasets (and potentially tools/resources) and making them broadly usable through public dissemination via www.facebase.org.
Which NIH Institute is sponsoring this opportunity?
The opportunity is sponsored by the National Institute of Dental and Craniofacial Research (NIDCR), part of the National Institutes of Health (NIH).
What is the overall mission of FaceBase?
FaceBase was launched in 2009 to accelerate craniofacial research by producing high-quality, carefully annotated datasets on normal craniofacial development and craniofacial dysmorphologies, and distributing those resources publicly so the research community can search, access, and reuse them.
What does "FaceBase 2" mean in this FOA?
This FOA is intended to expand the FaceBase Consortium into its second phase by funding a new round of spoke projects that add complementary datasets, tools, and resources that can be integrated into the consortium's central hub and shared through FaceBase.
What funding mechanism is used?
The mechanism is a U01 cooperative agreement, which generally indicates substantial NIH scientific or programmatic involvement compared with a standard research project grant.
How is the FaceBase Consortium organized?
The consortium uses a networked structure with multiple investigator-led spoke projects producing datasets, analytical tools, and other resources. These outputs feed into a central data management and integration hub that standardizes, integrates, and distributes the resources so they can be searched, accessed, and reused.
What kinds of projects does this FOA solicit?
The FOA solicits applications for spoke projects that generate experimental data and careful annotation, with strong attention to data coordination and integration so the outputs can be meaningfully combined with other FaceBase resources and redistributed publicly.
Is the main expected deliverable a research paper, or a resource?
The main expectation is a community-facing resource: comprehensive datasets (and possibly analytic tools/resources) accompanied by sufficient metadata and annotation to support integration into the FaceBase hub and public redistribution.
What scientific areas are within scope?
The program centers on normal craniofacial development and craniofacial dysmorphology. It is not limited to the midface and palate; applications may investigate other parts of the skull beyond those regions.
What scientific areas are considered high priority?
NIDCR states high priority for studies addressing facial development, palatal development, and cranial vault development, as well as dysmorphologies affecting these structures.
Are projects limited to midface and palate research?
No. The FOA explicitly allows studies investigating other parts of the skull beyond the midface and palate, while still emphasizing priority areas such as face, palate, and cranial vault development.
Does this FOA encourage creating brand-new resources, or can applicants replicate existing FaceBase datasets/tools?
The FOA emphasizes that new submissions should be complementary to what FaceBase already offers rather than duplicating existing datasets, tools, or resources.
How should applicants address existing FaceBase content in their application?
Applicants are expected to demonstrate awareness of what is currently available on FaceBase and justify how their proposed resource fills a gap, adds a new dimension, improves interoperability, or enables analyses not currently feasible with existing FaceBase content.
What does "complementary" mean in this context?
Based on the FOA description, complementary resources are those that add value without duplicating existing content, for example by filling a gap in available datasets, adding a new type of annotation, improving data interoperability, or enabling new analyses when combined with other FaceBase outputs.
What role does data coordination and integration play in this opportunity?
Data coordination and integration are central expectations. Projects should be designed so their datasets and resources can be standardized, integrated into the FaceBase hub, and distributed publicly in ways that support search, access, and reuse by other researchers.
What is the FaceBase data management and integration hub?
It is the central component of the consortium that receives outputs from spoke projects and performs standardization, integration, and distribution so that datasets, tools, and resources can be searched, accessed, and reused by the research community.
Where are FaceBase resources made publicly available?
FaceBase resources are disseminated publicly at www.facebase.org.
What activity category is associated with this FOA?
The opportunity is listed under the Health activity category.
What CFDA number is associated with this opportunity?
The CFDA number is 93.121 (Oral Diseases and Disorders Research).
How much total funding is estimated for this FOA?
The FOA lists an estimated total funding amount of $4,500,000.
Is cost sharing or matching required?
No. The FOA states there is no cost sharing or matching requirement.
When was the FOA posted?
The FOA was posted on April 5, 2013.
What is the application closing date?
The original and current closing date listed is August 22, 2013.
When was (or is) the FOA archived?
The archive date listed is September 22, 2013.
Who is eligible to apply?
Eligibility is broad and includes many organization types, such as federal, state, local, and tribal governments; public and private institutions of higher education; nonprofit organizations (including 501(c)(3) and other nonprofit types); for-profit organizations (including small businesses and other than small businesses); independent school districts; special district governments; and public housing authorities/Indian housing authorities.
Are minority-serving institutions and community-based organizations included in eligibility?
Yes. The FOA explicitly includes categories such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, AANAPISI institutions, and faith-based or community-based organizations, among others.
Can foreign (non-U.S.) organizations apply?
Yes. The FOA states that foreign organizations and foreign institutions may apply, non-U.S. components of U.S. organizations are eligible, and foreign components (as defined by NIH policy) are allowed.
What is the intended benefit of allowing foreign organizations or components?
As described, this approach supports inclusion of globally relevant expertise and datasets, provided they fit the consortium's goals for data sharing and integration into FaceBase.
What level of collaboration is implied by this program?
The consortium model implies that funded projects should be prepared to collaborate, follow common standards where applicable, and design outputs for interoperability and reuse across the network and the central hub.
Where can applicants find the full funding announcement?
The full announcement is available through NIH at http://grants.nih.gov/grants/guide/rfa-files/RFA-DE-14-004.html.
Who should be contacted for technical access issues with the NIH posting?
Technical access issues are directed to the NIH Office of Extramural Research webmaster at FBOWebmaster@OD.NIH.GOV.
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