Opportunity Information: Apply for RFA DK 08 006
Apply for RFA DK 08 006
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Fine Mapping and Function of Genes for Type 1 Diabetes (DP3)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research.
- This funding opportunity was created on Oct 16, 2008 and posted on Oct 16, 2008.
- Applicants must submit their applications by Mar 30, 2009. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $20,000,000.00 to eligible and selected applicants.
- Eligible applicants include: Small businesses Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Public and State controlled institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Non domestic (non U.S.) Entities (Foreign Organizations) Tribally Controlled Colleges and Universities (TCCUs) .
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Opportunity Summary:
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) at the National Institutes of Health offered this discretionary grant opportunity, titled "Fine Mapping and Function of Genes for Type 1 Diabetes (DP3)," under Funding Opportunity Number RFA-DK-08-006. The program was designed to push beyond initial genome-wide association study (GWAS) signals for type 1 diabetes by supporting the next steps needed to confirm, sharpen, and biologically interpret genetic associations. In practical terms, the goal was to fund research projects that take putative type 1 diabetes risk regions identified by GWAS and perform replication and fine-mapping work to rule out false positives, validate findings across additional cohorts, and narrow broad association regions down to smaller sets of candidate variants and genes. A strong emphasis was placed on extending findings to diverse populations, including diversity by ethnicity and by environmental exposures, because results from one population may not generalize cleanly to others and because population differences can help refine causal regions through differing linkage patterns.
A second major focus of the opportunity was functional follow-up: understanding what the implicated genes actually do and how specific variants might alter risk for type 1 diabetes. The FOA encouraged mechanistic studies aimed at connecting genetic variation to disease biology, including how these genes contribute to the etiopathogenesis of type 1 diabetes (for example, through effects on immune regulation, beta-cell vulnerability, or other pathways relevant to disease initiation and progression). By pairing fine mapping with functional studies, the initiative aimed to move the field from statistical association toward causal understanding. The announcement also explicitly invited proposals that applied new or emerging technologies to type 1 diabetes genetics and to studying how identified genes influence disease mechanisms, reflecting the intent to accelerate progress using improved genotyping/sequencing, analytical approaches, and experimental functional genomics tools available at the time.
The mechanism of support for this program was the NIH DP3 grant mechanism, described in the announcement as a Research Project Grant (DP3). The total estimated funding level was $20,000,000 for the five-year period, with an anticipated 4 to 10 awards. There was no cost-sharing or matching requirement listed. The opportunity was posted on October 16, 2008, with an original and current closing date of March 30, 2009, and an archive date of April 30, 2009.
Eligibility was broad and included a range of organizational types: public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations with and without 501(c)(3) status (excluding institutions of higher education for those categories as specified), for-profit organizations (including small businesses and other for-profits), and additional eligible applicants such as federally eligible agencies, Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and non-U.S. entities (foreign organizations). The program fell under the health funding activity category and was associated with CFDA number 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research).
Overall, this FOA targeted the critical gap between discovering genetic signals for type 1 diabetes and translating them into credible causal variants, validated across populations, with biological mechanisms mapped clearly enough to illuminate disease pathways and suggest new therapeutic targets. The full announcement was made available through the NIH grants guide at the link provided in the notice (http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-08-006.html), with NIH Office of Extramural Research contact points listed for technical access issues.
Frequently Asked Questions (FAQs)
What is the name of this grant opportunity?
The opportunity is titled "Fine Mapping and Function of Genes for Type 1 Diabetes (DP3)".
Which agency and institute offered this funding opportunity?
This discretionary grant opportunity was offered by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), which is part of the National Institutes of Health (NIH).
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-DK-08-006.
What is the main purpose of this program?
The program was designed to push beyond initial genome-wide association study (GWAS) signals for type 1 diabetes by funding the next steps needed to confirm, sharpen, and biologically interpret genetic associations.
What kinds of studies were this FOA trying to fund?
It aimed to support projects that take putative type 1 diabetes risk regions identified by GWAS and conduct:
- Replication work to rule out false positives and validate findings in additional cohorts
- Fine-mapping to narrow broad association regions down to smaller sets of candidate variants and genes
- Functional follow-up studies to understand what implicated genes do and how specific variants might alter type 1 diabetes risk
Why did the FOA emphasize replication and fine-mapping after GWAS?
The stated intent was to move past initial GWAS signals by confirming associations, reducing the chance of false positives, validating results across additional cohorts, and narrowing association regions to more credible candidate variants and genes.
Was there an emphasis on studying diverse populations?
Yes. The announcement placed strong emphasis on extending findings to diverse populations, including diversity by ethnicity and by environmental exposures. It noted that results from one population may not generalize to others and that population differences can help refine causal regions through differing linkage patterns.
What does “functional follow-up” mean in the context of this FOA?
Functional follow-up refers to mechanistic studies intended to connect genetic variation to type 1 diabetes biology. The FOA encouraged work investigating how implicated genes and variants contribute to the etiopathogenesis of type 1 diabetes, such as through effects on immune regulation, beta-cell vulnerability, or other pathways relevant to disease initiation and progression.
Did the FOA encourage the use of new or emerging technologies?
Yes. The announcement explicitly invited proposals applying new or emerging technologies to type 1 diabetes genetics and to studying how identified genes influence disease mechanisms, including improved genotyping/sequencing approaches, analytical methods, and experimental functional genomics tools available at the time.
What grant mechanism was used for this opportunity?
The mechanism of support was the NIH DP3 grant mechanism, described in the announcement as a Research Project Grant (DP3).
How much total funding was estimated for this program?
The total estimated funding level was $20,000,000 for the five-year period.
How many awards were anticipated?
The FOA anticipated making approximately 4 to 10 awards.
Was cost-sharing or matching required?
No. The announcement listed no cost-sharing or matching requirement.
When was the opportunity posted?
The opportunity was posted on October 16, 2008.
What were the closing date and archive date?
The original and current closing date was March 30, 2009. The archive date was April 30, 2009.
What types of organizations were eligible to apply?
Eligibility was broad and included:
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Nonprofit organizations with 501(c)(3) status (excluding institutions of higher education for that category as specified)
- Nonprofit organizations without 501(c)(3) status (excluding institutions of higher education for that category as specified)
- For-profit organizations (including small businesses and other for-profits)
- Additional eligible applicants such as federally eligible agencies
- Historically Black Colleges and Universities (HBCUs)
- Hispanic-serving institutions
- Tribally Controlled Colleges and Universities (TCCUs)
- Alaska Native and Native Hawaiian Serving Institutions
- Non-U.S. entities (foreign organizations)
Are foreign (non-U.S.) organizations eligible?
Yes. The eligibility list explicitly included non-U.S. entities (foreign organizations).
What funding activity category does this opportunity fall under?
The FOA fell under the health funding activity category.
What is the CFDA number associated with this program?
The program was associated with CFDA 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research).
What specific gap in the field was this FOA trying to address?
The FOA targeted the gap between discovering genetic signals for type 1 diabetes and translating them into:
- Credible causal variants
- Findings validated across populations
- Clear biological mechanisms linked to disease pathways
- Insights that could suggest new therapeutic targets
Where was the full announcement posted?
The full announcement was made available through the NIH Grants Guide at:
http://grants.nih.gov/grants/guide/rfa-files/RFA-DK-08-006.html
Who was listed for help with technical access issues?
The notice indicated that NIH Office of Extramural Research contact points were listed for technical access issues.
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