Opportunity Information: Apply for PA 07 035
Apply for PA 07 035
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Focal Cognitive Deficits in CNS Disorders (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.361 Nursing Research 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders 93.866 Aging Research.
- This funding opportunity was created on Dec 5, 2008 and posted on Nov 8, 2006.
- Applicants must submit their applications by Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education State governments Special district governments Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal organizations (other than Federally recognized tribal governments) Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education County governments Small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Native American tribal governments (Federally recognized) City or township governments Private institutions of higher education.
- Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith based or community based organizations can apply.
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Opportunity Summary:
The NIH funding opportunity "Focal Cognitive Deficits in CNS Disorders (R21)" (Funding Opportunity Number PA-07-035) is a discretionary grant program designed to stimulate new, exploratory research on specific, well-defined cognitive problems that occur in people living with central nervous system (CNS) disorders. The core aim is to broaden both basic and translational science, including intervention research, that clarifies what these focal cognitive deficits look like, how they arise, and what they mean for everyday functioning. Rather than focusing only on broad or global cognitive decline, this announcement highlights targeted deficits (for example, a particular impairment in attention, executive function, language, memory subcomponents, or processing speed) and encourages work that links those deficits to real-world outcomes and functional consequences for patients and caregivers.
The program is sponsored by multiple NIH components: the National Institute of Nursing Research (NINR), the National Institute on Aging (NIA), and the National Institute of Neurological Disorders and Stroke (NINDS), with the Office of Behavioral and Social Sciences Research (OBSSR) participating to advance research that addresses behavioral and social dimensions of health and illness. OBSSR involvement signals strong interest in studies that connect cognitive deficits to behavior, social functioning, self-management, adherence, caregiving dynamics, quality of life, and other life-context factors. Even so, the announcement makes clear that direct award funding will come from the participating NIH Institutes and Centers, not OBSSR itself.
This FOA uses the NIH R21 mechanism, which is generally intended for early-stage, high-impact, and sometimes higher-risk projects that can open up a new line of investigation, generate preliminary data, or test novel concepts or methods. In practice, that means the announcement is geared toward projects that may be at an earlier phase than a full-scale clinical or longitudinal trial, but that still have a clear rationale and the potential to push the field forward. The R21 here runs in parallel with companion announcements of the same scientific scope that use other mechanisms: an R01 version (PA-07-033) intended for more mature, larger research programs, and an R03 version (PA-07-034) aimed at smaller, short-term projects. Together, the trio offers a pathway for researchers to match the size and maturity of their idea to the most appropriate NIH grant mechanism.
In terms of what the NIH is trying to achieve, this opportunity emphasizes understanding the "types, nature, and functional consequences" of focal cognitive deficits in CNS disorders. That framing points to several broad research directions: carefully characterizing specific cognitive deficits within and across CNS conditions; identifying contributing mechanisms (neurological, behavioral, social, and environmental); improving measurement approaches that can sensitively detect focal impairments; and developing or piloting interventions that prevent, reduce, or help people compensate for these deficits. Because the announcement explicitly includes intervention research, applicants are not limited to observational or descriptive studies and can propose the development, adaptation, or early testing of strategies intended to improve cognitive functioning or mitigate downstream functional impacts.
Award decisions under this FOA depend on the availability of funds and on receiving enough applications that score well in peer review. The announcement does not promise a fixed number of awards, which is typical for many NIH program announcements; instead, it indicates that meritorious applications will be considered as budgets allow. The FOA lists multiple receipt dates rather than a single deadline, meaning applications were accepted on several cycles during its active period, with applicants directed to the full announcement for specific submission dates and details.
Eligibility is broad and includes many types of domestic applicants, such as public and private institutions of higher education, nonprofits (including both 501(c)(3) and certain non-501(c)(3) entities), small businesses, for-profit organizations (including those other than small businesses), state and local governments, independent school districts, special district governments, public housing authorities/Indian housing authorities, and tribal governments and tribal organizations. The opportunity also states that foreign institutions are eligible, eligible federal agencies may apply, and faith-based or community-based organizations are allowed to apply, which opens participation to a wide range of research and service settings that can contribute to studies on cognitive deficits and their practical impacts.
Administratively, this is an NIH grant in the Education/Health activity area and is associated with CFDA numbers that reflect the participating institutes program areas, including Nursing Research (93.361), Neurosciences and Neurological Disorders extramural research (93.853), and Aging Research (93.866). There is no cost sharing or matching requirement. The opportunity was posted on November 8, 2006, and while it originally accepted applications across multiple receipt dates, it was later archived (archive date listed as February 2, 2010). For the authoritative details, including application instructions and exact submission dates from the period it was active, the announcement points to the NIH Grants Guide page for PA-07-035 and provides the NIH Office of Extramural Research (OER) webmaster contact for technical access issues.
FAQs: NIH Focal Cognitive Deficits in CNS Disorders (R21) - PA-07-035
What is the "Focal Cognitive Deficits in CNS Disorders (R21)" funding opportunity?
It is an NIH discretionary grant program (Funding Opportunity Number PA-07-035) designed to stimulate new, exploratory research on specific, well-defined cognitive problems experienced by people living with central nervous system (CNS) disorders. The program emphasizes targeted (focal) cognitive deficits and their real-world consequences, rather than only broad or global cognitive decline.
What is the main goal of this FOA?
The core aim is to broaden both basic and translational science, including intervention research, that clarifies what focal cognitive deficits look like, how they arise, and what they mean for everyday functioning for patients and caregivers.
What does "focal cognitive deficits" mean in this announcement?
In this context, "focal" refers to targeted, specific impairments in defined cognitive domains or subcomponents (for example, a particular deficit in attention, executive function, language, memory subcomponents, or processing speed) rather than a general, overall decline in cognition.
How is this FOA different from research focused on general cognitive decline?
This announcement highlights specific, well-defined deficits and encourages linking those deficits to functional outcomes and daily life impacts. It is not limited to broad cognitive impairment measures or generalized decline; it prioritizes work that isolates and explains targeted cognitive problems and their consequences.
What types of research are encouraged under PA-07-035?
The FOA emphasizes understanding the "types, nature, and functional consequences" of focal cognitive deficits in CNS disorders. Examples of broad directions include characterizing specific deficits within/across CNS conditions, identifying contributing mechanisms (neurological, behavioral, social, environmental), improving sensitive measurement approaches, and developing or piloting interventions that prevent, reduce, or help people compensate for these deficits.
Does this FOA support intervention research, or only observational studies?
It explicitly includes intervention research. Applicants are not limited to descriptive or observational studies and may propose developing, adapting, or early testing strategies intended to improve cognitive functioning or reduce downstream functional impacts.
What is meant by "functional consequences" in the context of this FOA?
The program stresses connecting focal cognitive deficits to real-world outcomes and functional consequences, including how deficits affect everyday functioning for patients and caregivers.
Which NIH organizations sponsor or participate in this opportunity?
The FOA is sponsored by the National Institute of Nursing Research (NINR), the National Institute on Aging (NIA), and the National Institute of Neurological Disorders and Stroke (NINDS). The Office of Behavioral and Social Sciences Research (OBSSR) participates to advance work on behavioral and social dimensions of health and illness.
Does OBSSR provide the award funding for this FOA?
No. While OBSSR participates and signals interest in the behavioral and social dimensions of the research, the announcement specifies that direct award funding will come from the participating NIH Institutes and Centers, not OBSSR itself.
What does OBSSR participation suggest about the kinds of projects NIH is interested in?
OBSSR involvement signals strong interest in studies that connect cognitive deficits to behavior and social functioning, such as self-management, adherence, caregiving dynamics, quality of life, and other life-context factors.
What grant mechanism does this FOA use?
PA-07-035 uses the NIH R21 mechanism, which is generally intended for early-stage, exploratory, and potentially higher-risk projects that can open new lines of investigation, generate preliminary data, or test novel concepts or methods.
What does the R21 mechanism imply about project scope and maturity?
The R21 emphasis is on exploratory, high-impact work that may be earlier-phase than a full-scale clinical or longitudinal trial, while still requiring a clear rationale and strong potential to move the field forward.
Are there related funding opportunities with the same scientific scope?
Yes. This R21 FOA runs in parallel with companion announcements of the same scientific scope that use other mechanisms: an R01 version (PA-07-033) intended for more mature, larger research programs, and an R03 version (PA-07-034) aimed at smaller, short-term projects.
How are award decisions made under this FOA?
Award decisions depend on the availability of funds and on receiving enough applications that score well in peer review. The announcement does not promise a fixed number of awards; meritorious applications are considered as budgets allow.
Is there a single deadline for PA-07-035?
No. The FOA lists multiple receipt dates rather than a single deadline, meaning it accepted applications on several cycles during its active period. Applicants were directed to the full announcement for the specific submission dates and details.
When was this funding opportunity posted, and is it still active?
It was posted on November 8, 2006. The opportunity was later archived, with an archive date listed as February 2, 2010.
Who is eligible to apply?
Eligibility is broad and includes many types of domestic applicants, including public and private institutions of higher education, nonprofits (including 501(c)(3) and certain non-501(c)(3) entities), small businesses, for-profit organizations (including those other than small businesses), state and local governments, independent school districts, special district governments, public housing authorities/Indian housing authorities, and tribal governments and tribal organizations.
Are foreign institutions eligible to apply?
Yes. The opportunity states that foreign institutions are eligible.
Can federal agencies apply?
Yes. The opportunity indicates that eligible federal agencies may apply.
Are faith-based or community-based organizations allowed to apply?
Yes. The opportunity states that faith-based or community-based organizations are allowed to apply.
Is cost sharing or matching required?
No. The announcement states there is no cost sharing or matching requirement.
What activity area is associated with this NIH grant?
The FOA is an NIH grant in the Education/Health activity area.
What CFDA numbers are associated with this opportunity?
The announcement is associated with CFDA numbers reflecting participating institute program areas, including Nursing Research (93.361), Neurosciences and Neurological Disorders extramural research (93.853), and Aging Research (93.866).
Where can applicants find authoritative instructions and the official announcement details?
The announcement points to the NIH Grants Guide page for PA-07-035 for authoritative details, including application instructions and the exact submission dates that applied during its active period.
Who should be contacted for technical access issues related to the announcement?
For technical access issues, the opportunity provides the NIH Office of Extramural Research (OER) webmaster contact.
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