Opportunity Information: Apply for RFA DE 14 001
Apply for RFA DE 14 001
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Functional Characterization of Oral Cancer Initiating Cells (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121 Oral Diseases and Disorders Research.
- This funding opportunity was created on Mar 27, 2013 and posted on Mar 27, 2013.
- Applicants must submit their applications by Aug 15, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Special district governments State governments Private institutions of higher education For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments Native American tribal organizations (other than Federally recognized tribal governments) Public housing authorities/Indian housing authorities City or township governments Native American tribal governments (Federally recognized) Independent school districts Others (see text field entitled Additional Information on Eligibility for clarification) Small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Functional Characterization of Oral Cancer Initiating Cells (R01) funding opportunity (RFA-DE-14-001) was a National Institutes of Health (NIH) research grant announcement designed to push oral cancer research in a more translational direction. The main scientific goal was to support R01 projects that dig into the cellular, molecular, and functional features of oral Cancer Initiating Cells (CICs), along with the specialized microenvironments (often described as “nichesâ€) that help these cells survive, expand, resist therapy, or drive tumor recurrence. In practical terms, the FOA was looking for studies that move beyond describing oral tumors in bulk and instead focus on the specific subpopulations of cells believed to be responsible for initiating and sustaining cancer, and on the surrounding biological context that shapes their behavior.
The program sat within NIH’s health research mission and aligned with the Oral Diseases and Disorders Research program area (CFDA 93.121). It used the standard NIH Research Project Grant mechanism (R01), meaning it was intended for hypothesis-driven, investigator-led research projects with enough scope and rigor to produce clear mechanistic insights and, ideally, findings that could inform prevention, diagnostics, or treatment strategies for oral cancers. The emphasis on “functional characterization†signals that applicants were expected to do more than identify markers or associations; the spirit of the call was to clarify what oral CICs do, how they behave, how they interact with their environment, and why that matters for disease progression and patient outcomes.
Administratively, this was a discretionary grant opportunity with no cost sharing or matching requirement. It was posted on March 27, 2013, with an original and final application closing date of August 15, 2013, and the announcement was later archived on September 15, 2013. Those dates matter mainly for historical context, but they also indicate that NIH was running this as a time-limited targeted solicitation rather than an always-open program announcement, which typically reflects a desire to stimulate concentrated activity in a defined research area.
Eligibility was broad and inclusive, covering a wide range of U.S. and non-U.S. organizations. Eligible applicants included state and local governments (such as states, counties, cities or townships, special district governments, and independent school districts), public housing authorities/Indian housing authorities, tribal governments (both federally recognized and other than federally recognized), and a variety of academic and nonprofit institutions. Both public and state-controlled institutions of higher education and private institutions of higher education were eligible, along with nonprofits with or without 501(c)(3) status (with the exception language applying to institutions of higher education as specified). For-profit organizations other than small businesses were eligible, and small businesses were also eligible. The FOA also explicitly recognized and included mission-relevant institution types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based or community-based organizations where appropriate.
A notable feature is that non-U.S. participation was allowed: foreign organizations and foreign institutions could apply directly, non-U.S. components of U.S. organizations were eligible, and foreign components (as NIH defines them in its Grants Policy Statement) were permitted. This flexibility suggests NIH anticipated that key expertise, patient populations, model systems, or specialized technologies relevant to oral CIC biology might be distributed internationally, and it left room for collaborative or multi-site approaches when scientifically justified.
For applicants or institutions needing official details, NIH provided an additional information link to the full FOA text on the NIH grants site (http://grants.nih.gov/grants/guide/rfa-files/RFA-DE-14-001.html). The listed support contacts were within the NIH Office of Extramural Research (OER), specifically the NIH OER Webmaster (FBOWebmaster@OD.NIH.GOV) for access issues or linking problems.
FAQs: Functional Characterization of Oral Cancer Initiating Cells (R01) - RFA-DE-14-001
What is the name of this funding opportunity?
The opportunity is titled Functional Characterization of Oral Cancer Initiating Cells (R01) and is identified by the funding opportunity number RFA-DE-14-001.
Which agency offered this grant opportunity?
This was a research grant announcement from the National Institutes of Health (NIH).
What type of grant mechanism was used?
The announcement used the standard NIH Research Project Grant (R01) mechanism, supporting investigator-led, hypothesis-driven research projects.
What was the overall purpose of the announcement?
The purpose was to push oral cancer research in a more translational direction by supporting R01 projects that investigate the cellular, molecular, and functional features of oral Cancer Initiating Cells (CICs) and the microenvironments (or "niches") that support them.
What scientific area did this FOA focus on?
It focused on oral cancer biology, specifically on oral Cancer Initiating Cells (CICs) and the specialized niches that may help these cells survive, expand, resist therapy, or drive tumor recurrence.
What does "functional characterization" mean in the context of this FOA?
In this FOA, "functional characterization" indicates an emphasis on studies that go beyond identifying markers or associations. The intent was to clarify what oral CICs do, how they behave, how they interact with their environment, and why those functions matter for disease progression and patient outcomes.
What kind of research approach was encouraged?
The FOA emphasized moving beyond analyzing oral tumors as bulk tissue and instead focusing on specific subpopulations of cells believed to initiate and sustain cancer, along with the surrounding biological context that shapes their behavior.
How did this opportunity align with NIH program areas?
It fit within NIH's health research mission and aligned with the Oral Diseases and Disorders Research program area, listed under CFDA 93.121.
Was this an open, ongoing funding program or a time-limited solicitation?
It was a time-limited targeted solicitation, not an always-open program announcement. The dates provided indicate it was intended to stimulate concentrated activity in a defined research area during a set window.
When was the opportunity posted?
The opportunity was posted on March 27, 2013.
What were the application due dates?
The original and final application closing date was August 15, 2013.
Is this funding opportunity still active?
No. The announcement was later archived on September 15, 2013.
Was cost sharing or matching required?
No. The opportunity was described as a discretionary grant with no cost sharing or matching requirement.
What types of U.S. government entities were eligible to apply?
Eligible applicants included a wide range of U.S. government entities, such as states, counties, cities or townships, special district governments, and independent school districts.
Were tribal governments eligible?
Yes. Eligibility included tribal governments, both federally recognized and other than federally recognized.
Were public housing authorities eligible?
Yes. Public housing authorities/Indian housing authorities were included among eligible applicants.
Were colleges and universities eligible?
Yes. Eligibility included both public and state-controlled institutions of higher education and private institutions of higher education.
Were nonprofits eligible to apply?
Yes. Nonprofits with or without 501(c)(3) status were eligible, with the exception language applying to institutions of higher education as specified in the announcement description.
Were for-profit organizations eligible?
Yes. For-profit organizations other than small businesses were eligible, and small businesses were also eligible.
Did the FOA specifically encourage participation from certain institution types?
It explicitly recognized mission-relevant institution types, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs).
Were faith-based or community-based organizations eligible?
Yes. The eligibility list included faith-based or community-based organizations where appropriate.
Were foreign organizations allowed to apply directly?
Yes. Foreign organizations and foreign institutions were allowed to apply directly.
Could a U.S. organization include a non-U.S. component?
Yes. Non-U.S. components of U.S. organizations were eligible.
Were foreign components permitted under NIH policy?
Yes. The FOA permitted foreign components as NIH defines them in its Grants Policy Statement.
Where can applicants find the official FOA text?
The announcement provided a link to the full FOA text on the NIH grants site: http://grants.nih.gov/grants/guide/rfa-files/RFA-DE-14-001.html.
Who was listed as the contact for access issues or linking problems?
The listed support contact was the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV, specifically for access issues or linking problems.
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