Opportunity Information: Apply for PA 11 034
Apply for PA 11 034
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Functional Genetics, Epigenetics, and Non coding RNAs in Drug Addiction (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279 Drug Abuse and Addiction Research Programs.
- This funding opportunity was created on Dec 5, 2013 and posted on Nov 16, 2010.
- Applicants must submit their applications by Dec 5, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $275,000.00 in funding.
- Eligible applicants include: Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education City or township governments Others (see text field entitled Additional Information on Eligibility for clarification) Small businesses For profit organizations other than small businesses Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments County governments Native American tribal governments (Federally recognized) Independent school districts Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
Functional Genetics, Epigenetics, and Non coding RNAs in Drug Addiction (R21) (Funding Opportunity Number PA 11 034) is an NIH discretionary grant opportunity in the Drug Abuse and Addiction Research Programs area (CFDA 93.279). It is aimed at moving beyond gene discovery and association findings to the next, more difficult step: proving which candidate genes, gene variants, epigenetic marks, and non-coding RNA features actually matter in addiction biology, and then mapping out how they exert their effects at the molecular and cellular level. The announcement is grounded in the idea that large-scale genetic and genomic studies have already produced many plausible addiction-related candidates, but that candidates alone do not explain mechanism. This program is specifically designed to support basic functional genomic work that turns those candidates into validated biological insights.
The scientific focus is split into two main tracks. First, the FOA encourages functional validation studies that can distinguish true causal or mechanistically relevant candidates from signals that are merely correlated with addiction phenotypes. In practical terms, this could mean experiments that test whether changing the activity of a candidate gene or regulatory element alters addiction-relevant behaviors or neurobiological endpoints, or whether a specific variant changes gene regulation, protein function, neuronal signaling, or other processes in a way that plausibly contributes to addiction vulnerability, progression, or relapse. Second, it supports deeper mechanistic work to clarify the pathways and processes controlled by those candidates, with special interest in genes that show up in discovery studies but have an unanticipated or poorly understood connection to addiction. That second emphasis is important because it invites investigators to follow the biology where it leads, including into pathways that are not traditionally viewed as "addiction genes" but may be central once function is tested.
The funding mechanism is the NIH Exploratory/Developmental Grant (R21), which is commonly used for early-stage, higher-risk, or concept-proving projects that need support to generate strong preliminary data or establish feasibility. This FOA is presented as running in parallel with companion announcements that share the same scientific scope but use different mechanisms: PA 11 033 for the R01 (typically larger, more mature projects) and PA 11 035 for the R03 (smaller, more limited-scope studies). The idea is that investigators can choose the mechanism that matches the maturity and scale of their proposed work, while staying aligned with the same overarching functional genomics theme in addiction research.
On budget and project size, the announcement notes that the nature and scope of projects will vary, so award size and duration may vary as well. The listed award ceiling is $275,000, and there is no cost-sharing or matching requirement. The total number of awards and total dollars are not fixed in the text provided; instead, they depend on the number of applications received, their quality, their proposed duration, and their costs. In other words, it is a competitive NIH program where funding outcomes are driven by scientific merit and program priorities rather than a guaranteed set-aside.
Eligibility is broad and includes many categories of applicants across the public, private, nonprofit, and governmental landscape. Eligible applicants include public and state-controlled institutions of higher education and private institutions of higher education; nonprofits with and without 501(c)(3) status (excluding institutions of higher education in those categories); small businesses and for-profit organizations; state, county, city or township, and special district governments; independent school districts; public housing authorities and Indian housing authorities; and federally recognized tribal governments as well as other tribal organizations. The eligibility language also explicitly includes a range of mission-serving and community-based entities such as historically Black colleges and universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, tribally controlled colleges and universities (TCCUs), faith-based or community-based organizations, U.S. territories or possessions, regional organizations, and even non-U.S. entities (foreign organizations), along with eligible federal agencies. That breadth signals NIH interest in attracting diverse institutional participation and a wide range of research environments capable of functional genomics work.
Key administrative details in the source include a posted date of November 16, 2010, a creation date of December 5, 2013, and an original closing date of January 7, 2014, with a current closing date listed as December 5, 2013, and an archive date of January 5, 2014. While those dates indicate the particular listing is archived, the scientific framing remains a clear snapshot of NIH priorities at the time: leveraging the flood of genetic and genomic discoveries by investing in functional follow-up, especially around epigenetic regulation and non-coding RNA mechanisms in addiction. For full text, the announcement points to the NIH Grants Guide page at http://grants.nih.gov/grants/guide/pa-files/PA-11-034.html, and provides NIH Office of Extramural Research (OER) webmaster contacts for access or linking issues.
Frequently Asked Questions (FAQs)
What is this funding opportunity?
This opportunity is the NIH grant announcement titled "Functional Genetics, Epigenetics, and Non-coding RNAs in Drug Addiction (R21)", Funding Opportunity Number PA-11-034. It sits within NIH's Drug Abuse and Addiction Research Programs area and is associated with CFDA 93.279.
What is the main purpose of PA-11-034?
The purpose is to move beyond gene discovery and association findings and support the next step: functional validation and mechanistic follow-up. The emphasis is on proving which candidate genes, gene variants, epigenetic marks, and non-coding RNA features actually matter in addiction biology, and then mapping how they exert effects at the molecular and cellular level.
Why does NIH emphasize "functional" work here?
The announcement is based on the idea that large-scale genetic and genomic studies have already produced many plausible addiction-related candidates, but candidates alone do not explain mechanism. This program is designed to fund functional genomic work that converts candidate signals into validated biological insight.
What kinds of science does this FOA focus on?
The scientific scope is framed around functional genetics, epigenetics, and non-coding RNAs in the context of drug addiction, with an emphasis on experiments that test causality and clarify biological mechanisms.
What are the two main scientific tracks supported by this FOA?
The FOA highlights two complementary tracks:
- Functional validation to distinguish truly causal or mechanistically relevant candidates from signals that are only correlated with addiction-related phenotypes.
- Deeper mechanistic work to identify the pathways and processes controlled by validated candidates, including those with unexpected or poorly understood links to addiction.
What does "functional validation" mean in the context of this program?
Functional validation refers to studies that test whether changing the activity of a candidate gene or regulatory element alters addiction-relevant behaviors or neurobiological endpoints, or whether a specific variant changes gene regulation, protein function, neuronal signaling, or other molecular/cellular processes in a way that plausibly contributes to addiction vulnerability, progression, or relapse.
Does the FOA support mechanistic studies even if the candidate is not a traditional "addiction gene"?
Yes. A specific emphasis is placed on candidates emerging from discovery studies that have an unanticipated or poorly understood connection to addiction. The FOA explicitly encourages investigators to follow the biology into pathways that may not be traditionally viewed as addiction-related but may prove central once function is tested.
What grant mechanism does PA-11-034 use?
PA-11-034 uses the NIH Exploratory/Developmental Grant (R21) mechanism.
What is an NIH R21 typically used for?
Within the description provided, the R21 is characterized as supporting early-stage, higher-risk, or concept-proving projects that need support to generate strong preliminary data or establish feasibility.
Are there related announcements with the same scientific scope but different mechanisms?
Yes. The FOA is described as running in parallel with companion announcements that share the same scientific scope but use different mechanisms:
- PA-11-033 for the R01 (typically larger, more mature projects)
- PA-11-035 for the R03 (smaller, more limited-scope studies)
How should an applicant choose between the R21, R01, and R03 options mentioned?
Based on the information provided, applicants are expected to choose the mechanism that matches the maturity and scale of their proposed work while staying aligned with the same overall functional genomics theme in addiction research.
What is the maximum award amount mentioned for this R21 opportunity?
The listed award ceiling is $275,000. The announcement also notes that award size and duration may vary because the nature and scope of projects will vary.
Is cost-sharing or matching required?
No. The announcement states that there is no cost-sharing or matching requirement.
How many awards will NIH make under this announcement?
The total number of awards is not fixed in the text provided. Funding outcomes depend on the number of applications received, their quality, proposed duration, and costs.
Is the amount of total funding set aside for this FOA specified?
No. The text provided indicates that total dollars are not fixed and depend on application volume, quality, project duration, and costs.
What does it mean that funding outcomes depend on application quality and costs?
It means this is a competitive NIH program where funding decisions are driven by factors such as scientific merit and program priorities, rather than a guaranteed set-aside amount or guaranteed number of awards.
Who is eligible to apply?
Eligibility is broad and includes many categories of public, private, nonprofit, and governmental organizations. The eligible categories listed include:
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Nonprofits with and without 501(c)(3) status (excluding institutions of higher education in those nonprofit categories)
- Small businesses and for-profit organizations
- State governments
- County, city or township governments
- Special district governments
- Independent school districts
- Public housing authorities and Indian housing authorities
- Federally recognized tribal governments and other tribal organizations
- U.S. territories or possessions
- Regional organizations
- Non-U.S. entities (foreign organizations)
- Eligible federal agencies
Are minority-serving institutions and community-based organizations included in the eligible applicant types?
Yes. The eligibility language explicitly includes organizations such as HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, tribally controlled colleges and universities (TCCUs), and faith-based or community-based organizations.
Are foreign (non-U.S.) organizations eligible to apply?
Yes. The eligibility description explicitly includes non-U.S. entities (foreign organizations).
What is the posted date for this opportunity?
The posted date listed is November 16, 2010.
What creation date is listed in the opportunity details?
The creation date listed is December 5, 2013.
What are the closing and archive dates listed?
The source lists an original closing date of January 7, 2014, a current closing date of December 5, 2013, and an archive date of January 5, 2014.
Is this FOA still active?
Based on the dates provided (including the archive date), this particular listing appears to be archived.
Where can applicants find the full text of the announcement?
The full text is referenced as being available on the NIH Grants Guide page at:
http://grants.nih.gov/grants/guide/pa-files/PA-11-034.html
Who is listed as a contact for access or linking issues?
The information provided notes NIH Office of Extramural Research (OER) webmaster contacts for access or linking issues (without naming specific individuals in the text provided).
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Applicants also applied for:
Applicants who have applied for this opportunity (PA 11 034) also looked into and applied for these:
| Funding Opportunity |
|---|
| Functional Genetics, Epigenetics, and Non coding RNAs in Drug Addiction (R03) Apply for PA 11 035 Funding Number: PA 11 035 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Institutional Clinical and Translational Science Award (U54) Apply for RFA RM 10 020 Funding Number: RFA RM 10 020 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Limited Competition Fogarty International Research Collaboration Behavioral and Social Sciences (FIRCA BSS) Research Award (R03) Apply for PAR 11 036 Funding Number: PAR 11 036 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Women and Sex/Gender Differences in Drug and Alcohol Abuse/Dependence (R01) Apply for PA 11 047 Funding Number: PA 11 047 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Women and Sex/Gender Differences in Drug and Alcohol Abuse/Dependence (R21) Apply for PA 11 048 Funding Number: PA 11 048 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Women and Sex/Gender Differences in Drug and Alcohol Abuse/Dependence (R03) Apply for PA 11 049 Funding Number: PA 11 049 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Limited Competition Extramural Research Facilities Improvement Program (C06) Apply for RFA RR 11 001 Funding Number: RFA RR 11 001 Agency: National Institutes of Health Category: Education Health Funding Amount: $1,500,000 |
| Diversity promoting Institutions Drug Abuse Research Program (DIDARP) (R24) Apply for PAR 11 060 Funding Number: PAR 11 060 Agency: National Institutes of Health Category: Education Health Funding Amount: $350,000 |
| Advanced In Vivo Imaging to Understand Cancer Systems (R01) Apply for RFA CA 11 005 Funding Number: RFA CA 11 005 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Mitochondria in Cancer Epidemiology, Detection, Diagnosis and Prognosis (R01) Apply for PA 11 073 Funding Number: PA 11 073 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Mitochondria in Cancer Epidemiology, Detection, Diagnosis and Prognosis (R21) Apply for PA 11 074 Funding Number: PA 11 074 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Cancer Prevention Research Small Grant Program (R03) Apply for PAR 11 079 Funding Number: PAR 11 079 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Shared Instrumentation Grant Program (S10) Apply for PAR 11 081 Funding Number: PAR 11 081 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| NLM Grants for Scholarly Works in Biomedicine and Health (G13) Apply for PAR 11 084 Funding Number: PAR 11 084 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| New Molecular Entities to Treat Substance Use Disorders (R01) Apply for RFA DA 12 001 Funding Number: RFA DA 12 001 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Exploring Human Induced Pluripotent Stem Cells for Substance Abuse Research (R21) Apply for RFA DA 11 012 Funding Number: RFA DA 11 012 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Personalized Genomics for Symptom Management Bridging the Gaps from Genomic Discovery to Improved Health Outcomes (R01) Apply for RFA NR 11 003 Funding Number: RFA NR 11 003 Agency: National Institutes of Health Category: Education Health Funding Amount: $300,000 |
| Personalized Genomics for Symptom Management Bridging the Gaps from Genomic Discovery to Improved Health Outcomes (R21) Apply for RFA NR 11 004 Funding Number: RFA NR 11 004 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Acute Life Threatening Conditions and Opportunities for Palliative and End of Life Care Research (R01) Apply for RFA NR 11 008 Funding Number: RFA NR 11 008 Agency: National Institutes of Health Category: Education Health Funding Amount: $300,000 |
| Interdisciplinary Approaches for HIV/AIDS Risk Avoidance Decision Making in Developing Adolescents (R01) Apply for RFA NR 11 007 Funding Number: RFA NR 11 007 Agency: National Institutes of Health Category: Education Health Funding Amount: $350,000 |
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