Opportunity Information: Apply for PA 11 033
Apply for PA 11 033
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Functional Genetics, Epigenetics, and Non coding RNAs in Drug Addiction (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.270 Adult Viral Hepatitis Prevention and Control 93.279 Drug Abuse and Addiction Research Programs.
- This funding opportunity was created on Dec 5, 2013 and posted on Nov 16, 2010.
- Applicants must submit their applications by Dec 5, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Special district governments Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Small businesses Native American tribal organizations (other than Federally recognized tribal governments) Independent school districts City or township governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses State governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Opportunity Summary:
The NIH funding opportunity titled "Functional Genetics, Epigenetics, and Non coding RNAs in Drug Addiction (R01)" (Funding Opportunity Number PA 11 033) is aimed at moving addiction genetics beyond gene discovery and into mechanism. The core idea is that genome wide studies, sequencing projects, and other genetic and genomic approaches have already produced long lists of candidate genes, variants, epigenetic marks, and non coding RNA signals that appear to be associated with drug addiction related traits. This announcement emphasizes that identifying those candidates is only the starting point; the real bottleneck is proving which candidates are actually causal or biologically meaningful in addiction and then explaining exactly how they influence addiction relevant biology.
The program is focused on two tightly connected research directions. First, it encourages functional validation work to determine which candidate genes, gene variants, epigenetic features (such as DNA methylation or chromatin based regulation), and non coding RNAs (for example microRNAs and other regulatory RNAs) genuinely play an authentic role in addictive processes. In other words, applicants are expected to go beyond statistical association and provide experiments that test whether altering a candidate (or its regulatory context) changes addiction related phenotypes or relevant cellular and circuit level functions. Second, the announcement supports deeper mechanistic studies that map the molecular pathways, networks, and biological processes controlled by these candidates, especially when a gene implicated by genomic studies has an unexpected or previously unrecognized connection to addiction. The intent is to encourage projects that can explain mechanism, not just confirm that something matters.
This opportunity uses the NIH R01 mechanism, which is generally intended for mature, hypothesis driven projects with a substantial scope and a clear plan for producing a robust body of work. The FOA is part of a coordinated set of announcements with the same scientific scope offered under other grant mechanisms: PA 11 034 for the R21 mechanism (often used for exploratory or higher risk, earlier stage ideas) and PA 11 035 for the R03 mechanism (typically small, focused projects). Applicants whose work is better suited to pilot scale or exploratory validation could consider those parallel options, while PA 11 033 is positioned for more comprehensive functional and pathway level studies.
The announcement does not specify a fixed budget size or a set number of awards. Instead, NIH notes that award size and project duration will vary depending on what is proposed, and that both the total dollars and the number of funded projects will depend on factors like the scientific merit of the submissions, the requested costs, and the overall mix of applications received. There is no cost sharing or matching requirement, which means applicants are not expected to provide institutional matching funds as a condition of funding.
Eligibility is broad and includes many categories of domestic and international organizations. Eligible applicants span public and private institutions of higher education, nonprofit organizations (including both 501(c)(3) and non 501(c)(3) entities), for profit organizations (including small businesses), and a wide range of government bodies such as state, county, city or township governments, special district governments, and independent school districts. The eligibility list also explicitly includes tribal governments and tribal organizations, public housing authorities, and a variety of mission focused institution types such as Historically Black Colleges and Universities (HBCUs), Hispanic serving institutions, Alaska Native and Native Hawaiian serving institutions, and Tribally Controlled Colleges and Universities (TCCUs). Faith based and community based organizations are also included, along with eligible federal agencies and non U.S. entities (foreign organizations), regional organizations, and U.S. territories or possessions. This wide eligibility reflects the interdisciplinary nature of addiction research and the fact that functional genomics can be advanced by many types of research institutions.
Administratively, the opportunity is categorized as a discretionary grant within the health funding activity category, and it is associated with CFDA numbers 93.279 (Drug Abuse and Addiction Research Programs) and 93.270 (Adult Viral Hepatitis Prevention and Control), reflecting NIH program alignments relevant to substance use and related health outcomes. The opportunity was posted on November 16, 2010, and the record shows key dates including an original closing date of January 7, 2014, with archival shortly thereafter (archive date January 5, 2014), indicating this specific announcement is no longer active but remains a useful reference for the types of projects NIH sought to support under this topic area.
Overall, the takeaway is that PA 11 033 was designed for researchers who already have credible candidate genetic, epigenetic, or non coding RNA leads related to addiction and are prepared to do the hard next step: experimentally test which ones truly matter and then dissect the downstream biology with enough depth to clarify pathways, mechanisms, and potentially new therapeutic or prevention targets grounded in functional genomic evidence.
FAQs: Functional Genetics, Epigenetics, and Non coding RNAs in Drug Addiction (R01) - PA 11 033
What is the official title and funding opportunity number?
The opportunity is titled "Functional Genetics, Epigenetics, and Non coding RNAs in Drug Addiction (R01)" and the Funding Opportunity Number is PA 11 033.
What is the main purpose of this NIH opportunity?
The main purpose is to move addiction genetics beyond gene discovery and into mechanism. The emphasis is on using experiments to determine which candidate genes, variants, epigenetic features, and non coding RNAs are truly causal or biologically meaningful in drug addiction, and then explaining how they influence addiction-related biology.
What problem is this FOA trying to address?
The FOA highlights that genome-wide studies, sequencing projects, and other genetic/genomic approaches have generated long lists of candidates linked to addiction-related traits, but the major bottleneck is proving which candidates actually matter biologically and understanding the mechanisms by which they affect addiction processes.
What kinds of prior findings is this FOA built around?
It is built around candidate signals arising from genome-wide studies, sequencing efforts, and other genetic/genomic approaches, including candidate genes, gene variants, epigenetic marks, and non coding RNA signals that have shown statistical association with drug addiction-related traits.
What are the two main research directions supported by PA 11 033?
The FOA focuses on (1) functional validation to test whether candidates (genes, variants, epigenetic features, non coding RNAs) have authentic roles in addictive processes, and (2) mechanistic studies that define the molecular pathways, networks, and biological processes controlled by validated candidates.
What does "functional validation" mean in this context?
Functional validation means going beyond statistical association by conducting experiments that test whether changing a candidate (or its regulatory context) alters addiction-related phenotypes or relevant cellular- and circuit-level functions.
What does "mechanistic studies" mean in this context?
Mechanistic studies are intended to map the molecular pathways, networks, and biological processes influenced by the candidates, including situations where a gene implicated by genomic studies has an unexpected or previously unrecognized connection to addiction.
Is this FOA meant for gene discovery or for follow-up biology?
Based on the description, it is meant for follow-up biology: testing candidates for causal/biological relevance and then dissecting mechanisms, rather than generating additional lists of associated candidates.
What types of biological factors are specifically called out as in-scope?
The FOA specifically calls out candidate genes, gene variants, epigenetic features (such as DNA methylation or chromatin-based regulation), and non coding RNAs (including microRNAs and other regulatory RNAs).
What grant mechanism does this opportunity use?
This opportunity uses the NIH R01 mechanism, which is generally intended for mature, hypothesis-driven projects with substantial scope and a clear plan to produce a robust body of work.
Are there related opportunities for smaller or more exploratory projects?
Yes. The same scientific scope is offered under other mechanisms: PA 11 034 for the R21 mechanism (often exploratory or higher-risk/earlier-stage ideas) and PA 11 035 for the R03 mechanism (typically small, focused projects).
How should an applicant decide between the R01 and the related R21/R03 options?
PA 11 033 (R01) is positioned for more comprehensive functional and pathway-level studies, while projects better suited to pilot-scale or exploratory validation could consider the parallel R21 (PA 11 034) or R03 (PA 11 035) announcements.
Does the FOA specify a fixed budget amount or a set number of awards?
No. The FOA does not specify a fixed budget size or a set number of awards. Award size and project duration are expected to vary depending on what is proposed, and total dollars and award counts depend on factors such as scientific merit, requested costs, and the mix of applications received.
Is cost sharing or matching required?
No. The FOA states there is no cost sharing or matching requirement, meaning applicants are not expected to provide institutional matching funds as a condition of funding.
Who is eligible to apply?
Eligibility is broad and includes many domestic and international organizations. Eligible applicants include public and private institutions of higher education; nonprofit organizations (501(c)(3) and non-501(c)(3)); for-profit organizations (including small businesses); and many types of government entities.
Which government entities are included as eligible applicants?
Eligible government applicants include state, county, city or township governments; special district governments; independent school districts; tribal governments; and public housing authorities, among others listed in the FOA summary.
Are tribal and tribally controlled organizations included?
Yes. The eligibility list explicitly includes tribal governments and tribal organizations, as well as Tribally Controlled Colleges and Universities (TCCUs).
Are minority-serving institutions explicitly included?
Yes. The eligibility list explicitly includes institution types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and Tribally Controlled Colleges and Universities (TCCUs).
Are faith-based and community-based organizations eligible?
Yes. The eligibility list includes faith-based and community-based organizations.
Are non-U.S. organizations eligible?
Yes. The eligibility list includes non-U.S. entities (foreign organizations), as well as regional organizations and U.S. territories or possessions.
What funding activity category is associated with this opportunity?
It is categorized as a discretionary grant within the health funding activity category.
What CFDA numbers are associated with this opportunity?
The FOA is associated with CFDA 93.279 (Drug Abuse and Addiction Research Programs) and CFDA 93.270 (Adult Viral Hepatitis Prevention and Control).
When was this opportunity posted?
The opportunity was posted on November 16, 2010.
Is PA 11 033 currently active?
No. The record indicates an original closing date of January 7, 2014, and an archive date of January 5, 2014, which indicates this specific announcement is no longer active and is best treated as a reference for the types of projects NIH sought to support.
What kinds of applicants is this FOA best suited for (based on the description provided)?
It is designed for researchers who already have credible candidate genetic, epigenetic, or non coding RNA leads related to addiction and are prepared to experimentally test which ones truly matter and then dissect downstream biology in enough depth to clarify pathways and mechanisms.
What is the expected emphasis of the science: confirmation or explanation?
The emphasis is on explaining mechanism. The FOA encourages projects that can clarify pathways, networks, and biological processes, not projects that only confirm that a candidate is associated with addiction.
Does the FOA encourage work on unexpected or novel biological connections to addiction?
Yes. The FOA highlights interest in deeper mechanistic studies, including cases where a gene implicated by genomic studies has an unexpected or previously unrecognized connection to addiction.
Browse more opportunities from the same category: Health
Next opportunity: Functional Genetics, Epigenetics, and Non coding RNAs in Drug Addiction (R21)
Previous opportunity: Translational Tools for Clinical Studies of Mind/Body and Manual Therapy CAM Interventions (R01)
USGrants.org Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for PA 11 033
[Watch] how do funding administrators access proposals?
Applicants also applied for:
Applicants who have applied for this opportunity (PA 11 033) also looked into and applied for these:
| Funding Opportunity |
|---|
| Institutional Collaboration Between The Institute Pasteur Of Madagascar And The Centers For Disease Control And Prevention On Malaria And Vector Borne Diseases (U01) Apply for RFA GH 11 003 Funding Number: RFA GH 11 003 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $600,000 |
| Integrative Neuroscience Initiative on Alcoholism (INIA) Consortia (U01) Apply for RFA AA 11 006 Funding Number: RFA AA 11 006 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Integrated Health Social Marketing Program for Mozambique Apply for 656 11 001 Funding Number: 656 11 001 Agency: Mozambique USAID Maputo Category: Health Funding Amount: $20,557,019 |
| Integrative Neuroscience Initiative on Alcoholism (INIA) Consortia Resource and Support Cores (U24) Apply for RFA AA 11 007 Funding Number: RFA AA 11 007 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Social Science Research in Population and Reproductive Health Apply for APS OAA 10 000002 Funding Number: APS OAA 10 000002 Agency: Agency for International Development Category: Health Funding Amount: $5,000,000 |
| Sustainable Leadership, Managment and Governance RFA Apply for SOL OAA 11 000009 Funding Number: SOL OAA 11 000009 Agency: Agency for International Development Category: Health Funding Amount: $200,000,000 |
| Centers for Autism and Developmental Disabilities Research and Epidemiology (CADDRE) Study to Explore Early Development (SEED) II (U01) Apply for RFA DD 11 002 Funding Number: RFA DD 11 002 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $900,000 |
| Pilot Longitudinal Data Collection to inform Public Health Fragile X Syndrome Apply for RFA DD 11 007 Funding Number: RFA DD 11 007 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $550,000 |
| National Institute on Aging Revision Requests for Active Cooperative Agreements (U01) Apply for PAR 11 042 Funding Number: PAR 11 042 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Family History and Diamond Blackfan Anemia (U01) Apply for RFA DD 11 010 Funding Number: RFA DD 11 010 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $150,000 |
| School Mental Health Program and Policy Analysis Center Apply for HRSA 11 106 Funding Number: HRSA 11 106 Agency: Health Resources and Services Administration Category: Health Funding Amount: $450,000 |
| Sickle Cell Disease and Newborn Screening Program and National Coordination and Evaluation Center Apply for HRSA 11 031 Funding Number: HRSA 11 031 Agency: Health Resources and Services Administration Category: Health Funding Amount: $700,000 |
| Reducing New HIV Infections, Strengthening Health And Strategic Information Systems, Capacity Building And Increasing Access To Quality HIV/AIDS Services Through Support Programs Conducted By The Government Of Botswana Under PEPFAR Apply for CDC RFA GH11 1197 Funding Number: CDC RFA GH11 1197 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $23,000,000 |
| Centers without Walls for Collaborative Research in the Epilepsies Genetics and Genomics of Human Epilepsies (U01) Apply for RFA NS 11 007 Funding Number: RFA NS 11 007 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NIH Basic Behavioral and Social Science Opportunity Network (OppNet) Short term Mentored Career Development Awards in the Basic Behavioral and Social Sciences for Mid career and Senior Investigators (K18) Apply for RFA DE 11 003 Funding Number: RFA DE 11 003 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NEI Genomic Research Grant on Integrative Data Analysis for Vision Research (R01) Apply for RFA EY 11 001 Funding Number: RFA EY 11 001 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Genetics in Primary Care Apply for HRSA 11 136 Funding Number: HRSA 11 136 Agency: Health Resources and Services Administration Category: Health Funding Amount: $600,000 |
| Maternal Vitamin D Status and Preterm Birth Apply for RFA DP 11 002 Funding Number: RFA DP 11 002 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $225,000 |
| EMSC National Resource Center Apply for HRSA 11 059 Funding Number: HRSA 11 059 Agency: Health Resources and Services Administration Category: Health Funding Amount: $1,900,000 |
| Advanced Education Nursing Traineeship Apply for HRSA 11 043 Funding Number: HRSA 11 043 Agency: Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Subscribe to Leads
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "PA 11 033", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.