Opportunity Information: Apply for RFA AT 11 003
Apply for RFA AT 11 003
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Translational Tools for Clinical Studies of Mind/Body and Manual Therapy CAM Interventions (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.213 Research and Training in Complementary and Integrative Health.
- This funding opportunity was created on Nov 16, 2010 and posted on Nov 16, 2010.
- Applicants must submit their applications by Apr 29, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $3,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $300,000.00 in funding.
- Eligible applicants include: State governments Small businesses Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education County governments Public housing authorities/Indian housing authorities Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) City or township governments Private institutions of higher education Special district governments Independent school districts.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The NIH National Center for Complementary and Alternative Medicine (NCCAM) issued this R01 funding opportunity to strengthen the practical tools and research methods needed to run high-quality clinical studies of certain widely used complementary and alternative medicine (CAM) approaches. The central aim is not to test a specific therapy in a large definitive trial, but to build, refine, and validate "translational tools" that make future clinical research on these interventions more rigorous, interpretable, and reproducible. The FOA is grounded in national survey data (the National Health Interview Survey) showing that many Americans use CAM for health promotion, symptom relief, and treatment or prevention of disease, with chronic pain, back pain, and other musculoskeletal pain being especially common reasons for use.
The FOA targets three CAM domains only: mind-body interventions (with meditation given as a key example), manual therapies (such as spinal manipulation or massage), and yoga therapy. Applications are expected to focus on developing or improving methodology that allows researchers to better evaluate safety, efficacy, and real-world clinical effectiveness for these approaches. In practice, that means projects that create or validate measurement tools, standardize intervention delivery, improve outcome assessment, strengthen adherence and fidelity monitoring, address control or comparison conditions, or otherwise solve recurring design and implementation problems that have historically made these interventions difficult to study in a conventional clinical trial framework.
A major boundary in this announcement is what it does not support. Studies centered on other CAM areas are explicitly excluded, including natural products and dietary supplements, acupuncture, and traditional Chinese medicine. Proposals need to stay tightly aligned with mind-body interventions, manual therapies, and/or yoga, and should frame the work as methodology or tool development that enables better clinical studies rather than simply describing general interest in CAM.
The mechanism is an NIH R01 (research project grant), categorized as discretionary grant funding within the health activity area (CFDA 93.213, Research and Training in Complementary and Integrative Health). The announcement anticipated an estimated total program funding level of about $3,000,000, with an award ceiling listed at $300,000. There is no cost sharing or matching requirement.
Eligibility is broad and includes many organization types: public and private institutions of higher education, nonprofit organizations (both 501(c)(3) and non-501(c)(3)), for-profit organizations (including small businesses and other for-profits), and multiple levels of government (state, county, city/township, special districts), as well as independent school districts and public housing authorities/Indian housing authorities. The FOA also explicitly includes a wide set of additional eligible applicants such as federally recognized and other tribal entities, tribally controlled colleges and universities, Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, faith-based or community-based organizations, U.S. territories or possessions, regional organizations, and even non-U.S. (foreign) entities and eligible federal agencies.
Key administrative details in the source listing include: Funding Opportunity Number RFA-AT-11-003; posting and creation date November 16, 2010; original and current closing date April 29, 2011; and an archive date of May 30, 2011. The full announcement was hosted on the NIH grants website, and the NIH Office of Extramural Research (OER) webmaster contact was provided for access or linking issues.
Frequently Asked Questions (FAQs)
What is the main goal of this NIH NCCAM R01 funding opportunity?
The purpose of this R01 is to strengthen the practical tools and research methods needed to run high-quality clinical studies of certain widely used complementary and alternative medicine (CAM) approaches. The emphasis is on developing, refining, and validating "translational tools" that make future clinical research more rigorous, interpretable, and reproducible rather than running a large definitive clinical trial of a specific therapy.
Is this funding opportunity meant to support large definitive clinical trials of a CAM therapy?
No. The central aim is not to test a specific therapy in a large definitive trial. Instead, the focus is on methodology and tool development that enables better-designed and more reliable future clinical studies.
Which CAM domains are included (and eligible) under this FOA?
This FOA targets only three CAM domains: mind-body interventions (with meditation cited as a key example), manual therapies (such as spinal manipulation or massage), and yoga therapy.
What types of projects does the FOA encourage?
Applications are expected to focus on developing or improving methods that allow researchers to better evaluate safety, efficacy, and real-world clinical effectiveness for the included CAM approaches. Examples described in the opportunity include work to:
- Create, refine, or validate measurement tools
- Standardize intervention delivery
- Improve outcome assessment
- Strengthen adherence and fidelity monitoring
- Develop or improve control or comparison conditions
- Address recurring design and implementation problems that have made these interventions hard to study in conventional clinical trial frameworks
What does "translational tools" mean in the context of this FOA?
In this announcement, "translational tools" refers to practical research tools and methodological approaches that help clinical researchers run more rigorous and reproducible studies. The tools are meant to improve how interventions are delivered, measured, monitored, compared, and interpreted in future clinical research.
Why is NIH focusing on these CAM approaches in this FOA?
The FOA is grounded in national survey data from the National Health Interview Survey showing that many Americans use CAM for health promotion, symptom relief, and treatment or prevention of disease. Chronic pain, back pain, and other musculoskeletal pain are highlighted as especially common reasons for CAM use.
Are applications required to address chronic pain or musculoskeletal pain?
The information provided notes that chronic pain, back pain, and other musculoskeletal pain are common reasons people use CAM, and this is part of the rationale for the FOA. The listing does not state that applications must be limited to those conditions; it emphasizes methodology/tool development for the specified CAM domains.
What is explicitly not supported under this FOA?
The announcement draws clear boundaries around what it does not support. Studies centered on other CAM areas are explicitly excluded, including:
- Natural products and dietary supplements
- Acupuncture
- Traditional Chinese medicine
Proposals must stay tightly aligned with mind-body interventions, manual therapies, and/or yoga therapy, and should be framed as tool or methodology development for better clinical studies.
Can an application propose a project focused primarily on general interest in CAM?
No. The description indicates proposals should not simply describe general interest in CAM. They should clearly frame the work as methodology or translational tool development that enables better clinical studies for the included CAM domains.
What grant mechanism is used for this opportunity?
This is an NIH R01 (research project grant) funding opportunity.
What is the funding classification and CFDA number listed for this opportunity?
The listing categorizes this as discretionary grant funding within the health activity area. The CFDA number provided is 93.213 (Research and Training in Complementary and Integrative Health).
How much total program funding was anticipated, and what was the award ceiling?
The announcement anticipated an estimated total program funding level of about $3,000,000, with an award ceiling listed at $300,000.
Is cost sharing or matching required?
No. The listing states there is no cost sharing or matching requirement.
Who is eligible to apply?
Eligibility is broad and includes many types of organizations, including:
- Public and private institutions of higher education
- Nonprofit organizations (both 501(c)(3) and non-501(c)(3))
- For-profit organizations (including small businesses and other for-profits)
- State, county, and city/township governments
- Special district governments
- Independent school districts
- Public housing authorities/Indian housing authorities
- Federally recognized tribal governments and other tribal entities
- Tribally controlled colleges and universities
- Historically Black Colleges and Universities (HBCUs)
- Hispanic-serving institutions
- Alaska Native and Native Hawaiian-serving institutions
- Faith-based or community-based organizations
- U.S. territories or possessions
- Regional organizations
- Non-U.S. (foreign) entities
- Eligible federal agencies
Are non-U.S. (foreign) organizations eligible to apply?
Yes. The eligibility list explicitly includes non-U.S. (foreign) entities.
Are for-profit entities eligible to apply?
Yes. For-profit organizations, including small businesses and other for-profits, are included in the eligibility list.
Are tribal entities and tribally controlled institutions eligible?
Yes. The FOA explicitly includes federally recognized tribal entities and other tribal entities, as well as tribally controlled colleges and universities.
What is the Funding Opportunity Number for this announcement?
The Funding Opportunity Number is RFA-AT-11-003.
When was this opportunity posted and when did it close?
The posting and creation date listed is November 16, 2010. The original and current closing date listed is April 29, 2011.
Is this funding opportunity still open?
No. The listing includes an archive date of May 30, 2011, and the closing date shown is April 29, 2011.
Where was the full announcement hosted?
The full announcement was hosted on the NIH grants website.
Who was listed as the contact for access or linking issues?
The NIH Office of Extramural Research (OER) webmaster contact was provided for access or linking issues related to the full announcement.
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