Opportunity Information: Apply for PA 14 014
Apply for PA 14 014
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Functional Genetics, Epigenetics, and Non coding RNAs in Substance Abuse (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279 Drug Abuse and Addiction Research Programs.
- This funding opportunity was created on Dec 5, 2013 and posted on Dec 5, 2013.
- Applicants must submit their applications by Jan 7, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Independent school districts County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Special district governments City or township governments Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) For profit organizations other than small businesses Native American tribal organizations (other than Federally recognized tribal governments).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The NIH grant opportunity "Functional Genetics, Epigenetics, and Non coding RNAs in Substance Abuse (R01)" (Funding Opportunity Number PA-14-014) focuses on moving addiction genetics beyond gene discovery and into the hard work of proving biological function and mapping mechanisms. Large-scale genetic and genomic studies have already flagged many genes, variants, and genomic signals that appear to be associated with substance use disorders and related traits, but association alone does not explain how addiction biology works. This announcement is aimed at basic research that can close that gap by testing whether nominated genetic findings truly play a causal or meaningful role in addictive processes and by clarifying the downstream molecular and cellular pathways those findings influence.
The FOA emphasizes two main scientific thrusts. First, it encourages functional validation studies that can sort through candidate genes and genomic features and determine which ones have an authentic role in addiction-relevant biology. Importantly, the scope is broader than DNA sequence variants alone: it explicitly includes epigenetic features and non-coding RNA signals (such as regulatory elements, chromatin marks, and RNA regulators that do not code for proteins) that may be implicated by prior studies. The core idea is to strengthen the evidence base by applying experimental or functional approaches that can confirm whether a candidate locus or regulatory change actually affects addiction-related phenotypes, neural processes, or biological responses relevant to substance exposure, reinforcement, withdrawal, craving, relapse vulnerability, or other key components of addictive behavior.
Second, the announcement supports in-depth mechanistic work to explain how validated candidates exert their effects. That includes detailed elucidation of the molecular pathways and processes modulated by implicated genes, variants, epigenetic marks, and non-coding RNAs. A particular emphasis is placed on candidates that have an unanticipated role in addiction, meaning genes or pathways not previously linked to substance abuse biology that emerged from unbiased genomic approaches. For such findings, the FOA signals strong interest in careful follow-up studies that can uncover the biological logic connecting those genes to addiction phenotypes, potentially revealing new molecular targets, previously overlooked regulatory networks, or novel points of intervention.
This is an R01 mechanism, meaning it is intended for substantial, hypothesis-driven research projects with enough scope to support rigorous functional experiments and pathway-level investigation. The activity category is listed under education/health, and it falls under CFDA 93.279 (Drug Abuse and Addiction Research Programs). Cost sharing or matching is not required, which is typical for many NIH research project grants.
Eligibility is broad and includes many types of U.S. organizations such as public and private institutions of higher education, nonprofit organizations (including both 501(c)(3) and non-501(c)(3) entities), for-profit organizations (including small businesses and other for-profits), independent school districts, and a wide range of government entities (state, county, city/township, special district governments, public housing authorities, and tribal governments). The FOA also allows participation from non-U.S. entities: foreign organizations and foreign institutions are eligible to apply, non-U.S. components of U.S. organizations are eligible, and foreign components (as defined by NIH policy) are allowed. It also explicitly includes eligibility for institutions and organizations serving specific communities, including HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, and AANAPISISs, along with faith-based or community-based organizations and U.S. territories or possessions.
Administratively, the opportunity was posted on December 5, 2013, and had an original and current closing date of January 7, 2017, with an archive date of February 7, 2017, indicating it is no longer open for new submissions under that specific announcement. The sponsoring agency is the National Institutes of Health. The full announcement was hosted at http://grants.nih.gov/grants/guide/pa-files/PA-14-014.html, and the NIH Office of Extramural Research (OER) webmaster contact was provided for access or linking issues (FBOWebmaster@OD.NIH.GOV).
In practical terms, this FOA is about turning statistical signals from addiction genomics into biological understanding. It invites projects that can (1) demonstrate which genetic, epigenetic, and non-coding RNA candidates truly matter for addiction-relevant function and (2) explain, in mechanistic detail, what those candidates do in cells and circuits and how that biology contributes to addictive processes.
Frequently Asked Questions (FAQs)
What is the official title of this NIH funding opportunity?
The opportunity is titled "Functional Genetics, Epigenetics, and Non coding RNAs in Substance Abuse (R01)."
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is PA-14-014.
Which agency is sponsoring this grant opportunity?
The sponsoring agency is the National Institutes of Health (NIH).
What is the main goal of this FOA?
This FOA is focused on moving addiction genetics beyond gene discovery and into functional and mechanistic research. It supports studies that test whether nominated genetic/genomic findings are biologically meaningful for addiction and that map the molecular and cellular mechanisms linking those findings to addiction-relevant processes.
What problem is this FOA trying to address in the field?
Large-scale genetic and genomic studies have identified many genes, variants, and genomic signals associated with substance use disorders and related traits, but association alone does not explain how addiction biology works. This FOA aims to close that gap by supporting functional validation and mechanistic studies.
What type of research does this FOA emphasize?
The FOA emphasizes basic research designed to (1) functionally validate candidate genetic and genomic findings and (2) clarify downstream molecular and cellular pathways and mechanisms that influence addiction-related biology.
What are the two main scientific thrusts of the FOA?
The FOA highlights two core thrusts: (1) functional validation studies to determine which candidate genes/genomic features have authentic addiction-relevant roles, and (2) mechanistic studies to explain how validated candidates exert effects through molecular pathways and processes.
What does "functional validation" mean in the context of this FOA?
In this FOA, functional validation refers to applying experimental or functional approaches to confirm whether a nominated gene, variant, epigenetic feature, or non-coding RNA signal actually affects addiction-related phenotypes, neural processes, or biological responses relevant to substance use disorders.
Does the FOA only focus on DNA sequence variants?
No. The scope is explicitly broader than DNA sequence variants and includes epigenetic features and non-coding RNA signals implicated by prior studies.
What kinds of non-DNA findings are specifically included?
The FOA explicitly includes epigenetic features and non-coding RNAs, such as regulatory elements, chromatin marks, and RNA regulators that do not code for proteins.
What addiction-related outcomes or processes are considered relevant?
The FOA references addiction-relevant phenotypes and biological responses tied to substance exposure, reinforcement, withdrawal, craving, relapse vulnerability, and other key components of addictive behavior.
What does the FOA mean by "mechanistic work"?
Mechanistic work in this FOA means in-depth investigation of how validated genes, variants, epigenetic marks, and non-coding RNAs influence molecular pathways and cellular processes that contribute to addiction-related phenotypes.
Is there special interest in certain types of candidates?
Yes. The FOA places particular emphasis on candidates with unanticipated roles in addiction, including genes or pathways not previously linked to substance abuse biology that emerged from unbiased genomic approaches.
What is meant by "unanticipated role in addiction"?
It refers to genes or pathways that were not previously connected to substance abuse biology but were identified through unbiased genomic studies, and now require careful follow-up to uncover how they connect biologically to addiction phenotypes.
What funding mechanism is used for this opportunity?
This FOA uses the NIH R01 mechanism.
What does it imply that this is an R01?
An R01 is intended for substantial, hypothesis-driven research projects with enough scope to support rigorous functional experiments and pathway-level investigation.
What is the activity category listed for this opportunity?
The activity category is listed under education/health.
What is the CFDA number and program area associated with this FOA?
The FOA falls under CFDA 93.279, Drug Abuse and Addiction Research Programs.
Is cost sharing or matching required?
No. Cost sharing or matching is not required for this opportunity.
Who is eligible to apply?
Eligibility is broad and includes many types of U.S. organizations (public and private institutions of higher education, nonprofit organizations including 501(c)(3) and non-501(c)(3), for-profit organizations including small businesses, independent school districts, and many government entities). The FOA also allows foreign organizations and other non-U.S. participation as described by NIH policy.
Are for-profit organizations eligible?
Yes. For-profit organizations, including small businesses and other for-profits, are listed as eligible applicants.
Are nonprofit organizations eligible?
Yes. Nonprofit organizations are eligible, including both 501(c)(3) and non-501(c)(3) nonprofits.
Are universities and colleges eligible?
Yes. Public and private institutions of higher education are listed as eligible.
Are K-12-related entities eligible?
Independent school districts are listed as eligible.
Are government entities eligible to apply?
Yes. Eligibility includes a wide range of government entities such as state, county, city/township, special district governments, public housing authorities, and tribal governments.
Are tribal governments and tribal institutions included?
Yes. Tribal governments are listed among eligible government entities, and tribally controlled colleges and universities are explicitly included among eligible institution types.
Are foreign organizations eligible to apply?
Yes. Foreign organizations and foreign institutions are eligible to apply under this FOA.
Can non-U.S. components of U.S. organizations participate?
Yes. Non-U.S. components of U.S. organizations are eligible.
Are foreign components allowed under NIH policy?
Yes. Foreign components (as defined by NIH policy) are allowed.
Does the FOA explicitly include minority-serving or community-focused institutions?
Yes. The FOA explicitly includes institutions and organizations serving specific communities, including HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, and AANAPISISs, as well as faith-based or community-based organizations and U.S. territories or possessions.
When was this opportunity posted?
The opportunity was posted on December 5, 2013.
What was the closing date for submissions under this FOA?
The original and current closing date listed is January 7, 2017.
Is this FOA still open for new applications?
No. The archive date is February 7, 2017, indicating the announcement is no longer open for new submissions under that specific FOA.
Where was the full announcement hosted?
The full announcement was hosted at http://grants.nih.gov/grants/guide/pa-files/PA-14-014.html.
Who was the contact for access or linking issues related to the announcement?
The NIH Office of Extramural Research (OER) webmaster contact was provided for access or linking issues: FBOWebmaster@OD.NIH.GOV.
In one sentence, what is this FOA about in practical terms?
In practical terms, this FOA supports projects that turn statistical signals from addiction genomics into biological understanding by validating which genetic/epigenetic/non-coding RNA candidates truly matter and explaining how they work mechanistically in addiction-relevant biology.
Browse more opportunities from the same category: Education Health
Next opportunity: Functional Genetics, Epigenetics, and Non coding RNAs in Substance Abuse (R21)
Previous opportunity: Genomic Underpinnings of Response to Rehabilitation Interventions (R01)
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| Substance Use and Abuse, Risky Decision Making and HIV/AIDS (R21) Apply for PA 14 062 Funding Number: PA 14 062 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
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