Opportunity Information: Apply for PAR 14 011
Apply for PAR 14 011
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Genomic Underpinnings of Response to Rehabilitation Interventions (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.361 Nursing Research.
- This funding opportunity was created on Dec 5, 2013 and posted on Dec 5, 2013.
- Applicants must submit their applications by Jun 23, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $350,000.00 in funding.
- Eligible applicants include: City or township governments Public housing authorities/Indian housing authorities Private institutions of higher education Small businesses State governments County governments For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Special district governments Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
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Opportunity Summary:
The Genomic Underpinnings of Response to Rehabilitation Interventions (R01) funding opportunity (PAR-14-011) is a National Institutes of Health (NIH) discretionary grant program focused on figuring out how genomics influences the way people respond to rehabilitation. The central idea is that individuals with functional impairments or disabilities, whether caused by injury, aging, or chronic illness, often show very different outcomes even when they receive similar rehabilitation services. This FOA supports research that can explain those differences by identifying genetic or genomic factors that shape recovery, adaptation, symptom control, and long-term function, with the ultimate goal of improving functional abilities such as activities of daily living and overall quality of life.
The FOA invites two broad types of projects. One approach is discovery-oriented: studies that elucidate genomic variants, genomic signatures, or biological mechanisms associated with rehabilitation outcomes in people receiving rehabilitation interventions. In practice, this could include examining how specific genetic variants relate to strength gains, mobility improvements, pain or fatigue trajectories, neuroplasticity, or other measurable rehabilitation endpoints, and then connecting those variants to plausible molecular or physiological pathways. The second approach is more intervention-focused: developing and testing genomics-based rehabilitation interventions. This includes tailoring rehabilitation strategies based on genomic information and also includes interventions that emphasize symptom management or self-management as part of a broader plan to improve function. In other words, the FOA is not limited to identifying biomarkers; it also supports translating genomic insights into practical rehabilitation strategies that can be tested for real-world benefit.
A notable emphasis in the announcement is interdisciplinarity. NIH explicitly encourages project teams that include nurse scientists, reflecting the role nursing research often plays in rehabilitation, symptom management, patient-centered outcomes, adherence, and implementation in clinical settings. Applicants are also encouraged to leverage infrastructure and expertise from nearby or otherwise accessible Clinical and Translational Science Award (CTSA) sites and/or other federally funded research centers. This signals NIH interest in projects that are clinically grounded, methodologically rigorous, and positioned to translate findings into practice, potentially through access to shared resources such as biostatistics, genomics cores, recruitment support, clinical research units, or community engagement services.
From an administrative standpoint, this opportunity is an R01 grant mechanism under the NIH activity area of Education/Health, listed under CFDA 93.361 (Nursing Research). Cost sharing or matching is not required. The posted and created date was December 5, 2013, and the original and current closing date listed is June 23, 2014, with an archive date of July 24, 2014. The award ceiling shown in the opportunity record is $350,000. The sponsoring agency is the National Institutes of Health, and the full announcement was provided through the NIH grants guide.
Eligibility for this FOA is broad across U.S.-based organizations. Eligible applicants include state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations (including those with and without 501(c)(3) status, other than institutions of higher education); small businesses and other for-profit organizations (other than small businesses); public housing authorities/Indian housing authorities; and federally recognized tribal governments as well as other tribal organizations. The eligibility section also highlights inclusion of organizations such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian serving institutions, and Asian American and Native American Pacific Islander-serving institutions (AANAPISIs), along with faith-based or community-based organizations and U.S. territories or possessions. At the same time, the FOA makes clear that non-U.S. entities are not eligible to apply, non-U.S. components of U.S. organizations are not eligible, and foreign components (as defined by NIH policy) are not allowed.
In practical terms, a strong application under this FOA would typically connect a clearly defined rehabilitation intervention and functional outcome set to a genomics-informed research plan, explain how genomic measures will be collected and analyzed, and show how findings could improve prediction of response or guide more personalized rehabilitation approaches. The FOA is oriented toward work that moves beyond describing rehabilitation outcomes in general and instead explains why outcomes differ between individuals, using genomic evidence and mechanisms, and then uses that knowledge to refine or create interventions that better maintain, improve, or restore function. For reference, the full FOA was linked at http://grants.nih.gov/grants/guide/pa-files/PAR-14-011.html, and NIH provided contact support through the NIH Office of Extramural Research (OER) webmaster for access or linking issues.
Frequently Asked Questions (FAQs)
What is the name of this funding opportunity?
The opportunity is titled The Genomic Underpinnings of Response to Rehabilitation Interventions (R01). The NIH funding opportunity announcement (FOA) number is PAR-14-011.
Who is the sponsoring agency?
The sponsoring agency is the National Institutes of Health (NIH).
What is the main purpose of this FOA?
This FOA supports research to understand how genetic or genomic factors influence differences in how people respond to rehabilitation interventions. The aim is to explain why individuals with similar functional impairments or disabilities can have very different rehabilitation outcomes, and to use that knowledge to improve function and quality of life.
What types of conditions or populations are relevant to this FOA?
The FOA focuses on individuals with functional impairments or disabilities, including those caused by injury, aging, or chronic illness, who receive rehabilitation services or interventions.
What kinds of outcomes is NIH interested in for this program?
The FOA highlights rehabilitation outcomes such as recovery, adaptation, symptom control, and long-term function, with an ultimate goal of improving activities of daily living and overall quality of life.
What are the two broad types of projects this FOA invites?
The FOA invites (1) discovery-oriented studies that identify genomic variants, genomic signatures, or mechanisms associated with rehabilitation outcomes, and (2) intervention-focused studies that develop and test genomics-based rehabilitation interventions, including tailoring rehabilitation based on genomic information.
What is meant by a discovery-oriented project under this FOA?
Discovery-oriented projects aim to elucidate genomic variants, genomic signatures, or biological mechanisms linked to rehabilitation outcomes among people receiving rehabilitation interventions, and connect genomic findings to plausible molecular or physiological pathways.
What is meant by an intervention-focused project under this FOA?
Intervention-focused projects involve developing and testing rehabilitation interventions that use genomic information, including approaches that tailor rehabilitation strategies based on genomic factors and approaches that emphasize symptom management or self-management as part of improving function.
Does this FOA only support biomarker discovery?
No. The FOA supports both identifying genomic factors associated with rehabilitation response and translating genomic insights into practical rehabilitation strategies that can be tested for real-world benefit.
What kinds of rehabilitation endpoints are examples of what could be studied?
Examples described in the FOA context include relationships between genetic variants and outcomes such as strength gains, mobility improvements, pain or fatigue trajectories, neuroplasticity, and other measurable rehabilitation endpoints.
Is interdisciplinary collaboration encouraged?
Yes. A notable emphasis is interdisciplinarity, and NIH explicitly encourages project teams that include nurse scientists.
Why does the FOA encourage including nurse scientists?
Based on the FOA description, nurse scientists are encouraged because nursing research often contributes to rehabilitation through symptom management, patient-centered outcomes, adherence, and implementation in clinical settings.
Are applicants encouraged to use CTSA resources?
Yes. Applicants are encouraged to leverage infrastructure and expertise from nearby or otherwise accessible Clinical and Translational Science Award (CTSA) sites and/or other federally funded research centers.
What types of support might CTSA sites or research centers provide?
The FOA signals interest in clinically grounded work and notes that shared resources could include access to biostatistics, genomics cores, recruitment support, clinical research units, or community engagement services.
What grant mechanism is used for this opportunity?
This FOA uses the NIH R01 grant mechanism.
What activity area and CFDA number are associated with this opportunity?
The opportunity is listed under the NIH activity area of Education/Health and is associated with CFDA 93.361 (Nursing Research).
Is cost sharing or matching required?
No. The opportunity record states that cost sharing or matching is not required.
What is the award ceiling listed in the opportunity record?
The award ceiling shown in the opportunity record is $350,000.
When was this opportunity created and posted?
The posted/created date listed is December 5, 2013.
What is the closing date for this opportunity?
The original and current closing date listed is June 23, 2014.
Is this opportunity archived?
Yes. The archive date listed is July 24, 2014.
Who is eligible to apply?
Eligibility is broad across U.S.-based organizations, including various levels of government (state, county, city/township), special district governments, independent school districts, public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status, other than institutions of higher education), small businesses, other for-profit organizations (other than small businesses), public housing authorities/Indian housing authorities, federally recognized tribal governments, and other tribal organizations.
Are certain institution types specifically highlighted as eligible?
Yes. The eligibility section highlights inclusion of organizations such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian serving institutions, and Asian American and Native American Pacific Islander-serving institutions (AANAPISIs).
Are faith-based or community-based organizations eligible?
Yes. The eligibility section notes that faith-based or community-based organizations are included among eligible applicants.
Are U.S. territories or possessions eligible?
Yes. The eligibility section includes U.S. territories or possessions.
Are non-U.S. entities eligible to apply?
No. The FOA states that non-U.S. entities are not eligible to apply.
Are non-U.S. components of U.S. organizations allowed?
No. The FOA makes clear that non-U.S. components of U.S. organizations are not eligible.
Are foreign components permitted under NIH policy for this FOA?
No. The FOA states that foreign components (as defined by NIH policy) are not allowed.
What does NIH appear to be looking for in a strong application?
Based on the FOA description, a strong application would typically (1) connect a clearly defined rehabilitation intervention and functional outcomes to a genomics-informed research plan, (2) explain how genomic measures will be collected and analyzed, and (3) show how findings could improve prediction of response or guide more personalized rehabilitation approaches.
What is the overarching research theme of this FOA?
The FOA is oriented toward moving beyond describing outcomes in general and instead explaining why outcomes differ between individuals using genomic evidence and mechanisms, then using that knowledge to refine or create interventions that better maintain, improve, or restore function.
Where can the full FOA be found?
The FOA is linked at: http://grants.nih.gov/grants/guide/pa-files/PAR-14-011.html
Who is the contact for access or linking issues?
NIH provided contact support through the NIH Office of Extramural Research (OER) webmaster for access or linking issues.
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