Opportunity Information: Apply for W81XWH 12 MRPRA MRFA
Apply for W81XWH 12 MRPRA MRFA
- The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "FY12 Militarily Relevant Peer Reviewed Alzheimers Disease Research Program (MRPRA) Military Risk Factors Research Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
- This funding opportunity was created on Nov 3, 2012 and posted on Sep 29, 2012.
- Applicants must submit their applications by Feb 4, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $6,400,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $6,400,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:
The FY12 Militarily Relevant Peer Reviewed Alzheimer s Disease Research Program (MRPRA) Military Risk Factors Research Award is a Department of the Army, USAMRAA-funded research opportunity focused on the long-term neurological consequences of traumatic brain injury (TBI) in military populations, especially the potential link between TBI and Alzheimer s disease (AD). The program is sponsored under the Defense Health Program Medical Research and Development Office, with the Telemedicine and Advanced Technology Research Center (TATRC) managing the application process and USAMRAA issuing the announcement and negotiating any resulting awards. The rationale behind the opportunity is that service members who experience moderate or severe TBI are at elevated risk for serious chronic outcomes such as Alzheimer s-like dementia, memory loss, depression, aggression, and other neurological symptoms, and that even mild TBI may contribute to similar long-term problems.
The broader mission of MRPRA is to build an integrated, coordinated research effort that clarifies how TBI may contribute to AD-related pathology and outcomes, and to reduce the burden of these conditions, with a strong emphasis on military relevance. For FY12, the program highlights two major objectives. First, it seeks research that advances tools, measures, and clinically meaningful outcomes that can improve detection, characterization, and diagnosis of neurological changes associated with TBI-linked Alzheimer s disease. This includes work aimed at identifying measurable indicators of change and developing research approaches that help distinguish or track neurodegenerative processes in people with prior TBI. Second, it supports development of technologies intended to directly help individuals living with neurological impairment symptoms related to either TBI or AD, with an emphasis on maintaining or improving quality of life rather than purely descriptive science.
Within that framework, the specific Military Risk Factors Research Award (MRFA) is designed to fund high-impact, systematic, population-based research that investigates the association between TBI and AD. The expectation is that funded studies will be structured to generate broadly useful evidence, benefiting the military community while also serving a public purpose applicable to civilian health. A key application requirement is a clear, credible plan for access to the study cohort, since the award is oriented toward population-level research rather than small convenience samples. Applicants must also provide preliminary data demonstrating how the cohort will be used and showing strong support for the proposed hypotheses, signaling that the research questions are testable and grounded in early evidence rather than speculative.
Administratively, this is a discretionary funding opportunity using grant and cooperative agreement mechanisms under CFDA 12.420 (Military Medical Research and Development). The opportunity anticipated a single award, with an estimated total funding amount up to 6,400,000 dollars and an award ceiling of 6,400,000 dollars (no stated minimum). Cost sharing or matching is not required. Eligibility is listed as unrestricted, meaning a wide range of applicant organization types may apply unless further limited by clarifications in the full text. The funding opportunity number is W81XWH 12 MRPRA MRFA, it was posted September 29, 2012, and it closed February 4, 2013, with the archive date of March 6, 2013. For access issues related to the full announcement, the listed point of contact is Mary Rico, Grants Officer, for MRPRA MRFA electronic access problems.
FAQs - FY12 MRPRA Military Risk Factors Research Award (MRFA)
What is this funding opportunity?
The FY12 Militarily Relevant Peer Reviewed Alzheimer's Disease Research Program (MRPRA) Military Risk Factors Research Award (MRFA) is a Department of the Army, USAMRAA-funded research opportunity focused on the long-term neurological consequences of traumatic brain injury (TBI) in military populations, particularly the potential relationship between TBI and Alzheimer's disease (AD).
What problem is the program trying to address?
The program is based on concerns that service members who experience moderate or severe TBI may have elevated risk for serious chronic neurological outcomes, including Alzheimer's-like dementia, memory loss, depression, aggression, and other neurological symptoms. It also recognizes that even mild TBI may contribute to similar long-term problems.
What is the broader mission of MRPRA?
MRPRA aims to build an integrated and coordinated research effort that clarifies how TBI may contribute to AD-related pathology and outcomes, with a strong emphasis on military relevance. The mission also includes reducing the burden of these conditions in affected populations.
What are the main FY12 research objectives highlighted by MRPRA?
For FY12, the program highlights two major objectives: (1) advancing tools, measures, and clinically meaningful outcomes that improve detection, characterization, and diagnosis of neurological changes associated with TBI-linked Alzheimer's disease; and (2) developing technologies intended to directly help individuals living with neurological impairment symptoms related to TBI or AD, emphasizing quality of life improvements rather than purely descriptive research.
What does the Military Risk Factors Research Award (MRFA) specifically fund?
MRFA is designed to fund high-impact, systematic, population-based research that investigates the association between TBI and Alzheimer's disease, with the expectation that the results will generate broadly useful evidence.
What type of research design is expected under the MRFA?
The award is oriented toward population-level research rather than small convenience samples. Applications are expected to propose systematic, population-based studies that can generate evidence that is broadly useful to the military community and also applicable to civilian health.
Why is military relevance emphasized?
The opportunity focuses on military populations and service members, reflecting the goal of addressing health risks and long-term outcomes associated with TBI in the military context. Funded research is expected to benefit the military community while also serving a public purpose relevant to civilian health.
What are examples of the kinds of advances the program wants for detection and diagnosis?
The program seeks work that advances tools and measures to improve detection, characterization, and diagnosis of neurological changes associated with TBI-linked Alzheimer's disease. This includes identifying measurable indicators of change and developing research approaches that help distinguish or track neurodegenerative processes in individuals with prior TBI.
What kind of technology development does the program support?
It supports development of technologies intended to directly help individuals living with neurological impairment symptoms related to either TBI or Alzheimer's disease, with an emphasis on maintaining or improving quality of life.
Is a plan to access a study cohort required?
Yes. A key application requirement is a clear and credible plan for access to the study cohort, since the award is focused on population-based research.
What is expected regarding preliminary data?
Applicants must provide preliminary data demonstrating how the cohort will be used and showing strong support for the proposed hypotheses. This is intended to show that the research questions are testable and grounded in early evidence rather than speculative.
Who manages the application process and who issues the awards?
The program is sponsored under the Defense Health Program Medical Research and Development Office. The Telemedicine and Advanced Technology Research Center (TATRC) manages the application process, while USAMRAA issues the announcement and negotiates any resulting awards.
What agency is funding this opportunity?
This is a Department of the Army, USAMRAA-funded research opportunity.
What funding mechanisms are used?
This is a discretionary funding opportunity using grant and cooperative agreement mechanisms.
What is the CFDA number associated with this opportunity?
The CFDA number is 12.420 (Military Medical Research and Development).
How many awards were anticipated?
The opportunity anticipated a single award.
What was the estimated total funding available?
The estimated total funding amount was up to $6,400,000.
What is the maximum award amount (ceiling)?
The award ceiling was $6,400,000.
Was there a minimum award amount stated?
No stated minimum award amount was provided.
Is cost sharing or matching required?
No. Cost sharing or matching was not required.
Who was eligible to apply?
Eligibility was listed as unrestricted, meaning a wide range of applicant organization types could apply unless further limited by clarifications in the full announcement text.
What is the funding opportunity number?
The funding opportunity number is W81XWH 12 MRPRA MRFA.
When was the opportunity posted and when did it close?
It was posted on September 29, 2012, and closed on February 4, 2013.
When was the archive date?
The archive date was March 6, 2013.
Who should be contacted for electronic access problems related to the full announcement?
For electronic access issues related to the full announcement, the listed point of contact is Mary Rico, Grants Officer, for MRPRA MRFA electronic access problems.
Does the program focus only on Alzheimer's disease?
It focuses on Alzheimer's disease in connection with traumatic brain injury and related long-term neurological consequences, including a range of symptoms and outcomes that may resemble or relate to Alzheimer's-like dementia and other neurological impairments.
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Previous opportunity: FY12 Militarily Relevant Peer Reviewed Alzheimers Disease Research Program (MRPRA) Convergence Science Research Award
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