Genetic and Genomic Analysis of Xenopus (R03) | Apply Online

Opportunity Summary:

The Genetic and Genomic Analysis of Xenopus (R03) opportunity (Funding Opportunity Number PAR-09-242) is an NIH small-grant program meant to strengthen and expand the use of Xenopus (frog) models in biomedical research. It is sponsored by multiple NIH institutes, including the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the National Institute of Dental and Craniofacial Research (NIDCR), the National Institute of Neurological Disorders and Stroke (NINDS), the National Institute of Mental Health (NIMH), along with the Trans-NIH Xenopus Working Group (TXWG). The overall goal is to support investigator-initiated projects that either create high-impact genetic/genomic tools and resources for the broader Xenopus community or apply newer genetic/genomic approaches to answer important biological questions in ways that have not been widely done in Xenopus before.

Scientifically, the FOA targets projects that improve researchers' ability to detect, analyze, and interpret genes, pathways, and phenotypes relevant to vertebrate biology and human disease. The emphasis is on areas where Xenopus is especially powerful: developmental biology and organogenesis, as well as core cell biological processes such as cell division, cell signaling, and cell migration. A key theme is community value: proposals are encouraged when the resulting tools, methods, or datasets are likely to be broadly useful and fill recognized needs in Xenopus research. The announcement explicitly welcomes both tool/resource development (for example, new genetic or genomic resources, enabling technologies, or methodological advances) and research projects that leverage recently developed tools to push discovery forward, especially when they involve approaches not previously adopted in Xenopus work.

This FOA uses the NIH Small Research Grant (R03) mechanism, which is designed for short-duration, limited-budget projects that can be completed with relatively modest resources. The R03 format is well-suited to pilot and feasibility studies, secondary analyses of existing datasets, small self-contained research projects, development of research methodology, and development of new research technology. In practice, that means the program is aimed at enabling quick, focused efforts that can prove out an idea, build a needed capability, or generate preliminary data that may support larger follow-on projects.

The R03 announcement runs in parallel with two related NIH opportunities that share the same scientific scope but provide different funding mechanisms and project scales: PAR-09-241 (R21, exploratory/developmental) and PAR-09-240 (R01, standard research project grant). Applicants whose aims are similar but require more time or resources could consider those companion FOAs, while PAR-09-242 is specifically tailored to smaller, tightly scoped efforts.

From an administrative standpoint, this is a discretionary grant opportunity in the Health category (Health; Income Security and Social Services) and is associated with multiple CFDA numbers reflecting the participating institutes and research areas, including oral diseases and disorders research (93.121), mental health research grants (93.242), neuroscience and neurological disorders extramural programs (93.853), and child health and human development extramural research (93.865). There is no cost sharing or matching requirement.

Eligibility is broad and includes many types of U.S. and non-U.S. organizations. Eligible applicants span public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (including both 501(c)(3) and non-501(c)(3) entities), for-profit organizations other than small businesses (as well as small businesses), independent school districts, and various government entities such as city/township, county, state, special district governments, and public or Indian housing authorities. The FOA also notes additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Hispanic Serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), federally recognized and other tribal governments and organizations, faith-based or community-based organizations, U.S. territories or possessions, regional organizations, eligible federal agencies, and foreign (non-U.S.) entities.

Key dates in the public record include a posted and created date of July 27, 2009, an original and current closing date of September 30, 2011, and an archive date of October 31, 2011. The full announcement was made available through the NIH grants guide, and applicants with access issues were directed to the NIH Office of Extramural Research (OER) webmaster contacts listed in the notice.

In plain terms, this R03 opportunity was built to help the Xenopus field move faster by funding compact projects that either build shared genetic/genomic capacity (tools, resources, methods, technologies) or demonstrate innovative use of newer genomic and genetic approaches in Xenopus to uncover mechanisms relevant to development, organ formation, and fundamental cell behavior.

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Previous opportunity: Genetic and Genomic Analysis of Xenopus (R21)

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