Opportunity Information: Apply for RFA HD 12 200

  • The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "Global Network for Womens and Childrens Health Research (U10)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865 Child Health and Human Development Extramural Research.
  • This funding opportunity was created on May 24, 2011 and posted on May 24, 2011.
  • Applicants must submit their applications by Aug 11, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $4,300,000.00 to eligible and selected applicants.
  • Each selected applicant is eligible to receive up to $170,000.00 in funding.
  • The number of recipients for this funding is limited to 5 candidate(s).
  • Eligible applicants include: Small businesses Private institutions of higher education City or township governments Native American tribal organizations (other than Federally recognized tribal governments) County governments Public housing authorities/Indian housing authorities For profit organizations other than small businesses Special district governments Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) Others (see text field entitled Additional Information on Eligibility for clarification) Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Only U.S. institutions may apply on behalf of the RU partnership pairs. Non domestic (non U.S.) Entities (Foreign Organizations) are not eligible to apply. Foreign (non U.S.) components of U.S. Organizations are not allowed.
Apply for RFA HD 12 200

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Opportunity Summary:

The Global Network for Womens and Childrens Health Research (U10) funding opportunity (RFA-HD-12-200) is a National Institutes of Health initiative led by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) to continue and re-compete an established, multicenter international research network. The core aim is to support rigorous, collaborative studies that can reduce illness and death among mothers, newborns, infants, and young children in low and lower middle income countries. The program is structured around doing practical, high-quality research in real-world, resource-limited settings, with a strong emphasis on randomized clinical trials and intervention studies that address the most important drivers of maternal and child morbidity and mortality.

Funding is provided through a cooperative agreement (U10), which means the funded teams are not working in isolation under a standard grant model. Instead, awardees are expected to operate as part of a coordinated network in close scientific partnership with NICHD. In practice, this arrangement is meant to ensure that participating sites can carry out common protocols, use shared standards, contribute to network-wide trials, and collectively generate evidence that is comparable across multiple countries and populations. The network structure is designed to support large, multi-site studies where consistent methods, harmonized data collection, and coordinated oversight are essential, especially when evaluating interventions intended for widespread use in resource-poor environments.

Applicants are expected to form Research Units (RUs). Each RU is built as a partnership between a U.S.-based research center and one or more collaborating research centers located in low or lower middle income countries. While the research is conducted in international settings, only U.S. institutions are allowed to apply as the official applicant organization on behalf of the RU partnership. Non-U.S. entities cannot apply directly, foreign components of U.S. organizations are not permitted, and the application must be anchored in the U.S. institutional applicant. The intent is to preserve a clear administrative and compliance structure under NIH policies while still enabling deep, on-the-ground collaboration with international partners where the health burden is highest.

Scientifically, the network is oriented toward identifying and testing interventions that can make measurable improvements for women and children during pregnancy, delivery, the neonatal period, infancy, and early childhood. The opportunity highlights randomized clinical trials and intervention research as central approaches, reflecting the goal of generating strong causal evidence about what works. The interventions are expected to be evaluated under conditions similar to where they would ultimately be implemented, meaning the research should account for constraints common in low-resource settings, such as limitations in infrastructure, staffing, equipment, supply chains, and access to specialized care. Another explicit feature of the program is the expectation that catchment populations across the RUs will represent diverse ethnic, linguistic, and cultural groups, which strengthens the relevance and generalizability of findings across different communities.

From an administrative and funding standpoint, this is a discretionary funding opportunity in the Health category (CFDA 93.865: Child Health and Human Development Extramural Research). The announcement anticipated making about five awards, with an estimated total funding level of $4.3 million. The listed award ceiling was $170,000, and there was no cost sharing or matching requirement. Key dates show the opportunity was posted on May 24, 2011, with an original and current closing date of August 11, 2011, and an archive date of September 11, 2011, indicating it is a past competition cycle rather than an open solicitation today.

Eligibility is broad on the U.S. side and includes public and private institutions of higher education, nonprofits (including 501(c)(3) and non-501(c)(3) organizations), for-profit organizations, small businesses, and various government entities (state, county, city/township, special districts), as well as tribal governments and tribally controlled institutions. The announcement also explicitly notes inclusion of institutions serving specific communities and missions, such as Historically Black Colleges and Universities, Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities, Alaska Native and Native Hawaiian Serving Institutions, and faith-based or community-based organizations, among others. Even with this broad eligibility, the central structural rule remains that the applicant must be a U.S. institution applying to support a U.S.-led RU that is formally partnered with research centers in eligible low and lower middle income countries.

Overall, this grant opportunity is best understood as support for a coordinated, multi-country clinical research platform focused on high-impact maternal and child health problems in settings where the burden is high and the resources are limited. Awardees are expected to function as a true network: jointly planning and running studies, adhering to shared protocols, and collaborating closely with NICHD to produce evidence that can guide policy, clinical practice, and scalable public health interventions for women and children worldwide.

Frequently Asked Questions (FAQs)

What is the Global Network for Womens and Childrens Health Research (U10) opportunity?

It is a National Institutes of Health (NIH) initiative led by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) to continue and re-compete an established, multicenter international research network. The program supports collaborative research intended to reduce illness and death among mothers, newborns, infants, and young children in low and lower middle income countries.

What is the funding opportunity number and mechanism?

The funding opportunity is RFA-HD-12-200 and it uses a cooperative agreement mechanism (U10).

What does it mean that this award is a cooperative agreement (U10)?

A cooperative agreement means awardees are expected to work as part of a coordinated research network in close scientific partnership with NICHD, rather than operating independently under a standard grant model. The structure is intended to support common protocols, shared standards, network-wide trials, harmonized data collection, and coordinated oversight across multiple countries and populations.

What is the primary goal of this network?

The core aim is to support rigorous, collaborative studies that can reduce morbidity and mortality among women and children in resource-limited settings, with an emphasis on generating evidence that is comparable across multiple sites and countries.

What types of research are emphasized?

The opportunity highlights randomized clinical trials and intervention studies as central approaches. The focus is on practical, high-quality research that evaluates interventions aimed at the most important drivers of maternal and child morbidity and mortality.

Which populations and life stages are included in the research focus?

The scientific focus includes women and children during pregnancy, delivery, the neonatal period, infancy, and early childhood.

Where is the research expected to take place?

Research is expected to be conducted in low and lower middle income countries, in real-world settings where resources may be limited and where the health burden is high.

How should interventions be evaluated under this program?

Interventions are expected to be evaluated under conditions similar to where they would ultimately be implemented. This includes accounting for common constraints in low-resource environments, such as limitations in infrastructure, staffing, equipment, supply chains, and access to specialized care.

What is a Research Unit (RU) in this funding opportunity?

Applicants are expected to form Research Units (RUs). Each RU is structured as a partnership between a U.S.-based research center and one or more collaborating research centers located in low or lower middle income countries.

Who is allowed to apply as the official applicant organization?

Only U.S. institutions are allowed to apply as the official applicant organization on behalf of the RU partnership. The application must be anchored in the U.S. institutional applicant.

Can a non-U.S. entity apply directly?

No. Non-U.S. entities cannot apply directly under this opportunity.

Are foreign components of U.S. organizations permitted?

No. The opportunity states that foreign components of U.S. organizations are not permitted.

Why does the opportunity require a U.S. institution to apply?

The stated intent is to maintain a clear administrative and compliance structure under NIH policies while enabling substantial collaboration with international research centers where the burden of maternal and child illness and death is highest.

How many awards were anticipated?

The announcement anticipated making about five awards.

What was the estimated total funding level for the opportunity?

The estimated total funding level listed was $4.3 million.

What was the listed award ceiling?

The listed award ceiling was $170,000.

Is cost sharing or matching required?

No. The opportunity states there was no cost sharing or matching requirement.

What is the CFDA number and program category?

The opportunity is listed under CFDA 93.865, Child Health and Human Development Extramural Research, in the Health category.

What are the key dates for this opportunity?

It was posted on May 24, 2011. The original and current closing date was August 11, 2011. The archive date was September 11, 2011.

Is this an open solicitation right now?

Based on the listed closing and archive dates, this appears to be a past competition cycle rather than an open solicitation today.

What U.S. organizations were eligible to apply?

Eligibility included a broad range of U.S. organizations, such as public and private institutions of higher education; nonprofits (including 501(c)(3) and non-501(c)(3)); for-profit organizations; small businesses; and government entities at the state, county, city/township, and special district levels, as well as tribal governments and tribally controlled institutions.

Does the opportunity mention institutions serving specific communities or missions?

Yes. It explicitly notes inclusion of organizations such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities, Alaska Native and Native Hawaiian Serving Institutions, and faith-based or community-based organizations, among others.

What is the intended advantage of running research as a network?

The network model is designed to enable large, multi-site studies where consistent methods, harmonized data collection, and coordinated oversight are essential. It is intended to produce evidence that is comparable across multiple countries and populations, especially when evaluating interventions meant for widespread use in resource-poor environments.

Does the opportunity address diversity across study populations?

Yes. It explicitly expects catchment populations across the RUs to represent diverse ethnic, linguistic, and cultural groups to strengthen the relevance and generalizability of findings across different communities.

How closely are awardees expected to collaborate with NICHD?

Awardees are expected to operate in close scientific partnership with NICHD, jointly supporting coordinated network activities such as running common protocols and contributing to network-wide trials.

What is the overall purpose of the funded work?

The opportunity is intended to support a coordinated, multi-country clinical research platform that generates evidence to guide policy, clinical practice, and scalable public health interventions for women and children worldwide, particularly in settings where resources are limited.

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Applicants also applied for:

Applicants who have applied for this opportunity (RFA HD 12 200) also looked into and applied for these:

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Patient Safety Research During Neonatal Care (R01) Apply for PAR 11 225

Funding Number: PAR 11 225
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Patient Safety Research During Neonatal Care (R21) Apply for PAR 11 227

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Perinatally HIV Infected Youth In Africa and Asia (R01) Apply for RFA HD 12 207

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Safe and Effective Instruments and Devices for Use in the Neonatal Intensive Care Units (SBIR) R43) Apply for RFA HD 12 192

Funding Number: RFA HD 12 192
Agency: National Institutes of Health
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Safe and Effective Instruments and Devices for Use in the Neonatal Intensive Care Units (STTR) R41 Apply for RFA HD 12 193

Funding Number: RFA HD 12 193
Agency: National Institutes of Health
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Male Reproductive Health Research (MRHR) Career Development Program K12 Apply for RFA HD 12 187

Funding Number: RFA HD 12 187
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NICHD Continuing Education Training Programs (T15) Apply for PAR 11 233

Funding Number: PAR 11 233
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Funding Amount: $125,000

 

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