Opportunity Information: Apply for PAR 13 293
Apply for PAR 13 293
- The National Institutes of Health in the food and nutrition health sector is offering a public funding opportunity titled "Gut Microbiota Derived Factors in the Integrated Physiology and Pathophysiology of Diseases within NIDDKs Mission (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research.
- This funding opportunity was created on Aug 2, 2013 and posted on Aug 2, 2013.
- Applicants must submit their applications by Jan 7, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled Additional Information on Eligibility for clarification) Public and State controlled institutions of higher education City or township governments For profit organizations other than small businesses County governments Private institutions of higher education Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Special district governments Independent school districts State governments Public housing authorities/Indian housing authorities.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The NIH National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) issued this Funding Opportunity Announcement, PAR-13-293, to support investigator-initiated R01 research projects focused on how the human gut microbiota interacts with the host to shape normal physiology and contribute to disease processes that fall within NIDDKs mission areas. In practical terms, the FOA is looking for multidisciplinary studies that move beyond broad descriptions of "the microbiome" and instead identify concrete, specific microbiota-derived factors (for example, metabolites, small molecules, microbial products, or other bioactive components) that either influence host biology or are themselves changed by host physiology. A central emphasis is integrating microbiology with host physiology, including the role of diet and nutrition, to clarify how microbial outputs connect to homeostasis and to the development or progression of disease.
The scientific scope is centered on mechanistic discovery. Applicants are expected to uncover which gut microbe-derived factors matter, and then map the interactions and pathways through which those factors act. That includes effects within the gastrointestinal tract as well as effects at distant organs, reflecting the idea that microbial products can circulate or signal systemically and contribute to whole-body physiology. Projects supported under this FOA would typically be expected to define cause-and-effect relationships and biologic pathways rather than only reporting associations, with the broader goal of explaining how host-microbiota interactions regulate physiology and drive pathophysiology relevant to diabetes, digestive diseases, and kidney diseases (the core NIDDK portfolio reflected by the CFDA listing for diabetes, digestive, and kidney diseases extramural research).
From an administrative standpoint, this is a discretionary NIH grant opportunity using the R01 mechanism (a standard NIH Research Project Grant) under a food, nutrition, and health activity category. It does not require cost sharing or matching. The opportunity was posted and created on August 2, 2013, with an original and final closing date of January 7, 2017, and it was archived on February 7, 2017, meaning it is no longer open for new submissions under that specific announcement.
Eligibility is broad and includes many organization types that commonly apply for NIH funding. Eligible applicants include public and private institutions of higher education, nonprofits (including those with and without 501(c)(3) status, except where otherwise limited), small businesses and other for-profit entities (other than small businesses are explicitly listed), and a wide range of government organizations (state, county, city/township, special district governments, independent school districts, and public housing authorities/Indian housing authorities). The FOA also explicitly includes tribal governments and tribal organizations, including federally recognized tribes and other tribal entities, as well as tribally controlled colleges and universities. In addition, it highlights eligibility for institutions serving specific populations, such as Historically Black Colleges and Universities, Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and Asian American Native American Pacific Islander-serving institutions, along with faith-based and community-based organizations and eligible federal agencies. Importantly, non-U.S. entities are allowed to apply: foreign organizations and foreign institutions are eligible, non-U.S. components of U.S. organizations are eligible, and foreign components (as defined in NIH policy) are permitted.
The full announcement was hosted through the NIH Grants Guide at the provided link (http://grants.nih.gov/grants/guide/pa-files/PAR-13-293.html). For technical issues accessing the announcement or linking to it, the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs)
What is the funding opportunity covered here?
This opportunity is NIH Funding Opportunity Announcement (FOA) PAR-13-293 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). It supports investigator-initiated research projects using the NIH R01 (Research Project Grant) mechanism.
Which NIH institute is sponsoring this FOA?
The sponsoring institute is the NIH National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).
What research topic does PAR-13-293 focus on?
The FOA focuses on mechanistic research into how the human gut microbiota interacts with the host to shape normal physiology and to contribute to disease processes within NIDDK mission areas (diabetes, digestive diseases, and kidney diseases).
What is the main scientific emphasis of this FOA?
The central emphasis is moving beyond broad, descriptive studies of "the microbiome" and instead identifying specific microbiota-derived factors (such as metabolites, small molecules, microbial products, or other bioactive components), then mapping how those factors influence host biology or how host physiology changes those microbial outputs.
Does the FOA prioritize mechanistic (cause-and-effect) studies over association studies?
Yes. Projects are generally expected to define cause-and-effect relationships and biologic pathways rather than only reporting associations.
What kinds of microbiota-related factors are the FOA interested in?
The FOA highlights concrete microbiota-derived factors, including metabolites, small molecules, microbial products, and other bioactive components that impact host physiology or are altered by host physiology.
Is integration of microbiology and host physiology required?
Yes. A central theme is integrating microbiology with host physiology to clarify how microbial outputs connect to homeostasis and to the development or progression of disease.
How does diet or nutrition fit into the scope of this FOA?
The FOA explicitly emphasizes the role of diet and nutrition as part of understanding host physiology and its interaction with microbial outputs.
Are studies limited to effects within the gastrointestinal tract?
No. The FOA includes effects within the gastrointestinal tract and effects at distant organs, reflecting the idea that microbial products can circulate or signal systemically and influence whole-body physiology.
What diseases or mission areas are considered relevant to NIDDK for this FOA?
The FOA targets physiology and pathophysiology relevant to diabetes, digestive diseases, and kidney diseases, aligning with NIDDK mission areas and the CFDA listing for diabetes, digestive, and kidney diseases extramural research.
What grant mechanism is used for this opportunity?
The opportunity uses the NIH R01 mechanism (Research Project Grant), supporting investigator-initiated research projects.
Is this a discretionary grant opportunity?
Yes. It is described as a discretionary NIH grant opportunity.
Is cost sharing or matching required?
No. The FOA does not require cost sharing or matching.
What is the activity category for this FOA?
It is listed under a food, nutrition, and health activity category.
When was PAR-13-293 posted and created?
The FOA was posted and created on August 2, 2013.
What were the closing dates for this FOA?
The FOA lists an original and final closing date of January 7, 2017.
Is this FOA still open for applications?
No. It was archived on February 7, 2017, meaning it is no longer open for new submissions under that specific announcement.
Who is eligible to apply?
Eligibility is broad and includes many organization types commonly eligible for NIH funding, including higher education institutions, nonprofits, for-profit entities, small businesses, and many government organization types, as well as tribal governments and tribal organizations.
Are public and private institutions of higher education eligible?
Yes. Public and private institutions of higher education are eligible applicant organizations.
Are nonprofit organizations eligible, including those without 501(c)(3) status?
Yes. The FOA includes nonprofits with and without 501(c)(3) status (except where otherwise limited, as noted in the eligibility description).
Are for-profit organizations eligible to apply?
Yes. Small businesses are included, and other for-profit entities (other than small businesses are explicitly listed) are also included in the eligibility description.
What types of government organizations are eligible?
The eligibility description includes state governments, county governments, city/township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities.
Are tribal governments and tribal organizations eligible?
Yes. The FOA explicitly includes federally recognized tribal governments and other tribal entities, as well as tribal organizations and tribally controlled colleges and universities.
Are institutions serving specific populations explicitly included?
Yes. The FOA highlights eligibility for Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and Asian American Native American Pacific Islander-serving institutions.
Are faith-based and community-based organizations eligible?
Yes. Faith-based and community-based organizations are explicitly listed as eligible.
Are federal agencies eligible to apply?
Yes. Eligible federal agencies are included in the eligibility description.
Are non-U.S. (foreign) entities allowed to apply?
Yes. Foreign organizations and foreign institutions are eligible, non-U.S. components of U.S. organizations are eligible, and foreign components (as defined in NIH policy) are permitted.
Where can the full FOA text be found?
The full announcement is hosted in the NIH Grants Guide at: http://grants.nih.gov/grants/guide/pa-files/PAR-13-293.html
Who should be contacted for technical issues accessing the announcement or linking to it?
The listed contact for technical issues is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
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