Opportunity Information: Apply for PAR 13 291
Apply for PAR 13 291
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Research Centers in Injury and Peri operative Sciences (P50)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.859 Biomedical Research and Research Training.
- This funding opportunity was created on Aug 2, 2013 and posted on Aug 2, 2013.
- Applicants must submit their applications by Sep 7, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $8,100,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $1,800,000.00 in funding.
- The number of recipients for this funding is limited to 3 candidate(s).
- Eligible applicants include: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education Special district governments County governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) State governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
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Opportunity Summary:
The Research Centers in Injury and Peri operative Sciences (RCIPS) funding opportunity (PAR-13-291) is an NIH/National Institute of General Medical Sciences (NIGMS) P50 center grant program designed to support multidisciplinary research centers focused on the biology of injury and critical illness. The central aim is to deepen scientific understanding of the biological processes triggered after traumatic injury or burn injury, and in critically ill patients, across multiple levels of analysis. This includes molecular and cellular responses, whole-organism physiology, and integrated multi-system dynamics that reflect how the body loses and then attempts to re-establish homeostasis. Relevant dimensions such as wound healing are explicitly within scope, particularly when connected to broader systemic responses and recovery mechanisms.
A major emphasis of the program is translational research that moves in both directions between bench and bedside. On one hand, applicants are expected to bring basic scientific discoveries and mechanistic principles into clinical contexts where they can inform understanding, measurement, and potentially clinical approaches. On the other hand, the program also values clinical observations that can generate new mechanistic hypotheses or test and validate biological models developed in the laboratory. In practical terms, the program is looking for centers that can connect patient-facing realities of injury, perioperative physiology, and critical care with rigorous mechanistic science, rather than treating clinical and basic research as separate tracks.
Applications are expected to be organized around a clearly defined, unifying theme that ties together the proposed research projects and any shared resources. The center structure is meant to create synergy: the different projects should reinforce one another through shared questions, compatible methods, harmonized data or sample strategies, and coordinated scientific goals. While interventional studies can be included, they are only considered appropriate when they are tightly integrated with and supportive of the core biological and physiological investigations. A proposal that is essentially just an interventional clinical trial, without strong mechanistic integration and center-wide scientific cohesion, is specifically described as a poor fit for this mechanism.
From an administrative and strategic standpoint, NIGMS strongly encourages prospective applicants to contact the relevant NIGMS program official early during program planning. This reflects the complexity of P50 center applications and the importance of aligning the center theme, project structure, and translational rationale with NIGMS expectations before submission.
In terms of the basic funding details provided, this is a discretionary grant mechanism in the health funding category, with an expected three awards and an estimated total program funding level of $8.1 million. The award ceiling is listed as $1.8 million. There is no cost sharing or matching requirement. The opportunity was posted on August 2, 2013, with an original and final closing date of September 7, 2016, and it was archived on October 8, 2016. The CFDA number associated with the program is 93.859 (Biomedical Research and Research Training).
Eligibility is broad across U.S.-based organizations and governments, including public and private institutions of higher education, nonprofit organizations (including 501(c)(3) and other nonprofit statuses), and various levels of government (city/township, county, state, special district), as well as tribal governments and tribally controlled institutions. The announcement also explicitly includes categories such as HBCUs, Hispanic-serving institutions, AANAPISIs, Alaska Native and Native Hawaiian serving institutions, and TCCUs, and notes that eligible federal agencies may apply. Foreign institutions are not eligible, non-U.S. components of U.S. organizations are not eligible, and foreign components (as defined by NIH policy) are not allowed.
Overall, RCIPS is best read as a center-based mechanism intended for coordinated teams studying the integrated biology of trauma, burns, perioperative stress, and critical illness, with a strong expectation of mechanistic depth, cross-project cohesion, and meaningful translational linkage, rather than a stand-alone clinical trial platform.
RCIPS (PAR-13-291) Frequently Asked Questions
What is the RCIPS funding opportunity?
Research Centers in Injury and Peri operative Sciences (RCIPS), PAR-13-291, is an NIH/National Institute of General Medical Sciences (NIGMS) P50 center grant program that supports multidisciplinary research centers focused on the biology of injury and critical illness.
Which NIH institute sponsors this program?
The program is sponsored by the National Institute of General Medical Sciences (NIGMS) at NIH.
What is the grant mechanism?
It is a P50 center grant mechanism, meaning applications are expected to propose an integrated, center-based structure with multiple reinforcing projects and shared resources organized around a unifying scientific theme.
What is the central scientific aim of RCIPS?
The main aim is to deepen understanding of the biological processes triggered after traumatic injury or burn injury, and in critically ill patients, across multiple levels of analysis (molecular/cellular, whole-organism physiology, and integrated multi-system dynamics) including how homeostasis is disrupted and then re-established.
What kinds of injury or clinical contexts are considered relevant?
The opportunity highlights traumatic injury, burn injury, perioperative physiology/stress, and critical illness as key contexts, with an overall focus on the integrated biology of injury and critical care.
Is wound healing within the scope of RCIPS?
Yes. Wound healing is explicitly within scope, especially when it is tied to broader systemic responses and recovery mechanisms.
What does RCIPS mean by studying biology across multiple levels?
RCIPS emphasizes work that can span molecular and cellular responses, whole-organism physiology, and multi-system interactions that reflect integrated body responses to injury and critical illness.
Is translational research required or encouraged?
Translational research is a major emphasis. The program expects meaningful bench-to-bedside and bedside-to-bench linkage rather than treating basic and clinical research as separate tracks.
What does "bench-to-bedside" mean in this program?
It refers to bringing basic scientific discoveries and mechanistic principles into clinical contexts so they can inform clinical understanding, measurement, and potentially clinical approaches.
What does "bedside-to-bench" mean in this program?
It refers to using clinical observations from injury, perioperative care, or critical care to generate new mechanistic hypotheses or to test and validate biological models developed in the laboratory.
Do applications need a unifying theme?
Yes. Applications are expected to be organized around a clearly defined, unifying theme that ties together the proposed research projects and any shared resources.
How should multiple projects within the center relate to each other?
The center is expected to create synergy across projects. Projects should reinforce one another through shared questions, compatible methods, coordinated goals, and harmonized strategies for data and/or samples.
Are shared resources allowed or expected?
The opportunity notes that shared resources may be part of the center and should connect to the unifying theme and strengthen cross-project synergy.
Can interventional studies be included?
Yes, interventional studies can be included, but they are considered appropriate only when tightly integrated with and supportive of the core biological and physiological investigations.
Would a stand-alone interventional clinical trial be a good fit?
No. A proposal that is essentially an interventional clinical trial without strong mechanistic integration and center-wide cohesion is specifically described as a poor fit for this mechanism.
What is NIGMS looking for in terms of clinical and basic science integration?
NIGMS is looking for centers that connect patient-facing realities of injury, perioperative physiology, and critical care with rigorous mechanistic science, rather than splitting clinical and basic research into separate, loosely related tracks.
Is it recommended to contact NIH/NIGMS before applying?
Yes. NIGMS strongly encourages prospective applicants to contact the relevant NIGMS program official early during planning due to the complexity of P50 center applications and the importance of alignment with program expectations.
How many awards were expected under this opportunity?
The opportunity listed an expectation of three awards.
What was the estimated total funding level for the program?
The estimated total program funding level was $8.1 million.
What is the award ceiling?
The award ceiling was listed as $1.8 million.
Is cost sharing or matching required?
No. There was no cost sharing or matching requirement.
What is the funding category?
The opportunity is described as a discretionary grant mechanism in the health funding category.
What is the CFDA number for this program?
The CFDA number associated with the program is 93.859 (Biomedical Research and Research Training).
When was this opportunity posted?
It was posted on August 2, 2013.
What were the closing dates?
The original closing date and the final closing date were both listed as September 7, 2016.
Is this opportunity still open?
No. The opportunity was archived on October 8, 2016.
What types of U.S. organizations were eligible to apply?
Eligibility was broad across U.S.-based organizations, including public and private institutions of higher education, nonprofit organizations (including 501(c)(3) and other nonprofit statuses), and multiple levels of government (city/township, county, state, and special district), as well as tribal governments and tribally controlled institutions.
Are specific institution types explicitly included (for example, MSIs)?
Yes. The announcement explicitly included categories such as HBCUs, Hispanic-serving institutions, AANAPISIs, Alaska Native and Native Hawaiian serving institutions, and TCCUs.
Could federal agencies apply?
Yes. The announcement notes that eligible federal agencies may apply.
Are foreign institutions eligible?
No. Foreign institutions are not eligible.
Can a U.S. organization include a non-U.S. component?
No. Non-U.S. components of U.S. organizations are not eligible.
Are foreign components allowed under NIH policy?
No. Foreign components (as defined by NIH policy) are not allowed.
What is the best overall way to interpret what RCIPS is trying to fund?
RCIPS is best read as a center-based mechanism for coordinated teams studying the integrated biology of trauma, burns, perioperative stress, and critical illness, with strong expectations for mechanistic depth, cross-project cohesion, and genuine translational linkage rather than serving as a stand-alone clinical trial platform.
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