Opportunity Information: Apply for RFA DE 09 001
Apply for RFA DE 09 001
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Harnessing Inflammation for Reconstruction of Oral and Craniofacial Tissues (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121 Oral Diseases and Disorders Research.
- This funding opportunity was created on Jul 1, 2008 and posted on Jul 1, 2008.
- Applicants must submit their applications by Oct 31, 2008. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $3,000,000.00 to eligible and selected applicants.
- Eligible applicants include: State governments County governments Small businesses Native American tribal governments (Federally recognized) Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts City or township governments Others (see text field entitled Additional Information on Eligibility for clarification) For profit organizations other than small businesses Private institutions of higher education Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
Harnessing Inflammation for Reconstruction of Oral and Craniofacial Tissues (R01) is a National Institute of Dental and Craniofacial Research (NIDCR/NIH) funding opportunity that focuses on turning inflammation biology into practical strategies for repairing and regenerating oral and craniofacial tissues. The core idea is that inflammation is not only something to suppress; it is a dynamic process that can either drive healthy healing or lead to chronic damage, scarring, and fibrosis. This program is looking for R01 research projects that explain, in molecular and mechanistic detail, how the body resolves both acute and chronic inflammation, and then uses that knowledge to deliberately control and "pattern" inflammatory microenvironments in ways that improve tissue reconstruction outcomes in the mouth, jaws, and broader craniofacial region.
Scientifically, the FOA emphasizes two connected goals. First, applicants are expected to elucidate the molecular mechanisms that govern inflammation resolution, meaning the active processes that shut down inflammatory signaling, clear immune cells appropriately, and transition tissue from injury response into repair. This includes understanding why inflammation sometimes fails to resolve and becomes chronic, contributing to persistent tissue destruction and impaired healing. Second, the FOA wants novel multidisciplinary approaches that can predictably steer the inflammatory microenvironment, not just generally reduce inflammation. That language points to interventions that can shape the timing, intensity, spatial distribution, and cell composition of inflammatory responses so that regeneration is supported rather than blocked. The anticipated payoff is the development of new concepts and paradigms for promoting resolution, preventing or reversing fibrosis and scarring, and enabling more reliable regeneration and reconstruction of diseased or injured oral and craniofacial tissues.
A major feature of the opportunity is its strong push for interdisciplinary and multidisciplinary research. NIDCR highlights integration across fields such as cell biology, developmental biology, stem cell biology, and immunology, combined with chemistry, pharmacology, and bioengineering. In practice, this encourages projects that link fundamental immune and tissue biology with engineered materials, delivery systems, bioactive molecules, pharmacologic modulators, or other platform technologies that can manipulate inflammation in a controlled manner. Because this scope often requires multiple specialized skill sets, the FOA strongly encourages using the multiple-PI format, which is NIH's mechanism for formally supporting team science with shared leadership.
The mechanism of support is the NIH Research Project Grant (R01), with projects allowed up to a five-year period. This FOA runs alongside a companion announcement with the same scientific scope using the R21 mechanism (RFA-DE-09-002), which typically supports earlier-stage, exploratory work, while the R01 is positioned for more developed, hypothesis-driven projects with a broader or deeper research plan.
In terms of funding, NIDCR planned to commit up to a total of $3.0 million in fiscal year 2009 across this R01 announcement and the companion R21 announcement combined, with an expectation of roughly 7 to 9 total awards. As with standard NIH language, awards depend on the availability of funds and the number of high-quality, meritorious applications received. The opportunity does not require cost sharing or matching.
Eligibility is broad and includes many kinds of domestic organizations and governmental entities. Eligible applicants listed include public and state-controlled institutions of higher education, private institutions of higher education, nonprofits (including those with and without 501(c)(3) status), for-profit organizations (including small businesses and other for-profits), and various government entities such as state, county, city/township, special district governments, independent school districts, and public housing authorities/Indian housing authorities. The FOA also explicitly includes several categories of institutions serving specific populations, such as HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, tribally controlled colleges and universities, and certain tribal and regional organizations, as well as U.S. territories or possessions. The program is cataloged under CFDA 93.121 (Oral Diseases and Disorders Research).
Key administrative details in the source record include the funding opportunity number RFA-DE-09-001, posting and creation date of July 1, 2008, and an original/current closing date of October 31, 2008, with an archive date of November 30, 2008. For access issues or general help, NIH directs applicants to GrantsInfo (phone 301-435-0714; email GrantsInfo@nih.gov) and provides a TTY number for hearing-impaired individuals (301-451-0088).
Frequently Asked Questions (FAQs)
What is the "Harnessing Inflammation for Reconstruction of Oral and Craniofacial Tissues (R01)" funding opportunity?
This is a National Institute of Dental and Craniofacial Research (NIDCR/NIH) funding opportunity that supports R01 research projects aimed at turning inflammation biology into practical strategies for repairing and regenerating oral and craniofacial tissues.
Which NIH Institute is offering this opportunity?
The opportunity is offered by the National Institute of Dental and Craniofacial Research (NIDCR), part of the National Institutes of Health (NIH).
What is the funding opportunity number (FOA number)?
The funding opportunity number is RFA-DE-09-001.
What is the main scientific premise behind this FOA?
The FOA is built on the idea that inflammation is not only something to suppress. Inflammation is a dynamic process that can either support healthy healing or contribute to chronic damage, scarring, and fibrosis. The program seeks projects that explain how inflammation resolves (or fails to resolve) and then use that knowledge to deliberately control inflammatory microenvironments to improve reconstruction outcomes.
What kinds of tissues or anatomical areas are the focus of this program?
The focus is on oral and craniofacial tissues, including the mouth, jaws, and the broader craniofacial region, particularly in the context of injury or disease requiring regeneration, reconstruction, or repair.
What are the two connected scientific goals emphasized in the FOA?
First, applicants are expected to elucidate molecular mechanisms governing inflammation resolution, including why inflammation sometimes becomes chronic and destructive. Second, applicants are expected to develop novel multidisciplinary approaches that can predictably steer (pattern) inflammatory microenvironments to support regeneration and reconstruction rather than simply reducing inflammation.
What does the FOA mean by "inflammation resolution"?
In this FOA, inflammation resolution refers to the active biological processes that shut down inflammatory signaling, clear immune cells appropriately, and transition tissue from an injury response into repair.
Does the FOA focus only on suppressing inflammation?
No. The FOA emphasizes shaping and controlling inflammatory processes rather than generally suppressing them. It highlights the importance of directing the timing, intensity, spatial distribution, and cell composition of inflammatory responses to support tissue regeneration and reconstruction.
What is meant by "patterning" or "steering" the inflammatory microenvironment?
The FOA uses this language to describe interventions that can deliberately control key features of inflammation (such as timing, intensity, spatial distribution, and immune cell composition) so that healing and regeneration are supported and chronic damage, scarring, or fibrosis are reduced.
What kinds of outcomes or impacts is NIDCR aiming for with this program?
The anticipated payoff includes new concepts and paradigms for promoting inflammation resolution, preventing or reversing fibrosis and scarring, and enabling more reliable regeneration and reconstruction of diseased or injured oral and craniofacial tissues.
What research approaches does the FOA encourage?
The FOA strongly encourages interdisciplinary and multidisciplinary research that integrates fundamental immune and tissue biology with enabling approaches from chemistry, pharmacology, and bioengineering. This can include platform technologies, engineered materials, delivery systems, bioactive molecules, or pharmacologic modulators that can manipulate inflammation in controlled ways.
Is interdisciplinary team science explicitly encouraged?
Yes. A major feature of the opportunity is a strong push for interdisciplinary and multidisciplinary research spanning areas such as cell biology, developmental biology, stem cell biology, immunology, chemistry, pharmacology, and bioengineering.
Does the FOA encourage the NIH multiple-PI model?
Yes. Because the scope often requires multiple specialized skill sets, the FOA strongly encourages using the multiple-PI format to support team science with shared leadership.
What grant mechanism is being used for this opportunity?
The mechanism of support is the NIH Research Project Grant (R01).
How long can an R01 project period be under this FOA?
Projects are allowed up to a five-year period under this R01 opportunity.
Is there a companion funding opportunity with a similar scope?
Yes. This FOA runs alongside a companion announcement with the same scientific scope using the R21 mechanism (RFA-DE-09-002).
How does the companion R21 relate to the R01 in terms of scope and maturity?
Based on the provided description, the R21 is positioned for earlier-stage, exploratory work, while the R01 is positioned for more developed, hypothesis-driven projects with broader or deeper research plans.
How much funding was NIDCR planning to commit for this program?
NIDCR planned to commit up to a total of $3.0 million in fiscal year 2009 across this R01 announcement and the companion R21 announcement combined.
How many awards were expected under the combined R01 and R21 announcements?
The expectation was roughly 7 to 9 total awards across the R01 and the companion R21 combined.
Is funding guaranteed if an application is submitted?
No. As reflected in standard NIH language, awards depend on the availability of funds and the number of high-quality, meritorious applications received.
Is cost sharing or matching required for this opportunity?
No. The opportunity does not require cost sharing or matching.
Who is eligible to apply?
Eligibility is broad and includes many types of domestic organizations and governmental entities, including institutions of higher education (public/state-controlled and private), nonprofits (with and without 501(c)(3) status), for-profit organizations (including small businesses), and government entities such as state, county, city/township, special district governments, independent school districts, and public housing authorities/Indian housing authorities.
Are minority-serving or special-designation institutions included as eligible applicants?
Yes. The FOA explicitly includes categories such as HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, tribally controlled colleges and universities, and certain tribal and regional organizations.
Are U.S. territories or possessions included in eligibility?
Yes. U.S. territories or possessions are explicitly included among eligible applicants.
What is the CFDA number associated with this program?
The program is cataloged under CFDA 93.121 (Oral Diseases and Disorders Research).
When was this funding opportunity posted?
The posting and creation date listed in the source record is July 1, 2008.
What was the application closing date for this FOA?
The original/current closing date listed is October 31, 2008.
Is this FOA archived?
Yes. The archive date listed is November 30, 2008.
Where can applicants get help or ask questions about access issues?
NIH directs applicants to GrantsInfo for general help: phone 301-435-0714 and email GrantsInfo@nih.gov.
Is there a TTY number for hearing-impaired individuals?
Yes. The TTY number provided is 301-451-0088.
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