Health Services and Economic Research on the Prevention and Treatment of Drug, Alcohol, and Tobacco Abuse (R21) | Apply Online

Opportunity Summary:

The Health Services and Economic Research on the Prevention and Treatment of Drug, Alcohol, and Tobacco Abuse (R21) funding opportunity (PA 15-253) is a National Institutes of Health (NIH) grant program designed to support short, exploratory research projects that can strengthen how prevention, treatment, and recovery support services for drug, alcohol, and tobacco use are delivered. The central purpose is to generate practical, rigorous evidence that helps systems of care provide services that are more efficient, higher quality, and better aligned with real-world needs. Rather than focusing on basic science, this opportunity is aimed at health services research and economic research, meaning projects that study how care is organized, financed, implemented, measured, improved, and sustained across clinical and community settings.

A major emphasis of this FOA is on research that improves quality and performance in routine care. That includes clinical quality improvement work (for example, approaches to improve screening, brief intervention, medication adherence, continuity of care, or recovery monitoring in clinical practice), as well as quality improvement at the organizational and management level (such as workflow redesign, staffing models, integration of behavioral health with primary care, use of health IT to support evidence-based care, or strategies to reduce wait times and drop-off across the treatment cascade). The announcement also highlights implementation research, which typically examines how evidence-based prevention and treatment practices are adopted in the real world, what barriers and facilitators influence uptake, and what strategies improve fidelity, reach, equity, and sustainability. Alongside this, the FOA explicitly encourages economic and cost-focused studies, including cost analyses, cost-effectiveness, and other economic evaluations that help decision-makers understand value, resource allocation, and the financial impacts of prevention and treatment approaches. Finally, it invites methodological work, such as developing or improving research methods, analytic techniques, and measurement tools used to study prevention, treatment, and recovery services, which can include improving instruments for measuring quality, outcomes, service utilization, or system performance.

The mechanism is an R21, which is commonly used by NIH for early-stage, developmental, or high-impact pilot work that may lead to larger follow-on studies. The award ceiling listed for this opportunity is $200,000. There is no cost-sharing or matching requirement, which reduces barriers for applicants that may not have access to non-federal matching funds.

Eligibility is broad and spans many organization types that conduct or support applied research. Eligible applicants include public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status, aside from universities), for-profit organizations (including small businesses and other for-profits), and a wide range of government entities such as state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities. The eligibility language also extends to tribal governments and tribal organizations, including federally recognized tribes as well as other tribal entities, and it explicitly mentions institutions and organizations that serve specific populations, such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs). Faith-based and community-based organizations are included, as are eligible federal agencies, regional organizations, U.S. territories or possessions, and non-U.S. entities (foreign organizations), indicating NIH’s interest in a wide range of perspectives and settings where substance use-related services are delivered.

From an administrative standpoint, this was a discretionary grant opportunity under NIH, categorized under education and health-related activities, and associated with CFDA numbers 93.273 (Alcohol Research Programs) and 93.279 (Drug Abuse and Addiction Research Programs). The opportunity was posted on May 8, 2015, with an original and current closing date of May 7, 2018, and an archive date of June 7, 2018, meaning it is no longer active as written, but the summary reflects what the FOA sought to fund during its open period. For the full archived announcement and details such as application requirements, review criteria, and any institute-specific interests, the FOA pointed to the NIH guide page (http://grants.nih.gov/grants/guide/pa-files/PA-15-253.html). For technical issues accessing the announcement, the contact listed was the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.

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