Opportunity Information: Apply for PA 06 497
Apply for PA 06 497
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Health Services Research on Practice Improvement Utilizing Community Treatment Programs within the National Drug Abuse Clinical Trials Network (CTN) (R03)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279 Drug Abuse and Addiction Research Programs.
- This funding opportunity was created on Dec 5, 2008 and posted on Jul 26, 2006.
- Applicants must submit their applications by Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $50,000.00 in funding.
- Eligible applicants include: State governments Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts For profit organizations other than small businesses Native American tribal governments (Federally recognized) Others (see text field entitled Additional Information on Eligibility for clarification) Private institutions of higher education Public and State controlled institutions of higher education Small businesses Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) County governments.
- Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith based or community based organizations can apply. PARTICIPATION OF CTN INVESTIGATORS Most research projects proposed under this FOA, whether ancillary or platform studies, will require participation, collaboration, cooperation, or other support by CTN investigators or community treatment program staff or patients. Although the CTN has created a research infrastructure of CTPs and RRTCs that will support studies such as those encouraged here, some prospective studies involving sites affiliated with the CTN may not be feasible given the mission, goals, and timetables of the CTN cooperative agreement program or of specific ongoing trials. Thus, it is incumbent on the Principal Investigator of proposed research to contact NIDA CCTN staff and/or CTN grantee personnel (i.e., RRTC PIs and CTP directors) early in the application development process, to submit documentation of support from CTN entities that would be affected, and to obtain written approval for access to any required data that has not yet reached the public domain. See announcement for full details.
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Opportunity Summary:
The Health Services Research on Practice Improvement Utilizing Community Treatment Programs within the National Drug Abuse Clinical Trials Network (CTN) (R03) opportunity (Funding Opportunity Number PA-06-497) is a National Institutes of Health grant announcement that supports small-scale health services research projects focused on improving drug abuse treatment practices in real-world community settings. It is built around NIDA's Clinical Trials Network, a national partnership that links drug abuse researchers with more than 150 community treatment programs (CTPs) across multiple U.S. sites. The central idea is to use this broad, diverse treatment infrastructure to study how treatment programs actually implement improvements, what system-level factors help or block those improvements, and what research methods or tools are needed to generate stronger, more useful evidence about practice change in routine care.
This announcement uses the NIH Small Research Grant (R03) mechanism, which is designed for smaller, tightly defined projects rather than large multi-year trials. The FOA specifically encourages projects such as pilot and feasibility studies, secondary analyses of existing datasets, small self-contained studies that can be completed with limited resources, and development of research methodology or research technology that would make practice-improvement research in addiction treatment more rigorous, efficient, or scalable. In other words, applicants are not limited to testing an intervention directly; they can also propose work that strengthens the ability of the field to measure, understand, and accelerate practice improvement across treatment systems.
Scientifically, the FOA highlights two main themes. First, it invites research on systems-level influences that facilitate practice improvement in community treatment programs, such as organizational structure, staffing, workflow, financing and reimbursement pressures, leadership, regulatory environments, referral networks, and other contextual factors that shape whether evidence-based practices get adopted and sustained. Second, it encourages creation or refinement of research tools that improve the quality of health services research on practice improvement in drug abuse treatment, which could include better measures, data collection approaches, implementation tracking methods, or analytic strategies that are especially suited to complex, multi-site community treatment settings.
The program runs in parallel with two related announcements that share the same scientific scope but use different NIH mechanisms and project scales: an R01 version (PA-06-495) for larger, more definitive studies and an R21 version (PA-06-496) for exploratory/developmental research. This R03 version is the entry point for smaller projects, early-stage testing, methodological groundwork, and targeted analyses that can inform bigger studies or immediate improvements in service delivery.
Applicants should pay close attention to the CTN participation expectations. Because most proposed projects, whether they are ancillary studies that attach to ongoing CTN work or platform studies that leverage CTN sites and processes, will require active collaboration with CTN investigators, CTP staff, or patients, the FOA makes it the applicant's responsibility to coordinate early with NIDA's Center for the Clinical Trials Network (CCTN) staff and/or CTN grantee personnel such as Regional Research and Training Center (RRTC) principal investigators and CTP directors. This early contact is important to confirm feasibility given the CTN's mission, timelines, and any constraints from ongoing cooperative agreement trials. Applications are expected to include documentation of support from affected CTN entities, and if the project requires access to data that is not publicly available, written approval for that access must be obtained and included.
From an administrative and eligibility standpoint, the opportunity is categorized as discretionary grant funding in the education/health area and is tied to CFDA 93.279 (Drug Abuse and Addiction Research Programs). The award ceiling listed is $50,000, and there is no cost sharing or matching requirement. The eligible applicant pool is broad and includes state, county, city/township governments, special district governments, tribal governments and tribal organizations, public and private institutions of higher education, independent school districts, public housing authorities/Indian housing authorities, nonprofits (including both 501(c)(3) and certain non-501(c)(3) organizations), and for-profit organizations other than small businesses, with small businesses also eligible. The FOA also explicitly allows applications from foreign institutions, eligible federal government agencies, and faith-based or community-based organizations. The posting date is July 26, 2006, with multiple receipt dates (rather than a single deadline), and the announcement was later archived on October 2, 2009.
Overall, PA-06-497 is aimed at practical, clinic-connected research that can make addiction treatment services work better in community programs by identifying what drives successful practice improvement and by strengthening the methods used to study and support that improvement within the CTN's national provider-researcher network.
Frequently Asked Questions (FAQs)
What is PA-06-497?
PA-06-497 is an NIH grant funding opportunity titled "Health Services Research on Practice Improvement Utilizing Community Treatment Programs within the National Drug Abuse Clinical Trials Network (CTN) (R03)." It supports small-scale health services research projects that focus on improving drug abuse treatment practices in real-world community treatment settings using the infrastructure of NIDA's Clinical Trials Network (CTN).
What is the overall goal of this funding opportunity?
The goal is to generate practical, clinic-connected evidence about how community treatment programs improve care, what system-level factors help or hinder those improvements, and what research methods/tools are needed to produce stronger and more useful evidence about practice change in routine treatment settings.
Which NIH institute is connected to this opportunity?
This opportunity is built around the National Institute on Drug Abuse (NIDA), specifically leveraging NIDA's Clinical Trials Network (CTN) and the Center for the Clinical Trials Network (CCTN).
What is the CTN and why does it matter for this FOA?
The Clinical Trials Network (CTN) is a national partnership that links drug abuse researchers with more than 150 community treatment programs (CTPs) across multiple U.S. sites. This FOA is designed to use that diverse, real-world treatment infrastructure to study practice improvement and implementation in routine care environments.
What grant mechanism does PA-06-497 use?
PA-06-497 uses the NIH Small Research Grant (R03) mechanism. This mechanism is intended for smaller, tightly defined projects rather than large multi-year trials.
How is the R03 version different from the related R01 and R21 announcements?
This R03 opportunity (PA-06-497) runs in parallel with two related announcements that share the same scientific scope but support different project scales: an R01 version (PA-06-495) for larger, more definitive studies and an R21 version (PA-06-496) for exploratory/developmental research. The R03 is positioned as an entry point for smaller projects, early-stage testing, methodological groundwork, and targeted analyses.
What types of projects are encouraged under this R03?
The FOA encourages small, self-contained health services research projects such as pilot and feasibility studies, secondary analyses of existing datasets, tightly scoped studies that can be completed with limited resources, and development of research methodology or research technology that improves the rigor, efficiency, or scalability of practice-improvement research in addiction treatment.
Do projects have to directly test an intervention?
No. Applicants are not limited to directly testing an intervention. Projects can also focus on strengthening the field's ability to measure, understand, and accelerate practice improvement across treatment systems, including methods and tools development or refinement.
What scientific themes does the FOA emphasize?
The FOA highlights two main themes: (1) systems-level influences that facilitate (or impede) practice improvement in community treatment programs, and (2) creation or refinement of research tools that improve the quality of health services research on practice improvement in drug abuse treatment.
What are examples of systems-level influences that the FOA is interested in?
Examples mentioned include organizational structure, staffing, workflow, financing and reimbursement pressures, leadership, regulatory environments, referral networks, and other contextual factors that affect whether evidence-based practices are adopted and sustained in community treatment programs.
What kinds of research tools or methods does the FOA encourage developing or refining?
The FOA encourages tools that improve health services research on practice improvement, including better measures, improved data collection approaches, implementation tracking methods, or analytic strategies suited to complex, multi-site community treatment settings.
What are Community Treatment Programs (CTPs) in this context?
CTPs are community-based treatment programs that participate in the CTN. The CTN includes more than 150 CTPs, which provide the real-world settings where practice improvement and implementation can be studied.
Is collaboration with CTN entities expected?
Yes. The FOA indicates that many proposed projects will require active collaboration with CTN investigators, CTP staff, or patients. Applicants are responsible for coordinating early with NIDA's CCTN staff and/or CTN grantee personnel (such as Regional Research and Training Center principal investigators and CTP directors) to confirm feasibility.
Why is early coordination with CTN staff or CTN grantees important?
Early coordination helps confirm feasibility given the CTN's mission, timelines, and any constraints from ongoing cooperative agreement trials. It also supports appropriate planning for using CTN sites, processes, personnel, or data.
Does the application need documentation of CTN support?
Yes. Applications are expected to include documentation of support from affected CTN entities.
What if my project needs access to non-public CTN data?
If access is needed to data that is not publicly available, written approval for that access must be obtained and included with the application.
What is the CFDA number associated with this opportunity?
The opportunity is tied to CFDA 93.279, "Drug Abuse and Addiction Research Programs."
What is the award ceiling for PA-06-497?
The award ceiling listed for this opportunity is $50,000.
Is cost sharing or matching required?
No. The opportunity states there is no cost sharing or matching requirement.
What kinds of organizations are eligible to apply?
The eligible applicant pool is broad and includes state, county, and city/township governments; special district governments; tribal governments and tribal organizations; public and private institutions of higher education; independent school districts; public housing authorities/Indian housing authorities; nonprofits (including both 501(c)(3) and certain non-501(c)(3) organizations); and for-profit organizations (with eligibility including small businesses and for-profit organizations other than small businesses). The FOA also allows applications from foreign institutions, eligible federal government agencies, and faith-based or community-based organizations.
Are foreign institutions eligible under this FOA?
Yes. The FOA explicitly allows applications from foreign institutions.
Are faith-based or community-based organizations eligible to apply?
Yes. The FOA explicitly allows applications from faith-based or community-based organizations.
Is this opportunity classified as discretionary grant funding?
Yes. It is categorized as discretionary grant funding in the education/health area.
When was this opportunity posted and what is its status?
The posting date is July 26, 2006. The announcement was later archived on October 2, 2009.
Does the FOA have a single deadline?
No. The FOA indicates multiple receipt dates rather than a single deadline.
What makes this FOA "real-world" or "clinic-connected"?
It is designed around research conducted in community treatment programs (CTPs) within the CTN, focusing on routine care settings where treatment is actually delivered, and on practical system factors and methods that influence whether improvements are implemented and sustained.
Can projects be ancillary to ongoing CTN work?
Yes. The FOA notes that many projects may be ancillary studies that attach to ongoing CTN work or "platform" studies that leverage CTN sites and processes, which is why coordination and documentation of support are emphasized.
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