Opportunity Information: Apply for PA 06 496
Apply for PA 06 496
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Health Services Research on Practice Improvement Utilizing Community Treatment Programs within the National Drug Abuse Clinical Trials Network (CTN) (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279 Drug Abuse and Addiction Research Programs.
- This funding opportunity was created on Dec 5, 2008 and posted on Jul 26, 2006.
- Applicants must submit their applications by Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: For profit organizations other than small businesses Others (see text field entitled Additional Information on Eligibility for clarification) Independent school districts State governments Special district governments Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education County governments Public and State controlled institutions of higher education Small businesses Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Public housing authorities/Indian housing authorities Private institutions of higher education.
- Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith based or community based organizations can apply. PARTICIPATION OF CTN INVESTIGATORS Most research projects proposed under this FOA, whether ancillary or platform studies, will require participation, collaboration, cooperation, or other support by CTN investigators or community treatment program staff or patients. Although the CTN has created a research infrastructure of CTPs and RRTCs that will support studies such as those encouraged here, some prospective studies involving sites affiliated with the CTN may not be feasible given the mission, goals, and timetables of the CTN cooperative agreement program or of specific ongoing trials. Thus, it is incumbent on the Principal Investigator of proposed research to contact NIDA CCTN staff and/or CTN grantee personnel (i.e., RRTC PIs and CTP directors) early in the application development process, to submit documentation of support from CTN entities that would be affected, and to obtain written approval for access to any required data that has not yet reached the public domain. See announcement for full details.
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Opportunity Summary:
The Health Services Research on Practice Improvement Utilizing Community Treatment Programs within the National Drug Abuse Clinical Trials Network (CTN) (R21) opportunity (Funding Opportunity Number PA-06-496) is a National Institutes of Health program, led through NIDA, that funds exploratory and developmental health services research focused on improving real-world drug abuse treatment practices. It is built around NIDA's Clinical Trials Network, a large national partnership linking more than 150 community treatment programs (CTPs) with drug abuse researchers across multiple U.S. sites. The central idea is to use this established provider-and-research infrastructure to study how treatment programs actually change what they do in practice, what makes those improvements succeed or fail, and what kinds of methods and tools researchers need to measure and support practice improvement more effectively in everyday treatment settings.
From a scientific standpoint, the FOA emphasizes two broad research directions. First, it encourages studies of systems-level factors that enable or hinder practice improvement in community treatment programs. That can include organizational processes, staffing, leadership, workflow, financing, policy constraints, quality improvement strategies, data feedback systems, training models, adoption of evidence-based practices, and other structural or operational issues that influence whether improvements can be implemented and sustained. Second, it invites development of new research tools that raise the quality of health services research on practice improvement in drug abuse treatment. In practical terms, this can mean creating or refining measurement approaches, implementation metrics, data collection methods, analytic strategies, pragmatic study designs, or other methodological innovations that make it easier to evaluate practice change in busy community programs serving diverse patient populations.
This particular announcement uses the NIH Exploratory/Developmental R21 mechanism, which is generally intended for early-stage, proof-of-concept, or pilot-style projects that can open the door to larger, more definitive studies later. Consistent with that purpose, the listed award ceiling is $200,000, and there is no cost-sharing or matching requirement. The FOA is also explicitly paired with two companion announcements of the same scientific scope but different grant mechanisms: PA-06-495 (R01) for larger, more comprehensive projects and PA-06-497 (R03) for smaller, limited-scope studies. That structure signals that NIDA expected a pipeline of projects at different stages, from early exploration (R21), to small targeted efforts (R03), to full-scale research programs (R01), all centered on practice improvement in community drug treatment settings.
A key operational requirement is the expectation that most proposed projects, whether they are "ancillary" studies (building off existing CTN trials or activities) or "platform" studies (using the CTN infrastructure as the setting for new work), will need active participation or support from CTN investigators and/or community treatment program staff or patients. Because CTN sites operate under cooperative agreement priorities, timelines, and ongoing trial commitments, the FOA cautions that not every idea will be feasible at every CTN-affiliated site. Applicants are therefore expected to engage CTN leadership early, including NIDA CCTN staff and CTN grantee personnel such as Regional Research and Training Center (RRTC) principal investigators and CTP directors. The application should include documentation of support from the CTN entities that would be affected, and written approval is required if the project needs access to CTN data that are not yet publicly available. In other words, the FOA is not just inviting CTN-related projects in concept; it is signaling that feasibility and documented collaboration are central to being competitive and implementable.
In terms of who can apply, eligibility is broad. The FOA allows applications from many U.S.-based organization types, including public and private institutions of higher education, nonprofits (with and without 501(c)(3) status), small businesses, for-profit organizations (other than small businesses), independent school districts, and a range of governmental entities such as state, county, city/township, special district governments, and public housing authorities/Indian housing authorities. It also includes Native American tribal governments (federally recognized) and tribal organizations (other than federally recognized tribal governments). Importantly, foreign institutions are eligible, eligible agencies of the federal government may apply, and faith-based or community-based organizations are also eligible, which underscores NIH's intent to attract a wide range of applicants with relevant expertise in health services research, implementation, and substance use treatment systems.
Administratively, the opportunity is categorized as a discretionary grant in the health/education activity area under CFDA 93.279 (Drug Abuse and Addiction Research Programs). It was posted July 26, 2006, with multiple receipt dates (meaning applicants needed to follow the specific due-date schedule referenced in the full announcement), and awards were explicitly stated to be contingent on the availability of funds and the presence of enough high-quality, meritorious applications to support funding decisions. The archived date listed is October 2, 2009, indicating the announcement is no longer active, but it remains a useful snapshot of NIDA's priorities and the CTN's role as a national laboratory for studying how to improve the quality, delivery, and implementation of drug abuse treatment in community settings.
Frequently Asked Questions (FAQs)
What is the funding opportunity described here?
This opportunity is the NIH funding announcement titled "Health Services Research on Practice Improvement Utilizing Community Treatment Programs within the National Drug Abuse Clinical Trials Network (CTN) (R21)." The Funding Opportunity Number is PA-06-496, and it is led through the National Institute on Drug Abuse (NIDA).
What is the overall purpose of PA-06-496 (R21)?
The purpose is to support exploratory and developmental health services research focused on improving real-world drug abuse treatment practices in community treatment settings. The emphasis is on understanding how treatment programs change what they do in practice, what factors help or hinder those improvements, and how researchers can better measure and support practice improvement in everyday treatment environments.
What network or infrastructure is this FOA built around?
The FOA is built around NIDA's Clinical Trials Network (CTN), described as a large national partnership linking more than 150 community treatment programs (CTPs) with drug abuse researchers across multiple U.S. sites.
What kinds of organizations are involved in the CTN according to the announcement?
The CTN links community treatment programs (CTPs) and drug abuse researchers, operating across multiple sites. The FOA also references CTN entities such as Regional Research and Training Centers (RRTCs), including their principal investigators, as well as CTP directors.
What research topics does the FOA emphasize?
The FOA highlights two broad research directions: (1) studies of systems-level factors that enable or hinder practice improvement in community treatment programs, and (2) development of new research tools to improve the quality of health services research on practice improvement in drug abuse treatment.
What are examples of "systems-level factors" the FOA is interested in?
Examples listed include organizational processes, staffing, leadership, workflow, financing, policy constraints, quality improvement strategies, data feedback systems, training models, adoption of evidence-based practices, and other structural or operational issues that affect whether improvements can be implemented and sustained.
What does the FOA mean by developing "new research tools"?
It refers to creating or refining methods that make practice-improvement research stronger and more feasible in real-world programs. Examples in the announcement include measurement approaches, implementation metrics, data collection methods, analytic strategies, pragmatic study designs, and other methodological innovations suited to busy community treatment programs serving diverse patient populations.
What grant mechanism does this announcement use?
This announcement uses the NIH Exploratory/Developmental R21 mechanism, which is generally intended for early-stage, proof-of-concept, or pilot-style projects that can lead to larger, more definitive studies later.
What is the stated award ceiling for this R21 opportunity?
The listed award ceiling is $200,000.
Is cost-sharing or matching required?
No. The announcement states there is no cost-sharing or matching requirement.
Are there related or companion funding announcements?
Yes. The FOA is paired with companion announcements of the same scientific scope but different grant mechanisms: PA-06-495 (R01) for larger, more comprehensive projects and PA-06-497 (R03) for smaller, limited-scope studies.
What is the practical significance of having R21, R03, and R01 companion announcements?
Based on the announcement description, it signals an expected pipeline of projects at different stages: early exploration (R21), smaller targeted efforts (R03), and full-scale research programs (R01), all centered on practice improvement in community drug treatment settings using the CTN context.
Do projects need to involve CTN investigators or community treatment programs?
Yes, the announcement states that most proposed projects, whether "ancillary" studies building off existing CTN trials/activities or "platform" studies using CTN infrastructure for new work, are expected to require active participation or support from CTN investigators and/or community treatment program staff or patients.
What is the difference between "ancillary" and "platform" studies in this FOA?
As described, "ancillary" studies build off existing CTN trials or activities, while "platform" studies use the CTN infrastructure as the setting for new work.
Can any CTN site support any proposed project idea?
Not necessarily. The FOA cautions that CTN sites operate under cooperative agreement priorities, timelines, and ongoing trial commitments, so not every idea will be feasible at every CTN-affiliated site.
What does the FOA expect applicants to do to address feasibility within the CTN?
Applicants are expected to engage CTN leadership early, including NIDA CCTN staff and CTN grantee personnel such as RRTC principal investigators and CTP directors. The application should include documentation of support from the CTN entities that would be affected.
Is documentation of CTN support required in the application?
Yes. The FOA states the application should include documentation of support from the CTN entities that would be affected by the project.
Is written approval required to access CTN data?
Yes. The FOA states that written approval is required if the project needs access to CTN data that are not yet publicly available.
Who is eligible to apply?
Eligibility is described as broad. The FOA allows applications from many U.S.-based organization types, including public and private institutions of higher education, nonprofits (with and without 501(c)(3) status), small businesses, for-profit organizations (other than small businesses), independent school districts, and multiple governmental entities (state, county, city/township, special district governments, and public housing authorities/Indian housing authorities).
Are Native American tribal entities eligible?
Yes. The FOA includes Native American tribal governments (federally recognized) and tribal organizations (other than federally recognized tribal governments) as eligible applicants.
Are foreign institutions eligible to apply?
Yes. The FOA explicitly states that foreign institutions are eligible.
Can federal agencies apply?
Yes. The FOA states that eligible agencies of the federal government may apply.
Are faith-based or community-based organizations eligible?
Yes. The FOA states that faith-based or community-based organizations are eligible.
How is this opportunity categorized administratively?
The opportunity is categorized as a discretionary grant in the health/education activity area under CFDA 93.279 (Drug Abuse and Addiction Research Programs).
When was the opportunity posted?
The announcement was posted on July 26, 2006.
Does the announcement have multiple application receipt dates?
Yes. The information provided states there were multiple receipt dates and that applicants needed to follow the specific due-date schedule referenced in the full announcement.
Were awards guaranteed?
No. Awards were explicitly stated to be contingent on the availability of funds and on receiving enough high-quality, meritorious applications to support funding decisions.
Is this funding opportunity still active?
No. The archived date is listed as October 2, 2009, indicating the announcement is no longer active.
Even though it is archived, what does this FOA illustrate about NIDA priorities?
Based on the description provided, it serves as a snapshot of NIDA's priorities around using the CTN as a national laboratory for studying how to improve the quality, delivery, and implementation of drug abuse treatment in community settings.
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Applicants also applied for:
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| Funding Opportunity |
|---|
| Health Services Research on Practice Improvement Utilizing Community Treatment Programs within the National Drug Abuse Clinical Trials Network (CTN) (R03) Apply for PA 06 497 Funding Number: PA 06 497 Agency: National Institutes of Health Category: Education Health Funding Amount: $50,000 |
| Exfoliated Cells and Circulating DNA in Cancer Detection and Diagnosis(R21) Apply for PA 06 499 Funding Number: PA 06 499 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Pathophysiology of Bisphosphonates associated Osteonecrosis of the Jaw (R03) Apply for PA 06 502 Funding Number: PA 06 502 Agency: National Institutes of Health Category: Education Health Funding Amount: $50,000 |
| Pathophysiology of Bisphosphonates associated Osteonecrosis of the Jaw (R21) Apply for PA 06 501 Funding Number: PA 06 501 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| National Cancer Institute (NCI) Cancer Education and Career Development Program (R25) Apply for PAR 06 511 Funding Number: PAR 06 511 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Development and Application of PET and SPECT Imaging Ligands as Biomarkers for Drug Discovery and for Pathophysiological Studies of CNS Disorders (R21) Apply for PA 06 461 Funding Number: PA 06 461 Agency: National Institutes of Health Category: Education Health Funding Amount: $250,000 |
| Development and Application of PET and SPECT Imaging Ligands as Biomarkers for Drug Discovery and for Pathophysiological Studies of CNS Disorders (R33) Apply for PA 06 462 Funding Number: PA 06 462 Agency: National Institutes of Health Category: Education Health Funding Amount: $500,000 |
| Development and Application of PET and SPECT Imaging Ligands as Biomarkers for Drug Discovery and for Pathophysiological Studies of CNS Disorders (Phased Innovation Award R21/R33) Apply for PA 06 463 Funding Number: PA 06 463 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Dissemination and Implementation Research in Health (R03) Apply for PAR 06 520 Funding Number: PAR 06 520 Agency: National Institutes of Health Category: Education Health Funding Amount: $250,000 |
| Dissemination and Implementation Research in Health (R21) Apply for PAR 06 521 Funding Number: PAR 06 521 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
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| Behavioral Science Track Award for Rapid Transition (B/START) (R03) Apply for PAR 06 541 Funding Number: PAR 06 541 Agency: National Institutes of Health Category: Education Health Funding Amount: $50,000 |
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| Molecular genetics of drug addiction and related co morbidities (R01) Apply for PA 07 073 Funding Number: PA 07 073 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Development, Application, and Evaluation of Prediction Models for Cancer Risk and Prognosis (R01) Apply for PA 07 021 Funding Number: PA 07 021 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Basic Research in the Bladder and Lower Urinary Tract (R01) Apply for PA 07 023 Funding Number: PA 07 023 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Mechanisms of Alcohol Associated Cancers (R01) Apply for PA 07 069 Funding Number: PA 07 069 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
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