Opportunity Information: Apply for PAR 11 176
Apply for PAR 11 176
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "High Throughput Enabled Structural Biology Partnerships (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.859 Biomedical Research and Research Training.
- This funding opportunity was created on Feb 9, 2012 and posted on Mar 24, 2011.
- Applicants must submit their applications by May 8, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $250,000.00 in funding.
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Native American tribal governments (Federally recognized) Special district governments County governments Private institutions of higher education For profit organizations other than small businesses City or township governments Public and State controlled institutions of higher education State governments Small businesses Native American tribal organizations (other than Federally recognized tribal governments) Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Organizations) are not eligible to apply. However, such institutions may be included as part of consortium applications submitted by any other type of eligible institution. Foreign (non U.S.) components of U.S. Organizations are not allowed.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Opportunity Summary:
High Throughput Enabled Structural Biology Partnerships (U01) is an NIH funding opportunity (PAR-11-176) designed to support collaborative projects that combine two things: a major, well-defined biological question and access to high-throughput protein structure determination through the NIGMS PSI:Biology network. The central idea is that some biological problems are too large to solve with just one or two structures, so this program backs partnerships where solving the problem genuinely requires determining many protein structures. Projects should focus on proteins that can realistically move through high-throughput structure pipelines (for example, proteins that can be expressed, purified, and structurally characterized at scale), and the FOA also leaves room for targets that push the field forward by motivating new methods or technology development when existing approaches are not quite enough.
This opportunity uses a U01 cooperative agreement mechanism, meaning NIH expects to be actively involved rather than acting only as a passive funder. Awardees do not just run their own projects; the principal investigators also become part of the PSI:Biology Network Steering Committee and coordinate with other network investigators and NIH staff to help manage and advance the broader PSI:Biology initiative. In practice, that signals an emphasis on collaboration, data sharing, network-level planning, and alignment with program goals, not just producing structures in isolation.
The funding instrument is categorized as discretionary and falls under the health activity category, with CFDA number 93.859 (Biomedical Research and Research Training). The listed award ceiling is $250,000, and there is no cost-sharing or matching requirement. The FOA was posted March 24, 2011, with a creation date of February 9, 2012. Key dates shown in the record include an original closing date of September 7, 2014, a current closing date of May 8, 2012, and an archive date of June 9, 2012.
Eligibility is broad across U.S.-based organizations and government entities. Eligible applicants include public and private institutions of higher education, nonprofits with and without 501(c)(3) status, for-profit organizations (other than small businesses are explicitly listed as eligible, and small businesses are also listed), independent school districts, state governments, county and city or township governments, special district governments, public housing authorities/Indian housing authorities, and federally recognized tribal governments, along with tribal organizations that are not federally recognized. The FOA also explicitly includes a range of mission-focused institution types such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, and faith-based or community-based organizations, as well as regional organizations and U.S. territories or possessions. Foreign organizations are not eligible to apply directly, and foreign (non-U.S.) components of U.S. organizations are not allowed, but non-U.S. institutions may participate as part of a consortium led by an eligible U.S. applicant.
Overall, this FOA is aimed at teams that can articulate a big biological objective where many related protein structures will collectively answer important mechanistic or functional questions, and where the work fits a high-throughput structural biology model supported by the PSI:Biology network. It is also structured to pull awardees into an organized, NIH-involved network environment where coordination and shared program direction are part of the expected responsibilities.
The full announcement is linked here: http://grants.nih.gov/grants/guide/pa-files/PAR-11-176.html. For access or linking issues, the contact listed is the NIH OER Webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs)
What is the "High Throughput Enabled Structural Biology Partnerships (U01)" opportunity?
It is an NIH funding opportunity announcement (FOA) titled "High Throughput Enabled Structural Biology Partnerships (U01)" with FOA number PAR-11-176. It supports collaborative projects that pair a major, well-defined biological question with access to high-throughput protein structure determination through the NIGMS PSI:Biology network.
What is the main purpose of this FOA?
The program is meant for biological problems that are too large to solve with only one or two protein structures. It backs partnerships where answering the biological question genuinely requires determining many related protein structures, ideally using high-throughput structural biology pipelines.
What kinds of research projects are a good fit for this program?
Projects are expected to focus on a significant biological objective and to propose a structure determination strategy that involves many proteins/targets whose structures, taken together, address mechanistic or functional questions. The work should align with a high-throughput model supported by the PSI:Biology network.
Does the FOA require high-throughput structure determination?
Yes. The opportunity is built around access to high-throughput protein structure determination via the NIGMS PSI:Biology network, and it emphasizes projects where many protein structures are needed to solve the biological problem.
What types of protein targets are encouraged?
The FOA emphasizes proteins that can realistically move through high-throughput pipelines, such as targets that can be expressed, purified, and structurally characterized at scale. It also leaves room for targets that drive new methods or technology development when existing approaches are not quite enough.
Can projects include method or technology development?
Yes. The FOA leaves room for targets that push the field forward by motivating new methods or technology development when current high-throughput approaches are insufficient for the biological targets of interest.
What funding mechanism is used?
This opportunity uses a U01 cooperative agreement mechanism.
What does a U01 cooperative agreement imply for NIH involvement?
A U01 cooperative agreement indicates NIH expects to be actively involved in the project rather than acting only as a passive funder. The FOA signals an emphasis on collaboration, coordination, and alignment with broader PSI:Biology program goals.
Are awardees expected to participate in any network governance or coordination activities?
Yes. Principal investigators become part of the PSI:Biology Network Steering Committee and are expected to coordinate with other network investigators and NIH staff to help manage and advance the broader PSI:Biology initiative.
What does participation in the PSI:Biology Network Steering Committee suggest about project expectations?
It suggests expectations beyond producing structures in isolation, including collaboration, data sharing, network-level planning, and coordination with other investigators and NIH staff in support of PSI:Biology goals.
What is the CFDA number and activity/category information for this opportunity?
The CFDA number listed is 93.859 (Biomedical Research and Research Training). The opportunity is categorized as discretionary and falls under the health activity category.
What is the award ceiling listed for this opportunity?
The listed award ceiling is $250,000.
Is cost sharing or matching required?
No. The FOA states there is no cost-sharing or matching requirement.
Who is eligible to apply?
Eligibility is broad across U.S.-based organizations and government entities. Eligible applicants include public and private institutions of higher education; nonprofits with and without 501(c)(3) status; for-profit organizations (including small businesses and other than small businesses); independent school districts; and multiple levels of government (state, county, city/township, special district). Public housing authorities/Indian housing authorities are also listed as eligible.
Are tribal governments and tribal organizations eligible?
Yes. Federally recognized tribal governments are eligible, and tribal organizations that are not federally recognized are also explicitly listed as eligible.
Are mission-focused institution types (HBCUs, HSIs, etc.) included in eligibility?
Yes. The FOA explicitly includes institution types such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, and faith-based or community-based organizations. It also includes regional organizations and U.S. territories or possessions.
Can foreign organizations apply directly?
No. Foreign organizations are not eligible to apply directly.
Are foreign (non-U.S.) components of U.S. organizations allowed?
No. The FOA states that foreign (non-U.S.) components of U.S. organizations are not allowed.
Can non-U.S. institutions participate in any way?
Yes. Non-U.S. institutions may participate as part of a consortium led by an eligible U.S. applicant.
What are the key dates shown for this FOA?
The FOA was posted on March 24, 2011, and the creation date listed is February 9, 2012. The record shows an original closing date of September 7, 2014, a current closing date of May 8, 2012, and an archive date of June 9, 2012.
Where can applicants find the full announcement?
The full announcement is linked at: http://grants.nih.gov/grants/guide/pa-files/PAR-11-176.html.
Who should be contacted for access or linking issues with the FOA?
The contact listed for access or linking issues is the NIH OER Webmaster at FBOWebmaster@OD.NIH.GOV.
What is the overall theme of the projects NIH is trying to support through this FOA?
The FOA is aimed at teams that can articulate a large biological objective where many related protein structures collectively answer important mechanistic or functional questions, and where the work fits a high-throughput structural biology model within the PSI:Biology network with active NIH involvement and network coordination.
Browse more opportunities from the same category: Health
Next opportunity: Department of Defense Research and Educational Program for Historically Black Colleges and Universities and Minority Serving Institutions (HBCU/MI)
Previous opportunity: FANIKISHA Institutional Strengthening Project
USGrants.org Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for PAR 11 176
[Watch] how do funding administrators access proposals?
Applicants also applied for:
Applicants who have applied for this opportunity (PAR 11 176) also looked into and applied for these:
| Funding Opportunity |
|---|
| Translational Research for the Development of Novel Interventions for Mental Disorders (R21/R33) Apply for PAR 11 177 Funding Number: PAR 11 177 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Circadian Rhythms and Alcohol induced Tissue Injury (R01) Apply for PA 11 178 Funding Number: PA 11 178 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Circadian Rhythms and Alcohol induced Tissue Injury (R21) Apply for PA 11 179 Funding Number: PA 11 179 Agency: National Institutes of Health Category: Health Funding Amount: $200,000 |
| Health Careers Opportunity Program Apply for HRSA 11 065 Funding Number: HRSA 11 065 Agency: Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| Surveillance and Response to Seasonal and Pandemic Influenza by Regional Offices of the World Health Organization Apply for CDC RFA IP11 1104 Funding Number: CDC RFA IP11 1104 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $1,500,000 |
| Evaluation of Core Violence and Injury Prevention Program (Core VIPP) Apply for CDC RFA CE11 1106 Funding Number: CDC RFA CE11 1106 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $300,000 |
| Integrated Health Social Marketing Apply for RFA674 11 27 Funding Number: RFA674 11 27 Agency: South Africa USAID Pretoria Category: Health Funding Amount: $20,000,000 |
| Systems Approach to Immunity and Inflammation (U19) Apply for RFA AI 11 017 Funding Number: RFA AI 11 017 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Multidisciplinary Clinical Research Centers (P60) Apply for RFA AR 12 001 Funding Number: RFA AR 12 001 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Enhanced Comprehensive HIV Prevention Planning and Implementation for Metropolitan Statistical Areas Most Affected by HIV/AIDS Phase II Apply for CDC RFA PS11 1117 Funding Number: CDC RFA PS11 1117 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $600,000 |
| Integrated Economic, Dynamic Disease, Risk and Decision Analytic Modeling of Global and Domestic Policy Issues for Polio Apply for CDC RFA IP11 1102 Funding Number: CDC RFA IP11 1102 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: Case Dependent |
| Translation of Pluripotent Stem Cell Therapies for Blood Diseases (R01) Apply for PA 11 186 Funding Number: PA 11 186 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| A National Coalition to Enhance STD/HIV Prevention through Promotion of a Holistic Approach to Health and Wellness Apply for CDC RFA PS11 1112 Funding Number: CDC RFA PS11 1112 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $135,000 |
| Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (UM1) Apply for RFA AI 11 002 Funding Number: RFA AI 11 002 Agency: National Institutes of Health Category: Health Funding Amount: $19,000,000 |
| Initiatives to Educate State Officials and Policy Makers about Priority Public Health Issues Related to the Prevention and Control of Sexually Transmitted Diseases (STDs) and Human Immunodeficiency Virus (HIV) and Acquired Immunodeficiency Syndrome ( Apply for CDC RFA PS11 1118 Funding Number: CDC RFA PS11 1118 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $250,000 |
| Eliminating Mother to Child HIV Transmission in the United States through Continuous Quality Improvement The FIMR HIV Prevention Methodology Apply for CDC RFA PS11 1116 Funding Number: CDC RFA PS11 1116 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: Case Dependent |
| PPHF 2012 Immunization Capacity Building Assistance to Strengthen Public Health Immunization Infrastructure and Performance financed in part by 2012 Prevention and Public Health Funds Apply for CDC RFA IP11 1107PPHF11 Funding Number: CDC RFA IP11 1107PPHF11 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: Case Dependent |
| Next Generation PrEP II (R01) Apply for RFA AI 11 023 Funding Number: RFA AI 11 023 Agency: National Institutes of Health Category: Health Funding Amount: $300,000 |
| Cooperative Agreements for Screening, Brief Intervention and Referral to Treatment Apply for TI 11 005 Funding Number: TI 11 005 Agency: Substance Abuse Mental Health Services Adminis. Category: Health Funding Amount: $1,666,000 |
| Limited Competition for the Continuation of Rare Diseases Clinical Research Consortia in the Rare Diseases Clinical Research Network (U54) Apply for PAR 11 187 Funding Number: PAR 11 187 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Subscribe to Leads
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "PAR 11 176", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.