Opportunity Information: Apply for PA 07 340

  • The National Institutes of Health in the education health sector is offering a public funding opportunity titled "HIV Treatment Adherence Research (R21)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants 93.279 Drug Abuse and Addiction Research Programs 93.361 Nursing Research.
  • This funding opportunity was created on Dec 5, 2008 and posted on Mar 27, 2007.
  • Applicants must submit their applications by Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $200,000.00 in funding.
  • Eligible applicants include: Small businesses County governments Private institutions of higher education Special district governments Native American tribal organizations (other than Federally recognized tribal governments) City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Public and State controlled institutions of higher education Independent school districts Public housing authorities/Indian housing authorities State governments For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized).
  • Foreign institutions are eligible to apply.
Apply for PA 07 340

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Opportunity Summary:

The HIV Treatment Adherence Research (R21) opportunity (Funding Opportunity Number PA-07-340) is a National Institutes of Health (NIH) grant announcement aimed at improving the science behind HIV treatment adherence. It is sponsored by three NIH institutes: the National Institute of Mental Health (NIMH), the National Institute on Drug Abuse (NIDA), and the National Institute of Nursing Research (NINR). The central goal is to support research and intervention development that helps people living with HIV consistently take antiretroviral therapy as prescribed, recognizing that adherence is influenced by behavioral, clinical, mental health, substance use, and broader health systems factors.

This announcement uses the NIH Exploratory/Developmental Research Grant mechanism (R21). R21 awards are designed for early-stage, proof-of-concept, and developmental projects that test new ideas or emerging approaches before they are ready for larger-scale trials. The emphasis is on innovation and exploration, including projects that may be higher risk but have the potential to open up new directions in biomedical, behavioral, or clinical research. In practical terms, applicants are encouraged to propose novel methods, models, measurement approaches, intervention concepts, or other foundational work that could later justify a more definitive, larger study.

The FOA is part of a coordinated set of related funding announcements that share a similar scientific focus but differ in grant mechanism and intended project scale. In parallel, NIH offered an R01 version (PA-07-338) for full research projects, an R03 version (PA-07-339) for small research grants, and an R34 version (PAR-07-341) focused on exploratory grants for mental health interventions and services. Applicants are expected to choose the mechanism that best fits the maturity and scope of their proposed work, noting that the participating institutes may not be identical across each companion announcement.

Key administrative details include that it is a discretionary grant opportunity in the health and education activity categories and does not require cost sharing or matching. The listed award ceiling is $200,000. The posting date was March 27, 2007, and the program used multiple receipt dates (meaning applications could be submitted on several scheduled NIH due dates rather than a single deadline). The opportunity has since been archived (archive date February 7, 2010), which is important for historical reference even though it is no longer active in this exact form.

Eligibility is broad and includes many types of organizations such as public and private institutions of higher education, nonprofits (including both 501(c)(3) and non-501(c)(3) entities), for-profit organizations (including small businesses and other for-profits), state and local governments, independent school districts, special district governments, public housing authorities/Indian housing authorities, and tribal governments and tribal organizations. A notable feature is that foreign institutions are eligible to apply, expanding the applicant pool beyond U.S.-based organizations, which can be particularly relevant for HIV research conducted in global settings with high HIV burden.

For applicants seeking the original full announcement text, NIH provided an official link through the NIH Grants Guide (http://grants.nih.gov/grants/guide/pa-files/PA-07-340.html). For access or technical issues, the NIH Office of Extramural Research (OER) webmaster contact was listed (FBOWebmaster@OD.NIH.GOV), reflecting how applicants could get assistance navigating or retrieving the announcement materials.

FAQs: HIV Treatment Adherence Research (R21) - PA-07-340

What is the HIV Treatment Adherence Research (R21) opportunity (PA-07-340)?

PA-07-340 is a National Institutes of Health (NIH) grant announcement focused on improving the science behind HIV treatment adherence, particularly adherence to antiretroviral therapy (ART). It supports research and intervention development aimed at helping people living with HIV take ART consistently as prescribed.

What is the main goal of this funding opportunity?

The central goal is to advance research and early intervention development that improves HIV treatment adherence, recognizing that adherence is shaped by behavioral, clinical, mental health, substance use, and broader health system factors.

Which NIH institutes sponsor this announcement?

This opportunity is sponsored by three NIH institutes: the National Institute of Mental Health (NIMH), the National Institute on Drug Abuse (NIDA), and the National Institute of Nursing Research (NINR).

What grant mechanism does PA-07-340 use?

PA-07-340 uses the NIH Exploratory/Developmental Research Grant mechanism (R21).

What is an R21 award intended to support?

R21 awards are intended for exploratory, developmental, and proof-of-concept projects. They are commonly used to test new ideas, emerging approaches, novel methods, early models, new measurement strategies, or foundational intervention concepts that may not yet be ready for a larger-scale trial.

Is this opportunity focused on innovation or on established approaches?

The emphasis is on innovation and exploration. The announcement encourages proposals that may be higher risk but could open new directions in biomedical, behavioral, or clinical research related to HIV treatment adherence.

What kinds of factors does the FOA recognize as influencing HIV treatment adherence?

The FOA recognizes that adherence is influenced by multiple domains, including behavioral factors, clinical issues, mental health, substance use, and broader health systems factors.

Are there related funding announcements for the same general topic?

Yes. This FOA is part of a coordinated set of related announcements with similar scientific focus but different grant mechanisms and intended project scale.

What are the companion FOAs mentioned alongside PA-07-340?

The related announcements listed are: an R01 version (PA-07-338) for full research projects, an R03 version (PA-07-339) for small research grants, and an R34 version (PAR-07-341) focused on exploratory grants for mental health interventions and services.

How should an applicant choose between the R21 and the companion mechanisms (R01, R03, R34)?

Applicants are expected to choose the mechanism that best fits the maturity and scope of their proposed work. R21 is positioned for exploratory or developmental work, while the companion FOAs represent different project scales and purposes as described in the announcement set.

Are the participating NIH institutes the same across all companion announcements?

Not necessarily. The description notes that the participating institutes may not be identical across each companion announcement.

What is the award ceiling listed for PA-07-340?

The listed award ceiling is $200,000.

Does this opportunity require cost sharing or matching funds?

No. The announcement states that cost sharing or matching is not required.

What type of grant opportunity category is this?

It is described as a discretionary grant opportunity in the health and education activity categories.

When was PA-07-340 posted?

The posting date was March 27, 2007.

Were there multiple submission deadlines?

Yes. The program used multiple receipt dates, meaning applications could be submitted on several scheduled NIH due dates rather than a single deadline.

Is this funding opportunity still active?

No. The opportunity has been archived, with an archive date of February 7, 2010. That means it is no longer active in this exact form, though it may remain useful for historical reference.

Who is eligible to apply?

Eligibility is broad and includes public and private institutions of higher education; nonprofits (including 501(c)(3) and non-501(c)(3) organizations); for-profit organizations (including small businesses and other for-profits); state and local governments; independent school districts; special district governments; public housing authorities/Indian housing authorities; and tribal governments and tribal organizations.

Are foreign institutions eligible to apply?

Yes. A notable feature of this announcement is that foreign institutions are eligible to apply, allowing organizations outside the United States to submit applications.

Why might foreign eligibility matter for this particular research area?

Because HIV research is often conducted in global settings with high HIV burden, allowing foreign institutions to apply can expand the applicant pool and support research in diverse settings relevant to HIV treatment adherence.

Where can someone find the official full text of the announcement?

The official announcement text was provided through the NIH Grants Guide at: http://grants.nih.gov/grants/guide/pa-files/PA-07-340.html

Who was listed as a contact for access or technical issues related to the announcement?

The NIH Office of Extramural Research (OER) webmaster contact was listed for access or technical issues: FBOWebmaster@OD.NIH.GOV

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