Opportunity Information: Apply for PAR 09 134

  • The National Institutes of Health in the health sector is offering a public funding opportunity titled "HIV Vaccine Research and Design (HIVRAD) Program (P01)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.855 Allergy, Immunology and Transplantation Research 93.856 Microbiology and Infectious Diseases Research.
  • This funding opportunity was created on Mar 20, 2009 and posted on Mar 20, 2009.
  • Applicants must submit their applications by Jul 13, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $4,500,000.00 to eligible and selected applicants.
  • Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) Private institutions of higher education Small businesses State governments Native American tribal organizations (other than Federally recognized tribal governments) County governments Special district governments City or township governments Independent school districts Native American tribal governments (Federally recognized) For profit organizations other than small businesses Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:

The HIV Vaccine Research and Design (HIVRAD) Program (P01) is a National Institutes of Health (NIH) funding opportunity run through the National Institute of Allergy and Infectious Diseases (NIAID) to push forward HIV vaccine discovery and early-stage vaccine design. It was created in response to priorities highlighted at a March 2008 NIAID Vaccine Summit, where the field provided input on what kinds of scientific investments were most likely to accelerate progress toward a safe and effective prophylactic (preventive) HIV/AIDS vaccine. In practical terms, this program is meant to support coordinated, multidisciplinary teams that can tackle complex vaccine problems more effectively than a single-lab effort, linking complementary expertise such as immunology, virology, structural biology, computational approaches, antigen design, and related translational work that supports vaccine concepts.

This opportunity uses the NIH Program Project Grant mechanism (P01). A P01 is designed for a set of closely related research projects that share a unifying theme and benefit from being managed as an integrated program rather than separate grants. Under this announcement, an application must include at least two research projects and at least one core. The projects are expected to be scientifically connected and mutually reinforcing, while the core provides shared resources, services, or infrastructure that increases efficiency and strengthens the overall program (for example, centralized immunologic assays, reagent production, biostatistics and data management, animal model support, or other enabling capabilities appropriate to HIV vaccine research). The emphasis on multiple projects plus a core signals that reviewers will be looking for genuine synergy: evidence that the whole program accomplishes more than the individual parts would on their own.

Funding levels are described as variable, reflecting that different teams may propose different scopes and durations of work. The estimated total funding listed for the opportunity is about $4.5 million, and NIAID anticipated making roughly 1 to 2 new awards per year, depending on the number, quality, duration, and cost of applications received. There is no cost sharing or matching requirement, which means applicants are not required to provide non-federal matching funds as a condition of receiving the award.

The opportunity is categorized as a discretionary grant in the health area and is associated with CFDA numbers 93.855 (Allergy, Immunology and Transplantation Research) and 93.856 (Microbiology and Infectious Diseases Research). The funding opportunity number is PAR-09-134, and it was posted on March 20, 2009. The original closing date was June 23, 2011, with a later current closing date shown as July 13, 2011, and the archive date is August 13, 2011, indicating the announcement is now historical rather than active.

Eligibility is broad and includes many types of organizations that can carry out biomedical research. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (including both 501(c)(3) and certain non-501(c)(3) nonprofits), for-profit organizations (including small businesses and other for-profit entities), and multiple levels of government (state, county, city/township, special districts), as well as independent school districts and public housing authorities/Indian housing authorities. The announcement also explicitly notes additional eligible applicant categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian serving institutions, tribally controlled colleges and universities (TCCUs), federally recognized and other tribal governments, faith-based and community-based organizations, U.S. territories or possessions, eligible federal agencies, and even non-U.S. entities (foreign organizations) and regional organizations. That wide eligibility reflects the reality that HIV vaccine research often benefits from collaboration across academic, government, nonprofit, and industry settings, including international partners.

Overall, the HIVRAD P01 program is best understood as a team-science vehicle for HIV vaccine discovery and rational vaccine design, deliberately structured to support integrated, multi-project programs with shared cores. The aim is to create coordinated research efforts that align with NIAID-identified priorities and help move promising vaccine concepts forward by combining multiple disciplines, shared resources, and unified leadership under a single program framework. For the full archived announcement, the source link is listed as http://grants.nih.gov/grants/guide/pa-files/PAR-09-134.html, and NIH provided contacts through the NIH Office of Extramural Research (OER) webmaster for access or technical linking issues.

Frequently Asked Questions (FAQs): HIV Vaccine Research and Design (HIVRAD) Program (P01)

What is the HIV Vaccine Research and Design (HIVRAD) Program (P01)?

The HIVRAD Program (P01) is a National Institutes of Health (NIH) funding opportunity administered through the National Institute of Allergy and Infectious Diseases (NIAID). It is intended to advance HIV vaccine discovery and early-stage vaccine design, with the goal of accelerating progress toward a safe and effective prophylactic (preventive) HIV/AIDS vaccine.

Which NIH institute runs this opportunity?

This opportunity is run through NIAID (the National Institute of Allergy and Infectious Diseases), which is part of NIH.

What kind of research does this program support?

The program supports HIV vaccine discovery and rational, early-stage vaccine design work. It is geared toward coordinated efforts that can move vaccine concepts forward by integrating multiple scientific disciplines and shared resources within a unified program.

Why was the HIVRAD program created?

HIVRAD was created in response to priorities highlighted at a March 2008 NIAID Vaccine Summit, where the research community provided input on scientific investments most likely to speed progress toward a preventive HIV vaccine.

What funding mechanism is used for this opportunity?

This opportunity uses the NIH Program Project Grant mechanism (P01).

What is a P01 (Program Project Grant) in practical terms?

A P01 is designed to support a set of closely related research projects that share a unifying theme and benefit from being managed as an integrated program rather than as separate, stand-alone grants.

How many research projects are required in an application?

Under this announcement, an application must include at least two research projects.

Are cores required, and how many?

Yes. An application must include at least one core.

What is the purpose of a core in an HIVRAD P01 application?

The core is meant to provide shared resources, services, or infrastructure that improves efficiency and strengthens the overall program. It supports the multi-project structure by enabling work that benefits multiple projects within the program.

What are examples of core resources mentioned in the opportunity?

Examples include centralized immunologic assays, reagent production, biostatistics and data management, animal model support, and other enabling capabilities appropriate to HIV vaccine research.

What do reviewers look for in a multi-project, core-based P01 structure?

The announcement emphasizes synergy. Reviewers are expected to look for evidence that the integrated program accomplishes more than the individual projects would achieve on their own, through scientifically connected and mutually reinforcing projects supported by shared cores.

What scientific disciplines or expertise areas does the program encourage teams to integrate?

The program highlights linking complementary expertise such as immunology, virology, structural biology, computational approaches, antigen design, and related translational work that supports vaccine concepts.

How much funding is available under this opportunity?

Funding levels are described as variable because teams may propose different scopes and durations of work. The estimated total funding listed for the opportunity is about $4.5 million.

How many awards did NIAID anticipate making?

NIAID anticipated making roughly 1 to 2 new awards per year, depending on the number, quality, duration, and cost of applications received.

Is cost sharing or matching required?

No. There is no cost sharing or matching requirement, meaning applicants are not required to provide non-federal matching funds as a condition of receiving the award.

What type of grant category is this?

The opportunity is categorized as a discretionary grant in the health area.

What CFDA numbers are associated with this opportunity?

The opportunity is associated with CFDA 93.855 (Allergy, Immunology and Transplantation Research) and CFDA 93.856 (Microbiology and Infectious Diseases Research).

What is the funding opportunity number?

The funding opportunity number is PAR-09-134.

When was the opportunity posted?

It was posted on March 20, 2009.

What were the closing dates listed for this announcement?

The original closing date was June 23, 2011, and a later current closing date was shown as July 13, 2011.

Is this funding opportunity still active?

No. The archive date is August 13, 2011, which indicates the announcement is historical rather than active.

Who is eligible to apply?

Eligibility is broad and includes many organization types able to conduct biomedical research, including public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (including 501(c)(3) and certain non-501(c)(3) nonprofits), for-profit organizations (including small businesses), and various government entities.

Are government entities eligible, and which levels are included?

Yes. Eligibility includes state governments, county governments, city or township governments, and special district governments. Independent school districts and public housing authorities/Indian housing authorities are also listed as eligible.

Are minority-serving institutions and tribal organizations included in eligibility?

Yes. The announcement explicitly notes categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian serving institutions, and tribally controlled colleges and universities (TCCUs), as well as federally recognized and other tribal governments.

Are faith-based or community-based organizations eligible?

Yes. Faith-based and community-based organizations are explicitly listed among eligible applicants.

Are U.S. territories eligible?

Yes. U.S. territories or possessions are included in the eligible applicant categories.

Are foreign organizations eligible to apply?

Yes. The announcement includes non-U.S. entities (foreign organizations) and regional organizations as eligible applicants.

Where can the full (archived) announcement be found?

The source link for the full archived announcement is: http://grants.nih.gov/grants/guide/pa-files/PAR-09-134.html.

Who is listed as a contact for access or technical linking issues?

NIH provided contacts through the NIH Office of Extramural Research (OER) webmaster for access or technical linking issues.

What is the overall goal of structuring this as a multi-project program?

The program is designed as a team-science vehicle to support integrated, multidisciplinary efforts with unified leadership and shared cores, aligning with NIAID-identified priorities and enabling coordinated research that is stronger than isolated single-lab approaches.

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