Opportunity Information: Apply for PA 09 236

  • The National Institutes of Health in the education health sector is offering a public funding opportunity titled "HIV/AIDS, Drug Use, and Vulnerable Populations in the US (R01)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279 Drug Abuse and Addiction Research Programs 93.361 Nursing Research.
  • This funding opportunity was created on Jul 22, 2009 and posted on Jul 22, 2009.
  • Applicants must submit their applications by Sep 7, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Eligible applicants include: Native American tribal governments (Federally recognized) Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal organizations (other than Federally recognized tribal governments) Small businesses State governments County governments Special district governments Public and State controlled institutions of higher education Independent school districts For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities City or township governments.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
Apply for PA 09 236

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Opportunity Summary:

The HIV/AIDS, Drug Use, and Vulnerable Populations in the US (R01) funding opportunity (PA 09 236) is a National Institutes of Health discretionary grant program led by the National Institute on Drug Abuse and the National Institute of Nursing Research. Its central aim is to support research that clarifies how drug use helps drive HIV acquisition, transmission, and health outcomes in US populations that carry a disproportionately high burden of HIV. The FOA is especially focused on vulnerable groups such as racial and ethnic minorities, men who have sex with men, and youth, and it emphasizes the need for research that not only describes risk, but also produces practical, evidence-based interventions to prevent new infections and improve health and well-being among people living with HIV.

A major theme of the opportunity is that HIV disparities are not caused by a single factor, and applicants are encouraged to study the layered drivers behind unequal HIV outcomes. The FOA highlights a broad set of contributing influences that can be investigated, including biological, behavioral, psychosocial, environmental, and institutional factors. In other words, the NIH is looking for projects that take seriously the real-world context in which HIV risk occurs, including how substance use interacts with mental health, stigma, poverty, access to care, neighborhood conditions, and the policies and systems that shape prevention and treatment.

The research areas supported under this R01 span four main categories. First, the FOA supports studies that examine how drug abuse, both injection and non-injection, contributes to HIV acquisition and transmission. This includes classic risks such as needle sharing, but also the ways non-injection drug use can increase sexual risk, reduce adherence to prevention strategies, or influence decision-making and partner selection. Second, it invites work on HIV disease progression and disease outcomes in the context of drug use, which can include how substance use affects immune function, comorbidities, engagement in care, antiretroviral therapy adherence, viral suppression, and long-term morbidity and mortality. Third, it encourages the development of new interventions or the improvement of existing prevention and treatment approaches, with the expectation that findings will be relevant to real populations and settings where people receive services. Fourth, it explicitly supports research addressing organizational, structural, and community-level factors, including the role of social networks, drug-using networks, and sexual networks, recognizing that HIV spreads through interconnected systems of relationships and that interventions may need to work at the network or community level rather than only focusing on individuals.

This announcement uses the NIH Research Project Grant (R01) mechanism, which is typically intended for more mature, hypothesis-driven projects with a robust research plan compared to exploratory mechanisms. The FOA notes that it runs in parallel with a separate announcement of the same scientific scope that uses the R21 mechanism (PA 09 237), which generally supports earlier-stage or more exploratory work. Funding levels and the number of awards are not guaranteed and depend on available funds and the quality and volume of applications received, meaning proposals are expected to compete on scientific merit through the standard NIH peer review process.

Eligibility is broad and includes many types of domestic organizations and governmental entities. Eligible applicants include public and private institutions of higher education, nonprofit organizations with or without 501(c)(3) status, for-profit organizations (including small businesses and other for-profits), and various levels of government such as state, county, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities. The FOA also allows participation from Native American tribal governments and tribal organizations, including tribally controlled colleges and universities. In addition, the eligibility language explicitly includes organizations such as historically Black colleges and universities, Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, faith-based and community-based organizations, regional organizations, and US territories or possessions. There is no cost sharing or matching requirement stated for this opportunity.

Key administrative details in the source listing include a posted and created date of July 22, 2009, with an original and current closing date of September 7, 2012, and an archive date of October 8, 2012. The program is associated with CFDA numbers 93.279 (Drug Abuse and Addiction Research Programs) and 93.361 (Nursing Research). For full details, the FOA points applicants to the NIH guide page (PA 09 236) and provides NIH Office of Extramural Research webmaster contacts for access or linking issues.

Frequently Asked Questions (FAQs)

What is the name of this funding opportunity?

The opportunity is titled "The HIV/AIDS, Drug Use, and Vulnerable Populations in the US (R01)" and is identified as PA 09 236.

Which federal agency and institutes lead this program?

This is a National Institutes of Health (NIH) discretionary grant program led by the National Institute on Drug Abuse (NIDA) and the National Institute of Nursing Research (NINR).

What is the main goal of the FOA?

The central aim is to support research that clarifies how drug use drives HIV acquisition, transmission, and health outcomes in US populations that experience a disproportionately high burden of HIV, with an emphasis on producing practical, evidence-based interventions to prevent new infections and improve health and well-being among people living with HIV.

Which populations are emphasized as priorities in the FOA?

The FOA is especially focused on vulnerable groups, including:

  • Racial and ethnic minorities
  • Men who have sex with men
  • Youth

Is the FOA focused only on describing HIV risk, or also on solutions?

It emphasizes the need for research that goes beyond describing risk and produces practical, evidence-based interventions aimed at preventing HIV infections and improving outcomes for people living with HIV.

What does the FOA say about the causes of HIV disparities?

A major theme is that HIV disparities are not caused by a single factor. Applicants are encouraged to study layered drivers behind unequal HIV outcomes.

What types of contributing influences can be studied?

The FOA highlights a broad range of influences that may contribute to HIV disparities and can be investigated, including:

  • Biological factors
  • Behavioral factors
  • Psychosocial factors
  • Environmental factors
  • Institutional factors

It also stresses real-world context such as interactions between substance use and mental health, stigma, poverty, access to care, neighborhood conditions, and policies and systems shaping prevention and treatment.

What are the main research categories supported under this R01?

The FOA describes four main supported areas:

  1. Drug abuse and HIV acquisition/transmission (injection and non-injection drug use)
  2. HIV disease progression and outcomes in the context of drug use
  3. Development or improvement of interventions for prevention and treatment in real populations and service settings
  4. Organizational, structural, and community-level factors, including networks (social, drug-using, sexual)

Does the FOA include both injection and non-injection drug use?

Yes. It supports studies examining how drug abuse, including both injection and non-injection drug use, contributes to HIV acquisition and transmission.

What examples of HIV transmission risk related to drug use are mentioned?

The FOA references classic risks like needle sharing, and also emphasizes how non-injection drug use can increase sexual risk, reduce adherence to prevention strategies, influence decision-making, and affect partner selection.

What HIV outcomes are relevant for studies on disease progression in the context of drug use?

Examples include how substance use affects:

  • Immune function
  • Comorbidities
  • Engagement in care
  • Antiretroviral therapy adherence
  • Viral suppression
  • Long-term morbidity and mortality

Are organizational, structural, or community-level approaches within scope?

Yes. The FOA explicitly supports research addressing organizational, structural, and community-level factors, including the role of social networks, drug-using networks, and sexual networks.

Why does the FOA emphasize networks and community-level factors?

It recognizes that HIV spreads through interconnected systems of relationships, and that interventions may sometimes need to operate at the network or community level rather than focusing only on individuals.

What grant mechanism is used for this program?

This announcement uses the NIH Research Project Grant (R01) mechanism.

What does it mean that this is an R01 mechanism?

The FOA notes that an R01 is typically intended for more mature, hypothesis-driven projects with a robust research plan, compared to exploratory mechanisms.

Is there a related opportunity for more exploratory projects?

Yes. The FOA runs in parallel with a separate announcement of the same scientific scope that uses the R21 mechanism, identified as PA 09 237, which generally supports earlier-stage or more exploratory work.

Are funding levels or the number of awards guaranteed?

No. Funding levels and the number of awards are not guaranteed and depend on available funds and the quality and volume of applications received.

How are applications evaluated for this opportunity?

Proposals are expected to compete on scientific merit through the standard NIH peer review process.

Who is eligible to apply?

Eligibility is broad and includes many types of domestic organizations and governmental entities, including:

  • Public and private institutions of higher education
  • Nonprofit organizations with or without 501(c)(3) status
  • For-profit organizations (including small businesses and other for-profits)
  • State governments
  • County governments
  • City or township governments
  • Special district governments
  • Independent school districts
  • Public housing authorities / Indian housing authorities
  • Native American tribal governments
  • Native American tribal organizations
  • Tribally controlled colleges and universities
  • US territories or possessions

Are specific institution types explicitly included in the eligibility language?

Yes. The eligibility language explicitly includes organizations such as:

  • Historically Black colleges and universities (HBCUs)
  • Hispanic-serving institutions
  • Alaska Native and Native Hawaiian-serving institutions
  • Faith-based organizations
  • Community-based organizations
  • Regional organizations

Is cost sharing or a matching contribution required?

No cost sharing or matching requirement is stated for this opportunity.

What are the key dates listed for this FOA?

The source listing includes:

  • Posted/created date: July 22, 2009
  • Original closing date: September 7, 2012
  • Current closing date: September 7, 2012
  • Archive date: October 8, 2012

What CFDA numbers are associated with this program?

The program is associated with CFDA numbers:

  • 93.279 (Drug Abuse and Addiction Research Programs)
  • 93.361 (Nursing Research)

Where can applicants find the official FOA details?

For full details, the FOA points applicants to the NIH Guide page for PA 09 236.

Who is listed as a contact for access or linking issues?

The FOA provides NIH Office of Extramural Research webmaster contacts for access or linking issues.

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Applicants also applied for:

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