Opportunity Information: Apply for PAR 16 028
Apply for PAR 16 028
- The HHS-NIH11 in the health sector is offering a public funding opportunity titled "HIV/AIDS Vaccine Scholars Program (K01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.351,.
- This funding opportunity was created on Nov 02, 2015 and posted on Nov 02, 2015.
- Applicants must submit their applications by Jan 11, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $350,000.00 in funding.
- Eligible applicants include: Public and State controlled institutions of higher education, Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, Others (see text field entitled Additional Information on Eligibility for clarification).
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Opportunity Summary:
The HIV/AIDS Vaccine Scholars Program (K01) (Funding Opportunity Number PAR 16-028) is an NIH mentored career development grant designed to help early-stage investigators build the experience, training, and publication record needed to become independent HIV vaccine researchers. The award is structured as a Mentored Research Scientist Development Award, meaning it supports both the investigator's protected time (salary) and a defined research and career development plan carried out under close mentorship. The central theme of this program is HIV/AIDS vaccine development, specifically requiring that the proposed research and mentorship focus on nonhuman primates (NHPs) as the key pre-clinical model system and on translating NHP findings toward human application.
The opportunity targets investigators who are relatively early in their careers, specifically those within ten years of completing a terminal degree or residency training. The intent is to capture scientists and clinician-scientists who have moved beyond initial training but still need intensive, structured support to establish a clear research niche, demonstrate productivity, and learn the specialized skills required for HIV vaccine development in NHP systems. In practice, applicants would be expected to propose a coherent plan that combines hands-on research, career development activities, and mentorship that collectively moves them toward independence.
A defining feature of this K01 is the expectation of a strong, experienced mentorship team rather than a single mentor. NIH emphasizes mentor expertise in two linked areas: (1) the development and use of NHP vaccine models for HIV/AIDS research, and (2) the ability to translate results generated in NHP studies into work that informs human studies. This translation emphasis signals that the program is not only about refining animal model experiments, but also about positioning those experiments as credible stepping stones toward clinical evaluation, such as informing immunogen design, vaccination strategies, immune correlates, and other preclinical evidence needed to justify human trials.
The award provides three years of support for intensive research career development. Over that period, the scholar is expected to devote substantial effort to their K01 project, build technical and conceptual expertise in HIV vaccine science, and develop the professional competencies that lead to independence. The stated long-term goal is that K01 awardees will "launch independent research careers" and become competitive for subsequent major NIH research funding, particularly independent research project grants such as the R01. In other words, the K01 is positioned as a bridge between mentored training and fully independent grant support.
This funding initiative explicitly aligns with two objectives of the FY 2016 NIH Trans-NIH Plan for HIV-Related Research: first, exploring new HIV vaccine approaches, and second, expanding and strengthening the pipeline of new investigators in the HIV vaccine field. The program is therefore both scientific and workforce-oriented: it aims to stimulate innovative vaccine concepts while ensuring that promising early-career researchers gain the mentorship, resources, and translational perspective needed to push preclinical NHP findings toward human clinical testing.
Administratively, this is a discretionary grant opportunity administered by the U.S. Department of Health and Human Services through NIH (Agency listed as HHS-NIH11), with activity in the health category and CFDA numbers 93.351 (and listed alongside 93.351 in the source data). Eligible applicant organizations include a broad range of institutions where biomedical research is commonly conducted, such as public and state-controlled institutions of higher education, private institutions of higher education, and nonprofit organizations (including both 501(c)(3) and non-501(c)(3) entities), with an additional catch-all category noting that other applicants may be eligible as described in the full eligibility text. The opportunity was posted and created on November 2, 2015, and the listed closing date for the final cycle in the provided data was January 11, 2018. The source data lists an award ceiling of $350,000, indicating the maximum amount anticipated per award under this announcement.
Overall, PAR 16-028 is best understood as a targeted, mentored, three-year career development mechanism intended to cultivate the next generation of HIV vaccine scientists who can leverage sophisticated NHP preclinical models and produce translationally relevant findings that accelerate the path from vaccine concepts to human clinical trials.
FAQs: HIV/AIDS Vaccine Scholars Program (K01) - PAR 16-028
What is the HIV/AIDS Vaccine Scholars Program (K01) (PAR 16-028)?
The HIV/AIDS Vaccine Scholars Program (K01) is an NIH mentored career development grant designed to help early-stage investigators build the experience, training, and publication record needed to become independent HIV vaccine researchers. It is structured as a Mentored Research Scientist Development Award (K01), supporting both protected time (salary) and a defined research and career development plan carried out under close mentorship.
What is the main scientific focus of this K01 opportunity?
The central theme is HIV/AIDS vaccine development, with a specific requirement that the proposed research and mentorship focus on nonhuman primates (NHPs) as the key pre-clinical model system and on translating NHP findings toward human application.
Why does this program require a focus on nonhuman primates (NHPs)?
This opportunity specifically positions NHPs as the key pre-clinical model system for HIV vaccine development under this program. Applicants are expected to use NHP vaccine models and generate findings that can be translated toward human studies.
What does "translating NHP findings toward human application" mean in this program?
It means the program is not only about conducting NHP experiments, but also about positioning NHP results as credible stepping stones toward clinical evaluation in humans. The opportunity emphasizes translation that can inform areas such as immunogen design, vaccination strategies, immune correlates, and other preclinical evidence used to justify human trials.
Who is this program intended for?
The opportunity targets investigators who are relatively early in their careers, specifically those within ten years of completing a terminal degree or residency training. It is intended for scientists and clinician-scientists who have moved beyond initial training but still need intensive, structured support to establish a research niche and demonstrate productivity.
How long is the period of support?
The award provides three years of support for intensive research career development.
What does the award support?
As a mentored career development award, it supports the investigator's protected time (salary) and a defined research and career development plan carried out under close mentorship.
What level of mentorship is expected?
A defining feature of this K01 is the expectation of a strong, experienced mentorship team rather than a single mentor.
What expertise should the mentorship team have?
NIH emphasizes mentor expertise in two linked areas: (1) development and use of NHP vaccine models for HIV/AIDS research, and (2) the ability to translate results generated in NHP studies into work that informs human studies.
What is expected of the scholar during the three-year award?
Over the three years, the scholar is expected to devote substantial effort to the K01 project, build technical and conceptual expertise in HIV vaccine science, and develop professional competencies that lead to independence through a coherent plan combining hands-on research, career development activities, and mentorship.
What is the long-term goal of the program?
The stated long-term goal is that K01 awardees will launch independent research careers and become competitive for subsequent major NIH research funding, particularly independent research project grants such as the R01. The K01 is positioned as a bridge between mentored training and fully independent grant support.
How does this initiative align with NIH priorities?
This funding initiative explicitly aligns with two objectives of the FY 2016 NIH Trans-NIH Plan for HIV-Related Research: (1) exploring new HIV vaccine approaches, and (2) expanding and strengthening the pipeline of new investigators in the HIV vaccine field.
Is this opportunity focused only on science, or also on career development?
It is both scientific and workforce-oriented. It aims to stimulate innovative vaccine concepts while ensuring promising early-career researchers gain mentorship, resources, and translational perspective needed to move preclinical NHP findings toward human clinical testing.
Which agency administers this grant opportunity?
It is administered by the U.S. Department of Health and Human Services through NIH (agency listed as HHS-NIH11).
What type of grant is this?
This is a discretionary grant opportunity and an NIH mentored career development award (K01).
What category does this opportunity fall under?
The activity is in the health category.
What is the CFDA number for this opportunity?
The opportunity lists CFDA number 93.351 (and is listed alongside 93.351 in the source data).
What types of organizations are eligible to apply?
Eligible applicant organizations include public and state-controlled institutions of higher education, private institutions of higher education, and nonprofit organizations (including both 501(c)(3) and non-501(c)(3) entities). The source information also notes that other applicants may be eligible as described in the full eligibility text.
When was this opportunity posted?
The opportunity was posted and created on November 2, 2015.
What was the closing date listed in the provided information?
The listed closing date for the final cycle in the provided data was January 11, 2018.
What is the maximum award amount shown in the provided data?
The source data lists an award ceiling of $350,000, indicating the maximum amount anticipated per award under this announcement.
What makes this K01 distinct compared to a general mentored award?
The distinct elements described include its targeted focus on HIV/AIDS vaccine development, the requirement to center research on NHP preclinical models, the explicit emphasis on translation of NHP findings toward human application, and the expectation of a mentorship team with experience in both NHP vaccine modeling and translation to human studies.
What outcomes is NIH trying to achieve with this program?
The program aims to cultivate the next generation of HIV vaccine scientists who can leverage sophisticated NHP preclinical models and produce translationally relevant findings that accelerate the path from vaccine concepts to human clinical trials, while also strengthening the pipeline of new investigators in the field.
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