Home and Family Based Approaches for the Prevention or Management of Overweight or Obesity in Early Childhood (R01) | Apply Online

Opportunity Summary:

The Home and Family Based Approaches for the Prevention or Management of Overweight or Obesity in Early Childhood (R01) opportunity (Funding Opportunity Number PA-10-127) is an NIH research grant announcement led by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), with participation from the National Heart, Lung and Blood Institute (NHLBI) and the NIH Office of Behavioral and Social Sciences Research (OBSSR). It uses the R01 Research Project Grant mechanism and supports discretionary, investigator-initiated research that fits the goals described in the announcement. The central purpose is to fund rigorous randomized clinical trials that test new or improved interventions delivered through the home and family context to prevent or manage overweight and obesity during infancy through early childhood, specifically focusing on children from birth up to age six.

The program is built around the idea that early childhood is a critical window when eating patterns, activity habits, and daily routines are formed, and when parents and other caregivers have a strong influence over what children consume and how they spend their time. For that reason, proposed interventions are expected to emphasize the home environment and the role of parents, guardians, and other substantial caregivers or extended family members living with the child. NIH is looking for studies that do more than simply educate; the interventions can be behavioral (such as strategies related to diet, feeding practices, physical activity, sleep routines, or reducing sedentary time), environmental (such as modifying food availability in the home, screen access, or opportunities for active play), or other relevant approaches that plausibly affect energy balance and weight trajectories.

A key feature of this FOA is its focus on the family mechanisms that drive behavior change. Applicants are encouraged to examine how families initiate, support, and reinforce everyday behaviors tied to energy intake and expenditure. This includes fundamental patterns like food and beverage choices, portioning and feeding interactions, physical activity opportunities and modeling, and habits that contribute to sedentary behavior. In addition to testing whether an intervention works, the announcement signals interest in clarifying the underlying behavioral determinants that help start and sustain change, meaning research that can explain why an intervention succeeds or fails in real households and what ingredients are necessary to maintain healthier routines over time.

While the home and family must be the core setting, the FOA allows designs that connect the home intervention to other places where young children spend time. Applicants may incorporate linkages with daycare, preschool, clinics, or other community venues, and may involve other care providers such as healthcare professionals or teachers, as long as the primary study participant remains an infant or child under six and the intervention meaningfully involves parents and/or other family members in the child’s home. The long-term intent is to support projects that generate knowledge with practical translation potential, either for direct use in homes or for approaches that can be integrated with community systems that interact with families.

The overarching outcome goal is to identify interventions that shift both parent and child behaviors in ways that prevent inappropriate weight gain early in life. NIH frames this as an investment in later health: preventing or managing excess weight before age six is expected to reduce risk for downstream health problems in childhood, adolescence, and adulthood, particularly conditions where overweight is a recognized risk factor.

Administratively, this is a federal grant opportunity with no cost sharing or matching requirement. It falls under NIH assistance listings tied to cardiovascular diseases research (93.837) and diabetes, digestive, and kidney diseases extramural research (93.847). The announcement lists a broad range of eligible applicant organizations, including state and local governments, public and private institutions of higher education, independent school districts, tribal governments and tribal organizations, nonprofits (with or without 501(c)(3) status), for-profit organizations (including small businesses), public housing authorities, and other regional or community-based entities. Eligibility is expansive and explicitly includes faith-based and community-based organizations, minority-serving institutions (such as HBCUs, Hispanic-serving institutions, and Alaska Native/Native Hawaiian-serving institutions), tribally controlled colleges and universities, US territories or possessions, and even non-US (foreign) organizations, along with eligible federal agencies.

For reference, the opportunity was originally posted in 2010 and later archived in 2013 (with key dates including an original closing date of May 7, 2013, a current closing date of March 22, 2013, and an archive date of April 22, 2013). The full announcement was hosted on the NIH grants site under the PA-10-127 listing, and NIH provided an Office of Extramural Research (OER) webmaster contact for technical access issues.

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Previous opportunity: Home and Family Based Approaches for the Prevention or Management of Overweight or Obesity in Early Childhood (R21)

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