Opportunity Information: Apply for RFA RM 12 006

  • The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "Human Heredity and Health in Africa (H3Africa) Collaborative Centers (U54)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.172 Human Genome Research 93.310 Trans NIH Research Support 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders 93.865 Child Health and Human Development Extramural Research.
  • This funding opportunity was created on Oct 26, 2012 and posted on Aug 22, 2012.
  • Applicants must submit their applications by Oct 31, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Eligible applicants include: Public and State controlled institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Private institutions of higher education.
  • Other Eligible Applicants include the following Non domestic (non U.S.) Entities (Foreign Organizations) Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:

The Human Heredity and Health in Africa (H3Africa) Collaborative Centers (U54) opportunity (Funding Opportunity Number RFA-RM-12-006) is an NIH cooperative agreement that supports the creation of major research centers based at institutions in African countries. These centers, referred to as H3Africa Collaborative Centers (H3ACCs), are intended to lead and coordinate large-scale, high-impact research focused on understanding how genomic, genetic, and environmental factors influence health and disease within African populations. The program sits under the broader Human Heredity and Health in Africa (H3Africa) Initiative, a partnership between the NIH and the Wellcome Trust, and it is designed to strengthen the ability of African institutions to conduct cutting-edge genomics and related biomedical research on the continent, rather than relying primarily on external sites for leadership, analysis, and long-term capacity.

A central theme of the FOA is that the science and the infrastructure should grow together. In practical terms, NIH is looking for collaborative centers that not only carry out strong research projects using modern genomic research tools, but also build durable systems that make future research easier and more locally sustainable. That includes investment in physical and organizational infrastructure, the development of data and research resources, and the creation of shared capabilities that can support multiple studies over time. The intended outcome is a step-change in Africa-based genomics research capacity, where African investigators, institutions, and trainees increase their proficiency in genomics and bioinformatics and are able to sustain competitive biomedical research programs that directly address health priorities and disease burdens relevant to African communities.

Because this is a cooperative agreement (U54), the award structure signals that NIH expects an active partnership with awardees rather than a fully hands-off grant. Cooperative agreements typically involve substantial NIH programmatic involvement, which often means closer coordination around milestones, collaboration expectations, data/resource-sharing practices, and alignment with the broader H3Africa network goals. The FOA is supported by the NIH Common Fund and participating NIH Institutes and Centers, reflecting an emphasis on cross-cutting, trans-NIH priorities and broad scientific relevance rather than a narrow single-disease focus.

Eligibility is geared toward strengthening Africa-based leadership. The FOA explicitly invites applications from institutions in African countries, while also stating that non-U.S. entities (foreign organizations and foreign institutions) are eligible to apply, and that non-domestic components of U.S. organizations may apply as well. Foreign components, as defined by NIH policy, are allowed. The eligible applicant types listed include public and state-controlled institutions of higher education, private institutions of higher education, and other applicants as clarified in the full FOA. Importantly, the opportunity does not require cost sharing or matching, which can remove a major barrier for institutions building new genomics programs and infrastructure.

Key administrative details from the posting indicate this was a time-limited call released in 2012. The opportunity was posted on August 22, 2012, with an original closing date of October 29, 2012, a current closing date of October 31, 2012, and an archive date of November 30, 2012. The CFDA program areas tied to the announcement include Human Genome Research (93.172), Trans-NIH Research Support (93.310), Neurosciences and Neurological Disorders Extramural Research (93.853), and Child Health and Human Development Extramural Research (93.865), which underscores the wide range of health areas that genomics capacity-building in Africa can support. The sponsoring agency is the National Institutes of Health, and the official announcement and details are provided via the NIH grants website, with technical access support routed through the NIH Office of Extramural Research webmaster.

FAQs: H3Africa Collaborative Centers (U54) - RFA-RM-12-006

What is the H3Africa Collaborative Centers (U54) funding opportunity?

RFA-RM-12-006 is an NIH cooperative agreement (U54) that supports the creation of major research centers based at institutions in African countries. These centers are called H3Africa Collaborative Centers (H3ACCs) and are designed to lead and coordinate large-scale, high-impact research on how genomic, genetic, and environmental factors influence health and disease in African populations.

Who is the sponsoring agency for this opportunity?

The sponsoring agency is the National Institutes of Health (NIH).

How does this opportunity fit into the broader H3Africa Initiative?

This FOA sits under the Human Heredity and Health in Africa (H3Africa) Initiative, which is a partnership between NIH and the Wellcome Trust. The FOA is intended to strengthen Africa-based leadership and long-term capacity for genomics and related biomedical research on the continent.

What is the main purpose of establishing H3Africa Collaborative Centers (H3ACCs)?

The main purpose is to build Africa-based centers that can both conduct strong, modern genomics research and develop durable infrastructure, resources, and shared capabilities that make future research easier and more locally sustainable.

What types of research are these centers expected to conduct?

The FOA emphasizes large-scale, high-impact research focused on understanding how genomic, genetic, and environmental factors influence health and disease within African populations, using modern genomic research tools.

Does the FOA focus on a single disease area?

No. The FOA is supported by the NIH Common Fund and participating NIH Institutes and Centers, reflecting cross-cutting priorities and broad scientific relevance rather than a narrow single-disease focus.

What does it mean that this is a U54 cooperative agreement?

A U54 is a cooperative agreement, which signals that NIH expects an active partnership with awardees rather than a hands-off grant relationship. This typically involves substantial NIH programmatic involvement and closer coordination around expectations such as milestones, collaboration practices, and data/resource sharing aligned with the broader H3Africa network goals.

What is the central theme or philosophy of the FOA?

A central theme is that the science and the infrastructure should grow together. The FOA looks for centers that advance research while also building lasting systems, resources, and institutional capabilities that support multiple studies over time.

What kinds of capacity-building activities are implied in this FOA?

Based on the description, capacity-building includes investing in physical and organizational infrastructure, developing data and research resources, and creating shared capabilities that strengthen proficiency in genomics and bioinformatics among African investigators, institutions, and trainees.

What is the intended long-term outcome of this program?

The intended outcome is a step-change in Africa-based genomics research capacity so that African investigators, institutions, and trainees can sustain competitive biomedical research programs addressing health priorities and disease burdens relevant to African communities.

Who is eligible to apply?

Eligibility is geared toward strengthening Africa-based leadership. The FOA explicitly invites applications from institutions in African countries. It also states that non-U.S. entities (foreign organizations and foreign institutions) are eligible to apply, and that non-domestic components of U.S. organizations may apply. Foreign components, as defined by NIH policy, are allowed.

What types of applicant organizations are listed as eligible?

The eligible applicant types listed include public and state-controlled institutions of higher education, private institutions of higher education, and other applicants as clarified in the full FOA.

Are foreign components allowed under this opportunity?

Yes. The FOA states that foreign components (as defined by NIH policy) are allowed.

Is cost sharing or matching required?

No. The opportunity does not require cost sharing or matching.

When was this funding opportunity posted?

The opportunity was posted on August 22, 2012.

What were the closing dates for applications?

The posting lists an original closing date of October 29, 2012, and a current closing date of October 31, 2012.

When was the FOA archived?

The archive date listed is November 30, 2012.

Is this a current open opportunity?

Based on the provided dates (closing in October 2012 and archived in November 2012), this was a time-limited call released in 2012 and is not presented as currently open in the information provided.

Which NIH funding sources support this FOA?

The FOA is supported by the NIH Common Fund and participating NIH Institutes and Centers.

What CFDA program areas are associated with this announcement?

The CFDA program areas tied to the announcement include Human Genome Research (93.172), Trans-NIH Research Support (93.310), Neurosciences and Neurological Disorders Extramural Research (93.853), and Child Health and Human Development Extramural Research (93.865).

What do the CFDA areas suggest about the scope of the program?

The mix of CFDA areas underscores that genomics capacity-building in Africa can support a wide range of health and biomedical research areas, including (but not limited to) human genomics, trans-NIH priorities, neuroscience-related research, and child health and development.

Where are the official announcement and details provided?

The official announcement and details are provided via the NIH grants website, according to the information provided.

Where is technical access support directed?

Technical access support is routed through the NIH Office of Extramural Research webmaster.

What makes these centers different from projects led primarily outside Africa?

The FOA is designed to strengthen the ability of African institutions to conduct cutting-edge genomics and related biomedical research on the continent, rather than relying primarily on external sites for leadership, analysis, and long-term capacity.

What is meant by creating "shared capabilities"?

In the context provided, shared capabilities refer to systems, infrastructure, and research resources that can support multiple studies over time, helping make future research more efficient and sustainable within Africa-based institutions.

What kinds of coordination expectations come with the cooperative agreement structure?

The description indicates closer coordination around milestones, collaboration expectations, data/resource-sharing practices, and alignment with the broader H3Africa network goals, reflecting substantial NIH programmatic involvement.

What is the role of the H3Africa network in this FOA?

The FOA frames the centers as part of broader network goals, suggesting that awardees are expected to align collaboration and sharing practices with the wider H3Africa effort.

Browse more opportunities from the same agency: National Institutes of Health

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Next opportunity: Human Heredity and Health in Africa (H3Africa) H3Africa Research Grants (U01)

Previous opportunity: Human Heredity and Health in Africa (H3Africa) H3Africa Biorepository Grants. (UH2/UH3)

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