Opportunity Information: Apply for RFA HL 17 014
Apply for RFA HL 17 014
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Hypertension Outcomes for T4 REsearch within Lower Middle-Income Countries (Hy-TREC) (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.840.
- This funding opportunity was created on Aug 11, 2016.
- Applicants must submit their applications by Nov 08, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $268,500.00 in funding.
- The number of recipients for this funding is limited to 5 candidate(s).
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
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Opportunity Summary:
Hypertension Outcomes for T4 REsearch within Lower Middle-Income Countries (Hy-TREC) (U01) is a National Institutes of Health (NIH) funding opportunity from the U.S. Department of Health and Human Services focused on improving how proven hypertension interventions are implemented and scaled in World Bank-defined lower middle-income countries (Lower-MICs). The central idea is not to invent brand-new clinical treatments, but to make existing, evidence-based approaches for preventing, diagnosing, treating, and controlling high blood pressure work better in real-world health systems at a broad level. This program targets adults and emphasizes solutions that can be expanded beyond a single clinic or small pilot, aiming instead for regional or national impact.
The grant uses a U01 cooperative agreement mechanism, which typically means NIH expects a more hands-on partnership with awardees than with a standard research project grant. Projects funded under this mechanism are generally expected to align closely with the program goals, work collaboratively with NIH scientific staff, and often participate in cross-project coordination or shared expectations around implementation research methods and outcomes. The funding supports late-stage, locally driven T4 implementation research, meaning studies are expected to be close to real-world practice and policy, concentrating on strategies that move evidence into routine care at scale rather than early-stage efficacy testing.
A key feature of the opportunity is its focus on implementation strategies at the regional or national level. In practice, that means applicants are expected to study approaches that change or strengthen systems: how guidelines are adopted, how medicines and blood pressure measurement are reliably delivered, how care teams are organized, how patient follow-up is maintained, how data systems support performance improvement, and how policies and financing arrangements help or hinder sustained hypertension control. The research emphasis is on testing and evaluating these strategies in ways that can speed up large-scale adoption of proven interventions. The intended results are practical and transferable insights that governments, health systems, and partners in Lower-MICs can use to expand hypertension control programs effectively.
Administratively, this opportunity (Funding Opportunity Number RFA HL 17 014) falls under the NIH health research activity category and is associated with CFDA number 93.840. The award ceiling listed is $268,500, and the program anticipated making about five awards. The original posting indicates it was created on August 11, 2016, with an original closing date of November 8, 2016. Eligibility is described broadly as "Others (see text field entitled Additional Information on Eligibility for clarification)," which signals that eligibility details would be specified in the full announcement and may include a range of institution types depending on NIH rules and the specific FOA requirements, particularly given the international, Lower-MIC-centered focus.
Overall, Hy-TREC is designed for teams that can work closely with local stakeholders to evaluate real-world, scalable implementation approaches for hypertension control in Lower-MIC settings, producing evidence that can guide policy and system-level decisions and accelerate national or regional rollouts of interventions that are already known to reduce hypertension-related illness and death.
Hy-TREC (U01) Hypertension Outcomes for T4 Research within Lower Middle-Income Countries - FAQs
What is the Hy-TREC (U01) funding opportunity?
Hy-TREC (Hypertension Outcomes for T4 Research within Lower Middle-Income Countries) is an NIH funding opportunity focused on improving how proven hypertension interventions are implemented and scaled in World Bank-defined lower middle-income countries (Lower-MICs). It emphasizes real-world, system-level implementation research rather than developing new clinical treatments.
Which agency is offering this grant?
This opportunity is offered by the National Institutes of Health (NIH) within the U.S. Department of Health and Human Services.
What is the main purpose of this program?
The goal is to make existing, evidence-based approaches to preventing, diagnosing, treating, and controlling high blood pressure work better within real-world health systems, at a scale that can support regional or national impact in Lower-MICs.
Is this program meant to fund new hypertension drugs or novel clinical treatments?
No. The central idea is not to invent brand-new clinical treatments. The focus is on improving implementation and scale-up of interventions that are already known to work.
What does "T4 implementation research" mean in this context?
In this program, T4 refers to late-stage implementation research that is close to routine practice and policy. The emphasis is on strategies that move evidence into everyday care at scale, rather than early-stage efficacy testing.
What types of populations are targeted by Hy-TREC?
The program targets adults and is designed to support scalable hypertension control strategies that can be expanded beyond a single clinic or small pilot.
What countries are the focus of this funding opportunity?
The program is centered on World Bank-defined lower middle-income countries (Lower-MICs) and aims to generate evidence that can guide implementation and scale-up in those settings.
What kind of project scale is expected (pilot vs. regional/national)?
The opportunity emphasizes implementation strategies at the regional or national level. Projects are expected to go beyond isolated pilots and produce findings relevant to broader rollouts.
What kinds of implementation challenges or system changes might be studied under this program?
The opportunity highlights system-level strategies such as how guidelines are adopted, how medicines and blood pressure measurement are reliably delivered, how care teams are organized, how patient follow-up is maintained, how data systems support performance improvement, and how policies and financing arrangements affect sustained hypertension control.
What outcomes is NIH looking for from funded Hy-TREC projects?
The intended results are practical, transferable insights that governments, health systems, and partners in Lower-MICs can use to expand hypertension control programs effectively, supporting faster large-scale adoption of proven interventions.
What funding mechanism is used for Hy-TREC?
The program uses a U01 cooperative agreement mechanism.
What does a U01 cooperative agreement imply for how the project will be run?
A U01 cooperative agreement typically involves a more hands-on partnership with NIH than a standard research project grant. Awardees are generally expected to align closely with the program goals, work collaboratively with NIH scientific staff, and often participate in cross-project coordination or shared expectations around methods and outcomes.
How many awards were anticipated under this opportunity?
The opportunity anticipated making about five awards.
What is the award ceiling listed for this funding opportunity?
The listed award ceiling is $268,500.
What is the Funding Opportunity Number for Hy-TREC?
The Funding Opportunity Number is RFA HL 17 014.
What is the CFDA number associated with this program?
The opportunity is associated with CFDA number 93.840.
When was this funding opportunity originally posted?
The original posting indicates it was created on August 11, 2016.
What was the original closing date for applications?
The original closing date listed was November 8, 2016.
Who is eligible to apply?
Eligibility is described broadly as "Others (see text field entitled Additional Information on Eligibility for clarification)." This indicates that the full announcement would contain the specific eligibility details and may include a range of institution types depending on NIH rules and the FOA requirements, particularly given the Lower-MIC-centered focus.
What kinds of teams are a good fit for Hy-TREC?
The opportunity is designed for teams that can work closely with local stakeholders in Lower-MIC settings to evaluate real-world, scalable implementation approaches for hypertension control and produce evidence that can inform policy and system-level decisions.
Does the program encourage collaboration with local stakeholders?
Yes. The program is described as locally driven and emphasizes working closely with local stakeholders to ensure strategies are relevant to real-world health system conditions and can support regional or national scale-up.
What distinguishes this opportunity from clinical efficacy trials?
This opportunity concentrates on implementation and scale rather than testing whether an intervention works under controlled conditions. The emphasis is on strategies that help proven interventions get adopted, delivered reliably, and sustained within health systems.
What kinds of deliverables or value should projects produce for health systems?
Projects are expected to produce practical and transferable lessons about how to implement and scale hypertension control programs, with evidence useful to governments, health systems, and partners making decisions about broader rollouts.
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