Identification of Biomarkers for Early Detection of Environmentally Induced Mitochondrial Dysfunction (R01) | Apply Online

Opportunity Information: Apply for RFA ES 11 007

The grant opportunity invites applications aimed at identifying biomarkers for early detection of mitochondrial dysfunction influenced by environmental factors. The focus is on utilizing animal and experimental models to uncover how various environmental stressors disrupt normal mitochondrial function. The goal is to enhance the understanding of the mechanisms behind mitochondrial toxicants and develop candidate markers for early dysfunction that can be applied in human population studies linking environmental exposure to disease outcomes.

Mitochondrial biology presents challenges due to its complexity, with variations in stress responses across different tissues, diets, and developmental stages. To effectively create early biomarkers for human studies, several key issues must be resolved. These include investigating how severe mitochondrial impacts in specific tissues correlate with milder effects in other tissues, determining whether changes in mitochondrial function are adaptive or adverse, and identifying early indicators of mitochondrial dysfunction before severe tissue damage occurs. Addressing these questions through well-designed animal and experimental models will be crucial for uncovering reliable markers associated with both genetic and environmental influences on mitochondrial health.

• The National Institutes of Health in the environment health sector is offering a public funding opportunity titled "Identification of Biomarkers for Early Detection of Environmentally Induced Mitochondrial Dysfunction (R01)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113 Environmental Health.
• This funding opportunity was created on Nov 30, 2010 and posted on Nov 30, 2010.
• Applicants must submit their applications by Feb 3, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2025.)
• The funding agency has allocated a total of $2,500,000.00 to eligible and selected applicants.
• Eligible applicants include: Public and State controlled institutions of higher education County governments Special district governments Native American tribal governments (Federally recognized) For profit organizations other than small businesses Native American tribal organizations (other than Federally recognized tribal governments) City or township governments State governments Others (see text field entitled Additional Information on Eligibility for clarification) Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education.
• Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.

Apply for RFA ES 11 007

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