Opportunity Information: Apply for PAR 14 010
Apply for PAR 14 010
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Identification of Gene Variants for Addiction Related Traits by Next Gen Sequencing in Model Organisms Selectively Bred for Addiction Traits (UH2/UH3)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279 Drug Abuse and Addiction Research Programs.
- This funding opportunity was created on Feb 13, 2015 and posted on Nov 22, 2013.
- Applicants must submit their applications by Feb 13, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $125,000.00 in funding.
- Eligible applicants include: Native American tribal organizations (other than Federally recognized tribal governments) State governments Small businesses Independent school districts City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education For profit organizations other than small businesses Public housing authorities/Indian housing authorities Special district governments County governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
This funding opportunity, PAR 14 010, titled "Identification of Gene Variants for Addiction Related Traits by Next Gen Sequencing in Model Organisms Selectively Bred for Addiction Traits (UH2/UH3)," is a National Institutes of Health (NIH) discretionary grant program offered as a cooperative agreement. The central focus is on using next generation sequencing and modern genomic analysis to uncover genetic variants that contribute to addiction related traits, specifically by leveraging animal model organisms that have been selectively bred to show clear, measurable differences in addiction relevant behaviors or biological responses. In practical terms, the program is trying to connect the dots between well characterized addiction-like phenotypes in selectively bred lines and the underlying genomic differences that help explain why those traits emerge.
The opportunity is organized around two main scientific goals. First, it aims to support the development and refinement of strategies, tools, and methodologies for sequencing, mapping, and analyzing the genomes of selectively bred animal models that already have established addiction related phenotypes. This includes the technical and analytical work needed to confidently identify candidate variants: choosing appropriate sequencing approaches, designing mapping strategies that fit the breeding history of the lines, handling the complexities of genomic architecture in model organisms, and building rigorous analysis pipelines that can separate true signals from noise. Second, it aims to identify genetic variants, either from newly created or already existing selectively bred models, that have meaningful implications for addiction related traits. The expectation is that projects will not only generate data, but also produce interpretable results that point to specific variants, regions, or genes that plausibly influence addiction relevant outcomes.
Because the award mechanism is UH2/UH3, the program is structured as a phased cooperative agreement, which typically means an initial, milestone driven exploratory or development phase (UH2) followed by a second phase (UH3) that supports expansion, validation, or more definitive execution once feasibility and performance targets are met. The cooperative agreement aspect also signals substantial involvement from the NIH program side compared to a standard research grant. That usually translates into more coordinated project oversight, clearer go/no go milestones between phases, and closer alignment with program objectives such as data generation standards, genomic analysis expectations, and the overall translational relevance to addiction biology.
From an applicant and organizational standpoint, eligibility is broad. It includes many types of U.S. entities such as state and local governments, public and private institutions of higher education, independent school districts, nonprofits (including both 501(c)(3) and non-501(c)(3) organizations), small businesses, and for profit organizations (including those other than small businesses). It also explicitly includes tribal governments and tribal organizations, public housing authorities, and special district or county governments. In addition, the announcement includes a wide range of mission focused institutions and community connected organizations, such as Historically Black Colleges and Universities (HBCUs), Hispanic Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), and other designated serving institutions. Foreign participation is allowed: non U.S. entities (foreign organizations and foreign institutions) may apply, non U.S. components of U.S. organizations are eligible, and foreign components are permitted as defined under NIH policy. That wide eligibility reflects the reality that next generation sequencing, bioinformatics, and model organism genetics expertise can sit in many different kinds of research environments, not only traditional universities.
Administratively, the opportunity is tied to the NIH program area listed under CFDA 93.279, Drug Abuse and Addiction Research Programs, and it does not require cost sharing or matching. The source information indicates an award ceiling of $125,000. Key dates provided in the source show a posted date of November 22, 2013, with a listed original closing date of June 30, 2016, and a current closing date shown as February 13, 2015, along with an archive date of March 13, 2015. Those date fields suggest the announcement is now archived, but the description still provides a clear picture of what NIH was soliciting: milestone driven projects that use selectively bred addiction trait models as a powerful way to discover and prioritize genetic variants relevant to addiction.
The practical value of this initiative lies in its emphasis on selectively bred lines, which can offer strong, reproducible phenotype differences and therefore a clearer signal for genetic mapping than more heterogeneous populations. By combining those models with next generation sequencing, the program is designed to accelerate discovery of variants and genomic regions that influence addiction related behaviors or biological traits, while also improving the methodological playbook for doing sequencing and genomic analysis in these specialized breeding contexts. The end goal is not just data generation, but actionable genetic insights that can inform future functional studies, target discovery, and broader understanding of addiction vulnerability and mechanisms.
For further details, the full announcement is linked through NIH at http://grants.nih.gov/grants/guide/pa-files/PAR-14-010.html, and NIH provides support contacts through the Office of Extramural Research (OER) for access or linking issues via FBOWebmaster@OD.NIH.GOV.
FAQs: PAR-14-010 (UH2/UH3) - Identification of Gene Variants for Addiction Related Traits by Next Gen Sequencing in Selectively Bred Model Organisms
What is PAR-14-010?
PAR-14-010 is an NIH discretionary funding opportunity titled "Identification of Gene Variants for Addiction Related Traits by Next Gen Sequencing in Model Organisms Selectively Bred for Addiction Traits (UH2/UH3)." It is offered as a cooperative agreement and focuses on using next generation sequencing and modern genomic analysis to identify genetic variants related to addiction-relevant traits in selectively bred animal models.
Which NIH program area does this opportunity fall under?
The opportunity is tied to NIH's Drug Abuse and Addiction Research Programs under CFDA 93.279.
What type of funding mechanism is being used?
This opportunity uses the UH2/UH3 phased cooperative agreement mechanism. That structure typically includes an initial milestone-driven phase (UH2) followed by a second phase (UH3) that supports expansion or more definitive work once feasibility and performance targets are met.
What does "cooperative agreement" mean in this context?
As a cooperative agreement, the program indicates substantial NIH involvement compared to a standard research grant. Based on the description provided, that generally means more coordinated oversight, explicit milestones (including potential go/no-go decisions between phases), and closer alignment with program objectives such as data generation standards and genomic analysis expectations.
What is the main scientific focus of the program?
The central focus is to connect well-characterized addiction-like phenotypes in selectively bred animal lines with the genomic differences that help explain those traits, using next generation sequencing and modern genomic analysis.
Why does the program emphasize selectively bred model organisms?
Selectively bred lines can show clear, reproducible differences in addiction-relevant behaviors or biological responses. The opportunity description highlights that this can produce a stronger signal for genetic mapping than more heterogeneous populations, making it easier to discover meaningful variants and genomic regions.
What are the two major scientific goals described in the opportunity?
The opportunity is organized around two goals: (1) developing and refining strategies, tools, and methods for sequencing, mapping, and analyzing genomes in selectively bred animal models with established addiction-related phenotypes; and (2) identifying genetic variants (from newly created or existing selectively bred models) that have meaningful implications for addiction-related traits.
What kinds of activities are included under the methods/tool development goal?
Examples described include selecting appropriate sequencing approaches, designing mapping strategies that fit the breeding history of the lines, addressing complexities of genomic architecture in model organisms, and building rigorous analysis pipelines capable of distinguishing true genetic signals from noise.
What outcomes are expected from projects funded under this program?
The description indicates that projects are expected to generate data and produce interpretable results that point to specific variants, regions, or genes that plausibly influence addiction-relevant outcomes.
Does the program support work on newly created selectively bred models, existing models, or both?
Both are included. The opportunity states that variant identification may come from newly created or already existing selectively bred models, as long as they are relevant to addiction-related traits.
Is next generation sequencing required?
Next generation sequencing is the central technical approach emphasized in the opportunity description, paired with modern genomic analysis to uncover variants contributing to addiction-related traits.
Who is eligible to apply?
Eligibility is broad and includes many types of U.S. entities such as state and local governments; public and private institutions of higher education; independent school districts; nonprofits (501(c)(3) and non-501(c)(3)); small businesses; and for-profit organizations (including those other than small businesses). The opportunity also explicitly includes tribal governments and tribal organizations, public housing authorities, and special district or county governments.
Are specific institution types explicitly included (such as serving institutions)?
Yes. The announcement explicitly includes a wide range of mission-focused and community-connected institutions, including Historically Black Colleges and Universities (HBCUs), Hispanic Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), and other designated serving institutions.
Can non-U.S. (foreign) organizations apply?
Yes. The opportunity states that non-U.S. entities (foreign organizations and foreign institutions) may apply, non-U.S. components of U.S. organizations are eligible, and foreign components are permitted as defined under NIH policy.
Is cost sharing or matching required?
No. The information provided states that cost sharing or matching is not required.
What is the award ceiling listed for this opportunity?
The source information indicates an award ceiling of $125,000.
What are the key dates mentioned for this announcement?
The posted date is November 22, 2013. The source shows an original closing date of June 30, 2016, a current closing date shown as February 13, 2015, and an archive date of March 13, 2015.
Is this funding opportunity still open?
The date fields provided (including an archive date of March 13, 2015) suggest the announcement is now archived. The listing includes historical close dates, including a current closing date shown as February 13, 2015.
Where can applicants find the full funding announcement?
The full NIH announcement is linked at http://grants.nih.gov/grants/guide/pa-files/PAR-14-010.html.
Who should be contacted for access or linking issues related to the NIH posting?
For access or linking issues, NIH Office of Extramural Research (OER) support is listed as FBOWebmaster@OD.NIH.GOV.
What is the practical value of this initiative according to the description?
The description emphasizes accelerating discovery of variants and genomic regions influencing addiction-related behaviors or biological traits by combining selectively bred lines with next generation sequencing, while also improving the methodological playbook for sequencing and analysis in specialized breeding contexts.
How does this program describe its longer-term impact?
The stated end goal goes beyond data generation to producing actionable genetic insights that can inform future functional studies, target discovery, and broader understanding of addiction vulnerability and mechanisms.
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