Opportunity Information: Apply for PA 11 333
Apply for PA 11 333
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Immunopathogenesis of HIV/AIDS related Oral Manifestations and Host Immunity (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121 Oral Diseases and Disorders Research.
- This funding opportunity was created on Sep 8, 2011 and posted on Sep 8, 2011.
- Applicants must submit their applications by Sep 7, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Public housing authorities/Indian housing authorities Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Special district governments State governments City or township governments For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education County governments Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) Small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
This grant opportunity, titled "Immunopathogenesis of HIV/AIDS related Oral Manifestations and Host Immunity (R21)" (Funding Opportunity Number PA-11-333), was issued by the National Institute of Dental and Craniofacial Research (NIDCR) within the National Institutes of Health. It uses the NIH Exploratory/Developmental Research Grant (R21) mechanism, which is meant for early-stage projects that are intentionally higher risk but could produce high-impact advances. The central goal is to encourage research that turns emerging scientific insights about HIV infection in the oral environment into a clearer, more actionable understanding of how immune responses in the mouth contribute to disease, co-infections, and opportunistic infections linked to HIV/AIDS.
The scientific focus is on the immunopathogenesis of HIV-related oral manifestations, meaning the opportunity is aimed at studies that explain how HIV and the host immune system interact at oral and mucosal surfaces, and how those interactions shape susceptibility to infection, persistence of pathogens, inflammation, tissue damage, and clinical oral disease. A major emphasis is the complicated microbial landscape in the mouth, including oral pathogen co-infections and AIDS-related oral opportunistic infections across viruses, bacteria, and fungi. The FOA is looking for projects that explore the immune mechanisms behind these combined infections, including how HIV-associated immune dysregulation can change oral mucosal defenses and allow opportunistic organisms to cause disease, or how oral microbes and inflammation may in turn influence HIV infection, replication, or transmission risk at mucosal sites.
A key translational thread runs through the announcement: the research is intended to generate knowledge that can guide future development of novel oral mucosal prophylactic HIV vaccines as well as therapeutic strategies targeting HIV itself and the oral co-infections and opportunistic infections that often accompany HIV/AIDS. In practical terms, this means studies should not only describe phenomena but aim to produce insights that could inform interventions, such as identifying immune correlates of protection at oral surfaces, defining mechanisms of mucosal immune failure, clarifying pathogen interactions that amplify disease, or pointing toward targets for immune-based or antimicrobial therapies tailored to the oral cavity.
From an administrative and funding standpoint, this is a discretionary grant program in the health activity category, associated with CFDA number 93.121 (Oral Diseases and Disorders Research). The FOA was posted on September 8, 2011, with an original and final closing date of September 7, 2014, and it was archived on October 8, 2014. The award ceiling listed is $200,000. It does not require cost sharing or matching.
Eligibility is broad and includes many types of organizations. Eligible applicants include public and private institutions of higher education, nonprofits (including both 501(c)(3) and certain non-501(c)(3) entities), for-profit organizations (other than small businesses) as well as small businesses, and a wide range of government entities such as state, county, city or township governments, special district governments, independent school districts, public housing authorities/Indian housing authorities, and tribal governments and tribal organizations. The announcement explicitly includes eligibility for institutions and organizations serving specific populations, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and faith-based or community-based organizations. It also allows non-U.S. participation: foreign institutions may apply, non-U.S. components of U.S. organizations are eligible, and foreign components are allowed as defined by NIH policy.
For reference and official requirements, the full announcement was provided through the NIH Grants Guide at the link in the posting (http://grants.nih.gov/grants/guide/pa-files/PA-11-333.html). For technical access issues related to the electronic posting, NIH directs applicants to contact the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs)
1) What is the title of this grant opportunity?
The opportunity is titled "Immunopathogenesis of HIV/AIDS related Oral Manifestations and Host Immunity (R21)."
2) What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is PA-11-333.
3) Which NIH institute issued this FOA?
This FOA was issued by the National Institute of Dental and Craniofacial Research (NIDCR), within the National Institutes of Health (NIH).
4) What grant mechanism does this FOA use?
This FOA uses the NIH Exploratory/Developmental Research Grant (R21) mechanism.
5) What kinds of projects is the R21 mechanism intended for under this FOA?
The R21 mechanism is intended for early-stage, exploratory/developmental projects that are intentionally higher risk but have the potential to produce high-impact advances.
6) What is the central research goal of this funding opportunity?
The central goal is to encourage research that translates emerging scientific insights about HIV infection in the oral environment into a clearer, more actionable understanding of how immune responses in the mouth contribute to oral disease, co-infections, and opportunistic infections linked to HIV/AIDS.
7) What does "immunopathogenesis of HIV-related oral manifestations" mean in the context of this FOA?
In this FOA, it refers to studies that explain how HIV and the host immune system interact at oral and mucosal surfaces, and how those interactions influence susceptibility to infection, persistence of pathogens, inflammation, tissue damage, and clinical oral disease.
8) What scientific areas are emphasized?
The FOA emphasizes immune mechanisms at oral and mucosal surfaces in HIV/AIDS, including how HIV-associated immune dysregulation affects oral mucosal defenses and how this contributes to oral manifestations, co-infections, and opportunistic infections.
9) Does the FOA focus on co-infections and opportunistic infections in the mouth?
Yes. A major emphasis is the complex microbial landscape in the oral cavity, including oral pathogen co-infections and AIDS-related oral opportunistic infections across viruses, bacteria, and fungi.
10) What types of research questions related to combined infections are encouraged?
The FOA encourages projects that explore immune mechanisms behind combined infections, including how HIV-associated immune dysregulation changes oral mucosal defenses and enables opportunistic organisms to cause disease, and how oral microbes and inflammation may influence HIV infection, replication, or transmission risk at mucosal sites.
11) Is there a translational or intervention-oriented emphasis?
Yes. The announcement includes a strong translational thread, aiming for knowledge that can guide future development of novel oral mucosal prophylactic HIV vaccines and therapeutic strategies targeting HIV as well as oral co-infections and opportunistic infections associated with HIV/AIDS.
12) What kinds of translational outcomes does the FOA suggest projects should inform?
Examples described include identifying immune correlates of protection at oral surfaces, defining mechanisms of mucosal immune failure, clarifying pathogen interactions that amplify disease, and pointing toward targets for immune-based or antimicrobial therapies tailored to the oral cavity.
13) What is the activity category and program type for this opportunity?
It is a discretionary grant program in the health activity category.
14) What CFDA number is associated with this grant opportunity?
The CFDA number listed is 93.121 (Oral Diseases and Disorders Research).
15) What is the award ceiling listed in the announcement?
The award ceiling listed is $200,000.
16) Does this opportunity require cost sharing or matching?
No. The announcement states that cost sharing or matching is not required.
17) When was the FOA posted?
The FOA was posted on September 8, 2011.
18) What were the closing dates for this FOA?
The original and final closing date listed was September 7, 2014.
19) Is the FOA still active?
No. The FOA was archived on October 8, 2014.
20) What types of organizations are eligible to apply?
Eligibility is broad and includes public and private institutions of higher education, nonprofit organizations (including 501(c)(3) and certain non-501(c)(3) entities), for-profit organizations (including small businesses and other than small businesses), and many government entities.
21) Which government entities are included as eligible applicants?
The announcement includes eligibility for state governments, county governments, city or township governments, special district governments, independent school districts, public housing authorities/Indian housing authorities, and tribal governments and tribal organizations.
22) Are organizations serving specific populations explicitly included?
Yes. The FOA explicitly includes organizations such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and faith-based or community-based organizations.
23) Are foreign institutions or non-U.S. components allowed to participate?
Yes. Foreign institutions may apply, non-U.S. components of U.S. organizations are eligible, and foreign components are allowed as defined by NIH policy.
24) Where can applicants find the official FOA text and requirements?
The full announcement was provided through the NIH Grants Guide at: http://grants.nih.gov/grants/guide/pa-files/PA-11-333.html
25) Who should be contacted for technical access issues related to the electronic posting?
For technical access issues related to the electronic posting, NIH directs applicants to contact the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
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