Opportunity Information: Apply for PA 11 334
Apply for PA 11 334
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Immunopathogenesis of HIV/AIDS related Oral Manifestations and Host Immunity (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121 Oral Diseases and Disorders Research.
- This funding opportunity was created on Sep 8, 2011 and posted on Sep 8, 2011.
- Applicants must submit their applications by Sep 7, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: For profit organizations other than small businesses Special district governments Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) County governments City or township governments State governments Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The NIH National Institute of Dental and Craniofacial Research (NIDCR) created this Funding Opportunity Announcement, PA-11-334, to support R01 research projects focused on how HIV infection interacts with the mouth and oral immune system. The central theme is immunopathogenesis: understanding the immune mechanisms that drive HIV/AIDS-related oral manifestations, especially in the real-world context where people often experience co-infections with oral pathogens (viruses, bacteria, and fungi) and develop AIDS-related oral opportunistic infections. The FOA emphasizes translating newer scientific insights into a clearer, mechanistic picture of what is happening in oral mucosal tissues during HIV infection and during these co-infections, with the practical aim of informing next-step translational work.
A key goal is to generate knowledge that can guide development of novel oral mucosal prophylactic HIV vaccines. In other words, the announcement is not only interested in systemic immunity in general, but specifically in immune responses at the oral mucosa, where the biology and immune defenses can differ from other mucosal sites and from blood-based immune readouts. Alongside vaccine-relevant work, the FOA also encourages studies that can point toward therapeutic strategies for HIV itself as well as for oral co-infections and oral opportunistic infections. The expectation is that stronger mechanistic understanding of host immunity in the oral environment will help identify targets, pathways, and intervention concepts that could be developed into preventions or treatments.
This opportunity was offered as a discretionary grant under the R01 mechanism, meaning it supported investigator-initiated research projects that fit the scientific priorities laid out in the announcement. It falls under the health activity category and is associated with CFDA number 93.121 (Oral Diseases and Disorders Research). There was no cost-sharing or matching requirement, so applicants were not required to contribute non-federal funds as a condition of the award.
Eligibility was broad and included many types of U.S. organizations such as public and private institutions of higher education, nonprofits (including those with and without 501(c)(3) status), for-profit organizations (including small businesses and other for-profits), and multiple levels of government entities (state, county, city/township, special district governments, and certain housing authorities). The FOA also explicitly included a wide range of special categories and community-focused institutions, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, faith-based and community-based organizations, and regional organizations. Importantly, non-U.S. entities (foreign institutions) were eligible to apply, non-U.S. components of U.S. organizations could participate, and foreign components were allowed as defined by NIH policy, reflecting an openness to international expertise and study populations where appropriate.
In terms of timing and status, the FOA was posted and created on September 8, 2011, with an original and final closing date of September 7, 2014, and it was archived on October 8, 2014. That means it is no longer open for applications, but it remains a useful reference point for NIDCR priorities at the intersection of HIV, oral infections, oral mucosal immunity, and translational directions such as mucosal vaccine strategies and therapeutics.
For full details, the announcement was hosted on the NIH Grants Guide site at http://grants.nih.gov/grants/guide/pa-files/PA-11-334.html, and NIH’s Office of Extramural Research provided an electronic access contact (the NIH OER Webmaster) for technical issues with the posting.
FAQs: NIH/NIDCR Funding Opportunity PA-11-334 (R01)
What is PA-11-334?
PA-11-334 is a Funding Opportunity Announcement (FOA) created by the NIH National Institute of Dental and Craniofacial Research (NIDCR) to support R01 research projects focused on how HIV infection interacts with the mouth and the oral immune system, with an emphasis on immunopathogenesis.
Which NIH institute issued this FOA?
This FOA was issued by the NIH National Institute of Dental and Craniofacial Research (NIDCR).
What grant mechanism does this opportunity use?
The opportunity uses the NIH R01 mechanism and was offered as a discretionary grant supporting investigator-initiated research projects aligned with the FOA's scientific priorities.
What is the main scientific theme of this FOA?
The central theme is immunopathogenesis: understanding immune mechanisms that drive HIV/AIDS-related oral manifestations, especially in real-world settings where people often have co-infections with oral pathogens (viruses, bacteria, and fungi) and can develop AIDS-related oral opportunistic infections.
What kinds of co-infections does the FOA highlight?
The FOA highlights co-infections with oral pathogens including viruses, bacteria, and fungi, and it specifically notes the importance of AIDS-related oral opportunistic infections in the context of HIV infection.
What type of immune responses is this FOA especially interested in?
The FOA is especially interested in immune responses at the oral mucosa. It emphasizes that oral mucosal biology and immune defenses can differ from other mucosal sites and from blood-based immune readouts, and it seeks mechanistic clarity about what is happening in oral mucosal tissues during HIV infection and co-infections.
Is this FOA focused on basic science, translational science, or both?
Based on the description provided, it emphasizes translating newer scientific insights into a clearer mechanistic picture of oral mucosal immune processes during HIV and co-infections, with the practical aim of informing next-step translational work.
How does this FOA connect to HIV vaccine research?
A key goal is to generate knowledge that can guide the development of novel oral mucosal prophylactic HIV vaccines. The FOA is interested in vaccine-relevant immunity specifically at the oral mucosa rather than focusing only on systemic immunity.
Does the FOA support research relevant to therapies as well as vaccines?
Yes. Alongside vaccine-relevant work, the FOA encourages studies that can point toward therapeutic strategies for HIV itself and for oral co-infections and oral opportunistic infections.
What is the practical outcome NIDCR expects from projects funded under this FOA?
The FOA expects that stronger mechanistic understanding of host immunity in the oral environment will help identify targets, pathways, and intervention concepts that could be developed into preventions or treatments, including translational directions like mucosal vaccine strategies and therapeutics.
What is the CFDA number associated with this opportunity?
The opportunity is associated with CFDA number 93.121, titled Oral Diseases and Disorders Research.
What is the activity category for this opportunity?
It falls under the health activity category.
Was cost sharing or matching required?
No. There was no cost-sharing or matching requirement, so applicants were not required to contribute non-federal funds as a condition of the award.
Who was eligible to apply?
Eligibility was broad and included many types of U.S. organizations, including public and private institutions of higher education; nonprofits (with and without 501(c)(3) status); for-profit organizations (including small businesses and other for-profits); and government entities such as state, county, city/township, special district governments, and certain housing authorities.
Were community-based and special-category institutions eligible?
Yes. The FOA explicitly included categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, faith-based and community-based organizations, and regional organizations.
Could foreign (non-U.S.) institutions apply?
Yes. Non-U.S. entities (foreign institutions) were eligible to apply, non-U.S. components of U.S. organizations could participate, and foreign components were allowed as defined by NIH policy.
When was PA-11-334 posted and when did it close?
The FOA was posted and created on September 8, 2011. The original and final closing date was September 7, 2014.
Is PA-11-334 still open for applications?
No. The FOA was archived on October 8, 2014, which indicates it is no longer open for applications.
Why might this archived FOA still be useful?
Even though it is no longer open, it can still serve as a reference point for NIDCR priorities at the intersection of HIV, oral infections, oral mucosal immunity, and translational directions such as mucosal vaccine strategies and therapeutics.
Where can I find the original FOA text?
The announcement was hosted on the NIH Grants Guide site at http://grants.nih.gov/grants/guide/pa-files/PA-11-334.html.
Who should be contacted for technical issues accessing the FOA online?
NIH's Office of Extramural Research provided an electronic access contact for technical issues with the posting: the NIH OER Webmaster.
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Previous opportunity: Immunopathogenesis of HIV/AIDS related Oral Manifestations and Host Immunity (R21)
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