Opportunity Information: Apply for PA 14 129
Apply for PA 14 129
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Improving Delivery of HIV Prevention and Treatment through Implementation Science and Translational Research (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants 93.855 Allergy and Infectious Diseases Research 93.856 Microbiology and Infectious Diseases Research.
- This funding opportunity was created on Feb 28, 2014 and posted on Feb 28, 2014.
- Applicants must submit their applications by Jan 7, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Special district governments Private institutions of higher education Independent school districts City or township governments Others (see text field entitled Additional Information on Eligibility for clarification) For profit organizations other than small businesses Public housing authorities/Indian housing authorities County governments Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments Small businesses Native American tribal organizations (other than Federally recognized tribal governments).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The NIH funding opportunity PA-14-129, titled "Improving Delivery of HIV Prevention and Treatment through Implementation Science and Translational Research (R21)," supports exploratory, early-stage research aimed at closing the gap between interventions that work in controlled studies and interventions that actually reach people in everyday clinical and community settings. The central idea is straightforward: many HIV prevention and treatment strategies have already proven effective, but their real-world public health impact depends on whether they can be delivered consistently, efficiently, and equitably to the men, women, and children who need them. This FOA focuses on research that studies how to implement, adapt, scale, and sustain HIV-related interventions in real-world environments, including clinics, community programs, and other service settings.
A major emphasis of the announcement is implementation science and translational research, meaning projects should go beyond showing that an intervention can work and instead examine how to make it work in practice across different settings and populations. The FOA highlights several priority goals: improving the efficiency and effectiveness of delivering proven HIV prevention and treatment interventions in routine care; making it easier to transfer interventions from one population or setting to another (for example, adapting a clinic-based approach for community settings, or tailoring an intervention that worked in one region for use in another); and helping decision-makers choose smarter, evidence-informed combinations of interventions rather than relying on single strategies in isolation. In practice, this could include studying barriers to uptake, testing strategies to improve adherence and retention in care, optimizing workflows, strengthening linkage-to-care processes, evaluating provider or system-level supports, and designing implementation approaches that fit the realities of resource constraints, staffing, stigma, and local infrastructure.
This opportunity uses the NIH R21 mechanism, which is generally designed for innovative, developmental, or high-impact pilot work that can generate actionable evidence and position teams for larger-scale studies later. The award ceiling listed is $200,000, and the program does not require cost sharing or matching funds. The funding instrument type is a grant, and it falls within the broad health research activity area. The opportunity is associated with CFDA numbers 93.242 (Mental Health Research Grants), 93.855 (Allergy and Infectious Diseases Research), and 93.856 (Microbiology and Infectious Diseases Research), reflecting the cross-cutting nature of HIV research across behavioral, clinical, and infectious disease domains.
Eligibility is broad and includes a wide range of organizations that might be positioned to study real-world implementation, such as public and private institutions of higher education, nonprofit organizations (both with and without 501(c)(3) status), for-profit organizations (other than small businesses), small businesses, state and local governments (including counties, cities, townships, special districts, and independent school districts), public housing authorities/Indian housing authorities, and tribal governments and tribal organizations. The FOA also explicitly includes many institution types and community-centered organizations that are often critical partners in HIV implementation work, such as faith-based and community-based organizations, Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs). Importantly, non-U.S. entities (foreign organizations and foreign institutions) are eligible to apply, non-U.S. components of U.S. organizations may apply, and foreign components are allowed as defined by NIH policy, which aligns with the global nature of HIV and the need to test implementation strategies in diverse contexts.
Key administrative details reflect that this was a discretionary NIH grant opportunity posted on February 28, 2014, with an original and current closing date of January 7, 2017, and an archive date of February 7, 2017. While the FOA itself is archived, the description remains useful as a clear statement of NIH priorities around turning proven HIV interventions into real-world impact through better delivery systems, better adaptation across contexts, and better selection of combination intervention packages. The full announcement was hosted on the NIH grants site, and NIH provided standard technical contact support through the NIH Office of Extramural Research (OER) webmaster for access or linking issues.
FAQs: NIH PA-14-129 - Improving Delivery of HIV Prevention and Treatment through Implementation Science and Translational Research (R21)
What is NIH funding opportunity PA-14-129?
PA-14-129 is an NIH Funding Opportunity Announcement (FOA) titled "Improving Delivery of HIV Prevention and Treatment through Implementation Science and Translational Research (R21)." It supports exploratory, early-stage research focused on improving how proven HIV prevention and treatment interventions are delivered in real-world settings.
What is the main purpose of this FOA?
The purpose is to close the gap between HIV interventions that work in controlled research studies and interventions that actually reach people consistently and effectively in everyday clinical and community environments. The FOA emphasizes studying how to implement, adapt, scale, and sustain effective HIV-related interventions in practice.
What type of research does this announcement emphasize?
The FOA emphasizes implementation science and translational research. Instead of only demonstrating that an intervention can work, projects are expected to examine how to make it work in routine care and service settings across different populations and contexts.
What kinds of settings are relevant for proposed projects?
The FOA highlights real-world environments where HIV services are delivered, including clinics, community programs, and other service settings. The focus is on routine practice conditions rather than tightly controlled research environments.
What are the priority goals highlighted in the FOA?
The FOA highlights three major priority goals: (1) improve the efficiency and effectiveness of delivering proven HIV prevention and treatment interventions in routine care; (2) make it easier to transfer interventions from one population or setting to another (for example, from clinic-based delivery to community settings, or from one region to another); and (3) help decision-makers choose smarter, evidence-informed combinations of interventions rather than relying on single strategies alone.
What does "implementation science" mean in the context of this FOA?
In this FOA, implementation science refers to research on the methods and strategies used to adopt, integrate, deliver, and sustain evidence-based HIV interventions in real-world systems. The emphasis is on delivery processes, context, and practical barriers that affect whether proven interventions achieve public health impact.
What does "translational research" mean in the context of this FOA?
Here, translational research is framed as moving beyond controlled efficacy to practical, real-world use. It includes studying how interventions can be adapted and applied effectively across settings, populations, and service infrastructures so that more people can benefit.
What are examples of topics this FOA suggests applicants could study?
The FOA provides examples such as studying barriers to uptake of proven interventions, testing strategies to improve adherence and retention in care, optimizing workflows, strengthening linkage-to-care processes, evaluating provider- or system-level supports, and designing implementation approaches that reflect resource constraints, staffing limitations, stigma, and local infrastructure.
Does this opportunity focus on single interventions or combinations?
A specific emphasis is placed on supporting evidence-informed decisions about combinations of interventions, rather than focusing only on single strategies. The FOA notes that decision-makers often need guidance on selecting packages of interventions that work together in real settings.
What is the funding mechanism used for this FOA?
This opportunity uses the NIH R21 mechanism, which is generally intended for innovative, developmental, or high-impact pilot work that can generate actionable evidence and position teams for larger studies later.
What is the award ceiling for this R21 opportunity?
The award ceiling listed for this FOA is $200,000.
Is cost sharing or matching required?
No. The FOA states that cost sharing or matching funds are not required.
What is the funding instrument type?
The funding instrument type is a grant.
What general research area does this opportunity fall under?
It falls within the broad health research activity area, with an HIV-specific focus on prevention and treatment delivery in real-world systems.
Which CFDA numbers are associated with this FOA?
The opportunity is associated with CFDA numbers 93.242 (Mental Health Research Grants), 93.855 (Allergy and Infectious Diseases Research), and 93.856 (Microbiology and Infectious Diseases Research), reflecting HIV's cross-cutting behavioral, clinical, and infectious disease dimensions.
Who is eligible to apply?
Eligibility is broad and includes public and private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), for-profit organizations (other than small businesses), small businesses, and various government entities including state and local governments (counties, cities, townships, special districts, and independent school districts).
Are tribal entities eligible to apply?
Yes. Tribal governments and tribal organizations are explicitly included as eligible applicants.
Are public housing authorities eligible?
Yes. Public housing authorities and Indian housing authorities are listed as eligible organization types.
Are community-based and faith-based organizations eligible?
Yes. The FOA explicitly includes faith-based and community-based organizations, reflecting the importance of community-centered partners in HIV implementation efforts.
Does the FOA include eligibility for minority-serving institutions?
Yes. The FOA explicitly includes institutions such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs).
Are non-U.S. (foreign) organizations eligible to apply?
Yes. Non-U.S. entities (foreign organizations and foreign institutions) are eligible to apply.
Can non-U.S. components of U.S. organizations apply?
Yes. Non-U.S. components of U.S. organizations may apply.
Are foreign components allowed under this FOA?
Yes. Foreign components are allowed as defined by NIH policy, which aligns with the global nature of HIV and the need to evaluate implementation strategies in diverse settings.
When was this FOA posted?
The FOA was posted on February 28, 2014.
What were the closing date and archive date for this opportunity?
The original and current closing date listed is January 7, 2017, and the archive date is February 7, 2017.
Is this FOA still open for applications?
No. The FOA is archived, and the listed closing date has passed.
If the FOA is archived, why is it still useful?
Even though it is archived, the description provides a clear statement of NIH priorities for improving real-world delivery of proven HIV prevention and treatment interventions through implementation science, adaptation across contexts, and better selection of combination intervention packages.
Where was the full announcement hosted?
The full announcement was hosted on the NIH grants website.
Who provided technical contact support for access or linking issues?
NIH provided standard technical contact support through the NIH Office of Extramural Research (OER) webmaster for access or linking issues.
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