Opportunity Information: Apply for PA 12 131
Apply for PA 12 131
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Improving Translational and Basic Research to Control Itch in Humans (ITCH) (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.846 Arthritis, Musculoskeletal and Skin Diseases Research.
- This funding opportunity was created on Mar 20, 2012 and posted on Mar 20, 2012.
- Applicants must submit their applications by May 7, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Special district governments Public and State controlled institutions of higher education Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) Small businesses State governments Native American tribal governments (Federally recognized) City or township governments Public housing authorities/Indian housing authorities.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The NIH funding opportunity PA 12 131, titled "Improving Translational and Basic Research to Control Itch in Humans (ITCH) (R01)," is an R01 grant program designed to push forward both basic science and translational research focused on itch. Its central aim is to deepen understanding of the biological and neurological mechanisms that generate itch sensations and to support the development of strategies that can modulate, reduce, or otherwise control itch in the context of disease and rehabilitation. The program frames itch as an important, still-developing area of research and is intended to speed up progress by encouraging studies that can move efficiently from fundamental discovery toward practical approaches that could ultimately improve patient outcomes in areas relevant to the mission of the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS).
This FOA emphasizes a broad scientific scope rather than a narrow set of prescribed methods. It supports investigations using animal models, human models, or combinations of both, as long as the work meaningfully advances knowledge about itch pathways or itch control. The translational angle is central: projects are expected to help bridge bench and bedside by translating mechanistic insights into approaches that could inform future interventions. The announcement also highlights multidisciplinary collaboration as a priority, reflecting the reality that itch research often spans neuroscience, dermatology, immunology, pain research, rehabilitation science, and related fields. The intent is to foster faster exchange of ideas and findings between laboratory-based researchers and human-focused investigators, accelerating therapy development or therapeutic concepts even if the work does not yet involve testing an intervention in a clinical trial setting.
A key limitation is that the FOA is not intended to support applications proposing clinical trials. In practice, that means applicants should focus on mechanistic studies, tool and method development, translational experiments, biomarker or pathway characterization, and other preclinical or human-subject research that does not meet the definition of a clinical trial. Human studies may still be possible when they are observational, mechanistic, or otherwise structured to understand itch biology or modulation without testing a clinical intervention in a trial framework. Applicants would typically need to ensure their proposed work aligns with NIH definitions and policies so the application is clearly positioned as non-clinical-trial research under this announcement.
Administratively, this is a discretionary, health-related grant opportunity using the NIH R01 funding instrument. It falls under CFDA 93.846 (Arthritis, Musculoskeletal and Skin Diseases Research) and does not require cost sharing or matching. The opportunity was posted and created on March 20, 2012, with an original and final closing date of May 7, 2015, and it was archived on June 7, 2015. That timeline indicates it is no longer open for new applications under this specific FOA, though similar NIH itch-related funding may appear under newer announcements or parent R01 mechanisms.
Eligibility is broad and includes many organization types. Eligible applicants include nonprofit organizations (both with and without 501(c)(3) status), for-profit organizations (other than small businesses), small businesses, public and private institutions of higher education, and various government entities such as state, county, city/township governments, special district governments, and independent school districts. Tribal governments and tribal organizations are eligible, including federally recognized tribal governments as well as other tribal entities. The FOA also explicitly includes a range of mission-driven institutions and community-based organizations, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, and U.S. territories or possessions. Importantly, foreign institutions and non-U.S. entities are eligible to apply, and foreign components of U.S. organizations are allowed, consistent with the NIH Grants Policy Statement.
The sponsoring agency is the National Institutes of Health, with the scientific emphasis aligned to NIAMS interests in skin, musculoskeletal, and related conditions where itch is a major symptom burden. The full announcement was provided via the NIH grants guide at http://grants.nih.gov/grants/guide/pa-files/PA-12-131.html. For access or technical issues with the electronic posting, the listed point of contact is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
FAQs: NIH PA-12-131 - Improving Translational and Basic Research to Control Itch in Humans (ITCH) (R01)
What is PA-12-131?
PA-12-131 is an NIH Funding Opportunity Announcement (FOA) titled "Improving Translational and Basic Research to Control Itch in Humans (ITCH) (R01)." It uses the NIH R01 grant mechanism to support research aimed at improving understanding and control of itch.
What is the main goal of this funding opportunity?
The central goal is to advance both basic and translational research on itch by deepening understanding of the biological and neurological mechanisms that generate itch sensations and by supporting the development of strategies that can modulate, reduce, or otherwise control itch in the context of disease and rehabilitation.
What kinds of research does the FOA encourage?
The FOA encourages a broad range of studies that meaningfully advance knowledge about itch pathways or itch control. This includes mechanistic research, translational experiments that help bridge bench and bedside, and work intended to speed progress from fundamental discovery toward practical approaches that could ultimately improve patient outcomes.
Is the focus basic science, translational research, or both?
Both. The FOA is specifically designed to push forward basic research on itch mechanisms as well as translational research that connects mechanistic insights to approaches that may inform future therapies or therapeutic concepts.
Does the FOA require a specific methodology or research approach?
No. The FOA emphasizes broad scientific scope rather than prescribing narrow methods. Projects may use animal models, human models, or combinations of both, as long as the work advances understanding of itch biology or control.
Are animal models allowed?
Yes. Investigations using animal models are explicitly supported, provided they meaningfully contribute to understanding itch pathways, mechanisms, or control strategies.
Are human studies allowed under this FOA?
Yes. Human studies may be appropriate when they are observational, mechanistic, or otherwise designed to understand itch biology or modulation without testing a clinical intervention in a clinical trial framework.
Does this FOA support clinical trials?
No. A stated limitation is that the FOA is not intended to support applications proposing clinical trials. Applicants are expected to propose non-clinical-trial research consistent with NIH definitions and policies.
If clinical trials are not allowed, what types of projects fit best?
Projects that fit the FOA include mechanistic studies, tool and method development, translational experiments, and biomarker or pathway characterization, as well as other preclinical or human-subject research that does not meet the NIH definition of a clinical trial.
How does the FOA define the translational emphasis?
The translational angle is central and aims to bridge laboratory discovery and human relevance. The FOA encourages studies that move efficiently from mechanistic insights toward practical approaches that could inform future interventions, even if the project does not involve testing an intervention in a clinical trial setting.
Is multidisciplinary collaboration encouraged?
Yes. The FOA highlights multidisciplinary collaboration as a priority, reflecting that itch research commonly spans neuroscience, dermatology, immunology, pain research, rehabilitation science, and related fields. The intent is to encourage exchange between laboratory-based and human-focused investigators to accelerate progress.
Which NIH institute or mission area is this aligned with?
The sponsoring agency is the National Institutes of Health (NIH), with the scientific emphasis aligned to the mission of the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), particularly in conditions where itch is a major symptom burden.
What funding mechanism is used?
This opportunity uses the NIH R01 grant mechanism.
Is cost sharing or matching required?
No. The FOA specifies that cost sharing or matching is not required.
What is the CFDA number associated with this opportunity?
The FOA is associated with CFDA 93.846, "Arthritis, Musculoskeletal and Skin Diseases Research."
Is PA-12-131 still open for applications?
No. The opportunity was posted and created on March 20, 2012, had an original and final closing date of May 7, 2015, and was archived on June 7, 2015. That timeline indicates it is no longer open for new applications under this specific FOA.
If it is archived, can applicants still pursue NIH itch-related funding?
The FOA notes that while this specific announcement is no longer open, similar itch-related funding may appear under newer NIH announcements or through parent R01 mechanisms.
Who is eligible to apply?
Eligibility is broad and includes nonprofit organizations (with or without 501(c)(3) status), for-profit organizations (other than small businesses), small businesses, public and private institutions of higher education, and various government entities (including state, county, city/township, special district governments, and independent school districts). Tribal governments and tribal organizations are eligible, including federally recognized tribal governments and other tribal entities.
Are minority-serving or community-based institutions included in the eligibility list?
Yes. The FOA explicitly includes Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, and U.S. territories or possessions.
Are foreign institutions allowed to apply?
Yes. Foreign institutions and non-U.S. entities are eligible to apply, and foreign components of U.S. organizations are allowed, consistent with the NIH Grants Policy Statement.
Where can the official FOA be found?
The full announcement is available through the NIH Grants Guide at: http://grants.nih.gov/grants/guide/pa-files/PA-12-131.html
Who should be contacted for technical issues accessing the electronic posting?
For access or technical issues with the electronic posting, the listed contact is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
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