Opportunity Information: Apply for PAR 13 323
Apply for PAR 13 323
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Increased Knowledge and Innovative Strategies to Reduce HIV IncidenceiKnow Projects (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants 93.279 Drug Abuse and Addiction Research Programs 93.855 Allergy and Infectious Diseases Research 93.856 Microbiology and Infectious Diseases Research.
- This funding opportunity was created on Aug 8, 2013 and posted on Aug 8, 2013.
- Applicants must submit their applications by Jan 7, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments) Native American tribal governments (Federally recognized) Independent school districts Small businesses Special district governments For profit organizations other than small businesses Private institutions of higher education State governments City or township governments Others (see text field entitled Additional Information on Eligibility for clarification) Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Increased Knowledge and Innovative Strategies to Reduce HIV Incidence (iKnow) Projects (R01) funding opportunity, issued by the National Institutes of Health (NIH) under Funding Opportunity Number PAR-13-323, supported research aimed at reducing HIV incidence by improving how people with undiagnosed HIV are identified and how transmission is prevented. The FOA emphasized practical, innovative work that could generate actionable knowledge for public health and clinical settings, with a clear focus on populations where undiagnosed infection and ongoing transmission remain significant challenges. As an R01 mechanism, the opportunity was structured to fund full-scale, hypothesis-driven research projects rather than small pilot awards, while still encouraging novel approaches and integrated strategies.
The FOA had two core research objectives, and applicants could address either one or both. First, it sought optimal strategies to find people who are unaware of their HIV-1 infection and to successfully link them to key services. That includes improving identification methods (for example, more effective screening approaches, outreach models, or testing strategies) and ensuring that once someone is identified they are connected to HIV testing and then rapidly linked to treatment and prevention interventions. In practical terms, this objective targets the common real-world drop-offs between risk, testing, diagnosis, and engagement in care, where individuals can be lost at many points due to structural barriers, stigma, access issues, or ineffective service models.
Second, the FOA encouraged the development and evaluation of novel, integrated intervention packages that combine biomedical and behavioral strategies to reduce the likelihood of onward transmission. The emphasis on integration signals that NIH was looking for approaches that do not treat biomedical tools and behavioral interventions as separate silos. Instead, the goal was to examine combinations that work together in realistic settings and to evaluate whether those combined approaches are feasible and acceptable for the intended populations. Feasibility and acceptability are critical here because even highly effective biomedical tools can fail to reduce transmission if people cannot access them, do not adhere to them, or find the delivery model unworkable or culturally mismatched. While the announcement summary does not list specific required interventions, the language points toward research that tests how to package, deliver, and sustain multi-component prevention and treatment strategies in ways that people will actually use.
From an administrative standpoint, this was a discretionary grant opportunity using the NIH grant funding instrument and falling under education and health-related activity categories. It carried no cost-sharing or matching requirement, which typically lowers the barrier to entry for applicants that might not have the ability to provide significant non-federal contributions. The program was posted and created on August 8, 2013, with an original and final closing date of January 7, 2016, and it was archived on February 7, 2016. That means it is no longer open for new applications under that specific announcement, though similar NIH HIV prevention and implementation science opportunities may exist under newer FOAs.
Eligibility was broad and inclusive, spanning many types of U.S. organizations as well as non-U.S. entities. Eligible applicants included state, county, and city or township governments; special district governments; public and state-controlled institutions of higher education; private institutions of higher education; independent school districts; public housing authorities and Indian housing authorities; nonprofit organizations with or without 501(c)(3) status; small businesses and other for-profit organizations; and a variety of community-based and faith-based organizations. The FOA also explicitly included institutions and organizations serving specific populations, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American and Native American Pacific Islander Serving Institutions. In addition, foreign organizations and foreign institutions were eligible to apply, and non-domestic components of U.S. organizations could participate, with foreign components allowed as defined by NIH policy. This wide eligibility aligns with the reality that effective HIV incidence reduction work often requires partnerships across academic research, public health practice, community organizations, healthcare systems, and international settings.
The opportunity was associated with multiple CFDA program areas, reflecting NIH institute participation across mental health, substance use, and infectious disease domains: 93.242 (Mental Health Research Grants), 93.279 (Drug Abuse and Addiction Research Programs), 93.855 (Allergy and Infectious Diseases Research), and 93.856 (Microbiology and Infectious Diseases Research). This mix signals that NIH viewed the challenge of undiagnosed infection and transmission reduction as intersecting with behavioral health, substance use, and broader infectious disease research, not solely as a narrow clinical testing issue.
For applicants seeking the full archived announcement details, NIH provided an Additional Information link to the NIH Grants Guide page (http://grants.nih.gov/grants/guide/pa-files/PAR-13-323.html). The contact listed for access or linking problems was the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV, which is typical for technical assistance with the posting rather than scientific or programmatic questions.
Frequently Asked Questions (FAQs)
What is the iKnow Projects (R01) funding opportunity?
The Increased Knowledge and Innovative Strategies to Reduce HIV Incidence (iKnow) Projects (R01) was a National Institutes of Health (NIH) funding opportunity that supported research to reduce HIV incidence. It focused on improving how people with undiagnosed HIV are identified and on developing effective strategies to prevent onward transmission in real-world public health and clinical settings.
What is the Funding Opportunity Number for this announcement?
The Funding Opportunity Number (FOA) is PAR-13-323.
What type of grant mechanism was used?
This opportunity used the NIH R01 mechanism, which is designed for full-scale, hypothesis-driven research projects rather than small pilot awards. The FOA still encouraged innovative and integrated approaches within that full project structure.
What were the main goals of the FOA?
The FOA emphasized practical and innovative research that could produce actionable knowledge to reduce HIV incidence, particularly in populations where undiagnosed HIV infection and ongoing transmission remain significant challenges.
What were the two core research objectives applicants could address?
Applicants could propose work aligned to either or both of the following objectives: (1) develop optimal strategies to find people unaware of their HIV-1 infection and link them to key services, and/or (2) develop and evaluate novel, integrated intervention packages that combine biomedical and behavioral strategies to reduce onward transmission.
What does the FOA mean by identifying people who are unaware of their HIV-1 infection?
This refers to improving methods to find individuals who have HIV but have not yet been diagnosed. The FOA pointed to approaches such as more effective screening, outreach models, or testing strategies designed to reach people who are not being identified through existing systems.
What kinds of linkage activities were emphasized after identification?
The FOA highlighted the need to connect people to HIV testing and then rapidly link them to treatment and prevention interventions. The intent was to reduce real-world drop-offs between risk, testing, diagnosis, and engagement in care, where people can be lost due to barriers like stigma, access limitations, structural challenges, or ineffective service models.
What does "integrated intervention packages" mean in this FOA?
It means intervention approaches that combine biomedical and behavioral strategies together rather than treating them as separate silos. The FOA encouraged research on how combined components can work together in realistic settings, including how such packages are delivered and sustained.
Did the FOA require specific interventions to be included in the integrated packages?
The summary information provided does not list specific required interventions. Instead, it indicates that NIH was interested in research that tests how to package, deliver, and sustain multi-component prevention and treatment strategies in ways people will actually use.
Why did the FOA emphasize feasibility and acceptability?
The FOA treated feasibility and acceptability as critical because even effective biomedical tools may not reduce transmission if people cannot access them, do not adhere to them, or find the delivery approach unworkable or culturally mismatched. The emphasis was on strategies that can function in real-world contexts for the intended populations.
Was cost-sharing or matching required?
No. The opportunity had no cost-sharing or matching requirement.
What federal agency issued the opportunity?
The opportunity was issued by the National Institutes of Health (NIH).
What type of funding instrument was used?
This was a discretionary grant opportunity using the NIH grant funding instrument.
When was the FOA posted and when did it close?
The FOA was posted and created on August 8, 2013. The original and final closing date was January 7, 2016.
Is this funding opportunity still open?
No. The FOA was archived on February 7, 2016, meaning it is no longer open for new applications under that specific announcement.
Could similar opportunities still exist?
Yes. While this specific FOA is archived, similar NIH HIV prevention and implementation science opportunities may exist under newer funding announcements.
Who was eligible to apply?
Eligibility was broad and included many types of U.S. organizations and non-U.S. entities. Eligible applicants included various levels of government (state, county, city/township), special district governments, public and private institutions of higher education, independent school districts, public housing authorities and Indian housing authorities, nonprofit organizations (with or without 501(c)(3) status), small businesses and other for-profit organizations, and community-based and faith-based organizations.
Were organizations serving specific populations explicitly included?
Yes. The FOA explicitly included institutions and organizations such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American and Native American Pacific Islander Serving Institutions.
Were foreign organizations eligible to apply?
Yes. Foreign organizations and foreign institutions were eligible to apply. In addition, non-domestic components of U.S. organizations could participate, and foreign components were allowed as defined by NIH policy.
What does the FOA suggest about collaboration and settings?
The broad eligibility and the focus on practical, actionable knowledge reflect the reality that reducing HIV incidence often requires partnerships across academic research, public health practice, community organizations, healthcare systems, and in some cases international settings.
Which CFDA program areas were associated with this opportunity?
The FOA was associated with multiple CFDA areas: 93.242 (Mental Health Research Grants), 93.279 (Drug Abuse and Addiction Research Programs), 93.855 (Allergy and Infectious Diseases Research), and 93.856 (Microbiology and Infectious Diseases Research).
What do the listed CFDA areas imply about the research scope?
The mix of CFDA areas suggests NIH viewed undiagnosed infection and transmission reduction as intersecting with mental health, substance use, and infectious disease research, rather than as only a narrow clinical testing issue.
Where can applicants find the archived FOA details?
The archived announcement details were provided via the NIH Grants Guide page at: http://grants.nih.gov/grants/guide/pa-files/PAR-13-323.html
Who should be contacted for technical problems with access or linking?
The contact listed for access or linking problems was the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV. This contact is for technical assistance with the posting, not for scientific or programmatic questions.
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| Research Answers to NCIs Provocative Questions Group A (R01) Apply for RFA CA 13 016 Funding Number: RFA CA 13 016 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Research Answers to NCIs Provocative Questions Group A (R21) Apply for RFA CA 13 017 Funding Number: RFA CA 13 017 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Research Answers to NCIs Provocative Questions Group B (R01) Apply for RFA CA 13 018 Funding Number: RFA CA 13 018 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Research Answers to NCIs Provocative Questions Group C (R01) Apply for RFA CA 13 020 Funding Number: RFA CA 13 020 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
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| Research Answers to NCIs Provocative Questions Group B (R21) Apply for RFA CA 13 019 Funding Number: RFA CA 13 019 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Research Answers to NCIs Provocative Questions Group C (R21) Apply for RFA CA 13 021 Funding Number: RFA CA 13 021 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Research Answers to NCIs Provocative Questions Group E (R01) Apply for RFA CA 13 024 Funding Number: RFA CA 13 024 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
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