Opportunity Information: Apply for PAR 13 322
Apply for PAR 13 322
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Methods for Prevention Packages Program III (MP3 III) (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants 93.855 Allergy and Infectious Diseases Research 93.856 Microbiology and Infectious Diseases Research.
- This funding opportunity was created on Aug 8, 2013 and posted on Aug 8, 2013.
- Applicants must submit their applications by Jan 7, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Native American tribal organizations (other than Federally recognized tribal governments) City or township governments Small businesses Public and State controlled institutions of higher education Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education County governments For profit organizations other than small businesses Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities Others (see text field entitled Additional Information on Eligibility for clarification) State governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Methods for Prevention Packages Program III (MP3 III) (R01) funding opportunity (PAR-13-322) is a National Institutes of Health (NIH) discretionary grant program focused on advancing HIV prevention through well-designed, multidisciplinary research. Its core aim is to support research teams in developing "prevention packages," meaning combination HIV prevention strategies that bring together multiple interventions (often behavioral, biomedical, clinical, and structural elements) tailored to the needs and realities of a specific target population. Rather than funding single, stand-alone interventions in isolation, MP3 III emphasizes optimizing how multiple prevention components can work together as a coherent package for a defined group and setting.
A central requirement of this FOA is that applicants not only propose an evidence-informed, population-specific combination prevention approach, but also conduct feasibility and acceptability studies. In practical terms, the research is expected to show that the proposed prevention package makes sense for the intended community, is acceptable to participants, and can realistically be delivered and studied as designed. The FOA highlights the importance of demonstrating that the study procedures are workable (for example, recruitment, retention, intervention delivery, and data collection) and that the prevention package is likely to be adopted and used by the target population. This positions the supported work as a critical step between conceptual intervention design and larger-scale testing, helping ensure that later trials or implementation efforts are grounded in approaches that participants will actually engage with.
MP3 III is explicitly designed to encourage collaborations across disciplines that are often separated in traditional research projects. The announcement calls for partnerships among behavioral scientists and biomedical clinical specialists, epidemiologists, mathematical modelers, and clinical research experts. This reflects the reality that combination HIV prevention requires both an understanding of human behavior and community context and the ability to integrate biomedical tools, clinical workflows, and population-level dynamics. Mathematical modeling and epidemiologic methods are particularly relevant in this framework because they can help compare potential package configurations, estimate impact, and guide decisions about which combinations are most promising for a specific population before investing in larger studies.
Administratively, this opportunity uses the NIH R01 grant mechanism and falls under the health funding activity category. It is associated with CFDA numbers 93.242 (Mental Health Research Grants), 93.855 (Allergy and Infectious Diseases Research), and 93.856 (Microbiology and Infectious Diseases Research), signaling its alignment with NIH priorities spanning infectious disease prevention and related behavioral and mental health research. The FOA does not require cost sharing or matching, which reduces barriers for applicants that might otherwise struggle to meet non-federal contribution requirements.
Eligibility is broad and includes a wide range of organization types. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofits with or without 501(c)(3) status (other than institutions of higher education), small businesses, for-profit organizations (including those other than small businesses), and multiple levels of government such as state, county, city/township, special district governments, and independent school districts. The FOA also allows participation by tribal entities and housing authorities, including federally recognized tribal governments and public housing authorities/Indian housing authorities. In addition, the program extends eligibility to various mission- and population-serving institutions and organizations such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American and Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based and community-based organizations and eligible federal agencies.
Notably, MP3 III permits non-U.S. participation: foreign organizations and foreign institutions are eligible to apply, and non-domestic components of U.S. organizations may also apply. The FOA further allows foreign components as defined under the NIH Grants Policy Statement. This matters for HIV prevention research because high-burden settings and key populations may be located outside the United States, and the ability to conduct feasibility and acceptability work in diverse global contexts can be essential for developing prevention packages that reflect real-world conditions.
Key dates provided in the source information show the FOA was posted and created on August 8, 2013, with an original and current closing date of January 7, 2016, and an archive date of February 7, 2016. The sponsoring agency is NIH, and the full announcement was hosted through the NIH grants guide at http://grants.nih.gov/grants/guide/pa-files/PAR-13-322.html. For access or technical issues with the posting, the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
In summary, MP3 III (R01) was structured to move the field of HIV prevention toward rigorously designed, context-sensitive combination prevention approaches by funding multidisciplinary teams to assemble optimal prevention packages for specific populations and to generate early, practical evidence that those packages and the proposed study designs are feasible and acceptable in the real world.
Methods for Prevention Packages Program III (MP3 III) (R01) (PAR-13-322) FAQs
What is the MP3 III (R01) funding opportunity?
Methods for Prevention Packages Program III (MP3 III) (R01), PAR-13-322, is a National Institutes of Health (NIH) discretionary grant opportunity focused on advancing HIV prevention through well-designed, multidisciplinary research using the NIH R01 grant mechanism.
What is the main goal of MP3 III?
The core aim is to support research teams in developing HIV "prevention packages" (combination prevention strategies) tailored to a specific target population and setting, rather than studying single stand-alone interventions in isolation.
What does "prevention package" mean in this program?
In MP3 III, a prevention package is a combination HIV prevention approach that brings together multiple interventions, often spanning behavioral, biomedical, clinical, and structural elements, designed as a coherent set for a defined group and real-world context.
Does MP3 III fund single interventions?
The program emphasizes optimizing how multiple prevention components work together as a package for a defined population and setting, rather than funding single, stand-alone interventions in isolation.
What kinds of research activities are expected under this FOA?
Applicants are expected to propose an evidence-informed, population-specific combination prevention approach and conduct feasibility and acceptability studies to show the package makes sense for the intended community and can realistically be delivered and studied as designed.
What are the feasibility and acceptability requirements?
A central requirement is to include feasibility and acceptability work that demonstrates study procedures are workable (for example, recruitment, retention, intervention delivery, and data collection) and that the prevention package is likely to be adopted and used by the target population.
Why does MP3 III emphasize feasibility and acceptability studies?
The FOA positions this work as a critical step between conceptual intervention design and larger-scale testing, helping ensure later trials or implementation efforts are grounded in approaches participants will actually engage with.
What disciplines or expertise are encouraged for MP3 III teams?
The announcement explicitly encourages collaboration among disciplines that are often separated, including behavioral scientists, biomedical and clinical specialists, epidemiologists, mathematical modelers, and clinical research experts.
How do mathematical modeling and epidemiology fit into MP3 III?
Mathematical modeling and epidemiologic methods are highlighted as particularly relevant because they can help compare potential package configurations, estimate impact, and guide decisions about which combinations are most promising for a specific population before investing in larger studies.
What grant mechanism does MP3 III use?
This opportunity uses the NIH R01 grant mechanism.
What is the funding activity category for MP3 III?
The opportunity is listed under the health funding activity category.
Are cost sharing or matching funds required?
No. The FOA does not require cost sharing or matching.
What CFDA numbers are associated with MP3 III?
The opportunity is associated with CFDA numbers 93.242 (Mental Health Research Grants), 93.855 (Allergy and Infectious Diseases Research), and 93.856 (Microbiology and Infectious Diseases Research).
What types of organizations are eligible to apply?
Eligibility is broad and includes: public and state-controlled institutions of higher education; private institutions of higher education; nonprofits with or without 501(c)(3) status (other than institutions of higher education); small businesses; for-profit organizations (including those other than small businesses); and multiple levels of government (state, county, city/township, special district governments, and independent school districts).
Are tribal entities and housing authorities eligible?
Yes. The FOA allows participation by tribal entities (including federally recognized tribal governments) and by housing authorities, including public housing authorities/Indian housing authorities.
Are mission- and population-serving institutions specifically included in eligibility?
Yes. The FOA includes organizations such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American and Native American Pacific Islander Serving Institutions (AANAPISIs).
Can faith-based and community-based organizations apply?
Yes. The FOA explicitly includes faith-based and community-based organizations among eligible applicants.
Are federal agencies eligible to apply?
Yes. The FOA states that eligible federal agencies may participate.
Are foreign organizations eligible to apply?
Yes. The FOA permits non-U.S. participation, stating that foreign organizations and foreign institutions are eligible to apply.
Can a U.S. organization apply with a non-domestic component?
Yes. Non-domestic components of U.S. organizations may also apply.
Does the FOA allow "foreign components" under NIH policy?
Yes. The FOA allows foreign components as defined under the NIH Grants Policy Statement.
Why does the FOA include non-U.S. participation?
The FOA notes this matters for HIV prevention research because high-burden settings and key populations may be located outside the United States, and feasibility and acceptability work in diverse global contexts can be essential for developing prevention packages that reflect real-world conditions.
When was this FOA posted and created?
The source information states the FOA was posted and created on August 8, 2013.
What were the closing and archive dates for this FOA?
The original and current closing date listed was January 7, 2016, and the archive date was February 7, 2016.
Who is the sponsoring agency for MP3 III?
The sponsoring agency is the National Institutes of Health (NIH).
Where can the full announcement be found?
The full announcement was hosted through the NIH grants guide at http://grants.nih.gov/grants/guide/pa-files/PAR-13-322.html.
Who is the contact for access or technical issues with the posting?
For access or technical issues, the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
How would you summarize what MP3 III was designed to accomplish?
MP3 III (R01) was structured to move HIV prevention toward rigorously designed, context-sensitive combination prevention approaches by funding multidisciplinary teams to assemble optimal prevention packages for specific populations and generate early evidence that the packages and study designs are feasible and acceptable in real-world conditions.
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