Opportunity Information: Apply for PA 16 024
Apply for PA 16 024
- The HHS-NIH11 in the education, health sector is offering a public funding opportunity titled "Innovative Questions in Symptom Science and Genomics (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.361,.
- This funding opportunity was created on Oct 30, 2015 and posted on Oct 30, 2015.
- Applicants must submit their applications by Jan 07, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Opportunity Summary:
The Innovative Questions in Symptom Science and Genomics (R01) funding opportunity (PA-16-024) is a discretionary NIH grant program administered under HHS-NIH (listed as HHS-NIH11). It is designed to stimulate ambitious, high-impact research in nursing science by encouraging investigators to build projects around a set of identified "innovative questions" in two connected areas: symptom science and genomics. The central idea is to push beyond incremental work and instead generate studies that are more likely to produce conceptual breakthroughs (new ways of understanding symptoms and their mechanisms), methodological advances (new approaches to measuring, modeling, or predicting symptoms), and technological innovations (tools or platforms that improve how symptom and genomic data are collected, integrated, or applied).
The scientific focus is intentionally framed around broad domains rather than narrowly defined topics. The program emphasizes that the innovative questions function as starting points: they are meant to spark original, novel hypotheses and clearly defined problems that can be solved through rigorous research. In practice, this means applicants are expected to translate those big, field-shaping questions into well-justified R01 projects with specific aims, strong designs, and a plausible pathway to meaningful advances in understanding symptoms, symptom trajectories, and the biological (including genomic) factors that influence them. Although the notice highlights nursing science, the structure is meant to catalyze cross-cutting work that can intersect with clinical research, behavioral science, data science, and translational genomics, as long as the project remains anchored in the symptom/genomics innovation mandate.
Mechanistically, this opportunity uses the NIH Research Project Grant (R01) mechanism, which typically supports mature, hypothesis-driven or well-substantiated research programs that require a multi-year effort and can demonstrate strong feasibility and scientific premise. The listing identifies the activity category as Education and Health and references CFDA numbers 93.361 (commonly associated with nursing research) and 93.859. An award ceiling and expected number of awards are not specified in the provided data, which usually signals that budgets and award counts may depend on annual appropriations, NIH priorities, and application volume rather than a fixed program cap.
Eligibility is broad and includes many common NIH applicant types. Eligible applicants include state, county, city or township governments, special district governments, independent school districts, and public housing authorities/Indian housing authorities. Higher education institutions are eligible across the spectrum: public/state-controlled and private institutions of higher education. The opportunity is also open to federally recognized Native American tribal governments and tribal organizations (including those other than federally recognized tribal governments), as well as nonprofit organizations both with and without 501(c)(3) IRS status (so long as they are not higher education institutions, as categorized in the listing). For-profit organizations other than small businesses, small businesses, and other entities (as further clarified in the full eligibility text of the announcement) are also eligible, reflecting NIH's common practice of allowing a wide range of institutional applicants when the science warrants it.
Key timeline details from the source data show the opportunity was created and posted on October 30, 2015, with a closing date of January 7, 2019 (both original and current closing dates align). That date reflects the application due window associated with this particular announcement version. As with many NIH program announcements, applicants typically need to follow NIH submission rules, including the appropriate electronic submission pathway, compliance requirements, and the R01-specific expectations for significance, innovation, approach, investigator(s), and environment.
In plain terms, this funding opportunity is meant for research teams that want to tackle hard, field-defining questions at the intersection of symptom experiences and genomics, and who can propose an R01-level plan that credibly advances theory, measurement, and/or technology in ways that change how symptom science is studied and ultimately applied to improve health outcomes.
Frequently Asked Questions (FAQs)
What is the Innovative Questions in Symptom Science and Genomics (R01) opportunity?
This is a discretionary NIH funding opportunity titled "Innovative Questions in Symptom Science and Genomics (R01)" (PA-16-024). It is intended to stimulate ambitious, high-impact research by building projects around identified "innovative questions" in two connected areas: symptom science and genomics.
Which agency administers this grant program?
The opportunity is administered under HHS-NIH and is listed as HHS-NIH11.
What is the purpose of this funding opportunity?
The program is designed to push research beyond incremental work and encourage studies that are more likely to produce:
- Conceptual breakthroughs (new ways of understanding symptoms and their mechanisms)
- Methodological advances (new approaches to measuring, modeling, or predicting symptoms)
- Technological innovations (tools or platforms to improve how symptom and genomic data are collected, integrated, or applied)
What are the main scientific areas emphasized by the program?
The scientific emphasis is on symptom science and genomics, framed around broad domains rather than narrowly defined topics. Projects are expected to remain anchored in the symptom/genomics innovation mandate.
What are the "innovative questions" and how are they used in an application?
The innovative questions are intended as starting points to spark original hypotheses and clearly defined, solvable research problems. Applicants are expected to translate these broad, field-shaping prompts into a well-justified R01 project with specific aims, strong study design, and a credible pathway to meaningful advances in symptom-related knowledge.
Does the program focus only on nursing science?
The notice highlights nursing science, but it is structured to catalyze cross-cutting work that can intersect with clinical research, behavioral science, data science, and translational genomics, as long as the project remains centered on innovation at the intersection of symptoms and genomics.
What type of grant mechanism is used for this opportunity?
This opportunity uses the NIH Research Project Grant (R01) mechanism.
What does it mean that this is an R01 opportunity?
An R01 typically supports mature, hypothesis-driven or well-substantiated research programs that require a multi-year effort and can demonstrate strong feasibility and scientific premise. Applications should be aligned with R01 expectations for a rigorous plan and clear contribution to the field.
What activity category is associated with this opportunity?
The activity category listed for this opportunity is Education and Health.
Which CFDA numbers are referenced for this opportunity?
The listing references CFDA numbers 93.361 and 93.859.
Is there a stated award ceiling for this opportunity?
No award ceiling is specified in the provided information.
Is there a stated expected number of awards?
No expected number of awards is specified in the provided information.
What does it imply if award ceilings and number of awards are not specified?
Based on the provided description, this commonly suggests that budgets and award counts may depend on factors like annual appropriations, NIH priorities, and application volume rather than a fixed program cap.
Who is eligible to apply?
Eligibility is broad and includes many common NIH applicant types described in the opportunity listing.
Are state, local, or regional government entities eligible?
Yes. Eligible applicants include state governments, county governments, city or township governments, and special district governments.
Are public education entities eligible?
Yes. Independent school districts are listed as eligible applicants.
Are housing authorities eligible to apply?
Yes. Public housing authorities and Indian housing authorities are listed as eligible applicants.
Are institutions of higher education eligible?
Yes. Both public/state-controlled institutions of higher education and private institutions of higher education are eligible.
Are tribal governments and tribal organizations eligible?
Yes. Federally recognized Native American tribal governments and tribal organizations are eligible. The eligibility listing also includes tribal organizations other than federally recognized tribal governments.
Are nonprofit organizations eligible?
Yes. Nonprofit organizations with 501(c)(3) IRS status and nonprofits without 501(c)(3) status are eligible, as described in the listing (with the note that the listing distinguishes nonprofits that are not institutions of higher education, as categorized in the source).
Are for-profit organizations eligible?
Yes. For-profit organizations other than small businesses, as well as small businesses, are included among eligible applicant types.
When was this opportunity created and posted?
The opportunity was created and posted on October 30, 2015.
What is the closing date for this opportunity?
The closing date listed is January 7, 2019, and the original and current closing dates align in the provided information.
What does the January 7, 2019 closing date represent?
Based on the provided description, that date reflects the application due window associated with this particular version of the announcement.
What general expectations apply to submitting an application under this opportunity?
Applicants are expected to follow NIH submission rules, including the appropriate electronic submission pathway, compliance requirements, and R01-specific expectations for significance, innovation, approach, investigator(s), and environment.
What kinds of outcomes is the program trying to encourage?
The program aims to support research that changes how symptom science is studied and applied, including improvements in understanding symptoms and symptom trajectories, and clarifying biological influences (including genomic factors) that affect symptom experiences.
What types of research approaches fit this opportunity?
The opportunity emphasizes rigorous research that can credibly advance theory, measurement, and/or technology related to symptoms and genomics. It also supports cross-cutting work that can connect to clinical research, behavioral science, data science, and translational genomics, as long as it remains anchored to the symptom/genomics innovation focus.
What does "broad domains rather than narrowly defined topics" mean for applicants?
It means the program is intentionally not limited to a small set of prescriptive topics. Instead, applicants are expected to define a novel, well-justified problem inspired by the innovative questions and build a clear R01 project around it.
How should an applicant demonstrate that their project is not incremental?
Based on the program description, applicants should aim for ambitious, high-impact work that is positioned to deliver conceptual, methodological, or technological advances rather than small, stepwise additions to existing knowledge.
What is the plain-language summary of who this opportunity is for?
This opportunity is meant for research teams that want to tackle hard, field-defining questions at the intersection of symptom experiences and genomics and can propose an R01-level plan that credibly advances understanding, measurement, modeling, and/or technology in symptom science.
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| Global Noncommunicable Diseases and Injury Across the Lifespan: Exploratory Research (R21) Apply for PAR 16 052 Funding Number: PAR 16 052 Agency: HHS-NIH11 Category: Education, Health Funding Amount: $125,000 |
| Integration of Infectious Diseases and Substance Abuse Intervention Services for Individuals Living with HIV (R01) Apply for RFA DA 16 011 Funding Number: RFA DA 16 011 Agency: HHS-NIH11 Category: Education, Health Funding Amount: Case Dependent |
| Innovative Questions in Symptom Science and Genomics (R21) Apply for PA 16 023 Funding Number: PA 16 023 Agency: HHS-NIH11 Category: Education, Health Funding Amount: $200,000 |
| Research Projects to Enhance Applicability of Mammalian Models for Translational Research (R01) Apply for PAR 16 059 Funding Number: PAR 16 059 Agency: HHS-NIH11 Category: Education, Health Funding Amount: $450,000 |
| Applying Metabolomics to Drive Biomarker Discovery in Symptom Science (R01) Apply for PA 16 030 Funding Number: PA 16 030 Agency: HHS-NIH11 Category: Education, Health Funding Amount: Case Dependent |
| Innovative Molecular and Cellular Analysis Technologies for Basic and Clinical Cancer Research (R21) Apply for RFA CA 16 001 Funding Number: RFA CA 16 001 Agency: HHS-NIH11 Category: Education, Health Funding Amount: $200,000 |
| Applying Metabolomics to Drive Biomarker Discovery in Symptom Science (R21) Apply for PA 16 029 Funding Number: PA 16 029 Agency: HHS-NIH11 Category: Education, Health Funding Amount: $200,000 |
| Effects of Drugs of Abuse on Latent HIV Reservoirs in the CNS (R01) Apply for RFA DA 16 014 Funding Number: RFA DA 16 014 Agency: HHS-NIH11 Category: Education, Health Funding Amount: Case Dependent |
| NCI Research Specialist Award (R50) Apply for PAR 16 025 Funding Number: PAR 16 025 Agency: HHS-NIH11 Category: Education, Health Funding Amount: Case Dependent |
| Drug Discovery For Nervous System Disorders (R01) Apply for PAR 16 041 Funding Number: PAR 16 041 Agency: HHS-NIH11 Category: Education, Health Funding Amount: Case Dependent |
| HIV/AIDS High Priority Drug Abuse Research (R01) Apply for PAS 16 018 Funding Number: PAS 16 018 Agency: HHS-NIH11 Category: Education, Health Funding Amount: Case Dependent |
| Exploring Epigenomic or Non-Coding RNA Regulation in HIV/AIDS and Substance Abuse (R01) Apply for RFA DA 16 012 Funding Number: RFA DA 16 012 Agency: HHS-NIH11 Category: Education, Health Funding Amount: Case Dependent |
| Genomic Data Analysis Network: Visualization Genomic Data Center (U24) Apply for RFA CA 15 019 Funding Number: RFA CA 15 019 Agency: HHS-NIH11 Category: Education, Health Funding Amount: $660,000 |
| The NCI Predoctoral to Postdoctoral Fellow Transition Award (F99/K00) Apply for RFA CA 16 005 Funding Number: RFA CA 16 005 Agency: HHS-NIH11 Category: Education, Health Funding Amount: Case Dependent |
| Behavioral and Integrative Treatment Development Program (R03) Apply for PA 16 074 Funding Number: PA 16 074 Agency: HHS-NIH11 Category: Education, Health Funding Amount: $50,000 |
| Clinical Development of Minimally-Invasive Bioassays to Support Outpatient Clinical Trials of Therapeutics for Substance Use Disorders (R21) Apply for PA 16 075 Funding Number: PA 16 075 Agency: HHS-NIH11 Category: Education, Health Funding Amount: Case Dependent |
| Behavioral and Integrative Treatment Development Program (R34) Apply for PA 16 073 Funding Number: PA 16 073 Agency: HHS-NIH11 Category: Education, Health Funding Amount: $225,000 |
| Clinical Development of Minimally-Invasive Bioassays to Support Outpatient Clinical Trials of Therapeutics for Substance Use Disorders (R01) Apply for PA 16 076 Funding Number: PA 16 076 Agency: HHS-NIH11 Category: Education, Health Funding Amount: $500,000 |
| Behavioral Science Track Award for Rapid Transition (B/Start)(R03) Apply for PAR 16 071 Funding Number: PAR 16 071 Agency: HHS-NIH11 Category: Education, Health Funding Amount: $75,000 |
| Behavioral and Integrative Treatment Development Program (R01) Apply for PA 16 072 Funding Number: PA 16 072 Agency: HHS-NIH11 Category: Education, Health Funding Amount: Case Dependent |
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