Opportunity Information: Apply for RFA PM 16 002
Apply for RFA PM 16 002
- The HHS-NIH11 in the health sector is offering a public funding opportunity titled "Precision Medicine Initiative Cohort Program Healthcare Provider Organization Enrollment Centers (UG3/UH3)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310,.
- This funding opportunity was created on Nov 16, 2015 and posted on Nov 16, 2015.
- Applicants must submit their applications by Feb 17, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 7 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Opportunity Summary:
The Precision Medicine Initiative Cohort Program Healthcare Provider Organization Enrollment Centers (UG3/UH3) funding opportunity (RFA-PM-16-002) is a National Institutes of Health (NIH) cooperative agreement designed to stand up and support a set of enrollment centers whose main job is to recruit and enroll participants through U.S. healthcare provider organizations into the Precision Medicine Initiative (PMI) Cohort Program. The central aim of the PMI Cohort Program is ambitious and long-range: to build and sustain a national research cohort of one million or more volunteers in the United States who do not simply serve as study subjects, but are actively engaged as partners over time. By following people longitudinally, the program seeks to generate the kind of deep, real-world data needed to improve understanding of why individuals differ in health outcomes and disease risk, ultimately helping to drive more precise prevention, diagnosis, and treatment strategies.
This opportunity sits in the “Health” activity category and is offered by HHS/NIH (agency listing shown as HHS-NIH11). It uses a cooperative agreement mechanism rather than a standard grant, which typically means NIH expects substantial involvement in guiding, coordinating, or collaborating on key components of the work. The FOA specifically targets “enrollment centers” connected to healthcare provider organizations, reflecting a strategy to recruit participants where care actually happens, leveraging clinical settings and existing relationships with patients to support large-scale, diverse enrollment and long-term follow-up.
The funding instrument is listed as UG3/UH3, a two-phase structure commonly used for projects that require an initial planning, start-up, or feasibility period followed by a larger implementation phase. In practical terms, this structure is generally meant to allow awardees to first demonstrate readiness, build workflows, and meet early milestones (UG3), and then transition into full operations and enrollment at scale (UH3) once those milestones are achieved. While the excerpt does not spell out specific milestones or budgets, the UG3/UH3 format strongly signals that NIH anticipated complex operational build-out and wanted a mechanism to manage risk while accelerating capable sites into full enrollment.
Eligibility is broad and includes a wide range of domestic entities that could plausibly operate or partner with healthcare provider organizations. Eligible applicants include state, county, city/township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized tribal governments and other tribal organizations; public housing authorities and Indian housing authorities; nonprofits with or without 501(c)(3) status (outside of higher education); for-profit organizations (other than small businesses); small businesses; and other entities as described in the FOA’s additional eligibility language. This broad eligibility suggests NIH expected applications from academic medical centers, integrated delivery systems, large health networks, community-based organizations with strong clinical ties, and other institutions capable of recruiting participants through healthcare settings and supporting a long-term national research effort.
Key administrative details include an original and current closing date of February 17, 2016, with a posting and creation date of November 16, 2015. The FOA lists an expectation of seven awards. No award ceiling is provided in the supplied text, and the CFDA numbers associated with the program are 93.310 (and another entry shown as “93.,” likely truncated in the source). Overall, the opportunity can be understood as NIH’s effort to fund a small number of strategically positioned enrollment centers that, together, could drive substantial participant recruitment from clinical environments and help launch the infrastructure needed for a national, million-person precision medicine cohort built for long-term engagement and discovery.
Frequently Asked Questions (FAQs)
What is the RFA-PM-16-002 funding opportunity?
RFA-PM-16-002 is a National Institutes of Health (NIH) cooperative agreement funding opportunity titled "Precision Medicine Initiative Cohort Program Healthcare Provider Organization Enrollment Centers (UG3/UH3)." It is designed to establish and support a set of enrollment centers whose primary role is to recruit and enroll participants into the Precision Medicine Initiative (PMI) Cohort Program through U.S. healthcare provider organizations.
What is the main purpose of these Healthcare Provider Organization Enrollment Centers?
The main purpose is to recruit and enroll participants via U.S. healthcare provider organizations into the PMI Cohort Program. The intent is to leverage clinical settings and existing relationships within healthcare systems to support large-scale, diverse enrollment and enable long-term follow-up over time.
What is the central aim of the Precision Medicine Initiative (PMI) Cohort Program?
The PMI Cohort Program aims to build and sustain a national research cohort of one million or more volunteers in the United States. Participants are intended to be actively engaged as partners over time, not simply traditional study subjects.
How does the program plan to use the cohort over time?
The cohort is intended to be followed longitudinally. By tracking participants over time, the program seeks to generate deep, real-world data to improve understanding of why individuals differ in health outcomes and disease risk.
What long-term outcomes is the PMI Cohort Program trying to achieve?
The program is designed to support improved understanding of differences in health outcomes and disease risk, with the longer-range goal of helping drive more precise prevention, diagnosis, and treatment strategies.
Which agency is offering this opportunity?
This opportunity is offered by the U.S. Department of Health and Human Services (HHS), National Institutes of Health (NIH). The agency listing is shown as HHS-NIH11.
What activity category does this opportunity fall under?
The opportunity is listed under the "Health" activity category.
What type of funding mechanism is used (grant vs. cooperative agreement)?
This opportunity uses a cooperative agreement mechanism rather than a standard grant. The description indicates this typically means NIH expects substantial involvement in guiding, coordinating, or collaborating on key components of the funded work.
What does it mean that the award mechanism is UG3/UH3?
UG3/UH3 is a two-phase structure commonly used when projects need an initial planning, start-up, or feasibility period followed by a larger implementation phase. In this context, it signals that awardees would generally begin with a UG3 phase focused on readiness and workflow build-out, and then transition to the UH3 phase for full operations and enrollment at scale once early milestones are achieved.
What is the difference between the UG3 phase and the UH3 phase in practical terms?
Based on the description provided, the UG3 phase is generally intended to allow awardees to demonstrate readiness, establish processes, and meet early milestones. The UH3 phase is generally intended for full operations, including enrollment at scale, after successful completion of the early phase.
Does the provided information list specific milestones or budgets for the UG3/UH3 phases?
No. The supplied text does not specify particular milestones, budget amounts, or an award ceiling. It only explains the general purpose of the UG3/UH3 structure.
Why does the FOA focus on enrollment centers connected to healthcare provider organizations?
The focus reflects a strategy to recruit participants where care happens, using clinical environments and existing patient relationships to support large-scale enrollment and long-term engagement.
Who is eligible to apply for this funding opportunity?
Eligibility is broad and includes many domestic entity types, including: state, county, city/township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized tribal governments and other tribal organizations; public housing authorities and Indian housing authorities; nonprofits with or without 501(c)(3) status (outside of higher education); for-profit organizations (other than small businesses); small businesses; and other entities as described in the FOA's additional eligibility language.
Does the FOA appear limited only to academic medical centers?
No. The broad eligibility suggests NIH anticipated applications from a wide range of organizations that could operate or partner with healthcare provider organizations, potentially including academic medical centers, integrated delivery systems, large health networks, and other institutions capable of recruiting participants through healthcare settings and supporting long-term follow-up.
Is this opportunity limited to U.S.-based recruitment?
The description emphasizes recruitment and enrollment through U.S. healthcare provider organizations and building a cohort of volunteers in the United States.
How many awards does NIH expect to make under this FOA?
The FOA lists an expectation of seven awards.
What are the key dates for this opportunity?
The posting and creation date is November 16, 2015. The original closing date and the current closing date are both listed as February 17, 2016.
Is an award ceiling provided in the supplied information?
No. The supplied text indicates that no award ceiling is provided.
What CFDA number(s) are associated with this opportunity?
The CFDA numbers associated with the program include 93.310 and another entry shown as "93.," which appears truncated in the source excerpt.
What is the overall role of these enrollment centers in the national program?
Overall, the enrollment centers are intended to be strategically positioned sites that collectively drive substantial participant recruitment from clinical environments and help launch infrastructure needed for a national, million-person precision medicine cohort designed for long-term engagement and discovery.
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