Opportunity Information: Apply for PAR 14 271
Apply for PAR 14 271
- The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "Innovative Therapies and Tools for Screenable Disorders in Newborns (R03)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Jul 2, 2014 and posted on Jul 2, 2014.
- Applicants must submit their applications by Sep 7, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $50,000.00 in funding.
- Eligible applicants include: Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Public and State controlled institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Independent school districts City or township governments State governments County governments Native American tribal governments (Federally recognized) Small businesses Special district governments Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Foreign Institutions Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
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Opportunity Summary:
The NIH funding opportunity PAR-14-271, titled "Innovative Therapies and Tools for Screenable Disorders in Newborns (R03)," supported small, focused research projects aimed at improving how disorders detected (or potentially detectable) through newborn screening can be treated. The core idea was to fund early-stage or targeted studies that strengthen the basic scientific understanding of these conditions and accelerate the development of therapeutic interventions. The program emphasized disorders already included in newborn screening panels as well as "high priority" genetic conditions that are not routinely screened yet but could become practical candidates for screening in the near future. In this context, a high priority condition was defined very specifically: it is a condition where having an effective therapy would be the key factor that makes population-wide newborn screening worthwhile and feasible, because screening only has strong public health value when it leads to timely intervention and improved outcomes.
This opportunity used the NIH R03 mechanism, which is designed for smaller research grants. The award ceiling listed for this announcement was $50,000, indicating that projects were expected to be modest in scope and budget, such as proof-of-concept studies, development of a tool or assay, preliminary therapeutic testing, or tightly defined experiments that can generate data needed to move a therapy or intervention forward. The activity category was Health, Income Security, and Social Services, and the CFDA number associated with the program was 93.865, linked to the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) extramural research portfolio. No cost sharing or matching was required, which is typical for many NIH research grants and lowers the barrier to participation for a range of institutions.
Eligibility was broad across U.S.-based organizations. Applicants could include public and private institutions of higher education, nonprofit organizations (both 501(c)(3) and non-501(c)(3)), for-profit organizations other than small businesses as well as small businesses, and multiple levels of government entities such as state, county, city or township governments, special district governments, independent school districts, and public housing authorities including Indian housing authorities. The announcement also explicitly named many mission-driven and community-serving organizations and institution types as eligible, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian-serving institutions, and Asian American Native American Pacific Islander-serving institutions (AANAPISIs), along with faith-based and community-based organizations, regional organizations, U.S. territories or possessions, and eligible federal agencies. At the same time, the FOA clearly excluded non-U.S. participation: foreign institutions and other non-domestic entities could not apply, non-domestic components of U.S. organizations were not eligible, and foreign components (as NIH defines them) were not allowed under this announcement.
Administratively, this was a discretionary grant opportunity posted on July 2, 2014, with an original and final closing date of September 7, 2017, and it was archived on October 8, 2017. The sponsoring agency was the National Institutes of Health, and the official announcement was available through the NIH Grants Guide. For technical access issues, the listed contact route was the NIH Office of Extramural Research (OER) webmaster support email.
Overall, the FOA was aimed at practical, near-term progress: building the scientific and translational foundation for therapies and tools that can change the value of newborn screening by making early detection actionable. By focusing on conditions already screened and on disorders that could become screenable once effective treatments exist, the program linked therapeutic development directly to public health impact in the newborn period, where timing is often the difference between preventing irreversible harm and treating established disease.
Frequently Asked Questions (FAQs)
What is the name and number of this NIH funding opportunity?
The funding opportunity is NIH PAR-14-271, titled "Innovative Therapies and Tools for Screenable Disorders in Newborns (R03)."
What is the main purpose of PAR-14-271?
The opportunity supported small, focused research projects intended to improve how disorders detected (or potentially detectable) through newborn screening can be treated. It emphasized early-stage or targeted studies that strengthen basic scientific understanding and speed the development of therapeutic interventions and practical tools.
What kinds of disorders were in scope for this FOA?
The FOA emphasized (1) disorders already included in newborn screening panels and (2) "high priority" genetic conditions that are not routinely screened yet but could become practical candidates for screening in the near future.
How did the FOA define a "high priority" condition?
A "high priority" condition was defined as one where having an effective therapy would be the key factor that makes population-wide newborn screening worthwhile and feasible. The FOA framed screening as having strong public health value when it leads to timely intervention and improved outcomes.
What grant mechanism did this opportunity use?
This opportunity used the NIH R03 mechanism, which is designed for smaller research grants and modest-scope projects.
What was the award ceiling for this announcement?
The award ceiling listed for this FOA was $50,000, reflecting an expectation that projects would be limited in scope and budget.
What types of projects did the FOA expect to fund under the R03?
Based on the description provided, expected projects could include proof-of-concept studies, development of a tool or assay, preliminary therapeutic testing, or tightly defined experiments that generate data needed to move a therapy or intervention forward.
Which agency and NIH institute were associated with this opportunity?
The sponsoring agency was the National Institutes of Health (NIH). The program was associated with CFDA 93.865, linked to the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) extramural research portfolio.
What was the activity category listed for this grant opportunity?
The activity category was listed as Health, Income Security, and Social Services.
Was cost sharing or matching required?
No. The FOA stated that no cost sharing or matching was required, which lowers barriers for eligible applicants.
Who was eligible to apply (in general terms)?
Eligibility was broad across U.S.-based organizations, including higher education institutions, nonprofit organizations, for-profit organizations (including small businesses), and multiple levels of government entities.
What types of higher education institutions were eligible?
Both public and private institutions of higher education were eligible to apply.
Were nonprofit organizations eligible?
Yes. Both 501(c)(3) and non-501(c)(3) nonprofit organizations were listed as eligible applicants.
Were for-profit organizations eligible, including small businesses?
Yes. The FOA included for-profit organizations other than small businesses as well as small businesses among eligible applicant types.
Which government entities were eligible to apply?
Eligible government applicants included state, county, city or township governments, special district governments, independent school districts, and public housing authorities (including Indian housing authorities).
Did the FOA explicitly include mission-driven and community-serving organizations?
Yes. The eligibility list explicitly included faith-based and community-based organizations, regional organizations, U.S. territories or possessions, and eligible federal agencies.
Were Historically Black Colleges and Universities (HBCUs) eligible?
Yes. HBCUs were explicitly named as eligible.
Were Hispanic-serving institutions eligible?
Yes. Hispanic-serving institutions were explicitly named as eligible.
Were Tribally Controlled Colleges and Universities (TCCUs) eligible?
Yes. TCCUs were explicitly named as eligible.
Were Alaska Native and Native Hawaiian-serving institutions eligible?
Yes. Alaska Native and Native Hawaiian-serving institutions were explicitly named as eligible.
Were AANAPISIs eligible?
Yes. Asian American Native American Pacific Islander-serving institutions (AANAPISIs) were explicitly named as eligible.
Could foreign institutions or other non-U.S. entities apply?
No. The FOA explicitly excluded non-U.S. participation: foreign institutions and other non-domestic entities could not apply.
Were non-domestic components of U.S. organizations eligible?
No. Non-domestic components of U.S. organizations were not eligible under this announcement.
Were foreign components (as NIH defines them) allowed?
No. Foreign components (as NIH defines them) were not allowed under this FOA.
When was this opportunity posted, and what were the closing dates?
It was posted on July 2, 2014. The original and final closing date listed was September 7, 2017.
Is this funding opportunity still open?
No. The FOA was archived on October 8, 2017, and the final closing date was September 7, 2017.
Where was the official announcement published?
The official announcement was available through the NIH Grants Guide.
Who should be contacted for technical access issues related to the announcement?
For technical access issues, the listed contact route was the NIH Office of Extramural Research (OER) webmaster support email.
What was the overall emphasis or strategy behind this FOA?
The FOA emphasized practical, near-term progress by building the scientific and translational foundation for therapies and tools that make early detection through newborn screening actionable. It linked therapeutic development to public health impact in the newborn period, where timing can strongly influence outcomes.
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Previous opportunity: Innovative Therapies and Tools for Screenable Disorders in Newborns (R01)
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Applicants also applied for:
Applicants who have applied for this opportunity (PAR 14 271) also looked into and applied for these:
| Funding Opportunity |
|---|
| Pharmacogenetics, Pharmacoepigenetics and Personalized Medicine in Children (R01) Apply for PAR 14 274 Funding Number: PAR 14 274 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Medically Assisted Reproduction Investigation of Mechanisms Underlying the Adverse Outcomes and Development of New and Improved Methods to Overcome the Adverse Outcomes (R01) Apply for PAR 14 272 Funding Number: PAR 14 272 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Medically Assisted Reproduction Investigation of Mechanisms Underlying the Adverse Outcomes and Development of New and Improved Methods to Overcome the Adverse Outcomes (R21) Apply for PAR 14 273 Funding Number: PAR 14 273 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $200,000 |
| Pediatric Cardiac Genomics Consortium (UM1) Apply for RFA HL 15 012 Funding Number: RFA HL 15 012 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $269,000 |
| In vivo Methods for Assessing Placental Development and Function (SBIR) R43/R44 Apply for RFA HD 15 018 Funding Number: RFA HD 15 018 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| In vivo Methods for Assessing Placental Development and Function (STTR) R41/R42 Apply for RFA HD 15 019 Funding Number: RFA HD 15 019 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $2,000,000 |
| Obstetric Fetal Pharmacology Research Centers (OPRC) (U54) Apply for RFA HD 14 013 Funding Number: RFA HD 14 013 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $4,800,000 |
| Patient Safety in the Context of Perinatal, Neonatal, and Pediatric Care (R01) Apply for PA 14 312 Funding Number: PA 14 312 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Patient Safety in the Context of Perinatal, Neonatal, and Pediatric Care (R21) Apply for PA 14 311 Funding Number: PA 14 311 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Patient Safety in the Context of Perinatal, Neonatal, and Pediatric Care (R03) Apply for PA 14 313 Funding Number: PA 14 313 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $50,000 |
| NICHD Consortium for Research on Pediatric Trauma and Injury Prevention (R24) Apply for PAR 14 324 Funding Number: PAR 14 324 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $750,000 |
| Improving Health through Rehabilitation Robotic Technology (R43/R44) Apply for RFA HD 15 001 Funding Number: RFA HD 15 001 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Tools for Assessment and Improvement of Neurologic Outcomes in Perinatal Medicine (R41) Apply for RFA HD 15 005 Funding Number: RFA HD 15 005 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $150,000 |
| Tools for Assessment and Improvement of Neurologic Outcomes in Perinatal Medicine (R43) Apply for RFA HD 15 006 Funding Number: RFA HD 15 006 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $150,000 |
| Senator Paul D. Wellstone Muscular Dystrophy Cooperative Research Centers (U54) Apply for RFA AR 15 002 Funding Number: RFA AR 15 002 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $1,000,000 |
| Biomarkers of Alzheimers Disease in Down Syndrome (R01) Apply for RFA AG 15 011 Funding Number: RFA AG 15 011 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $2,500,000 |
| Biomedical/Biobehavioral Research Administration Development (BRAD) Award (G11) Apply for PAR 14 333 Funding Number: PAR 14 333 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $85,000 |
| Consortium on Biomarker and Outcome Measures of Social Impairment for Use in Clinical Trials in Autism Spectrum Disorder (U19) Apply for RFA MH 15 800 Funding Number: RFA MH 15 800 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $5,250,000 |
| Studies in Neonatal and Pediatric Resuscitation (R01) Apply for PA 14 350 Funding Number: PA 14 350 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Studies in Neonatal and Pediatric Resuscitation (R03) Apply for PA 14 351 Funding Number: PA 14 351 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $50,000 |
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