Opportunity Information: Apply for PAR 14 270
Apply for PAR 14 270
- The National Institutes of Health in the food and nutrition health income security and social services sector is offering a public funding opportunity titled "Innovative Therapies and Tools for Screenable Disorders in Newborns (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Jul 2, 2014 and posted on Jul 2, 2014.
- Applicants must submit their applications by Sep 7, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Small businesses County governments Public housing authorities/Indian housing authorities Native American tribal governments (Federally recognized) Private institutions of higher education Special district governments State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Public and State controlled institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Foreign Institutions Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
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Opportunity Summary:
The Innovative Therapies and Tools for Screenable Disorders in Newborns (R01) opportunity (PAR-14-270) is a National Institutes of Health (NIH) Funding Opportunity Announcement focused on advancing research that can lead to effective treatments for disorders that are already part of newborn screening programs, as well as certain genetic conditions that could realistically become screenable in the near future. The central idea is to fund R01 research projects that deepen the basic scientific understanding of these diseases and translate that knowledge into therapeutic interventions or enabling tools. A key concept in the announcement is the definition of a "high priority" condition: it is a disorder where the creation of an effective therapy would be the turning point that makes newborn screening worthwhile and actionable, because early identification would then lead to a meaningful medical benefit.
This is a discretionary grant mechanism using the NIH Research Project Grant (R01) format, which typically supports hypothesis-driven research programs that can include preclinical studies, technology development, and other rigorous experimental work aimed at producing concrete therapeutic advances. The FOA is aligned with NIH interests across multiple biomedical areas reflected in the listed CFDA program numbers, including diabetes/digestive/kidney disease research (93.847), neuroscience and neurological disorders (93.853), and child health and human development (93.865). In practical terms, that breadth signals that proposed projects may span many organ systems and disease categories, as long as the work clearly targets conditions relevant to newborn screening and the development of interventions that would matter within the newborn or early-infant timeframe.
Eligibility is broad and includes many types of U.S.-based organizations and governmental entities. Eligible applicants include public and private institutions of higher education, nonprofits (including 501(c)(3) and certain non-501(c)(3) organizations), for-profit organizations (including small businesses and other for-profits), and a wide range of government bodies such as state, county, city/township, special district governments, and independent school districts. The announcement also explicitly includes a number of institution types and community-focused entities under "other eligible applicants," such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and other minority-serving institutions, as well as faith-based or community-based organizations, regional organizations, and eligible federal agencies. At the same time, the FOA restricts foreign involvement: non-U.S. (foreign) institutions are not eligible to apply, non-U.S. components of U.S. organizations are not eligible, and foreign components (as NIH defines them) are not allowed. No cost sharing or matching is required, which lowers barriers for applicants who might not have additional institutional funds to contribute.
From an administrative timeline perspective, the FOA was posted and created on July 2, 2014, with an original and final closing date of September 7, 2017, and it was archived on October 8, 2017. That means this specific announcement is no longer active, but it provides a clear snapshot of NIH priorities during that period around building the therapeutic and technological foundation needed to expand or strengthen newborn screening. The sponsoring agency is NIH, and the primary access point for the full archived announcement was the NIH grants guide page linked in the source. For technical issues accessing the announcement, the contact provided is the NIH Office of Extramural Research (OER) webmaster via FBOWebmaster@OD.NIH.GOV.
Frequently Asked Questions (FAQs)
What is the Innovative Therapies and Tools for Screenable Disorders in Newborns (R01) opportunity (PAR-14-270)?
PAR-14-270 is a National Institutes of Health (NIH) Funding Opportunity Announcement (FOA) that focused on supporting R01 research projects to advance therapies and enabling tools for disorders relevant to newborn screening. The goal was to deepen basic scientific understanding of these diseases and translate that knowledge into interventions that could deliver meaningful benefit when conditions are identified early through newborn screening.
What is the main purpose of this FOA?
The FOA aimed to fund research that can lead to effective treatments (and related enabling tools) for disorders already included in newborn screening programs, as well as certain genetic conditions that could realistically become screenable in the near future. The emphasis is on producing concrete therapeutic advances and/or tools that support actionable care in the newborn or early-infant timeframe.
What types of conditions were the focus of this FOA?
The FOA targeted disorders that are already part of newborn screening programs and certain genetic conditions that could become screenable in the near future. Projects needed to clearly connect the research to conditions relevant to newborn screening and to interventions that would matter during the newborn or early-infant period.
What does the FOA mean by a "high priority" condition?
In this announcement, a "high priority" condition was defined as a disorder where the creation of an effective therapy would be the turning point that makes newborn screening worthwhile and actionable. In other words, early identification would lead to meaningful medical benefit because an effective intervention would exist.
What funding mechanism does this FOA use?
This FOA used the NIH Research Project Grant (R01) mechanism. It was described as a discretionary grant mechanism using the standard R01 format.
What kinds of research activities could an R01 under this FOA support?
Based on the description provided, the R01 projects were intended to support hypothesis-driven research programs that could include preclinical studies, technology development, and other rigorous experimental work aimed at producing therapeutic advances or enabling tools tied to newborn-screenable conditions.
Does the FOA limit projects to certain organ systems or disease areas?
The information provided suggests the scope was broad across biomedical areas (multiple CFDA program numbers were listed), indicating projects could span many organ systems and disease categories. The key constraint was that the work needed to clearly target conditions relevant to newborn screening and the development of interventions that matter in the newborn or early-infant timeframe.
Which NIH-related program areas (CFDA numbers) are referenced?
The FOA references multiple CFDA program numbers, including diabetes/digestive/kidney disease research (93.847), neuroscience and neurological disorders (93.853), and child health and human development (93.865). This breadth signals alignment with NIH interests across multiple biomedical domains.
Who was the sponsoring agency for this opportunity?
The sponsoring agency was the National Institutes of Health (NIH).
What organizations were eligible to apply?
Eligibility was described as broad for U.S.-based organizations and governmental entities. Eligible applicants included public and private institutions of higher education, nonprofits (including 501(c)(3) and certain non-501(c)(3) organizations), for-profit organizations (including small businesses and other for-profits), and many types of government bodies (state, county, city/township, special district governments, and independent school districts).
Are minority-serving institutions specifically included as eligible applicants?
Yes. The FOA explicitly included multiple institution types under "other eligible applicants," including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and other minority-serving institutions.
Are faith-based or community-based organizations eligible?
Yes. The FOA explicitly noted faith-based or community-based organizations among the "other eligible applicants," along with regional organizations and eligible federal agencies.
Are U.S. government entities eligible to apply?
Yes. The eligibility list included a wide range of government bodies such as state, county, city/township, special district governments, and independent school districts.
Are for-profit organizations eligible to apply?
Yes. The FOA stated that for-profit organizations, including small businesses and other for-profits, were eligible applicants.
Are foreign (non-U.S.) institutions eligible to apply?
No. The FOA restricted foreign involvement. Non-U.S. (foreign) institutions were not eligible to apply.
Can a U.S. organization include non-U.S. components in its application?
No. The FOA specified that non-U.S. components of U.S. organizations were not eligible, and foreign components (as NIH defines them) were not allowed.
Is cost sharing or matching required?
No. The FOA stated that no cost sharing or matching was required.
When was this FOA posted and created?
The FOA was posted and created on July 2, 2014.
What were the closing dates for this FOA?
The FOA had an original and final closing date of September 7, 2017.
Is this funding opportunity still active?
No. This FOA is no longer active. It was archived on October 8, 2017.
Where was the full announcement available?
The primary access point for the full archived announcement was the NIH grants guide page linked in the source information.
Who should be contacted for technical issues accessing the announcement?
For technical issues accessing the announcement, the contact provided was the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
Browse more opportunities from the same category: Food and Nutrition Health Income Security and Social Services
Next opportunity: Innovative Therapies and Tools for Screenable Disorders in Newborns (R03)
Previous opportunity: Innovative Therapies and Tools for Screenable Disorders in Newborns (R21)
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| Small Business Innovation Research to Develop New Therapeutics and Monitoring Technologies for Type 1 Diabetes (T1D). Towards an Artificial Pancreas (SBIR) (R43/R44) Apply for RFA DK 10 008 Funding Number: RFA DK 10 008 Agency: National Institutes of Health Category: Food and Nutrition Health Income Security and Social Services Funding Amount: Case Dependent |
| Innovative Therapies and Tools for Screenable Disorders in Newborns (R01) Apply for PAR 10 230 Funding Number: PAR 10 230 Agency: National Institutes of Health Category: Food and Nutrition Health Income Security and Social Services Funding Amount: Case Dependent |
| Innovative Therapies and Tools for Screenable Disorders in Newborns (R21) Apply for PAR 10 232 Funding Number: PAR 10 232 Agency: National Institutes of Health Category: Food and Nutrition Health Income Security and Social Services Funding Amount: $200,000 |
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| Lifestyle Interventions in Overweight and Obese Pregnant Women Consortium (U01) Apply for RFA DK 10 014 Funding Number: RFA DK 10 014 Agency: National Institutes of Health Category: Food and Nutrition Health Income Security and Social Services Funding Amount: Case Dependent |
| Feasibility Studies for Clinical Trials in Type 1 Diabetes (R03) Apply for RFA DK 11 007 Funding Number: RFA DK 11 007 Agency: National Institutes of Health Category: Food and Nutrition Health Income Security and Social Services Funding Amount: $50,000 |
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