Opportunity Information: Apply for PAR 14 269
Apply for PAR 14 269
- The National Institutes of Health in the health income security and social services sector is offering a public funding opportunity titled "Innovative Therapies and Tools for Screenable Disorders in Newborns (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Jul 2, 2014 and posted on Jul 2, 2014.
- Applicants must submit their applications by Sep 7, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Public and State controlled institutions of higher education Independent school districts For profit organizations other than small businesses Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Others (see text field entitled Additional Information on Eligibility for clarification) County governments Special district governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Small businesses State governments Public housing authorities/Indian housing authorities Native American tribal organizations (other than Federally recognized tribal governments).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Foreign Institutions Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
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Opportunity Summary:
The NIH funding opportunity PAR 14 269, titled "Innovative Therapies and Tools for Screenable Disorders in Newborns (R21)," supports early stage, exploratory research aimed at improving treatments and practical tools for disorders that are already part of newborn screening panels, as well as certain genetic conditions that could realistically become screenable in the near future. The central idea is to accelerate the development of therapies and intervention strategies so that early identification through newborn screening actually leads to meaningful health benefits. In this context, the announcement defines a "high priority" condition as one where having an effective therapy would be the key factor that makes newborn screening worthwhile and appropriate, because screening is most impactful when it can trigger timely treatment that changes outcomes.
This opportunity uses the NIH Exploratory/Developmental Research Grant mechanism (R21), which is typically designed for proof of concept, early validation, and other development work that may be too preliminary for larger, more definitive awards. Projects under this FOA are expected to focus on research that strengthens the basic understanding of screened or potentially screenable disorders and translates that knowledge into therapeutic approaches, intervention methods, or enabling tools. The emphasis is on innovation and development: work that can open new therapeutic directions, refine emerging interventions, or create capabilities that help therapies reach newborns and infants earlier and more effectively.
Administrative details show that this is a discretionary grant program in the Health category, listed under CFDA 93.865 (Child Health and Human Development Extramural Research) and run through the National Institutes of Health. Cost sharing or matching is not required. The award ceiling listed is $200,000, indicating a relatively modest budget scale consistent with exploratory projects rather than large clinical trials or multi site programs.
Eligibility is broad and includes many types of domestic U.S. organizations and governments. Eligible applicants include public and state controlled institutions of higher education, private institutions of higher education, nonprofits (including 501(c)(3) organizations and certain nonprofits without 501(c)(3) status), for profit organizations other than small businesses, small businesses, independent school districts, and a wide range of government entities such as city or township governments, county governments, special district governments, and state governments. Tribal eligibility is also extensive, covering federally recognized Native American tribal governments as well as tribal organizations that are not federally recognized, along with tribally controlled colleges and universities. The FOA also explicitly includes various mission serving and community based categories such as HBCUs, Hispanic serving institutions, Alaska Native and Native Hawaiian serving institutions, and Asian American Native American Pacific Islander serving institutions, as well as faith based or community based organizations, regional organizations, U.S. territories or possessions, and eligible federal agencies.
Foreign participation is restricted. Foreign institutions and other non U.S. entities are not eligible to apply, non domestic components of U.S. organizations are not eligible, and foreign components (as defined by NIH policy) are not allowed. In practice, this means the applicant organization and the proposed work must be structured so the project remains domestic under NIH rules.
Timing information in the source indicates the FOA was posted and created on July 2, 2014, with an original and final closing date of September 7, 2017, and an archive date of October 8, 2017. That means the specific announcement is no longer open for applications today, but it can still be useful as a reference point for understanding NIH priorities in newborn screening related therapeutics and for finding newer, related funding opportunities.
For access and technical issues, the listing points applicants to the NIH Office of Extramural Research (OER) webmaster contacts for help reaching the full announcement and resolving broken links. The full FOA text was hosted through the NIH grants policy and guide page referenced in the additional information link.
Frequently Asked Questions (FAQs) - NIH PAR 14-269: Innovative Therapies and Tools for Screenable Disorders in Newborns (R21)
What is the funding opportunity PAR 14-269?
PAR 14-269 is an NIH Funding Opportunity Announcement (FOA) titled "Innovative Therapies and Tools for Screenable Disorders in Newborns (R21)." It supports early-stage, exploratory research intended to improve therapies and practical tools for disorders that are already included in newborn screening panels, as well as certain genetic conditions that could realistically become screenable in the near future.
What is the main goal of this FOA?
The main goal is to accelerate development of therapies and intervention strategies so that early identification through newborn screening leads to meaningful health benefits. The FOA emphasizes the idea that screening is most impactful when it can trigger timely treatment that changes outcomes for newborns and infants.
What types of conditions does this FOA focus on?
The FOA focuses on (1) disorders already on newborn screening panels and (2) certain genetic conditions that could realistically become screenable in the near future. The program prioritizes conditions where an effective therapy would make newborn screening worthwhile and appropriate.
What does the FOA mean by a "high priority" condition?
In this announcement, a "high priority" condition is one where having an effective therapy would be the key factor that makes newborn screening worthwhile and appropriate. The rationale is that screening is most valuable when it leads directly to timely treatment that improves health outcomes.
What grant mechanism does PAR 14-269 use?
This opportunity uses the NIH Exploratory/Developmental Research Grant mechanism (R21). The R21 mechanism is generally intended for proof-of-concept research, early validation studies, and other developmental work that may be too preliminary for larger and more definitive NIH awards.
What stage of research is this FOA intended to support?
The FOA is intended to support early-stage, exploratory, and developmental work. It is positioned for projects that help establish feasibility, generate early evidence, or create new approaches and capabilities rather than large, definitive efforts.
What kinds of projects are expected under this FOA?
Projects are expected to strengthen the basic understanding of screened or potentially screenable disorders and translate that knowledge into therapeutic approaches, intervention methods, or enabling tools. The emphasis is on innovation and development that can open new therapeutic directions, refine emerging interventions, or create capabilities that help therapies reach newborns and infants earlier and more effectively.
Does the FOA emphasize therapies, tools, or both?
Both. The title and description highlight innovative therapies and practical tools, with a consistent emphasis on translating knowledge into therapeutic approaches, intervention strategies, or enabling tools that support earlier and more effective treatment following newborn screening.
What is the award ceiling listed for this opportunity?
The listing indicates an award ceiling of $200,000, reflecting a relatively modest budget scale consistent with exploratory R21 projects rather than large clinical trials or multi-site programs.
Is cost sharing or matching required?
No. Cost sharing or matching is not required for this program, based on the administrative details provided.
What is the CFDA number associated with this program?
The program is listed under CFDA 93.865, identified as Child Health and Human Development Extramural Research.
Which federal agency runs this opportunity?
The opportunity is run through the National Institutes of Health (NIH).
What category is this grant listed under?
The listing describes this as a discretionary grant program in the Health category.
Who is eligible to apply?
Eligibility is broad and includes many types of domestic U.S. organizations and governments. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (including 501(c)(3) organizations and certain nonprofits without 501(c)(3) status), for-profit organizations other than small businesses, small businesses, independent school districts, and multiple types of government entities.
Are state and local governments eligible?
Yes. The eligibility list includes city or township governments, county governments, special district governments, and state governments.
Are tribal governments and tribal organizations eligible?
Yes. Tribal eligibility is extensive and includes federally recognized Native American tribal governments, tribal organizations that are not federally recognized, and tribally controlled colleges and universities.
Are minority-serving institutions and mission-serving organizations included as eligible applicants?
Yes. The FOA explicitly includes categories such as HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and Asian American Native American Pacific Islander-serving institutions. It also includes faith-based or community-based organizations and regional organizations.
Are U.S. territories or possessions eligible?
Yes. The eligibility description explicitly includes U.S. territories or possessions.
Are federal agencies eligible to apply?
Yes. The eligibility list includes eligible federal agencies.
Can foreign institutions apply?
No. Foreign institutions and other non-U.S. entities are not eligible to apply under this FOA.
Are non-domestic components of U.S. organizations allowed?
No. The FOA states that non-domestic components of U.S. organizations are not eligible.
Are foreign components allowed under NIH policy for this FOA?
No. The FOA indicates that foreign components (as defined by NIH policy) are not allowed.
What do the foreign participation restrictions mean in practical terms?
Based on the description provided, the applicant organization and the proposed work must be structured so the project remains domestic under NIH rules. Non-U.S. entities cannot apply, and the project cannot include non-domestic components or foreign components as defined by NIH policy.
When was PAR 14-269 posted, and is it still open?
The FOA was posted and created on July 2, 2014. The original and final closing date listed is September 7, 2017, and the archive date is October 8, 2017. This means the specific announcement is no longer open for applications today.
If the FOA is closed, why is it still useful?
Even though it is archived and no longer open, it can still serve as a reference point for understanding NIH priorities in newborn screening-related therapeutics and tools, and for informing searches for newer, related funding opportunities.
Where was the full FOA text hosted?
The full FOA text was hosted through the NIH Grants Policy and Guide page referenced in the additional information link described in the source.
Who should applicants contact for access issues or broken links?
For access and technical issues, the listing points to NIH Office of Extramural Research (OER) webmaster contacts for help reaching the full announcement and resolving broken links.
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Applicants also applied for:
Applicants who have applied for this opportunity (PAR 14 269) also looked into and applied for these:
| Funding Opportunity |
|---|
| Innovative Therapies and Tools for Screenable Disorders in Newborns (R03) Apply for PAR 14 271 Funding Number: PAR 14 271 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $50,000 |
| Pharmacogenetics, Pharmacoepigenetics and Personalized Medicine in Children (R01) Apply for PAR 14 274 Funding Number: PAR 14 274 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Medically Assisted Reproduction Investigation of Mechanisms Underlying the Adverse Outcomes and Development of New and Improved Methods to Overcome the Adverse Outcomes (R01) Apply for PAR 14 272 Funding Number: PAR 14 272 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Medically Assisted Reproduction Investigation of Mechanisms Underlying the Adverse Outcomes and Development of New and Improved Methods to Overcome the Adverse Outcomes (R21) Apply for PAR 14 273 Funding Number: PAR 14 273 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $200,000 |
| Pediatric Cardiac Genomics Consortium (UM1) Apply for RFA HL 15 012 Funding Number: RFA HL 15 012 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $269,000 |
| In vivo Methods for Assessing Placental Development and Function (SBIR) R43/R44 Apply for RFA HD 15 018 Funding Number: RFA HD 15 018 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| In vivo Methods for Assessing Placental Development and Function (STTR) R41/R42 Apply for RFA HD 15 019 Funding Number: RFA HD 15 019 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $2,000,000 |
| Obstetric Fetal Pharmacology Research Centers (OPRC) (U54) Apply for RFA HD 14 013 Funding Number: RFA HD 14 013 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $4,800,000 |
| Patient Safety in the Context of Perinatal, Neonatal, and Pediatric Care (R01) Apply for PA 14 312 Funding Number: PA 14 312 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Patient Safety in the Context of Perinatal, Neonatal, and Pediatric Care (R21) Apply for PA 14 311 Funding Number: PA 14 311 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Patient Safety in the Context of Perinatal, Neonatal, and Pediatric Care (R03) Apply for PA 14 313 Funding Number: PA 14 313 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $50,000 |
| NICHD Consortium for Research on Pediatric Trauma and Injury Prevention (R24) Apply for PAR 14 324 Funding Number: PAR 14 324 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $750,000 |
| Improving Health through Rehabilitation Robotic Technology (R43/R44) Apply for RFA HD 15 001 Funding Number: RFA HD 15 001 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
| Tools for Assessment and Improvement of Neurologic Outcomes in Perinatal Medicine (R41) Apply for RFA HD 15 005 Funding Number: RFA HD 15 005 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $150,000 |
| Tools for Assessment and Improvement of Neurologic Outcomes in Perinatal Medicine (R43) Apply for RFA HD 15 006 Funding Number: RFA HD 15 006 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $150,000 |
| Senator Paul D. Wellstone Muscular Dystrophy Cooperative Research Centers (U54) Apply for RFA AR 15 002 Funding Number: RFA AR 15 002 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $1,000,000 |
| Biomarkers of Alzheimers Disease in Down Syndrome (R01) Apply for RFA AG 15 011 Funding Number: RFA AG 15 011 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $2,500,000 |
| Biomedical/Biobehavioral Research Administration Development (BRAD) Award (G11) Apply for PAR 14 333 Funding Number: PAR 14 333 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $85,000 |
| Consortium on Biomarker and Outcome Measures of Social Impairment for Use in Clinical Trials in Autism Spectrum Disorder (U19) Apply for RFA MH 15 800 Funding Number: RFA MH 15 800 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: $5,250,000 |
| Studies in Neonatal and Pediatric Resuscitation (R01) Apply for PA 14 350 Funding Number: PA 14 350 Agency: National Institutes of Health Category: Health Income Security and Social Services Funding Amount: Case Dependent |
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