Opportunity Information: Apply for RFA RM 11 001
Apply for RFA RM 11 001
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Integrating Comparative Effectiveness Research Findings into Care Delivery through Economic Incentives (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310 Trans NIH Research Support.
- This funding opportunity was created on Nov 12, 2010 and posted on Nov 12, 2010.
- Applicants must submit their applications by Jan 18, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $1,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled Additional Information on Eligibility for clarification) Small businesses State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Public housing authorities/Indian housing authorities County governments Native American tribal governments (Federally recognized) Special district governments Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Private institutions of higher education For profit organizations other than small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
Integrating Comparative Effectiveness Research Findings into Care Delivery through Economic Incentives (R21) (Funding Opportunity Number RFA-RM-11-001) was a National Institutes of Health (NIH) grant opportunity designed to support early-stage, exploratory studies on how comparative effectiveness research (CER) can be translated into real changes in U.S. health care delivery through the use of economic incentives. The basic premise of the announcement is that CER findings are often available but not consistently used in day-to-day clinical decision-making, and that better-aligned incentives for providers, patients/consumers, and payers could help move evidence into practice. The aim is not simply to generate more clinical evidence, but to study how to embed existing CER evidence into the financial and organizational environment that shapes behavior across the health system, with the dual goal of improving care quality and slowing health care cost growth.
This FOA specifically targeted research that would advance knowledge about incentive-driven pathways for adoption of CER findings. In practical terms, that means applicants were expected to explore questions like how payment models, insurance benefit design, performance measurement, and other economic levers could be structured so that clinicians and health care organizations have clearer reasons to follow evidence-based approaches, patients face fewer barriers to choosing high-value care, and payers can encourage effective care without blunt cost-cutting. The announcement emphasized “meaningful changes in clinical practice,†reflecting an expectation that funded projects would focus on mechanisms that can plausibly shift real-world decisions rather than purely theoretical models. Because it was an R21 mechanism, the intent was to fund developmental work, proof-of-concept studies, pilots, or innovative methods that could later be scaled or tested more definitively.
The opportunity sat within the NIH Common Fund initiative on Health Economics for Health Care Reform, signaling an emphasis on policy-relevant, system-level economic research tied to contemporary reform efforts. In that context, this FOA can be read as encouraging interdisciplinary work at the intersection of health economics, implementation science, outcomes research, and health services research, particularly where financial incentives interact with clinical behavior. Rather than treating “incentives†narrowly, the scope implicitly includes the broader set of economic signals that influence decision-making, such as reimbursement rules, patient cost-sharing structures, provider bonuses or penalties, and payer contracting approaches that can encourage uptake of higher-value practices supported by CER.
From an administrative standpoint, it was a discretionary grant opportunity using the NIH R21 funding instrument type (exploratory/developmental). The activity category was Health, and the CFDA number associated with the program was 93.310 (Trans-NIH Research Support). The FOA was posted on November 12, 2010, with an application closing date of January 18, 2011, and it was later archived on February 18, 2011, meaning it was a time-limited solicitation rather than an open-ended standing program announcement. The estimated total funding amount listed was $1,000,000, and the award ceiling was $200,000, which indicates a relatively small, pilot-oriented portfolio intended to seed multiple projects rather than fund large-scale trials.
Eligibility was broad and included many types of U.S. and non-U.S. organizations. Eligible applicants included state, county, city/township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations (both 501(c)(3) and non-501(c)(3), excluding higher education where specified); small businesses and other for-profit organizations (other than small businesses); public housing authorities/Indian housing authorities; and multiple categories of tribal entities, including federally recognized tribal governments and other Native American tribal organizations. The FOA also explicitly noted additional eligible applicant categories such as historically black colleges and universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, tribally controlled colleges and universities (TCCUs), faith-based or community-based organizations, regional organizations, U.S. territories or possessions, eligible agencies of the federal government, and foreign organizations (non-domestic entities). The FOA stated there was no cost-sharing or matching requirement, reducing barriers for applicants who might not be able to provide institutional matching funds.
The primary agency contact listed for technical access issues was the NIH Office of Extramural Research (OER) Webmaster (FBOWebmaster@OD.NIH.GOV), and the full announcement was available through the NIH grants guide page referenced in the additional information link. Overall, the opportunity was structured to stimulate innovative, early-stage research on how to turn CER results into routine, value-improving care by studying and designing the economic incentives that shape provider, consumer, and payer behavior across the U.S. health care system.
Frequently Asked Questions (FAQs)
What is the purpose of this funding opportunity?
This NIH grant opportunity, titled "Integrating Comparative Effectiveness Research Findings into Care Delivery through Economic Incentives (R21)" (Funding Opportunity Number RFA-RM-11-001), was designed to support early-stage, exploratory studies on how to translate existing comparative effectiveness research (CER) findings into real changes in U.S. health care delivery by using economic incentives.
What problem is the FOA trying to address?
The FOA is based on the premise that CER findings are often available but not consistently used in everyday clinical decision-making. It seeks research on how better-aligned economic incentives for providers, patients/consumers, and payers could help move evidence into practice, improving quality while slowing health care cost growth.
Is this opportunity intended to generate new clinical evidence?
No. The announcement emphasizes that the aim is not simply to generate more clinical evidence. Instead, it focuses on studying how to embed existing CER evidence into the financial and organizational environment that influences behavior across the health system.
What types of research topics were encouraged under this FOA?
The FOA specifically targeted research that advances knowledge about incentive-driven pathways for adoption of CER findings. Examples of the kinds of topics emphasized include how payment models, insurance benefit design, performance measurement, and other economic levers could be structured to encourage evidence-based care and reduce barriers to high-value choices.
What does the FOA mean by “economic incentives�
The scope includes a broad set of economic signals that influence decision-making in health care, such as reimbursement rules, patient cost-sharing structures, provider bonuses or penalties, and payer contracting approaches that may encourage uptake of higher-value practices supported by CER.
What does “meaningful changes in clinical practice†imply for project design?
It indicates an expectation that funded projects would focus on mechanisms that can plausibly shift real-world decisions and day-to-day clinical practice, rather than being limited to purely theoretical models.
What is the NIH activity mechanism used for this opportunity?
This was an NIH R21 mechanism, which is an exploratory/developmental research grant intended to support early-stage work such as pilots, proof-of-concept studies, developmental research, and innovative methods that could later be scaled or tested more definitively.
How does this FOA relate to broader NIH initiatives?
The opportunity sat within the NIH Common Fund initiative on Health Economics for Health Care Reform, indicating an emphasis on policy-relevant, system-level economic research linked to health care reform efforts.
What disciplines or research areas did this FOA implicitly encourage?
Based on the description, it encouraged interdisciplinary work at the intersection of health economics, implementation science, outcomes research, and health services research, particularly where financial incentives interact with clinical behavior.
What is the CFDA number associated with this program?
The CFDA number associated with the program was 93.310 (Trans-NIH Research Support).
When was the FOA posted, and what were the key dates?
The FOA was posted on November 12, 2010. The application closing date was January 18, 2011. It was later archived on February 18, 2011, indicating it was a time-limited solicitation rather than an ongoing program announcement.
What was the estimated total funding amount for this opportunity?
The estimated total funding amount listed was $1,000,000.
What was the award ceiling for individual grants?
The award ceiling was $200,000, which suggests a small, pilot-oriented set of awards intended to seed multiple projects rather than fund large-scale trials.
What was the activity category?
The activity category was Health.
Was cost sharing or matching required?
No. The FOA stated there was no cost-sharing or matching requirement.
What types of organizations were eligible to apply?
Eligibility was broad and included many U.S. and non-U.S. organizations. Eligible applicants included state, county, city/township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations (both 501(c)(3) and non-501(c)(3), excluding higher education where specified); small businesses; other for-profit organizations; public housing authorities/Indian housing authorities; and tribal entities including federally recognized tribal governments and other Native American tribal organizations.
Were foreign (non-U.S.) organizations eligible to apply?
Yes. The FOA explicitly included foreign organizations (non-domestic entities) among eligible applicant categories.
Did the FOA call out any specific institution types as eligible?
Yes. It explicitly noted additional eligible categories such as historically black colleges and universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, tribally controlled colleges and universities (TCCUs), faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and eligible agencies of the federal government.
Who was the primary contact for technical access issues?
The primary agency contact listed for technical access issues was the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
Where could applicants find the full announcement?
The full announcement was available through the NIH grants guide page referenced in the additional information link noted in the opportunity description.
Is this FOA still active?
No. It was archived on February 18, 2011, and had a defined application closing date of January 18, 2011, indicating it was not an open-ended, continuously accepting program announcement.
What overall outcome was this opportunity trying to stimulate?
Overall, it was structured to stimulate innovative, early-stage research on how to make CER results part of routine care by studying and designing the economic incentives that shape provider, consumer, and payer behavior, with the dual goal of improving care quality and slowing health care cost growth.
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