Opportunity Information: Apply for PAR 12 155
Apply for PAR 12 155
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Integrative Omics Data Analysis for Discovery in Lung Diseases (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.233 National Center on Sleep Disorders Research 93.838 Lung Diseases Research.
- This funding opportunity was created on Apr 10, 2012 and posted on Apr 10, 2012.
- Applicants must submit their applications by Jun 19, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: For profit organizations other than small businesses Native American tribal governments (Federally recognized) Private institutions of higher education County governments Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments City or township governments Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Small businesses Others (see text field entitled Additional Information on Eligibility for clarification) State governments Public and State controlled institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Integrative Omics Data Analysis for Discovery in Lung Diseases (R01) funding opportunity (PAR-12-155) was a discretionary NIH research grant program led by the National Heart, Lung, and Blood Institute (NHLBI). Its central goal was to push lung disease research beyond single-dataset findings by encouraging investigators to combine multiple existing "omics" data types (such as genomics, transcriptomics, proteomics, and metabolomics) into integrative, systems-level analyses. The intent was to move from lists of genes or molecules to coherent models that explain how biological networks and pathways drive pulmonary disease processes, including disease initiation, progression, and response to exposures or treatment.
A key emphasis of the announcement was the creation of systems-level models of pulmonary pathobiology built specifically from integrative analyses of already available datasets, rather than focusing primarily on generating entirely new omics data. Applicants were expected to use computational and statistical approaches to connect signals across different omics layers, identify relationships that would be hard to detect in isolation, and produce testable mechanistic hypotheses. In addition to the informatics work, the opportunity explicitly required experimental follow-up: investigators were expected to experimentally validate novel predictions that emerged from their integrative models using human tissues and/or cells and/or mammalian animal models. In practice, this meant the computational component and the biological validation component were meant to be tightly linked, with modeling producing concrete predictions and experiments designed to confirm or refute them.
The activity mechanism was an R01, meaning it supported full research projects rather than small pilot studies, and it fell under NIH health-related research activities. It was associated with CFDA numbers 93.838 (Lung Diseases Research) and 93.233 (National Center on Sleep Disorders Research), reflecting the broader NHLBI mission areas potentially relevant to lung biology and related conditions. There was no cost-sharing or matching requirement, which is typical for many NIH investigator-initiated research grants.
Eligibility was broad and included a wide range of domestic U.S. organizations and government entities, as well as foreign institutions and foreign components as allowed under the NIH Grants Policy Statement. Eligible applicants included public and private institutions of higher education, nonprofit organizations (including 501(c)(3) and certain non-501(c)(3) nonprofits), for-profit organizations (including small businesses and other for-profits), and multiple levels of government (state, county, city/township, special districts, and others). The opportunity also explicitly included a variety of mission-focused and community-anchored institutions and organizations, such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, tribal governments and tribal organizations, faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and federal agencies.
Administratively, the opportunity was posted and created on April 10, 2012, with an original and final closing date of June 19, 2014, and it was archived on July 20, 2014. The full announcement was made available through the NIH grants guide at http://grants.nih.gov/grants/guide/pa-files/PAR-12-155.html. For technical issues accessing the announcement or links, the contact listed was the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
Overall, this R01 opportunity was designed for projects that combine rigorous integrative omics analytics with real biological testing in relevant lung disease systems, aiming to uncover network-level mechanisms and actionable, experimentally supported insights into pulmonary diseases.
Frequently Asked Questions (FAQs)
What is the Integrative Omics Data Analysis for Discovery in Lung Diseases (R01) opportunity?
It was a discretionary NIH research grant program titled "Integrative Omics Data Analysis for Discovery in Lung Diseases (R01)" under funding opportunity number PAR-12-155, led by the National Heart, Lung, and Blood Institute (NHLBI).
What was the main goal of PAR-12-155?
The central goal was to move lung disease research beyond single-dataset findings by supporting integrative, systems-level analyses that combine multiple existing omics data types to produce coherent models of lung disease biology.
What types of data were meant by "omics" in this announcement?
The opportunity referenced multiple existing omics data types, including examples such as genomics, transcriptomics, proteomics, and metabolomics.
What did "integrative" analysis mean in this context?
What kinds of scientific outputs was the program trying to promote?
The program emphasized producing systems-level models and network/pathway-based explanations of pulmonary disease processes, rather than only generating lists of genes, molecules, or individual associations.
What aspects of lung disease biology were specifically mentioned as in scope?
The description highlighted pulmonary disease initiation, disease progression, and responses to exposures or treatment as examples of disease processes that the integrative models could help explain.
Was the focus on generating new omics data or analyzing existing data?
A key emphasis was on building systems-level models from integrative analyses of already available datasets, rather than focusing primarily on generating entirely new omics data.
Were applicants expected to perform experimental work, or was it purely computational?
Experimental follow-up was explicitly required. Investigators were expected to experimentally validate novel predictions that emerged from their integrative models.
What kinds of experimental validation systems were allowed or expected?
The announcement specified experimental validation using human tissues and/or cells and/or mammalian animal models.
How were the computational and experimental components intended to relate to each other?
They were meant to be tightly linked: modeling was expected to generate concrete, testable predictions, and experiments were expected to confirm or refute those predictions.
What is the activity mechanism for this opportunity?
The activity mechanism was an R01, supporting full research projects (not described as small pilot studies) under NIH health-related research activities.
Which institute led this funding opportunity?
The opportunity was led by the National Heart, Lung, and Blood Institute (NHLBI).
Which CFDA numbers were associated with this opportunity?
It was associated with CFDA 93.838 (Lung Diseases Research) and CFDA 93.233 (National Center on Sleep Disorders Research).
Was cost sharing or matching required?
No. The opportunity stated there was no cost-sharing or matching requirement.
Who was eligible to apply?
Eligibility was broad and included a wide range of domestic U.S. organizations and government entities, as well as foreign institutions and foreign components as allowed under the NIH Grants Policy Statement.
What types of U.S. organizations were included as eligible applicants?
Eligible applicants included public and private institutions of higher education; nonprofit organizations (including 501(c)(3) and certain non-501(c)(3) nonprofits); for-profit organizations (including small businesses and other for-profits); and multiple levels of government.
Which levels of government were listed as eligible?
The eligibility list included state, county, city/township, special district governments, and other government entities.
Were minority-serving institutions and community-anchored organizations included?
Yes. The opportunity explicitly included mission-focused and community-anchored institutions and organizations such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and others listed in the announcement summary.
Were tribal governments and tribal organizations eligible?
Yes. Tribal governments and tribal organizations were explicitly included among eligible applicants.
Were faith-based and community-based organizations eligible?
Yes. Faith-based or community-based organizations were explicitly listed among eligible applicants.
Could U.S. territories or possessions apply?
Yes. U.S. territories or possessions were explicitly included in the eligibility description.
Were federal agencies listed as eligible applicants?
Yes. Federal agencies were included among the entities described as eligible.
Were foreign institutions allowed to apply?
Yes. Foreign institutions and foreign components were allowed as permitted under the NIH Grants Policy Statement.
When was this opportunity posted and created?
It was posted and created on April 10, 2012.
What were the closing dates for applications?
The original and final closing date listed was June 19, 2014.
When was the opportunity archived?
It was archived on July 20, 2014.
Where could applicants find the full announcement?
The full announcement was available through the NIH Grants Guide at http://grants.nih.gov/grants/guide/pa-files/PAR-12-155.html.
Who was the contact for technical issues accessing the announcement or links?
The listed contact for technical issues was the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
What kind of projects was PAR-12-155 designed to support overall?
It was designed to support projects that combine rigorous integrative omics analytics with real biological testing in relevant lung disease systems, aiming to uncover network-level mechanisms and generate actionable, experimentally supported insights into pulmonary diseases.
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