Opportunity Information: Apply for RFA AI 11 046
Apply for RFA AI 11 046
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "International Centers of Excellence for Malaria Research (ICEMR) Competitive Revision (U19)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.855 Allergy and Infectious Diseases Research 93.856 Microbiology and Infectious Diseases Research.
- This funding opportunity was created on Aug 10, 2011 and posted on Aug 10, 2011.
- Applicants must submit their applications by Jan 12, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $250,000.00 in funding.
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
- Other Eligible Applicants include the following Eligible Organizations Eligible institutions are current NIAID awardees of the ICEMR program. Foreign Institutions Eligible foreign institutions are current NIAID awardees of the ICEMR program.
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Opportunity Summary:
The International Centers of Excellence for Malaria Research (ICEMR) Competitive Revision (U19) opportunity (Funding Opportunity Number RFA-AI-11-046) is a National Institutes of Health (NIH), National Institute of Allergy and Infectious Diseases (NIAID) funding announcement that invites competitive revision applications from currently funded ICEMR cooperative agreement awardees. Rather than creating brand-new ICEMR centers, this call is designed to expand and strengthen the work already underway in existing ICEMR awards by adding a new, focused immunology research project. The intent is to leverage the established infrastructure, field sites, and well-characterized cohorts that ICEMRs have built, and then connect those resources more directly with cutting-edge immunology expertise.
The central scientific purpose is to accelerate progress on understanding immunity to malaria at a detailed cellular and molecular level. The FOA emphasizes fostering true collaborations between immunologists and ICEMR investigators so that immunology-driven questions can be answered using real-world cohorts and longitudinal data already being collected. In practical terms, applicants are expected to propose an additional immunology project that increases the overall research activity of their current ICEMR and uses existing cohorts to investigate how protective immunity develops, why it sometimes fails, and what immune responses can be measured as credible indicators of protection.
Key research aims highlighted in the announcement include defining the cellular and molecular events involved in generating protective immunity to malaria, identifying mechanisms that could induce long-term immunity, and clarifying mechanisms of immune pathogenesis as well as immune-mediated protection. The FOA also points to transmission-related immunity, encouraging studies on immune mechanisms that interrupt transmission (for example, immune responses that reduce parasite carriage or gametocyte transmission potential) and efforts to determine correlates of protective immunity. These correlates are especially valuable because they can guide vaccine development, help interpret clinical and epidemiological findings, and improve how interventions are evaluated in endemic settings.
From an administrative standpoint, the award mechanism is a cooperative agreement (U19), which generally means the NIH anticipates an active partnership role with funded projects compared with a standard research grant. The opportunity is categorized as discretionary funding, with activity areas aligned to CFDA 93.855 (Allergy and Infectious Diseases Research) and 93.856 (Microbiology and Infectious Diseases Research). No cost sharing or matching is required. The estimated total funding amount listed is $2,000,000, with an award ceiling of $250,000, indicating that supported revisions are intended to be targeted additions to existing center activities rather than full-scale new center awards.
Eligibility is narrowly limited to current NIAID ICEMR awardees, including eligible foreign institutions, as long as they are existing ICEMR program award recipients. The application window for this archived FOA shows a posted and created date of August 10, 2011, an original and current closing date of January 12, 2012, and an archive date of February 12, 2012. Applicants seeking full details, requirements, and submission instructions were directed to the NIH grants guide announcement webpage referenced in the FOA, with NIH Office of Extramural Research (OER) webmaster contacts provided for access or linking issues.
FAQs: International Centers of Excellence for Malaria Research (ICEMR) Competitive Revision (U19) - RFA-AI-11-046
What is this funding opportunity?
This is a National Institutes of Health (NIH), National Institute of Allergy and Infectious Diseases (NIAID) funding announcement inviting competitive revision applications under the International Centers of Excellence for Malaria Research (ICEMR) program. The Funding Opportunity Number is RFA-AI-11-046, and the award mechanism is a U19 cooperative agreement revision.
Is this opportunity for creating new ICEMR centers?
No. This call is specifically designed to expand and strengthen work already underway in existing, currently funded ICEMR cooperative agreements by adding a new, focused immunology research project. It is not intended to establish brand-new ICEMR centers.
Who is eligible to apply?
Eligibility is limited to current NIAID ICEMR cooperative agreement awardees (existing ICEMR program award recipients). The announcement notes that eligible foreign institutions may apply, as long as they are current ICEMR awardees.
What type of application is required?
The announcement invites competitive revision applications from currently funded ICEMR awardees. The revision is expected to add an additional immunology project that increases overall research activity within the existing ICEMR award.
What is the main scientific purpose of the competitive revision?
The central purpose is to accelerate progress in understanding immunity to malaria at a detailed cellular and molecular level by adding immunology-focused research to an existing ICEMR. The FOA emphasizes connecting ICEMR infrastructure and cohorts with cutting-edge immunology expertise.
What kind of collaboration does the FOA emphasize?
The FOA stresses fostering true collaborations between immunologists and ICEMR investigators so that immunology-driven questions can be addressed using real-world cohorts, longitudinal data, and other established ICEMR resources.
What are applicants expected to propose?
Applicants are expected to propose an additional, focused immunology research project as part of their existing ICEMR. The project should leverage established infrastructure, field sites, and well-characterized cohorts already supported by the ICEMR.
Does the new project need to use existing ICEMR cohorts?
Yes. The FOA describes leveraging well-characterized cohorts and longitudinal data already being collected within ICEMRs to address immunology questions related to protective immunity, failed immunity, and measurable indicators of protection.
What research topics and aims are highlighted?
Highlighted aims include: defining cellular and molecular events involved in generating protective immunity to malaria; identifying mechanisms that could induce long-term immunity; and clarifying mechanisms of immune pathogenesis as well as immune-mediated protection.
Does the FOA mention transmission-related immunity?
Yes. The FOA encourages studies on immune mechanisms that interrupt transmission, such as immune responses that reduce parasite carriage or decrease gametocyte transmission potential.
What are "correlates of protective immunity" and why are they emphasized here?
The FOA emphasizes determining correlates of protective immunity, described as measurable immune responses that serve as credible indicators of protection. These correlates are valuable for guiding vaccine development, interpreting clinical and epidemiological findings, and improving evaluation of interventions in endemic settings.
What is the award mechanism, and what does it imply?
The mechanism is a U19 cooperative agreement. In general, a cooperative agreement indicates NIH anticipates having an active partnership role with funded projects compared with a standard research grant.
What are the related activity areas or CFDA listings?
The opportunity is aligned with CFDA 93.855 (Allergy and Infectious Diseases Research) and 93.856 (Microbiology and Infectious Diseases Research).
Is cost sharing or matching required?
No. The announcement states that no cost sharing or matching is required.
How much funding is available under this opportunity?
The estimated total funding amount listed is $2,000,000, and the award ceiling is $250,000. This framing indicates the supported revisions are intended as targeted additions to existing center activities.
Is this a current or archived opportunity?
The FOA is archived. The provided timeline shows it was posted/created on August 10, 2011, with an original and current closing date of January 12, 2012, and an archive date of February 12, 2012.
Where were applicants directed for full details and submission instructions?
Applicants were directed to the NIH grants guide announcement webpage referenced in the FOA for full details, requirements, and submission instructions.
Who was listed as a contact for access or linking issues?
The NIH Office of Extramural Research (OER) webmaster contacts were provided for access or linking issues related to the announcement webpage.
What is the overall intent of adding a focused immunology project to an ICEMR?
The intent is to use the ICEMR's established infrastructure, field sites, and cohorts and link them more directly with advanced immunology expertise to answer questions about how protective immunity develops, why it sometimes fails, and which immune responses can credibly indicate protection.
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